AU3595689A

AU3595689A – Anthracycline derivatives having cytostatic activity
– Google Patents

AU3595689A – Anthracycline derivatives having cytostatic activity
– Google Patents
Anthracycline derivatives having cytostatic activity

Info

Publication number
AU3595689A

AU3595689A
AU35956/89A
AU3595689A
AU3595689A
AU 3595689 A
AU3595689 A
AU 3595689A
AU 35956/89 A
AU35956/89 A
AU 35956/89A
AU 3595689 A
AU3595689 A
AU 3595689A
AU 3595689 A
AU3595689 A
AU 3595689A
Authority
AU
Australia
Prior art keywords
hydrogen
hydroxyl
hydroxyl group
group
cytostatic activity
Prior art date
1988-06-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU35956/89A
Other versions

AU623892B2
(en

Inventor
Manfred Gerken
Peter Hermentin
Dieter Hoffmann
Cenek Kolar
Hans Peter Kraemer
Ernst Raab
Ulrich Stache
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Siemens Healthcare Diagnostics GmbH Germany

Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-06-04
Filing date
1989-06-01
Publication date
1989-12-07

1989-06-01
Application filed by Behringwerke AG
filed
Critical
Behringwerke AG

1989-12-07
Publication of AU3595689A
publication
Critical
patent/AU3595689A/en

1992-05-28
Application granted
granted
Critical

1992-05-28
Publication of AU623892B2
publication
Critical
patent/AU623892B2/en

2009-06-01
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS

C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals

C07H15/20—Carbocyclic rings

C07H15/24—Condensed ring systems having three or more rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS

C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals

C07H15/20—Carbocyclic rings

C07H15/24—Condensed ring systems having three or more rings

C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/70—Carbohydrates; Sugars; Derivatives thereof

A61K31/7042—Compounds having saccharide radicals and heterocyclic rings

A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00—Antineoplastic agents

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS

C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals

C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Abstract

The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I, I which can optionally also be in the form of an acid addition salt of physiologically acceptable inorganic or organic acids, where R1 is hydrogen or a hydroxyl group, R2 is hydrogen, a hydroxyl or a methoxy group, R3 is hydrogen or a hydroxyl group, R4 is hydrogen or a hydroxyl group, R5 hydrogen, a hydroxyl or a methoxycarbonyl group, R6 is CH2CH3, COCH3, COCH2OH, CHOHCH3 or CHOHCH2OH and R7 is an organic substituent which has 2 to 6 carbon atoms and which contains at least one oxygen, nitrogen or sulfur atom or a C-C double bond or a C-C triple bond, it being possible for the double bond also to be a constituent of a heteroaromatic system and for the oxygen, nitrogen or sulfur atom to be a constituent of an open-chain or heterocyclic system, to a process for the preparation thereof and to the use thereof in a pharmaceutical.

AU35956/89A
1988-06-04
1989-06-01
Anthracycline derivatives having cytostatic activity

Ceased

AU623892B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE3819092

1988-06-04

DE3819092A

DE3819092A1
(en)

1988-06-04
1988-06-04

CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES

Publications (2)

Publication Number
Publication Date

AU3595689A
true

AU3595689A
(en)

1989-12-07

AU623892B2

AU623892B2
(en)

1992-05-28

Family
ID=6355890
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU35956/89A
Ceased

AU623892B2
(en)

1988-06-04
1989-06-01
Anthracycline derivatives having cytostatic activity

Country Status (12)

Country
Link

US
(1)

US5260425A
(en)

EP
(1)

EP0345598B1
(en)

JP
(1)

JP2838145B2
(en)

KR
(1)

KR0132566B1
(en)

AT
(1)

ATE169630T1
(en)

AU
(1)

AU623892B2
(en)

CA
(1)

CA1340021C
(en)

DE
(2)

DE3819092A1
(en)

DK
(1)

DK270889A
(en)

ES
(1)

ES2120944T3
(en)

FI
(1)

FI93220C
(en)

PT
(1)

PT90706B
(en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE3913743A1
(en)

*

1989-04-26
1990-10-31
Behringwerke Ag

CYTOSTATICALLY EFFECTIVE RHODOMYCINE DERIVATIVES

DE3913742A1
(en)

*

1989-04-26
1990-10-31
Behringwerke Ag

CYTOSTATICALLY EFFECTIVE RHODOMYCINE DERIVATIVES

DE4036155A1
(en)

*

1990-11-14
1992-05-21
Behringwerke Ag

SEMISYNTHETIC DIASTEREOMERIC PURE N-GLYCIDYL ANTHRACYCLINE, METHOD FOR THEIR STEREOSELECTIVE PRODUCTION AND THEIR USE AS CYTOSTATICS

KR100741280B1
(en)

*

2003-04-30
2007-07-19
주식회사 만도
Upper part cap that a shock absorber height control is available

KR20190050433A
(en)

2017-11-03
2019-05-13
신영훈
Found of express train location

Family Cites Families (13)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

JPS5287158A
(en)

*

1976-01-14
1977-07-20
Microbial Chem Res Found
Deoxypypromycin and antimalignant tumor agents containing it as active constituent

JPS54141759A
(en)

*

1978-04-24
1979-11-05
Microbial Chem Res Found
Novel anthracycline derivative

CH648327A5
(en)

*

1980-10-16
1985-03-15
Hoffmann La Roche

ANTHRACYCLINE.

JPS57176995A
(en)

*

1981-04-23
1982-10-30
Sanraku Inc
Novel anthracyclinone glycoside and its preparation

DE3325957A1
(en)

*

1983-07-19
1985-02-07
Hoechst Ag, 6230 Frankfurt

ANTHRACYCLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A CYTOSTATIKA

US4591637A
(en)

*

1985-01-17
1986-05-27
Sri International
Open chain-morpholino adriamycins

JPS61227588A
(en)

*

1985-04-02
1986-10-09
Sanraku Inc
Novel anthracycline antibiotic

JPS61236792A
(en)

*

1985-04-12
1986-10-22
Sanraku Inc
Novel anthracycline antibiotic

FR2591599B1
(en)

*

1985-12-17
1988-08-05
Hoechst Lab

NEW ANTHRACYCLINES AND MEDICINES CONTAINING THEM

DE3641833A1
(en)

*

1986-12-08
1988-06-09
Behringwerke Ag

CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES

JPS63227599A
(en)

*

1987-03-14
1988-09-21
Kirin Brewery Co Ltd
Anthracycline compound and use thereof

DE3716308A1
(en)

*

1987-05-15
1988-11-24
Paals Packpressen Fabrik Gmbh

CHANNEL BALING PRESS

DE3722699A1
(en)

*

1987-07-09
1989-01-19
Behringwerke Ag

CYTOSTATICALLY EFFECTIVE ANTHACYCLIN CONJUGATES

1988

1988-06-04
DE
DE3819092A
patent/DE3819092A1/en
not_active
Withdrawn

1989

1989-05-30
DE
DE58909836T
patent/DE58909836D1/en
not_active
Expired – Fee Related

1989-05-30
EP
EP89109689A
patent/EP0345598B1/en
not_active
Expired – Lifetime

1989-05-30
AT
AT89109689T
patent/ATE169630T1/en
not_active
IP Right Cessation

1989-05-30
ES
ES89109689T
patent/ES2120944T3/en
not_active
Expired – Lifetime

1989-06-01
PT
PT90706A
patent/PT90706B/en
not_active
IP Right Cessation

1989-06-01
FI
FI892685A
patent/FI93220C/en
active
IP Right Grant

1989-06-01
AU
AU35956/89A
patent/AU623892B2/en
not_active
Ceased

1989-06-02
US
US07/360,807
patent/US5260425A/en
not_active
Expired – Fee Related

1989-06-02
CA
CA000601592A
patent/CA1340021C/en
not_active
Expired – Fee Related

1989-06-02
JP
JP1139372A
patent/JP2838145B2/en
not_active
Expired – Fee Related

1989-06-02
DK
DK270889A
patent/DK270889A/en
not_active
Application Discontinuation

1989-06-03
KR
KR1019890007656A
patent/KR0132566B1/en
not_active
IP Right Cessation

Also Published As

Publication number
Publication date

JPH0225497A
(en)

1990-01-26

EP0345598B1
(en)

1998-08-12

AU623892B2
(en)

1992-05-28

CA1340021C
(en)

1998-09-01

JP2838145B2
(en)

1998-12-16

EP0345598A2
(en)

1989-12-13

EP0345598A3
(en)

1990-07-18

FI892685A0
(en)

1989-06-01

DE3819092A1
(en)

1989-12-14

KR0132566B1
(en)

1998-04-14

FI93220C
(en)

1995-03-10

ES2120944T3
(en)

1998-11-16

US5260425A
(en)

1993-11-09

FI93220B
(en)

1994-11-30

KR910000777A
(en)

1991-01-30

PT90706A
(en)

1989-12-29

DK270889D0
(en)

1989-06-02

ATE169630T1
(en)

1998-08-15

DE58909836D1
(en)

1998-09-17

PT90706B
(en)

1993-12-31

DK270889A
(en)

1989-12-05

FI892685A
(en)

1989-12-05

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