AU3236897A – Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
– Google Patents
AU3236897A – Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
– Google Patents
Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
Info
Publication number
AU3236897A
AU3236897A
AU32368/97A
AU3236897A
AU3236897A
AU 3236897 A
AU3236897 A
AU 3236897A
AU 32368/97 A
AU32368/97 A
AU 32368/97A
AU 3236897 A
AU3236897 A
AU 3236897A
AU 3236897 A
AU3236897 A
AU 3236897A
Authority
AU
Australia
Prior art keywords
apoptosis
modulation
isoxazole
halo
alkyl
Prior art date
1996-07-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU32368/97A
Other versions
AU718728B2
(en
Inventor
Claudia Dax
Stefan Mullner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1996-07-31
Filing date
1997-07-29
Publication date
1998-02-05
1996-10-01
Priority claimed from DE19640555A
external-priority
patent/DE19640555A1/en
1997-07-29
Application filed by Hoechst AG
filed
Critical
Hoechst AG
1998-02-05
Publication of AU3236897A
publication
Critical
patent/AU3236897A/en
2000-04-20
Application granted
granted
Critical
2000-04-20
Publication of AU718728B2
publication
Critical
patent/AU718728B2/en
2017-07-29
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/33—Heterocyclic compounds
A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
A61K31/445—Non condensed piperidines, e.g. piperocaine
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/275—Nitriles; Isonitriles
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/33—Heterocyclic compounds
A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
A61K31/42—Oxazoles
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/70—Carbohydrates; Sugars; Derivatives thereof
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K38/00—Medicinal preparations containing peptides
A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
A61K38/13—Cyclosporins
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 – A61K41/00
A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P11/00—Drugs for disorders of the respiratory system
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P13/00—Drugs for disorders of the urinary system
A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P13/00—Drugs for disorders of the urinary system
A61P13/12—Drugs for disorders of the urinary system of the kidneys
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P15/00—Drugs for genital or sexual disorders; Contraceptives
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P17/00—Drugs for dermatological disorders
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P31/04—Antibacterial agents
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P31/12—Antivirals
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P37/00—Drugs for immunological or allergic disorders
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/08—Vasodilators for multiple indications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Use of compounds of formula (I) or (II) and their salts is claimed for the modulation of apoptosis. R1 = 1-4C alkyl, 3-5C cycloalkyl, 2-6C alkenyl or 2-6C alkynyl; R2 = CF3, OCF3, SCF3, OH, NO2, halo, benzyl, phenyl, CN or phenoxy (optionally substituted by 1-4C alkyl, halo, OCF3 or OCH3); R3 = 1-4C alkyl, halo or H; and X = CH or N.
AU32368/97A
1996-07-31
1997-07-29
Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
Ceased
AU718728B2
(en)
Applications Claiming Priority (4)
Application Number
Priority Date
Filing Date
Title
DE19630838
1996-07-31
DE19630838
1996-07-31
DE19640555
1996-10-01
DE19640555A
DE19640555A1
(en)
1996-10-01
1996-10-01
Use of isoxazole-amide or croton-amide derivatives to modulate apoptosis
Publications (2)
Publication Number
Publication Date
AU3236897A
true
AU3236897A
(en)
1998-02-05
AU718728B2
AU718728B2
(en)
2000-04-20
Family
ID=26027963
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU32368/97A
Ceased
AU718728B2
(en)
1996-07-31
1997-07-29
Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
Country Status (10)
Country
Link
US
(1)
US6011051A
(en)
EP
(1)
EP0821952B1
(en)
JP
(1)
JPH1087484A
(en)
AT
(1)
ATE262901T1
(en)
AU
(1)
AU718728B2
(en)
CA
(1)
CA2212207C
(en)
DE
(1)
DE59711463D1
(en)
DK
(1)
DK0821952T3
(en)
ES
(1)
ES2218623T3
(en)
PT
(1)
PT821952E
(en)
Families Citing this family (11)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE19711800A1
(en)
*
1997-03-21
1998-09-24
Hoechst Ag
Extension of expression of transgenic proteins by immunomodulating treatment
DE19860802A1
(en)
*
1998-12-30
2000-10-26
Virgene Pharmaceuticals Ag
Production of an agent against hepatitis B, HI, Paramyxo and Orthomyxo viruses
WO2001021160A2
(en)
*
1999-09-23
2001-03-29
Axxima Pharmaceuticals Aktiengesellschaft
Carboxymide and aniline derivatives as selective inhibitors of pathogens
US6589992B2
(en)
1999-11-30
2003-07-08
Parker Hughes Institute
Inhibiting collagen-induced platelet aggregation
JP2003516351A
(en)
*
1999-11-30
2003-05-13
パーカー ヒューズ インスティテュート
Collagen-induced platelet aggregation inhibitor
US6458930B1
(en)
2000-11-28
2002-10-01
Cytokinetics, Inc.
Aspergillus fumigatus cofilin
GB0123571D0
(en)
2001-04-05
2001-11-21
Aventis Pharm Prod Inc
Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4′-trifluoromethylphenyl)-amide for treating multiple sclerosis
CN1329078C
(en)
2001-12-28
2007-08-01
阿斯比奥制药株式会社
Agents promoting proliferation and/or differentiation of hematopoietic stem cells and/or hematopoietic precursor cells
GB0224014D0
(en)
*
2002-10-15
2002-11-27
Oxford Glycosciences Uk Ltd
A protein involved in therapy
ES2398606T3
(en)
*
2007-05-03
2013-03-20
Pfizer Limited
2-Pyridine-carboxamide derivatives as modulators of sodium channels
ES2591355T3
(en)
*
2010-08-24
2016-11-28
Algiax Pharmaceuticals Gmbh
Novel use of leflunomide and malononitrilamides
Family Cites Families (19)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
NL186239B
(en)
*
1975-06-05
Hoechst Ag
PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT WITH ANTIFLOGISTICAL AND / OR ANALGETICAL ACTION AND PROCEDURE FOR THE PREPARATION OF A 2-HYDROXYETHYLIDE ENCYANAACETIC ANILIDE SUITABLE FOR USE IN THIS PROCESS.
DE3534440A1
(en)
*
1985-09-27
1987-04-02
Hoechst Ag
DRUGS AGAINST CHRONIC GRAFT VERSUS HOST DISEASES AND AUTO AUTO DISEASES, IN PARTICULAR SYSTEMIC LUPUS ERYTHEMATODES
US5268382A
(en)
*
1985-09-27
1993-12-07
Hoechst Aktiengesellschaft
Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
DD297328A5
(en)
*
1989-08-18
1992-01-09
�������@���������k���Kk��
5-METHYL-ISOXALOL-4-CARBONSAEANEANILIDE AND 2 HYDROXYETHYLIDENE CYANO ACID ACIDANILIDES FOR THE TREATMENT OF EYE DISEASES
US5494911A
(en)
*
1990-05-18
1996-02-27
Hoechst Aktiengesellschaft
Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
IL99811A
(en)
*
1990-10-30
1996-03-31
Roussel Uclaf
3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them
DE4127737A1
(en)
*
1991-08-22
1993-02-25
Hoechst Ag
MEDICINAL PRODUCTS FOR TREATMENT OF REPELLATION REACTIONS IN ORGAN PLANTING
NZ244814A
(en)
*
1991-10-23
1994-06-27
Hoechst Ag
N-phenyl-2-cyano-3-hydroxycrotonamide derivatives and pharmaceutical compositions
GB9200275D0
(en)
*
1992-01-08
1992-02-26
Roussel Lab Ltd
Chemical compounds
DE59407414D1
(en)
*
1993-01-08
1999-01-21
Hoechst Ag
Use of leflunomide to inhibit tumor necrosis factor alpha
ES2124799T3
(en)
*
1993-01-08
1999-02-16
Hoechst Ag
USE OF LEFLUNOMIDE FOR INTERLEUKIN 1 ALPHA INHIBITION.
EP0607775B1
(en)
*
1993-01-08
1998-12-09
Hoechst Aktiengesellschaft
Use of leflunomid for the inhibition of interleukin 1 beta
ATE174220T1
(en)
*
1993-01-08
1998-12-15
Hoechst Ag
USE OF LEFLUNOMIDE TO INHIBIT INTERLEUKIN 8
TW314467B
(en)
*
1993-03-31
1997-09-01
Hoechst Ag
GB9313365D0
(en)
*
1993-06-29
1993-08-11
Roussel Lab Ltd
Chemical compounds
US5700823A
(en)
*
1994-01-07
1997-12-23
Sugen, Inc.
Treatment of platelet derived growth factor related disorders such as cancers
US5519042A
(en)
*
1994-01-13
1996-05-21
Hoechst Aktiengesellschaft
Method of treating hyperproliferative vascular disease
US5624946A
(en)
*
1994-07-05
1997-04-29
Williams; James
Use of leflunomide to control and reverse chronic allograft rejection
US5856330A
(en)
*
1996-07-31
1999-01-05
Hoechst Aktiengesellschaft
Use of xanthine derivatives for the inhibition of dephosphorylation of cofilin
1997
1997-07-23
US
US08/898,756
patent/US6011051A/en
not_active
Expired – Lifetime
1997-07-28
PT
PT97112938T
patent/PT821952E/en
unknown
1997-07-28
DK
DK97112938T
patent/DK0821952T3/en
active
1997-07-28
EP
EP97112938A
patent/EP0821952B1/en
not_active
Expired – Lifetime
1997-07-28
AT
AT97112938T
patent/ATE262901T1/en
active
1997-07-28
DE
DE59711463T
patent/DE59711463D1/en
not_active
Expired – Lifetime
1997-07-28
ES
ES97112938T
patent/ES2218623T3/en
not_active
Expired – Lifetime
1997-07-29
AU
AU32368/97A
patent/AU718728B2/en
not_active
Ceased
1997-07-30
CA
CA002212207A
patent/CA2212207C/en
not_active
Expired – Fee Related
1997-07-30
JP
JP9204344A
patent/JPH1087484A/en
active
Pending
Also Published As
Publication number
Publication date
PT821952E
(en)
2004-08-31
EP0821952B1
(en)
2004-03-31
US6011051A
(en)
2000-01-04
CA2212207C
(en)
2008-12-30
EP0821952A1
(en)
1998-02-04
JPH1087484A
(en)
1998-04-07
DE59711463D1
(en)
2004-05-06
ES2218623T3
(en)
2004-11-16
ATE262901T1
(en)
2004-04-15
DK0821952T3
(en)
2004-06-28
AU718728B2
(en)
2000-04-20
CA2212207A1
(en)
1998-01-31
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Legal Events
Date
Code
Title
Description
2000-08-17
FGA
Letters patent sealed or granted (standard patent)
