AU4824099A - Creación de Inventos y Patentes con Inteligencia Artificial

AU4824099A – Expandable stent and method of use
– Google Patents

AU4824099A – Expandable stent and method of use
– Google Patents
Expandable stent and method of use

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Publication number
AU4824099A

AU4824099A
AU48240/99A
AU4824099A
AU4824099A
AU 4824099 A
AU4824099 A
AU 4824099A
AU 48240/99 A
AU48240/99 A
AU 48240/99A
AU 4824099 A
AU4824099 A
AU 4824099A
AU 4824099 A
AU4824099 A
AU 4824099A
Authority
AU
Australia
Prior art keywords
stent
apexes
extending
elements
serpentine
Prior art date
1998-06-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU48240/99A
Other versions

AU760202B2
(en

Inventor
Daniel L. Cox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Cardiovascular Systems Inc

Original Assignee
Advanced Cardiovascular Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1998-06-17
Filing date
1999-06-16
Publication date
2000-01-05

1999-06-16
Application filed by Advanced Cardiovascular Systems Inc
filed
Critical
Advanced Cardiovascular Systems Inc

2000-01-05
Publication of AU4824099A
publication
Critical
patent/AU4824099A/en

2003-05-08
Application granted
granted
Critical

2003-05-08
Publication of AU760202B2
publication
Critical
patent/AU760202B2/en

2019-06-16
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

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Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS

A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure

A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure

A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure

A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure

A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure

A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure

A61F2002/91516—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a change in frequency along the band

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure

A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure

A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure

A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure

A61F2002/9155—Adjacent bands being connected to each other

A61F2002/91575—Adjacent bands being connected to each other connected peak to trough

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61F2230/00—Geometry of prostheses classified in groups A61F2/00 – A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof

A61F2230/0002—Two-dimensional shapes, e.g. cross-sections

A61F2230/0028—Shapes in the form of latin or greek characters

A61F2230/0054—V-shaped

Description

WO 99/65421 PCT/US99/13618 EXPANDABLE STENT AND METHOD OF USE BACKGROUND OF THE INVENTION The present invention generally relates to intravascular stents and more particularly pertains to improvements thereto that provide for increased coverage and greater expansion ratios without a compromise in strength. 5 Stents or expandable grafts are implanted in a variety of body lumens in an effort to maintain their patency. These devices are typically intraluminally implanted by use of a catheter which is inserted at an easily accessible location and then advanced to the deployment site. The stent is initially in a radially compressed or collapsed state to enable it to be maneuvered through the lumen. Once in 10 position, the stent is deployed which, depending upon its configuration, is achieved either automatically or actively by the inflation of a balloon about which the stent is carried on the catheter. As stents are normally employed to hold open an otherwise blocked, constricted or occluded lumen, a stent must exhibit sufficient radial or hoop strength 15 in its expanded state to effectively counter the anticipated forces. Not only is it advantageous to distribute such loads over as much of the stent as possible but it also is most beneficial to distribute the load over as much lumen wall as possible. This will help minimize injury to the vessel wall. Also by minimizing the gaps between stent struts it is possible to prevent prolapse of the plaque between the 20 struts into the lumen. As a consequence, it is desirable to maximize the coverage of the lumen wall by creating uniform, small gaps between the stent struts. It is, however, simultaneously necessary for the stent to be as small and compact as possible in its collapsed state in order to facilitate its advancement through the lumen. As large an expansion ratio as possible is therefore most desirable. 25 A number of very different approaches have been previously devised in an effort to address these various requirements. A popular approach calls for the stent to be constructed wholly of wire. The wire is bent, woven and/or coiled to WO 99/65421 PCT/US99/13618 -2 define a generally cylindrical structure in a configuration that has the ability to undergo radial expansion. The use of wire has a number of disadvantages associated therewith including for example, a substantially constant cross-section which may cause greater or lesser than an ideal amount of material to be 5 concentrated at certain locations along the stent. Additionally, wire has limitations with respect to the shapes it can be formed into thus limiting the expansion ratio, coverage area and strength that can ultimately be attained therewith. The welding of adjoining sections of wire together has also been previously employed to increase strength albeit with a substantial increase in manufacturing costs. 10 As an alternative to wire-based structures, stents have been constructed from tube stock. By selectively removing material from such tubular starting material, a desired degree of flexibility and expandability can be imparted to the structure. Chemical etching techniques as well as laser-cutting processes are utilized to remove material from the tube. Laser etching provides for a high degree 15 of precision and accuracy with which very well defined patterns of material can be removed from the tube to conversely leave very precisely and accurately defined patterns of material in tact. The performance parameters of such stents are very much a function of the pattern in which material is removed form the tube stock. The selection of a particular pattern has a profound effect on the coverage area, 20 expansion ratio and strength of the resulting stent. While the tube-based stents offer many advantages over the wire based designs, it is nonetheless desirable to improve upon such designs in an effort to further increase coverage area and expansion ratios while maintaining strength.
WO 99/65421 PCT/US99/13618 -3 SUMMARY OF THE INVENTION The present invention provides for an improved tube-based stent having an increased coverage area, expansion ratio and strength. The improvements arise with the selection of a precisely defined pattern of voids that are 5 cut or etched into the tube stock. The pattern of material that remains to define the stent comprises a series of nested serpentine elements wherein selected apexes are interconnected to one another by bridging members. More particularly, each serpentine element extends circumferentially about the stent such that successive apexes of each element alternatively extend distally and proximally along the stent’s 10 surface. Adjacent serpentine elements are spaced about the stent wherein each element is nested in the adjacent elements such that the apexes of one element extend into the space between the apexes of the adjacent element. The serpentine elements are joined to one another along either all of their distal or all of their proximal apexes. Each of a particular element’s apexes extending along its 15 interconnected edge is alternatingly joined to the corresponding apexes of proximally and distally adjoining serpentine elements by bridging elements. By properly shaping the junction area between each bridging element and apex, stress risers are reduced or eliminated with a corresponding decrease in the potential for fracturing during expansion. By curving the transverse sections that extend between 20 each of the apexes of a given element, adjacent elements become more tightly packed. Coverage exceeding 2 0% with expansion ratios of 3.0 are thereby achievable, and expansion ratios exceeding 6.0 are also achievable. More importantly, this dense coverage is uniformly distributed throughout the stent. These and other features and advantages of the present invention will 25 become apparent from the following detailed description of preferred embodiments which, taken in conjunction with the accompanying drawings, illustrate by way of example the principles of the invention.
WO 99/65421 PCT/US99/13618 -4 BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1, is a flattened plan view of a section of stent of the present invention in its collapsed state. FIG. 2 is a flattened plan view of a section of an alternative 5 embodiment stent in its collapsed state. FIG. 3 is flattened plan view of a section of another alternative embodiment stent in its collapsed state. FIG. 4 is flattened plan view of a section of another alternative embodiment stent in its collapsed state. 10 FIG. 5 is view of the stent shown in FIG. 4, in its partially expanded state. FIG. 6 is view of the stent shown in FIG. 5 in a further expanded state. FIG. 7 is a flattened plan view of a section of yet another alternative 15 embodiment stent of the present invention in its collapsed state. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The invention is directed to a stent formed from tube stock having a configuration that imparts greater coverage and expansion ratios than heretofore have been possible without compromising strength. Each of the figures illustrates a 20 section of such stents in a flattened plan view for enhanced clarity. Typically, the WO 99/65421 PCT/US99/13618 -5 stents of the present invention are formed from tubular members utilizing a chemical etching process or by a laser cutting process. A typical chemical etching process is disclosed in U.S. Patent No. 5,421,955 (Lau et al.), which is commonly assigned and commonly owned by Advanced Cardiovascular Systems, Inc., and 5 which is incorporated herein by reference thereto. Preferably, stents according to the present invention are formed by a laser cutting process as disclosed in U.S. Patent Application Serial No. 08/783,698, which is commonly assigned and commonly owned by Advanced Cardiovascular Systems, Inc., and which is incorporated herein by reference thereto. 10 FIG. 1 illustrates the general concept of the present invention. Shown is an assembly 12 of serpentine elements 14 wherein apexes 16 of adjacent elements are nested between one another. In its three dimensional form, each serpentine element extends circumferentially about the stent such that for example, end 20 is attached to end 22. The total number of elements assembled in such fashion 15 determine the overall length of the stent. Each of the parallel serpentine elements is joined to the adjacent elements by bridging members 18 that extend from the apexes located along one edge of the serpentine element. Such apexes are alternatingly joined to the corresponding apexes of the proximally and distally adjoining serpentine elements. 20 FIG. 2 illustrates an alternative embodiment nested design 24 wherein further improvement in terms of coverage area is realized with the modification of the bridging elements 26. Each bridging element is widened to achieve a commensurate increase in surface area. Sufficient clearance 28, 30 is maintained between the bridging element and the adjoining sections of the serpentine elements 25 so as to preclude contact and interference during expansion. FIG. 3 illustrates a further alternative embodiment 32 wherein the stresses generated during expansion of the stent near the junction 34 of the bridging element 36 with the concave side 38 of the apex 40 are reduced when compared to. the embodiments shown in Figs. 1 and 2. The configurations shown in Figs. 1 and WO 99/65421 PCT/US99/13618 -6 2 define acute angles at such junctures along with an increased concentration of mass at such point. During expansion, the bending of the material would therefore be concentrated adjacent the acute corners and greatly diminished at the center of the apex and thereby promote fractures and the potential for failure. By eliminating 5 the acute angles and the concentration of mass at the apex with its formation into a «W» shape, stress is more evenly distributed along the apex during expansion. FIG. 4 illustrates a further alternative embodiment 42 which incorporates the advantageous features of the embodiment shown in FIG. 3 along with additional features that serve to increase the stent’s coverage area as well as its 10 expansion ratio. As is visible in the figure, the transverse section 44 of each serpentine element that links successive apexes 46, 48 is curved at 50 to accommodate the apex of the adjacent serpentine element and to thereby achieve denser packing. The sections are sufficiently curved to come as close as possible to the bridge member at 52 prior to curving around the adjacent apex. Alternating 15 sections are sufficiently curved to substantially close off the apex at 54. The configuration imparts a substantially enhanced coverage area and expansion ratio while nonetheless allowing for the stent to undergo unimpeded expansion. FIG. 5 illustrates such stent configuration partially expanded to show the lack of interference as all elements are caused to move away from one another. FIG. 6 20 illustrates the stent in a substantially more expanded state. The configuration shown in FIG. 6 yields a theoretical expansion ratio of up to 6.7. FIG. 7 illustrates the most preferred embodiment of the present invention which incorporates many of the features of the embodiments shown in the other Figures, including the nested configuration of parallel serpentine elements, 25 bridging members joining corresponding apexes of adjacent serpentine elements, the stress-reliefed «W» patterned apex and the curved linking segments. The wider serpentine elements and bridging members along with the tighter radii yield a stent with an exceptionally high coverage area and expansion ratio along with substantial strength.
WO 99/65421 PCT/US99/13618 -7 The stents of the present invention are preferably formed utilizing laser cutting techniques well known in the art. The material used in the manufacture of such stents may be substantially worked stainless steel of low ductility materials such as titanium for balloon expandable versions. Alternatively, NiTi may be used 5 for self expanding embodiments. While a particular form of the invention has been illustrated and described, it will also be apparent to those skilled in the art that various modifications can be made without departing from the spirit and scope of the invention. The present invention is not limited to stents for any particular body 10 lumen. The size of the stent can vary in terms of inner diameter, outer diameter, wall thickness and length. Accordingly, it is not intended that the invention be limited except by the appended claims.

Claims (9)

1. A stent, comprising: a series of circumferentially disposed serpentine elements, each such elements including a series of apexes extending toward a proximal side and a series 5 of apexes extending toward a distal side, wherein apexes of adjacent serpentine elements are nested within one another and wherein adjacent serpentine elements are linked by bridging members extending between apexes located on the same side of each element.

2. The stent of claim 1, wherein the bridging elements extending from a serpentine element alternatingly extend between the apexes of the distally and proximally adjoining serpentine elements.

3. The stent of claim 2, wherein the bridging elements extend between apexes extending toward the distal side.

4. The stent of claim 3, wherein each distally extending apex that is linked to a distally extending apex of a proximally adjoining serpentine element is «W» shaped.

5. The stent of claim 2, wherein the bridging elements extend between apexes extending toward the proximal side. WO 99/65421 PCT/US99/13618 -9

6. The stent of claim 5, wherein each proximally extending apex that is linked to a proximally extending apex of a distally adjoining serpentine element is «W» shaped.

7. The stent of claim 2, further comprising transverse sections extending between apexes of serpentine elements which are sufficiently curved such that transverse sections extending from the same apex substantially contact one another.

8. The stent of claim 2, further comprising transverse sections extending between apexes of serpentine elements which are sufficiently curved so as to substantially contact bridging elements extending therebetween.

9. The stent of claim 1, wherein the stent is formed from a metal alloy taken from the group of alloys consisting of stainless steel, titanium, tantalum, and nickel-titanium.

AU48240/99A
1998-06-17
1999-06-16
Expandable stent and method of use

Ceased

AU760202B2
(en)

Applications Claiming Priority (3)

Application Number
Priority Date
Filing Date
Title

US09/099008

1998-06-17

US09/099,008

US6171334B1
(en)

1998-06-17
1998-06-17
Expandable stent and method of use

PCT/US1999/013618

WO1999065421A2
(en)

1998-06-17
1999-06-16
Expandable stent and method of use

Publications (2)

Publication Number
Publication Date

AU4824099A
true

AU4824099A
(en)

2000-01-05

AU760202B2

AU760202B2
(en)

2003-05-08

Family
ID=22272002
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU48240/99A
Ceased

AU760202B2
(en)

1998-06-17
1999-06-16
Expandable stent and method of use

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US
(1)

US6171334B1
(en)

EP
(1)

EP1087728A2
(en)

JP
(1)

JP2002518087A
(en)

CN
(1)

CN1310599A
(en)

AU
(1)

AU760202B2
(en)

CA
(1)

CA2335083A1
(en)

WO
(1)

WO1999065421A2
(en)

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1991-02-22
1992-05-26
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1995-09-11
1997-07-21
Cook William Europ

Expandable endovascular stent

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1996-01-19
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1998

1998-06-17
US
US09/099,008
patent/US6171334B1/en
not_active
Expired – Lifetime

1999

1999-06-16
JP
JP2000554303A
patent/JP2002518087A/en
active
Pending

1999-06-16
WO
PCT/US1999/013618
patent/WO1999065421A2/en
active
IP Right Grant

1999-06-16
CN
CN99808897A
patent/CN1310599A/en
active
Pending

1999-06-16
EP
EP99931813A
patent/EP1087728A2/en
not_active
Withdrawn

1999-06-16
CA
CA002335083A
patent/CA2335083A1/en
not_active
Abandoned

1999-06-16
AU
AU48240/99A
patent/AU760202B2/en
not_active
Ceased

Also Published As

Publication number
Publication date

US6171334B1
(en)

2001-01-09

CA2335083A1
(en)

1999-12-23

CN1310599A
(en)

2001-08-29

AU760202B2
(en)

2003-05-08

WO1999065421A3
(en)

2000-01-27

WO1999065421A2
(en)

1999-12-23

EP1087728A2
(en)

2001-04-04

JP2002518087A
(en)

2002-06-25

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