AU2700584A – Preparation of acemetacin
– Google Patents
AU2700584A – Preparation of acemetacin
– Google Patents
Preparation of acemetacin
Info
Publication number
AU2700584A
AU2700584A
AU27005/84A
AU2700584A
AU2700584A
AU 2700584 A
AU2700584 A
AU 2700584A
AU 27005/84 A
AU27005/84 A
AU 27005/84A
AU 2700584 A
AU2700584 A
AU 2700584A
AU 2700584 A
AU2700584 A
AU 2700584A
Authority
AU
Australia
Prior art keywords
acemetacin
preparation
acidic conditions
protecting group
under
Prior art date
1983-04-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU27005/84A
Other versions
AU562759B2
(en
Inventor
Yasuo Kikugawa
Yoshinori Kyotani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Kowa Co Ltd
Original Assignee
Troponwerke GmbH
Kowa Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1983-04-28
Filing date
1984-04-17
Publication date
1984-11-01
1984-04-17
Application filed by Troponwerke GmbH, Kowa Co Ltd
filed
Critical
Troponwerke GmbH
1984-11-01
Publication of AU2700584A
publication
Critical
patent/AU2700584A/en
1987-06-18
Application granted
granted
Critical
1987-06-18
Publication of AU562759B2
publication
Critical
patent/AU562759B2/en
2004-04-17
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
C07D209/04—Indoles; Hydrogenated indoles
C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
Y02P20/00—Technologies relating to chemical industry
Y02P20/50—Improvements relating to the production of bulk chemicals
Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
A process for preparing acemetacin which process comprises removing a protecting group, which is other than tetrahydropyranyl group and is removable under acidic conditions, from an acemetacin ester represented by the formula
AU27005/84A
1983-04-28
1984-04-17
Preparation of acemetacin
Ceased
AU562759B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
JP58075869A
JPS59204172A
(en)
1983-04-28
1983-04-28
Preparation of acemetacin
JP58-75869
1983-04-28
Publications (2)
Publication Number
Publication Date
AU2700584A
true
AU2700584A
(en)
1984-11-01
AU562759B2
AU562759B2
(en)
1987-06-18
Family
ID=13588693
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU27005/84A
Ceased
AU562759B2
(en)
1983-04-28
1984-04-17
Preparation of acemetacin
Country Status (16)
Country
Link
US
(1)
US4603210A
(en)
EP
(1)
EP0126942B1
(en)
JP
(1)
JPS59204172A
(en)
KR
(1)
KR910006125B1
(en)
AT
(1)
ATE30020T1
(en)
AU
(1)
AU562759B2
(en)
CA
(1)
CA1331602C
(en)
DE
(1)
DE3466535D1
(en)
DK
(1)
DK157539C
(en)
ES
(1)
ES531924A0
(en)
FI
(1)
FI78467C
(en)
GR
(1)
GR81853B
(en)
IE
(1)
IE57288B1
(en)
PH
(1)
PH20577A
(en)
PT
(1)
PT78477B
(en)
ZA
(1)
ZA843151B
(en)
Families Citing this family (6)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
CH653326A5
(en)
*
1981-12-28
1985-12-31
Siegfried Ag
METHOD FOR PRODUCING AN INDOLDER DERIVATIVE.
DE3416895A1
(en)
*
1984-05-08
1985-11-14
Bayer Ag, 5090 Leverkusen
METHOD FOR PRODUCING ACEMETACIN
DE3443993A1
(en)
*
1984-12-01
1986-06-05
Bayer Ag, 5090 Leverkusen
METHOD FOR PRODUCING NEW INDOLDER DERIVATIVES AND THE USE THEREOF
FI88500C
(en)
*
1991-11-18
1993-05-25
Orion Yhtymae Oy
Process for the preparation of 1- (p-chlorobenzoyl) -5-methoxy-2-methylindo-3-acetic acid carboxymethyl ester
US7989554B2
(en)
2006-01-10
2011-08-02
Enzon Pharmaceuticals, Inc.
Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
CN111960986A
(en)
*
2019-05-19
2020-11-20
河南东泰制药有限公司
Preparation method of acemetacin
Family Cites Families (12)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
CA837084A
(en)
*
1970-03-17
Sletzinger Meyer
Method for preparing indolylacetic acid esters
GB1176348A
(en)
*
1966-01-12
1970-01-01
Sumitomo Chemical Co
Indole Derivatives
US3564008A
(en)
*
1967-01-14
1971-02-16
Sumitomo Chemical Co
Process for preparing 1-acyl-2-phenyl-3-indolylaliphatic acid derivatives
US3483220A
(en)
*
1967-05-03
1969-12-09
Merck & Co Inc
Process for preparing 1-aroylindole-3-acetic acid compounds
DE2234651C3
(en)
*
1972-07-14
1978-11-09
Troponwerke Gmbh & Co Kg, 5000 Koeln
Square brackets on l- (p-chlorobenzoyl) -5-methoxy-2-methyl-3-indole] -acetoxj acetic acid, its salts with bases, processes for their production and pharmacological preparations
US4104278A
(en)
*
1972-11-25
1978-08-01
Troponwerke Dinklage & Co.
Process for the production of compounds with antiphlogistic activity
GB1531546A
(en)
*
1976-05-19
1978-11-08
Pierrel Spa
Anti-inflammatory indole derivative
JPS52156862A
(en)
*
1976-06-22
1977-12-27
Hisamitsu Pharmaceut Co Inc
Novel indoleacetic acid ester derivatives
DE2735537A1
(en)
*
1977-08-06
1979-02-22
Troponwerke Gmbh & Co Kg
INDOLACETOXYACETYLAMINO ACID DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND USE AS A MEDICINAL PRODUCT
IT1144692B
(en)
*
1981-04-03
1986-10-29
Unibios Spa
NEW PROCEDURE FOR THE PREPARATION OF 1-P-CHLOROBENZOIL-2-METHYL-5-METHOXY-2-INDOLACETOHYDROXAMIC ACID
CH653326A5
(en)
*
1981-12-28
1985-12-31
Siegfried Ag
METHOD FOR PRODUCING AN INDOLDER DERIVATIVE.
DE3206885A1
(en)
*
1982-02-26
1983-09-15
Troponwerke GmbH & Co KG, 5000 Köln
INDOLDER DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
1983
1983-04-28
JP
JP58075869A
patent/JPS59204172A/en
active
Granted
1984
1984-03-26
GR
GR74206A
patent/GR81853B/el
unknown
1984-04-11
US
US06/599,096
patent/US4603210A/en
not_active
Expired – Lifetime
1984-04-12
PH
PH30612A
patent/PH20577A/en
unknown
1984-04-16
DE
DE8484104281T
patent/DE3466535D1/en
not_active
Expired
1984-04-16
AT
AT84104281T
patent/ATE30020T1/en
not_active
IP Right Cessation
1984-04-16
EP
EP84104281A
patent/EP0126942B1/en
not_active
Expired
1984-04-17
AU
AU27005/84A
patent/AU562759B2/en
not_active
Ceased
1984-04-24
PT
PT78477A
patent/PT78477B/en
unknown
1984-04-26
CA
CA000452849A
patent/CA1331602C/en
not_active
Expired – Fee Related
1984-04-26
FI
FI841651A
patent/FI78467C/en
not_active
IP Right Cessation
1984-04-26
ES
ES531924A
patent/ES531924A0/en
active
Granted
1984-04-27
ZA
ZA843151A
patent/ZA843151B/en
unknown
1984-04-27
IE
IE1050/84A
patent/IE57288B1/en
not_active
IP Right Cessation
1984-04-27
KR
KR1019840002272A
patent/KR910006125B1/en
not_active
IP Right Cessation
1984-04-27
DK
DK212484A
patent/DK157539C/en
not_active
IP Right Cessation
Also Published As
Publication number
Publication date
PT78477B
(en)
1986-05-27
KR910006125B1
(en)
1991-08-13
FI841651A
(en)
1984-10-29
ES8603821A1
(en)
1986-01-01
DE3466535D1
(en)
1987-11-05
PT78477A
(en)
1984-05-01
DK157539B
(en)
1990-01-22
ATE30020T1
(en)
1987-10-15
US4603210A
(en)
1986-07-29
IE841050L
(en)
1984-10-28
EP0126942A1
(en)
1984-12-05
DK212484A
(en)
1984-10-29
ES531924A0
(en)
1986-01-01
DK212484D0
(en)
1984-04-27
JPS59204172A
(en)
1984-11-19
FI841651A0
(en)
1984-04-26
EP0126942B1
(en)
1987-09-30
PH20577A
(en)
1987-02-18
GR81853B
(en)
1984-12-12
IE57288B1
(en)
1992-07-15
FI78467C
(en)
1989-08-10
ZA843151B
(en)
1984-12-24
KR840008320A
(en)
1984-12-14
FI78467B
(en)
1989-04-28
DK157539C
(en)
1990-06-11
CA1331602C
(en)
1994-08-23
JPH0557265B2
(en)
1993-08-23
AU562759B2
(en)
1987-06-18
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Legal Events
Date
Code
Title
Description
2002-11-21
MK14
Patent ceased section 143(a) (annual fees not paid) or expired
