AU3914285A – Pyrido-benzothiazine derivatives
– Google Patents
AU3914285A – Pyrido-benzothiazine derivatives
– Google Patents
Pyrido-benzothiazine derivatives
Info
Publication number
AU3914285A
AU3914285A
AU39142/85A
AU3914285A
AU3914285A
AU 3914285 A
AU3914285 A
AU 3914285A
AU 39142/85 A
AU39142/85 A
AU 39142/85A
AU 3914285 A
AU3914285 A
AU 3914285A
AU 3914285 A
AU3914285 A
AU 3914285A
Authority
AU
Australia
Prior art keywords
pyrido
chem
general formula
processes
derivatives
Prior art date
1984-02-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU39142/85A
Other versions
AU573780B2
(en
Inventor
Arnaldo Fravolini
Giuseppe Mascellani
Patrizia Terni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mediolanum Farmaceutici SpA
Original Assignee
Mediolanum Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1984-02-24
Filing date
1985-02-25
Publication date
1985-09-05
1985-02-25
Application filed by Mediolanum Farmaceutici SpA
filed
Critical
Mediolanum Farmaceutici SpA
1985-09-05
Publication of AU3914285A
publication
Critical
patent/AU3914285A/en
1988-06-23
Application granted
granted
Critical
1988-06-23
Publication of AU573780B2
publication
Critical
patent/AU573780B2/en
1992-09-03
Assigned to MEDIOLANUM FARMACEUTICI S.P.A.
reassignment
MEDIOLANUM FARMACEUTICI S.P.A.
Request to Amend Deed and Register
Assignors: MEDIOLANUM FARMACEUTICI S.R.L.
2005-02-25
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 – C07D507/00
C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 – C07D507/00 in which the condensed system contains two hetero rings
C07D513/06—Peri-condensed systems
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P31/04—Antibacterial agents
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
C07D277/62—Benzothiazoles
C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
C07D277/82—Nitrogen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Abstract
Pyridobenzothiazine derivatives with high antimicrobial activity having the following general formula:
wherein
R is H or CH3; n is 0 or 1 or 2 and Y is Cl or F,
wherein R<1> is a C1-C6 alkyl
or a C2-C6 alkenyl, or an arylalkyl, arylalkylcarbonyl, alkylcarbonyl, alkyloxycarbonyl, possibly substituted with halogens or hydroxy groups.
The present invention relates also to the processes for obtaining the compounds having the general formula (I). Such processes consist in synthesis routes using as starting products 3-chloro-4-fluoraniline, or 2,3,4-trifluoronitrobenzene.
AU39142/85A
1984-02-24
1985-02-25
Pyrido-benzothiazine derivatives
Ceased
AU573780B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
IT19790/84
1984-02-24
IT19790/84A
IT1173374B
(en)
1984-02-24
1984-02-24
PYRID-BENZOTHIAZINIC DERIVATIVES WITH HIGH ANTIMICROBIAL ACTIVITY
Publications (2)
Publication Number
Publication Date
AU3914285A
true
AU3914285A
(en)
1985-09-05
AU573780B2
AU573780B2
(en)
1988-06-23
Family
ID=11161233
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU39142/85A
Ceased
AU573780B2
(en)
1984-02-24
1985-02-25
Pyrido-benzothiazine derivatives
Country Status (22)
Country
Link
US
(2)
US4668784A
(en)
EP
(1)
EP0165375B1
(en)
JP
(2)
JPS60208987A
(en)
KR
(1)
KR880000024B1
(en)
AT
(1)
ATE57532T1
(en)
AU
(1)
AU573780B2
(en)
CA
(1)
CA1340554C
(en)
DE
(1)
DE3580124D1
(en)
DK
(1)
DK81885A
(en)
EG
(1)
EG17585A
(en)
ES
(3)
ES8801923A1
(en)
FI
(1)
FI83327C
(en)
GR
(1)
GR850482B
(en)
IE
(1)
IE57974B1
(en)
IT
(1)
IT1173374B
(en)
MX
(5)
MX172473B
(en)
NO
(1)
NO171163C
(en)
NZ
(1)
NZ211224A
(en)
PH
(2)
PH22239A
(en)
PT
(1)
PT80003B
(en)
YU
(1)
YU43401B
(en)
ZA
(1)
ZA851379B
(en)
Families Citing this family (23)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2358580A1
(en)
*
1976-07-16
1978-02-10
Comet
IMPROVEMENTS TO CAGES FOR PRISONER NUTS AND TO APPARATUS AND METHODS FOR MANUFACTURING SUCH CAGES
IT1196429B
(en)
*
1986-07-01
1988-11-16
Mediolanum Farmaceutici Srl
PROCESS FOR THE PREPARATION OF PYRID BENZOTIAZINS FOR ANTIBACTERIAL ACTIVITY AND THEIR SALTS WITH SULPHONIC ACIDS
IT1197841B
(en)
*
1986-10-14
1988-12-06
Mediolanum Farmaceutici Srl
PYRID-BENZOTHIAZINIC DERIVATIVES WITH ANTIBACTERIAL ACTIVITY AND LONG LIFE
IT1222833B
(en)
*
1987-10-06
1990-09-12
Mediolanum Farmaceutici Srl
PYROID BENZOTHIAZINIC DERIVATIVES EQUIPPED WITH HIGH ANTIBACTERIAL ACTIVITY AND HIGH TISSUE BIO AVAILABILITY
US4840525A
(en)
*
1987-12-09
1989-06-20
Unistrut International Corp.
Fastener restrainer for framing system
DE3906365A1
(en)
*
1988-07-15
1990-01-18
Bayer Ag
7- (1-PYRROLIDINYL) -3-CHINOLONE AND NAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVES, METHOD AND SUBSTITUTED (OXA) DIAZABICYCLOOCTANES AND NONANESE AS INTERMEDIATE PRODUCTS, AND ANTIBACTERIAL AGENTS AND FOOD ADDITIVES CONTAINING THEM
US5308843A
(en)
*
1990-09-11
1994-05-03
Sterling Drug Inc.
Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids
IT1248011B
(en)
*
1991-06-07
1995-01-05
Mediolanum Farmaceutici Spa
PROCEDURE FOR THE PREPARATION OF 9-FLUORO-10- (4-METHYL-1-PIPERAZINYL) -7-OXO-2,3-DIHYDRO-7H-PYRID (1,2,3-DE) acid (1,4) BENZOTIADIN-6-CARBOXYL HYDROCHLORIDE.
US5532239A
(en)
*
1993-08-02
1996-07-02
Assistance Publique – Hopitaux De Paris
Therapeutic application of fluoroquinolone derivatives
IT1270834B
(en)
*
1993-10-27
1997-05-13
Archimica Spa
DISINFURO QUINOLICO
US6326391B1
(en)
1998-12-04
2001-12-04
Influx, Inc.
Inhibitors of multidrug transporters
US6262072B1
(en)
1999-10-12
2001-07-17
Yung Shin Pharmaceutical Industrial Co. Ltd.
Orally administered antimicrobial pharmaceutical formulations of ciprofloxacin
SE9904108D0
(en)
1999-11-15
1999-11-15
New Pharma Research Ab
New compounds
KR100440192B1
(en)
*
2001-11-22
2004-07-12
이수화학 주식회사
Method of preparing optical active quinolonecarboxylic acid derivatives
US6957105B2
(en)
*
2002-03-26
2005-10-18
Cardiac Pacemakers, Inc.
Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals
US20070196398A1
(en)
*
2006-02-17
2007-08-23
Murthy Yerramilli V S
Fluoroquinolone fatty acid salt compositions
US20070197548A1
(en)
*
2006-02-17
2007-08-23
Murthy Yerramilli V S
Fluoroquinolone compositions
US7973022B2
(en)
*
2006-02-17
2011-07-05
Idexx Laboratories, Inc.
Fluoroquinolone carboxylic acid salt compositions
WO2013076590A1
(en)
*
2011-11-23
2013-05-30
Oxygen Healthcare Research Pvt. Ltd
Benzothiazine compounds as h3 receptor ligands
DE102013101756A1
(en)
2012-11-30
2014-06-05
Hamberger Industriewerke Gmbh
Connector e.g. glueless connector, for e.g. floor element for flooring applications, has structural element moved to latch position in which locking lip of locking element is non-positively or positively locked in direction
DE102013108539A1
(en)
2013-08-07
2015-02-12
Hamberger Industriewerke Gmbh
Connection and locking element
DE102013108538A1
(en)
2013-08-07
2015-02-12
Hamberger Industriewerke Gmbh
Connection and locking element
DE102015106035A1
(en)
2014-07-31
2016-02-04
Hamberger Industriewerke Gmbh
Connection for plate-shaped components and spring
Family Cites Families (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
JPS57203085A
(en)
*
1981-06-09
1982-12-13
Dai Ichi Seiyaku Co Ltd
1,8-cyclic substituted quinoline derivative
JPS5976091A
(en)
*
1982-10-22
1984-04-28
Otsuka Pharmaceut Co Ltd
Pyrido (1,2,3-de)(1,4)benzothiazine derivative
1984
1984-02-24
IT
IT19790/84A
patent/IT1173374B/en
active
Protection Beyond IP Right Term
1985
1985-02-21
EP
EP85101881A
patent/EP0165375B1/en
not_active
Expired – Lifetime
1985-02-21
DE
DE8585101881T
patent/DE3580124D1/en
not_active
Expired – Fee Related
1985-02-21
AT
AT85101881T
patent/ATE57532T1/en
not_active
IP Right Cessation
1985-02-21
IE
IE432/85A
patent/IE57974B1/en
not_active
IP Right Cessation
1985-02-22
DK
DK81885A
patent/DK81885A/en
not_active
Application Discontinuation
1985-02-22
FI
FI850741A
patent/FI83327C/en
not_active
IP Right Cessation
1985-02-22
ZA
ZA851379A
patent/ZA851379B/en
unknown
1985-02-22
NO
NO850710A
patent/NO171163C/en
unknown
1985-02-22
PT
PT80003A
patent/PT80003B/en
not_active
IP Right Cessation
1985-02-22
CA
CA000474952A
patent/CA1340554C/en
not_active
Expired – Fee Related
1985-02-23
KR
KR8501180A
patent/KR880000024B1/en
not_active
IP Right Cessation
1985-02-23
ES
ES541170A
patent/ES8801923A1/en
not_active
Expired
1985-02-24
EG
EG115/85A
patent/EG17585A/en
active
1985-02-25
MX
MX013422A
patent/MX172473B/en
unknown
1985-02-25
MX
MX013420A
patent/MX172472B/en
unknown
1985-02-25
MX
MX013421A
patent/MX173934B/en
unknown
1985-02-25
JP
JP60036261A
patent/JPS60208987A/en
active
Granted
1985-02-25
MX
MX5776A
patent/MX162343A/en
unknown
1985-02-25
AU
AU39142/85A
patent/AU573780B2/en
not_active
Ceased
1985-02-25
NZ
NZ211224A
patent/NZ211224A/en
unknown
1985-02-25
PH
PH31907A
patent/PH22239A/en
unknown
1985-02-25
YU
YU290/85A
patent/YU43401B/en
unknown
1985-02-26
GR
GR850482A
patent/GR850482B/el
not_active
IP Right Cessation
1985-08-13
US
US06/765,154
patent/US4668784A/en
not_active
Expired – Lifetime
1986
1986-10-24
US
US06/922,712
patent/US4684647A/en
not_active
Expired – Lifetime
1987
1987-01-16
ES
ES557332A
patent/ES8802456A1/en
not_active
Expired
1987-01-16
ES
ES557331A
patent/ES8802455A1/en
not_active
Expired
1987-08-05
PH
PH35622A
patent/PH23882A/en
unknown
1989
1989-11-29
JP
JP1307826A
patent/JPH0327389A/en
active
Granted
1992
1992-06-26
MX
MX9203608A
patent/MX9203608A/en
unknown
Also Published As
Publication number
Publication date
JPH0327389A
(en)
1991-02-05
ZA851379B
(en)
1985-10-30
CA1340554C
(en)
1999-05-25
MX172473B
(en)
1993-12-17
ATE57532T1
(en)
1990-11-15
YU43401B
(en)
1989-06-30
AU573780B2
(en)
1988-06-23
FI850741A0
(en)
1985-02-22
US4668784A
(en)
1987-05-26
EP0165375A3
(en)
1986-10-08
EG17585A
(en)
1993-08-30
IE850432L
(en)
1985-08-24
DK81885A
(en)
1985-08-25
EP0165375B1
(en)
1990-10-17
FI850741L
(en)
1985-08-25
ES557331A0
(en)
1988-06-16
PH23882A
(en)
1989-12-18
ES8802455A1
(en)
1988-06-16
IE57974B1
(en)
1993-06-02
GR850482B
(en)
1985-06-26
PT80003A
(en)
1985-03-01
MX173934B
(en)
1994-04-11
FI83327C
(en)
1991-06-25
IT8419790D0
(en)
1984-02-24
ES8802456A1
(en)
1988-06-16
KR850006426A
(en)
1985-10-05
NO171163C
(en)
1993-02-03
ES541170A0
(en)
1988-03-01
MX162343A
(en)
1991-04-26
MX172472B
(en)
1993-12-17
NO850710L
(en)
1985-08-26
DK81885D0
(en)
1985-02-22
US4684647A
(en)
1987-08-04
PH22239A
(en)
1988-07-01
DE3580124D1
(en)
1990-11-22
ES557332A0
(en)
1988-06-16
FI83327B
(en)
1991-03-15
MX9203608A
(en)
1992-07-01
NZ211224A
(en)
1992-03-26
YU29085A
(en)
1987-12-31
JPH0259153B2
(en)
1990-12-11
NO171163B
(en)
1992-10-26
JPS60208987A
(en)
1985-10-21
JPH0413326B2
(en)
1992-03-09
PT80003B
(en)
1987-06-17
KR880000024B1
(en)
1988-02-15
EP0165375A2
(en)
1985-12-27
ES8801923A1
(en)
1988-03-01
IT1173374B
(en)
1987-06-24
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