AU4754193A

AU4754193A – Trisubstituted biphenyls
– Google Patents

AU4754193A – Trisubstituted biphenyls
– Google Patents
Trisubstituted biphenyls

Info

Publication number
AU4754193A

AU4754193A
AU47541/93A
AU4754193A
AU4754193A
AU 4754193 A
AU4754193 A
AU 4754193A
AU 47541/93 A
AU47541/93 A
AU 47541/93A
AU 4754193 A
AU4754193 A
AU 4754193A
AU 4754193 A
AU4754193 A
AU 4754193A
Authority
AU
Australia
Prior art keywords
stands
carboxyl
radical
trisubstituted biphenyls
biphenyls
Prior art date
1992-10-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU47541/93A
Other versions

AU670315B2
(en

Inventor
Martin Dr. Beuck
Jurgen Dr. Dressel
Peter Dr. Fey
Rudolf Dr. Hanko
Walter Dr. Hubsch
Stanislav Prof. Dr. Kazda
Andreas Dr. Knorr
Thomas Dr. Kramer
Ulrich E. Dr. Muller
Matthias dr. Muller-Gliemann
Johannes-Peter Dr. Stasch
Stefan Dr. Wohlfeil
Siegfried dr. Zaiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1992-10-23
Filing date
1993-09-22
Publication date
1994-05-05

1993-09-22
Application filed by Bayer AG
filed
Critical
Bayer AG

1994-05-05
Publication of AU4754193A
publication
Critical
patent/AU4754193A/en

1996-07-11
Application granted
granted
Critical

1996-07-11
Publication of AU670315B2
publication
Critical
patent/AU670315B2/en

2013-09-22
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom

C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/12—Antihypertensives

Abstract

Trisubstituted biphenyls of the general formula in which R<1> stands for a carboxyl radical, or for a C1-C8-alkoxycarbonyl radical, R<2> stands for straight-chain or branched C1-C8-alkyl, R<3> stands for halogen, hydroxyl, cyano, C1-C6-alkoxy, straight-chain or branched C1-C8-alkyl, trifluoromethyl, trifluoromethoxy, carboxamido, carboxyl, C1-C8-alkoxycarbonyl or nitro, and R<4> stands for a carboxyl radical, or for tetrazolyl, and their salts. The trisubstituted biphenyls can be employed as active ingredients in medicaments, for example as angiotensin II antagonists.

AU47541/93A
1992-10-23
1993-09-22
Trisubstituted biphenyls

Ceased

AU670315B2
(en)

Applications Claiming Priority (4)

Application Number
Priority Date
Filing Date
Title

DE4235933

1992-10-23

DE4235933

1992-10-23

DE4319041A

DE4319041A1
(en)

1992-10-23
1993-06-08

Trisubstituted biphenyls

DE4319041

1993-06-08

Publications (2)

Publication Number
Publication Date

AU4754193A
true

AU4754193A
(en)

1994-05-05

AU670315B2

AU670315B2
(en)

1996-07-11

Family
ID=25919778
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU47541/93A
Ceased

AU670315B2
(en)

1992-10-23
1993-09-22
Trisubstituted biphenyls

Country Status (22)

Country
Link

US
(2)

US5596006A
(en)

EP
(1)

EP0594019B1
(en)

JP
(1)

JPH06199838A
(en)

KR
(1)

KR100304225B1
(en)

CN
(1)

CN1040435C
(en)

AT
(1)

ATE189893T1
(en)

AU
(1)

AU670315B2
(en)

CA
(1)

CA2108814A1
(en)

CZ
(1)

CZ283482B6
(en)

DE
(2)

DE4319041A1
(en)

DK
(1)

DK0594019T3
(en)

ES
(1)

ES2145021T3
(en)

FI
(1)

FI934646A
(en)

GR
(1)

GR3033207T3
(en)

HU
(1)

HUT65819A
(en)

IL
(1)

IL107333A
(en)

MX
(1)

MX9306419A
(en)

NO
(1)

NO304651B1
(en)

NZ
(1)

NZ250002A
(en)

PT
(1)

PT594019E
(en)

SK
(1)

SK279675B6
(en)

TW
(1)

TW248555B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU666222B2
(en)

*

1992-10-23
1996-02-01
Bayer Aktiengesellschaft
Alkoxymethyl-substituted pyridonebiphenyls

Families Citing this family (14)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU2001277731A1
(en)

*

2000-08-09
2002-02-18
Welfide Corporation
Fused bicyclic amide compounds and medicinal use thereof

CA2469435A1
(en)

*

2001-12-21
2003-07-24
X-Ceptor Therapeutics, Inc.
Modulators of lxr

US7482366B2
(en)

2001-12-21
2009-01-27
X-Ceptor Therapeutics, Inc.
Modulators of LXR

ES2251292B1
(en)

*

2004-04-20
2007-07-01
Inke, S.A.

PROCEDURE FOR OBTAINING A PHARMACEUTICALLY ACTIVE COMPOUND AND ITS SYNTHESIS INTERMEDIATES.

WO2006130901A1
(en)

*

2005-06-07
2006-12-14
Bayer Healthcare Ag
Control of metabolic abnormalities

DE102005030522A1
(en)

*

2005-06-30
2007-01-04
Bayer Healthcare Ag

Salt of the Embusartan

TWI448284B
(en)

2007-04-24
2014-08-11
Theravance Inc
Dual-acting antihypertensive agents

DE102007028406A1
(en)

2007-06-20
2008-12-24
Bayer Healthcare Ag

Substituted oxazolidinones and their use

DE102007028319A1
(en)

2007-06-20
2008-12-24
Bayer Healthcare Ag

Substituted oxazolidinones and their use

DE102007028407A1
(en)

2007-06-20
2008-12-24
Bayer Healthcare Ag

Substituted oxazolidinones and their use

DE102007028320A1
(en)

2007-06-20
2008-12-24
Bayer Healthcare Ag

Substituted oxazolidinones and their use

EP2138178A1
(en)

2008-06-28
2009-12-30
Bayer Schering Pharma Aktiengesellschaft
Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma

ES2698950T3
(en)

2012-05-10
2019-02-06
Bayer Pharma AG

Antibodies capable of binding Coagulation Factor XI and / or its activated form, Factor XIa, and uses thereof

KR20200021576A
(en)

2018-08-20
2020-03-02
삼성디스플레이 주식회사
Method of manufacturing display apparatus

Family Cites Families (20)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE3800785A1
(en)

*

1988-01-09
1989-07-20
Hoechst Ag

SUBSTITUTED 7- (PYRIDAZIN-5-YL) -3,5-DIHYDROXYHEPTANE (EN) – ACID, YOUR CORRESPONDING (DELTA) -LACTONE OR. DERIVATIVES, PROCESS FOR THEIR PRODUCTION, THEIR USE AS MEDICINAL PRODUCTS, PHARMACEUTICAL PREPARATIONS AND INTERMEDIATE PRODUCTS

GB8911854D0
(en)

*

1989-05-23
1989-07-12
Ici Plc
Heterocyclic compounds

IE64514B1
(en)

*

1989-05-23
1995-08-09
Zeneca Ltd
Azaindenes

EP0403158A3
(en)

*

1989-06-14
1991-12-18
Smithkline Beecham Corporation
Imidazolyl-alkenoic acids

DK0403159T3
(en)

*

1989-06-14
2000-08-14
Smithkline Beecham Corp

imidazolyl

US5164407A
(en)

*

1989-07-03
1992-11-17
Merck & Co., Inc.
Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists

EP0485410A1
(en)

*

1989-07-06
1992-05-20
The Secretary Of State For Defence In Her Britannic Majesty’s Government Of The United Kingdom Of Great Britain And Northern
A detector for monitoring low molecular weight compounds

AU640417B2
(en)

*

1989-10-25
1993-08-26
Smithkline Beecham Corporation
Substituted 5-((tetrazolyl)alkenyl)imidazoles

EP0460234B1
(en)

*

1989-12-25
1997-05-02
Nippon Steel Corporation
Sheet of titanium-aluminum intermetallic compound and process for producing the same

EP0453210A3
(en)

*

1990-04-19
1993-01-13
Imperial Chemical Industries Plc
Pyridine derivatives

CN1034934C
(en)

*

1990-06-19
1997-05-21
明治制果株式会社
Pyridine derivatives having angiotensin II antagonism

US5250548A
(en)

*

1990-09-10
1993-10-05
Abbott Laboratories
Angiotensin II receptor antagonists

CN1068109A
(en)

*

1991-02-16
1993-01-20
菲索斯有限公司
New angiotension II antagonists and the preparation of preparation and application

IL100917A0
(en)

*

1991-02-16
1992-11-15
Fisons Plc
Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them

DE4221583A1
(en)

*

1991-11-12
1993-05-13
Bayer Ag

SUBSTITUTED BIPHENYLPYRIDONE

SK280887B6
(en)

*

1991-11-18
2000-09-12
E. I. Du Pont De Nemours And Company
Method of preparing biphenyltetrazole compounds and intermediates thereof

US5206374A
(en)

*

1991-11-18
1993-04-27
E. I. Du Pont De Nemours And Company
Process for preparing tetrazolylphenylboronic acid intermediates

US5310928A
(en)

*

1991-11-18
1994-05-10
E. I. Du Pont De Nemours And Company
Process for preparing biphenyltetrazole compounds

US5130439A
(en)

*

1991-11-18
1992-07-14
Lo Young S
Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists

DE4319040A1
(en)

*

1992-10-23
1994-04-28
Bayer Ag

Alkoxymethyl-substituted pyridone biphenyls

1993

1993-06-08
DE
DE4319041A
patent/DE4319041A1/en
not_active
Withdrawn

1993-09-22
AU
AU47541/93A
patent/AU670315B2/en
not_active
Ceased

1993-10-06
TW
TW082108238A
patent/TW248555B/zh
active

1993-10-07
NO
NO933591A
patent/NO304651B1/en
not_active
IP Right Cessation

1993-10-11
DK
DK93116404T
patent/DK0594019T3/en
active

1993-10-11
DE
DE59309956T
patent/DE59309956D1/en
not_active
Expired – Fee Related

1993-10-11
ES
ES93116404T
patent/ES2145021T3/en
not_active
Expired – Lifetime

1993-10-11
AT
AT93116404T
patent/ATE189893T1/en
active

1993-10-11
PT
PT93116404T
patent/PT594019E/en
unknown

1993-10-11
EP
EP93116404A
patent/EP0594019B1/en
not_active
Expired – Lifetime

1993-10-15
MX
MX9306419A
patent/MX9306419A/en
not_active
IP Right Cessation

1993-10-20
CZ
CZ932217A
patent/CZ283482B6/en
not_active
IP Right Cessation

1993-10-20
CA
CA002108814A
patent/CA2108814A1/en
not_active
Abandoned

1993-10-20
IL
IL107333A
patent/IL107333A/en
not_active
IP Right Cessation

1993-10-20
NZ
NZ250002A
patent/NZ250002A/en
unknown

1993-10-21
FI
FI934646A
patent/FI934646A/en
unknown

1993-10-22
JP
JP5286167A
patent/JPH06199838A/en
active
Pending

1993-10-22
SK
SK1169-93A
patent/SK279675B6/en
unknown

1993-10-22
KR
KR1019930021987A
patent/KR100304225B1/en
not_active
IP Right Cessation

1993-10-22
CN
CN93118766A
patent/CN1040435C/en
not_active
Expired – Fee Related

1993-10-22
HU
HU9302997A
patent/HUT65819A/en
unknown

1995

1995-01-03
US
US08/368,252
patent/US5596006A/en
not_active
Expired – Fee Related

1995-12-18
US
US08/574,082
patent/US5863930A/en
not_active
Expired – Fee Related

2000

2000-04-12
GR
GR20000400901T
patent/GR3033207T3/en
not_active
IP Right Cessation

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU666222B2
(en)

*

1992-10-23
1996-02-01
Bayer Aktiengesellschaft
Alkoxymethyl-substituted pyridonebiphenyls

Also Published As

Publication number
Publication date

IL107333A
(en)

1998-01-04

CZ221793A3
(en)

1994-05-18

NO304651B1
(en)

1999-01-25

PT594019E
(en)

2000-08-31

US5596006A
(en)

1997-01-21

FI934646A0
(en)

1993-10-21

ES2145021T3
(en)

2000-07-01

CN1040435C
(en)

1998-10-28

US5863930A
(en)

1999-01-26

GR3033207T3
(en)

2000-08-31

CN1089260A
(en)

1994-07-13

KR100304225B1
(en)

2004-05-10

DE59309956D1
(en)

2000-03-30

MX9306419A
(en)

1994-05-31

CZ283482B6
(en)

1998-04-15

JPH06199838A
(en)

1994-07-19

TW248555B
(en)

1995-06-01

HU9302997D0
(en)

1994-01-28

SK279675B6
(en)

1999-02-11

KR940009174A
(en)

1994-05-20

NO933591L
(en)

1994-04-25

EP0594019B1
(en)

2000-02-23

NO933591D0
(en)

1993-10-07

HUT65819A
(en)

1994-07-28

DE4319041A1
(en)

1994-04-28

NZ250002A
(en)

1995-03-28

ATE189893T1
(en)

2000-03-15

SK116993A3
(en)

1994-11-09

DK0594019T3
(en)

2000-07-03

CA2108814A1
(en)

1994-04-24

AU670315B2
(en)

1996-07-11

FI934646A
(en)

1994-04-24

IL107333A0
(en)

1994-01-25

EP0594019A1
(en)

1994-04-27

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Legal Events

Date
Code
Title
Description

2002-05-02
MK14
Patent ceased section 143(a) (annual fees not paid) or expired

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