AU3595289A

AU3595289A – Oligopeptides with cyclic proline-analogous amino acids
– Google Patents

AU3595289A – Oligopeptides with cyclic proline-analogous amino acids
– Google Patents
Oligopeptides with cyclic proline-analogous amino acids

Info

Publication number
AU3595289A

AU3595289A
AU35952/89A
AU3595289A
AU3595289A
AU 3595289 A
AU3595289 A
AU 3595289A
AU 35952/89 A
AU35952/89 A
AU 35952/89A
AU 3595289 A
AU3595289 A
AU 3595289A
AU 3595289 A
AU3595289 A
AU 3595289A
Authority
AU
Australia
Prior art keywords
oligopeptides
amino acids
optionally substituted
alkyl
analogous amino
Prior art date
1988-06-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU35952/89A
Other versions

AU624142B2
(en

Inventor
Dietrich Brocks
Volkmar Gunzler-Pukall
Stephan Henke
Kari Ilkka Kivirikko
Raili Mirja Helena Myllyla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-06-03
Filing date
1989-06-01
Publication date
1989-12-07

1989-06-01
Application filed by Hoechst AG
filed
Critical
Hoechst AG

1989-12-07
Publication of AU3595289A
publication
Critical
patent/AU3595289A/en

1992-06-04
Application granted
granted
Critical

1992-06-04
Publication of AU624142B2
publication
Critical
patent/AU624142B2/en

2009-06-01
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07K—PEPTIDES

C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof

C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links

C07K5/08—Tripeptides

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07K—PEPTIDES

C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof

C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links

C07K5/08—Tripeptides

C07K5/0802—Tripeptides with the first amino acid being neutral

C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P11/00—Drugs for disorders of the respiratory system

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P17/00—Drugs for dermatological disorders

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00—Antineoplastic agents

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P37/00—Drugs for immunological or allergic disorders

A61P37/02—Immunomodulators

A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07K—PEPTIDES

C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof

C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links

C07K5/06—Dipeptides

C07K5/06008—Dipeptides with the first amino acid being neutral

C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to compounds of the formula I in which A is an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc is an optionally substituted heterocyclic carbonyl compound; D is NH, NCH3, O or CH2; E is CHOH, CO, SO or optionally N-substituted C=NH; F is O, NH, NCH3 or a bond; R<4> is an optionally substituted radical from the series comprising alkyl, cycloalkyl, aryl and heteroaryl; and R<8> is hydrogen or optionally substituted alkyl, process for the preparation thereof and the use thereof as inhibitors of prolyl hydroxylase.

AU35952/89A
1988-06-03
1989-06-01
Oligopeptides with cyclic proline-analogous amino acids

Ceased

AU624142B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE3818850A

DE3818850A1
(en)

1988-06-03
1988-06-03

OLIGOPEPTIDES WITH CYCLIC PROLIN ANALOG AMINO STUFFS

DE3818850

1988-06-03

Publications (2)

Publication Number
Publication Date

AU3595289A
true

AU3595289A
(en)

1989-12-07

AU624142B2

AU624142B2
(en)

1992-06-04

Family
ID=6355744
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU35952/89A
Ceased

AU624142B2
(en)

1988-06-03
1989-06-01
Oligopeptides with cyclic proline-analogous amino acids

Country Status (18)

Country
Link

US
(1)

US5206343A
(en)

EP
(1)

EP0344682B1
(en)

JP
(1)

JPH0242098A
(en)

KR
(1)

KR900000381A
(en)

AT
(1)

ATE97420T1
(en)

AU
(1)

AU624142B2
(en)

CA
(1)

CA1331498C
(en)

DE
(2)

DE3818850A1
(en)

DK
(1)

DK270289A
(en)

ES
(1)

ES2061789T3
(en)

FI
(1)

FI93646C
(en)

HU
(1)

HU204539B
(en)

IE
(1)

IE62846B1
(en)

IL
(1)

IL90482A0
(en)

NO
(1)

NO177677C
(en)

NZ
(1)

NZ229384A
(en)

PT
(1)

PT90740B
(en)

ZA
(1)

ZA894178B
(en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB8929070D0
(en)

*

1989-12-22
1990-02-28
Fujisawa Pharmaceutical Co
Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same

JPH062347B2
(en)

*

1989-12-29
1994-01-12
東レ株式会社

Fiber-reinforced resin tubular body and prepreg for molding the same

DK0796855T3
(en)

1996-03-20
2002-05-27
Hoechst Ag

Inhibitors of bone resorption and vitronectin receptor antagonists

FR2746394B1
(en)

1996-03-20
1998-05-29
Roussel Uclaf

NOVEL TRICYCLIC COMPOUNDS, THEIR PREPARATION PROCESS, AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

DE19653647A1
(en)

1996-12-20
1998-06-25
Hoechst Ag

Vitronectin receptor antagonists, their preparation and their use

DE19741235A1
(en)

1997-09-18
1999-03-25
Hoechst Marion Roussel De Gmbh

Novel imidazolidine derivatives, their preparation, their use and pharmaceutical compositions containing them

DE19741873A1
(en)

*

1997-09-23
1999-03-25
Hoechst Marion Roussel De Gmbh

New 5-ring heterocycles, their preparation, their use and pharmaceutical preparations containing them

DE19751251A1
(en)

1997-11-19
1999-05-20
Hoechst Marion Roussel De Gmbh

Substituted imidazolidine derivatives, their manufacture, their use and pharmaceutical preparations containing them

DE19821483A1
(en)

1998-05-14
1999-11-18
Hoechst Marion Roussel De Gmbh
New imidazolidine derivatives useful as leukocyte adhesion and migration inhibitors and/or VLA-4 receptor antagonists for treating E.G. inflammatory and allergic disorders

US6855510B2
(en)

*

2001-03-20
2005-02-15
Dana Farber Cancer Institute, Inc.
Pharmaceuticals and methods for treating hypoxia and screening methods therefor

AU2002323368B2
(en)

*

2001-08-23
2006-12-07
The Government Of The United States Of America As Represented By The Secretary, Department Of Health & Human Services
Methods of inhibiting formation of vascular channels and profileration using pyridinone derivatives

GB0206711D0
(en)

*

2002-03-21
2002-05-01
Isis Innovation
HIF Inhibitor

US7638295B2
(en)

*

2004-03-26
2009-12-29
Isis Innovation Limited
Assays for identifying modulators of the hydroxylation of ankyrin repeat proteins by 2-oxoglutarate dependent oxygenase and methods of using the same

GB0519605D0
(en)

2005-09-26
2005-11-02
Isis Innovation
Assay

KR100600032B1
(en)

*

2006-02-15
2006-07-13
주식회사유라텍
Method of producing roller for cleaning and moving flat panel display

GB201102659D0
(en)

2011-02-15
2011-03-30
Isis Innovation
Assay

GB201113101D0
(en)

2011-07-28
2011-09-14
Isis Innovation
Assay

Family Cites Families (9)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

JPS56139455A
(en)

*

1980-04-02
1981-10-30
Santen Pharmaceut Co Ltd
Sulfur-containing acylaminoacid

DE3378909D1
(en)

*

1982-10-20
1989-02-16
Takeda Chemical Industries Ltd
Physiologically active substance p-23924, its production and use

US4833471A
(en)

*

1984-03-26
1989-05-23
Canon Kabushiki Kaisha
Data processing apparatus

IT1176983B
(en)

*

1984-10-16
1987-08-26
Zambon Spa

DIPEPTIDES WITH PHARMACOLOGICAL ACTIVITY

EP0190852A3
(en)

*

1985-01-31
1988-11-02
Ajinomoto Co., Inc.
Dipeptide derivatives and antihypertensive drugs containing them

DE3544338A1
(en)

*

1985-12-14
1987-06-19
Hoechst Ag

PEPTIDE DERIVATIVES WITH INHIBITORIC EFFECT ON HYDROXYLATING ENZYMS, METHOD FOR THE PRODUCTION THEREOF, THE CONTAINERS THEREOF AND THEIR USE

IT1196485B
(en)

*

1986-07-14
1988-11-16
Zambon Spa

THIAZOLIDIN-4-CARBOXYLIC ACID DERIVATIVES FOR PHARMACEUTICAL ACTIVITIES

DE3643012A1
(en)

*

1986-12-17
1988-06-30
Hoechst Ag

2,3-DISUBSTITUTED ISOXAZOLIDINE, METHOD FOR THE PRODUCTION THEREOF, THE CONTAINERS THEREOF AND THEIR USE

IT1223565B
(en)

*

1987-12-21
1990-09-19
Zambon Spa

THIAZOLIDIN 4 CARBOXYLIC ACID DERIVATIVES FOR PHARMACEUTICAL ACTIVITIES

1988

1988-06-03
DE
DE3818850A
patent/DE3818850A1/en
not_active
Withdrawn

1989

1989-05-29
ES
ES89109647T
patent/ES2061789T3/en
not_active
Expired – Lifetime

1989-05-29
EP
EP89109647A
patent/EP0344682B1/en
not_active
Expired – Lifetime

1989-05-29
AT
AT89109647T
patent/ATE97420T1/en
not_active
IP Right Cessation

1989-05-29
DE
DE89109647T
patent/DE58906191D1/en
not_active
Expired – Fee Related

1989-06-01
FI
FI892688A
patent/FI93646C/en
not_active
IP Right Cessation

1989-06-01
NZ
NZ229384A
patent/NZ229384A/en
unknown

1989-06-01
IL
IL90482A
patent/IL90482A0/en
not_active
IP Right Cessation

1989-06-01
US
US07/360,177
patent/US5206343A/en
not_active
Expired – Fee Related

1989-06-01
AU
AU35952/89A
patent/AU624142B2/en
not_active
Ceased

1989-06-01
HU
HU892809A
patent/HU204539B/en
not_active
IP Right Cessation

1989-06-02
JP
JP1139376A
patent/JPH0242098A/en
active
Pending

1989-06-02
DK
DK270289A
patent/DK270289A/en
not_active
Application Discontinuation

1989-06-02
PT
PT90740A
patent/PT90740B/en
not_active
IP Right Cessation

1989-06-02
CA
CA000601590A
patent/CA1331498C/en
not_active
Expired – Fee Related

1989-06-02
NO
NO892265A
patent/NO177677C/en
unknown

1989-06-02
ZA
ZA894178A
patent/ZA894178B/en
unknown

1989-06-03
KR
KR1019890007659A
patent/KR900000381A/en
active
IP Right Grant

1989-06-12
IE
IE181389A
patent/IE62846B1/en
not_active
IP Right Cessation

Also Published As

Publication number
Publication date

PT90740A
(en)

1989-12-29

IE62846B1
(en)

1995-03-08

IL90482A0
(en)

1990-01-18

NO892265L
(en)

1989-12-04

FI93646C
(en)

1995-05-10

CA1331498C
(en)

1994-08-16

HU204539B
(en)

1992-01-28

DK270289A
(en)

1989-12-04

HUT51294A
(en)

1990-04-28

JPH0242098A
(en)

1990-02-13

US5206343A
(en)

1993-04-27

FI892688A0
(en)

1989-06-01

FI93646B
(en)

1995-01-31

ATE97420T1
(en)

1993-12-15

DE58906191D1
(en)

1993-12-23

FI892688A
(en)

1989-12-04

DE3818850A1
(en)

1989-12-07

NO177677C
(en)

1995-11-01

ES2061789T3
(en)

1994-12-16

IE891813L
(en)

1989-12-03

DK270289D0
(en)

1989-06-02

KR900000381A
(en)

1990-01-30

PT90740B
(en)

1994-10-31

NO177677B
(en)

1995-07-24

NZ229384A
(en)

1991-12-23

EP0344682A3
(en)

1991-06-26

AU624142B2
(en)

1992-06-04

EP0344682A2
(en)

1989-12-06

NO892265D0
(en)

1989-06-02

EP0344682B1
(en)

1993-11-18

ZA894178B
(en)

1990-02-28

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