AU3979489A – Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
– Google Patents
AU3979489A – Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
– Google Patents
Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
Info
Publication number
AU3979489A
AU3979489A
AU39794/89A
AU3979489A
AU3979489A
AU 3979489 A
AU3979489 A
AU 3979489A
AU 39794/89 A
AU39794/89 A
AU 39794/89A
AU 3979489 A
AU3979489 A
AU 3979489A
AU 3979489 A
AU3979489 A
AU 3979489A
Authority
AU
Australia
Prior art keywords
complexes
antibody conjugates
bifunctional chelants
chelants
macrocyclic bifunctional
Prior art date
1988-06-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU39794/89A
Other versions
AU634167B2
(en
Inventor
Sharon Baughman
Roberta C. Cheng
William A. Fordyce
Richard Keith Frank
Joseph R. Garlich
William F. Goeckeler
Garry E. Kiefer
Willam J. Kruper Jr.
Kenneth Mcmillan
Jaime Simon
David A. Wilson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-06-24
Filing date
1989-06-23
Publication date
1990-01-12
1989-06-23
Application filed by Dow Chemical Co
filed
Critical
Dow Chemical Co
1990-01-12
Publication of AU3979489A
publication
Critical
patent/AU3979489A/en
1993-02-18
Application granted
granted
Critical
1993-02-18
Publication of AU634167B2
publication
Critical
patent/AU634167B2/en
2009-06-23
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/33—Heterocyclic compounds
A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
A61K51/04—Organic compounds
A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
A61K51/04—Organic compounds
A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
A61K51/04—Organic compounds
A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00—Antineoplastic agents
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K2121/00—Preparations for use in therapy
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K2123/00—Preparations for testing in vivo
Abstract
A group of functionalized polyaminocarboxylate chelants that form complexes with rare earth-type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes.
AU39794/89A
1988-06-24
1989-06-23
Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
Expired
AU634167B2
(en)
Applications Claiming Priority (4)
Application Number
Priority Date
Filing Date
Title
US21149688A
1988-06-24
1988-06-24
US211496
1988-06-24
US37095689A
1989-06-21
1989-06-21
US370956
1989-06-21
Publications (2)
Publication Number
Publication Date
AU3979489A
true
AU3979489A
(en)
1990-01-12
AU634167B2
AU634167B2
(en)
1993-02-18
Family
ID=26906194
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU39794/89A
Expired
AU634167B2
(en)
1988-06-24
1989-06-23
Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
Country Status (20)
Country
Link
US
(1)
US5435990A
(en)
EP
(2)
EP0420942A1
(en)
JP
(1)
JP2831073B2
(en)
KR
(1)
KR0137930B1
(en)
AT
(1)
ATE120457T1
(en)
AU
(1)
AU634167B2
(en)
BR
(1)
BR8907507A
(en)
CA
(1)
CA1341373C
(en)
DE
(2)
DE353450T1
(en)
DK
(1)
DK175393B1
(en)
ES
(1)
ES2013978A4
(en)
FI
(2)
FI103792B1
(en)
GR
(1)
GR900300034T1
(en)
HK
(1)
HK60696A
(en)
HU
(1)
HU219485B
(en)
IE
(1)
IE67273B1
(en)
IL
(1)
IL90730A0
(en)
NO
(1)
NO179008C
(en)
NZ
(1)
NZ229700A
(en)
WO
(1)
WO1989012631A1
(en)
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1992-03-27
1995-10-12
Nihon Medi-Physics Co., Ltd.
Tetraazacyclododecane derivative and its use
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1989-11-21
1997-07-22
Schering Aktiengesellschaft
Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
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上海复宏汉霖生物技术股份有限公司
Methods and compositions directed to anti-CD 73 antibodies and variants
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(en)
2020-01-10
2020-04-24
上海复宏汉霖生物技术股份有限公司
anti-TIGIT antibodies and methods of use
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CA
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ES
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IL
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BR
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patent/DE353450T1/en
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PCT/US1989/002788
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1989-11-21
1997-07-22
Schering Aktiengesellschaft
Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
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Cascade polymer bound complexing compounds for MRI
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1989-11-21
2001-02-27
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Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
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1989-11-21
2003-06-10
Schering Aktiengesellschaft
Cascade polymer bound complexing compounds, their complexes and conjugates, process for their production and pharmaceutical agents containing them
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1989-11-21
2005-02-15
Schering, Ag
Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
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(en)
1989-11-21
2007-04-24
Schering Ag
Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
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1992-03-27
1995-10-12
Nihon Medi-Physics Co., Ltd.
Tetraazacyclododecane derivative and its use
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FI103792B
(en)
1999-09-30
DE68921941D1
(en)
1995-05-04
IE892045L
(en)
1989-12-24
DK49390A
(en)
1990-02-23
FI103792B1
(en)
1999-09-30
EP0420942A1
(en)
1991-04-10
WO1989012631A1
(en)
1989-12-28
FI906368A0
(en)
1990-12-21
ES2013978A4
(en)
1990-06-16
DK49390D0
(en)
1990-02-23
GR900300034T1
(en)
1991-07-31
KR900701765A
(en)
1990-12-04
JPH04504247A
(en)
1992-07-30
NO179008C
(en)
1996-07-17
JP2831073B2
(en)
1998-12-02
NO179008B
(en)
1996-04-09
US5435990A
(en)
1995-07-25
FI982303A0
(en)
1998-10-23
EP0353450B1
(en)
1995-03-29
KR0137930B1
(en)
1998-05-15
IL90730A0
(en)
1990-01-18
NZ229700A
(en)
1993-01-27
HU219485B
(en)
2001-04-28
IE67273B1
(en)
1996-03-20
EP0353450A1
(en)
1990-02-07
DK175393B1
(en)
2004-09-20
HU894432D0
(en)
1992-02-28
ATE120457T1
(en)
1995-04-15
HK60696A
(en)
1996-04-19
NO900869D0
(en)
1990-02-23
NO900869L
(en)
1990-04-11
FI982303A
(en)
1998-10-23
CA1341373C
(en)
2002-07-02
HUT70200A
(en)
1995-09-28
AU634167B2
(en)
1993-02-18
DE68921941T2
(en)
1995-07-27
FI117889B
(en)
2007-04-13
BR8907507A
(en)
1991-06-11
DE353450T1
(en)
1990-09-06
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