AU5183279A

AU5183279A – Compounds
– Google Patents

AU5183279A – Compounds
– Google Patents
Compounds

Info

Publication number
AU5183279A

AU5183279A
AU51832/79A
AU5183279A
AU5183279A
AU 5183279 A
AU5183279 A
AU 5183279A
AU 51832/79 A
AU51832/79 A
AU 51832/79A
AU 5183279 A
AU5183279 A
AU 5183279A
AU 5183279 A
AU5183279 A
AU 5183279A
Authority
AU
Australia
Prior art keywords
carboxy
hydrogen
physiologically acceptable
salt
base
Prior art date
1978-10-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU51832/79A
Other versions

AU529643B2
(en

Inventor
Helmut Biere
Dr. Irmgard Bottcher
Joachim-Friedrich Kapp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1978-10-18
Filing date
1979-10-16
Publication date
1980-04-24

1979-10-16
Application filed by Schering AG
filed
Critical
Schering AG

1980-04-24
Publication of AU5183279A
publication
Critical
patent/AU5183279A/en

1983-06-16
Application granted
granted
Critical

1983-06-16
Publication of AU529643B2
publication
Critical
patent/AU529643B2/en

1999-10-16
Anticipated expiration
legal-status
Critical

Status
Expired – Fee Related
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00

C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains two hetero rings

C07D471/04—Ortho-condensed systems

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P25/00—Drugs for disorders of the nervous system

A61P25/04—Centrally acting analgesics, e.g. opioids

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P37/00—Drugs for immunological or allergic disorders

A61P37/08—Antiallergic agents

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom

C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring

C07D209/04—Indoles; Hydrogenated indoles

C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring

C07D209/32—Oxygen atoms

C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members

C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D213/61—Halogen atoms or nitro radicals

Abstract

Pyrido[2,1-b]quinazolinones of the formula wherein X is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl, carboxy, carboxy in the form of a salt thereof with a physiologically compatible base, carboxy esterified with a physiologically acceptable alcohol or carboxy amidated with a physiologically acceptable amine; R1 is hydrogen or methyl; and R2 through R5 are independently each hydrogen, halogen, alkyl of 1-4 carbon atoms, trifluoromethyl, carboxy, thiocyano, methylthio, methylsulfinyl, methylsulfonyl, methylsulfonimidoyl or methylsulfonamido with the proviso that two or three of the groups R2 through R5 are hydrogen; or a salt thereof with a physiologically acceptable acid or base; possess valuable pharmacological properties.

AU51832/79A
1978-10-18
1979-10-16
Compounds

Expired – Fee Related

AU529643B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE28457661

1978-10-18

DE19782845766

DE2845766A1
(en)

1978-10-18
1978-10-18

PYRIDO ANGLE CLAMP ON 2,1-B ANGLE CLAMP ON -CHINAZOLINONE DERIVATIVES, THEIR PRODUCTION AND USE

Publications (2)

Publication Number
Publication Date

AU5183279A
true

AU5183279A
(en)

1980-04-24

AU529643B2

AU529643B2
(en)

1983-06-16

Family
ID=6052696
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU51832/79A
Expired – Fee Related

AU529643B2
(en)

1978-10-18
1979-10-16
Compounds

Country Status (25)

Country
Link

US
(1)

US4457927A
(en)

EP
(1)

EP0011142B1
(en)

JP
(1)

JPS5557588A
(en)

AT
(1)

ATE2146T1
(en)

AU
(1)

AU529643B2
(en)

CA
(1)

CA1130805A
(en)

CS
(1)

CS216512B2
(en)

DD
(1)

DD147242A5
(en)

DE
(2)

DE2845766A1
(en)

DK
(1)

DK154297C
(en)

EG
(1)

EG14028A
(en)

ES
(1)

ES8103745A1
(en)

FI
(1)

FI793229A
(en)

FR
(1)

FR2439199A1
(en)

GB
(1)

GB2034705B
(en)

GR
(1)

GR73819B
(en)

IE
(1)

IE48852B1
(en)

IL
(1)

IL58474A0
(en)

NO
(1)

NO793344L
(en)

NZ
(1)

NZ191828A
(en)

PL
(3)

PL123075B1
(en)

PT
(1)

PT70329A
(en)

RO
(1)

RO78339A
(en)

SU
(1)

SU1001857A3
(en)

ZA
(1)

ZA795559B
(en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE3300477A1
(en)

*

1983-01-08
1984-07-12
Boehringer Ingelheim KG, 6507 Ingelheim

NEW HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE

US4587339A
(en)

*

1983-10-14
1986-05-06
Sun Chemical Corporation
Nickel complex pigments of bis-azomethines

JPH06509576A
(en)

*

1991-07-29
1994-10-27
ワーナー−ランバート・コンパニー

Quinazoline derivatives as acetylcholinesterase inhibitors

CA2238283C
(en)

1997-05-30
2002-08-20
Cell Pathways, Inc.
Method for identifying compounds for inhibition of neoplastic lesions, pharmaceutical compositions from such compounds and uses of such compounds and compositions for treating neoplastic lesions

US5858694A
(en)

*

1997-05-30
1999-01-12
Cell Pathways, Inc.
Method for identifying compounds for inhibition of cancerous lesions

US6410584B1
(en)

*

1998-01-14
2002-06-25
Cell Pathways, Inc.
Method for inhibiting neoplastic cells with indole derivatives

US6200771B1
(en)

1998-10-15
2001-03-13
Cell Pathways, Inc.
Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia

US6130053A
(en)

*

1999-08-03
2000-10-10
Cell Pathways, Inc.
Method for selecting compounds for inhibition of neoplastic lesions

US6133271A
(en)

*

1998-11-19
2000-10-17
Cell Pathways, Inc.
Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives

US6187779B1
(en)

1998-11-20
2001-02-13
Cell Pathways, Inc.
Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives

US6369092B1
(en)

1998-11-23
2002-04-09
Cell Pathways, Inc.
Method for treating neoplasia by exposure to substituted benzimidazole derivatives

US6077842A
(en)

*

1998-11-24
2000-06-20
Cell Pathways, Inc.
Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives

US6486155B1
(en)

1998-11-24
2002-11-26
Cell Pathways Inc
Method of inhibiting neoplastic cells with isoquinoline derivatives

US6034099A
(en)

*

1998-11-24
2000-03-07
Cell Pathways, Inc.
Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones

US6025394A
(en)

1999-01-29
2000-02-15
Cell Pathways, Inc.
Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols

US6020379A
(en)

*

1999-02-19
2000-02-01
Cell Pathways, Inc.
Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia

US6555547B1
(en)

2000-02-28
2003-04-29
Cell Pathways, Inc.
Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative

US6569638B1
(en)

2000-03-03
2003-05-27
Cell Pathways, Inc
Method for screening compounds for the treatment of neoplasia

Family Cites Families (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB1064259A
(en)

*

1963-12-19
1967-04-05
Union Pharma Scient Appl
New derivatives of 2-anilino-nicotinic acid and process for their preparation

US4033961A
(en)

*

1975-10-07
1977-07-05
Warner-Lambert Company
Pyrido[2-1-b]quinazolin-ones and their methods of preparation

DE2557425A1
(en)

*

1975-12-19
1977-06-30
Boehringer Sohn Ingelheim

CHINAZOLONE DERIVATIVES

US4066767A
(en)

*

1976-11-01
1978-01-03
Warner-Lambert Company
8-(1H-Tetrazol-5-yl)-11H-pyrido[2,1-b]quinazolin-11-ones and method of treating bronchial asthma using them

ES468126A1
(en)

*

1977-03-24
1979-09-01
Hoffmann La Roche
Pyridol(2,1-b)quinazoline derivatives

1978

1978-10-18
DE
DE19782845766
patent/DE2845766A1/en
not_active
Withdrawn

1979

1979-10-11
NZ
NZ191828A
patent/NZ191828A/en
unknown

1979-10-15
DD
DD79216232A
patent/DD147242A5/en
unknown

1979-10-15
EP
EP79103974A
patent/EP0011142B1/en
not_active
Expired

1979-10-15
AT
AT79103974T
patent/ATE2146T1/en
not_active
IP Right Cessation

1979-10-15
DE
DE7979103974T
patent/DE2964431D1/en
not_active
Expired

1979-10-16
AU
AU51832/79A
patent/AU529643B2/en
not_active
Expired – Fee Related

1979-10-16
RO
RO7998984A
patent/RO78339A/en
unknown

1979-10-16
PL
PL1979227126A
patent/PL123075B1/en
unknown

1979-10-16
PL
PL1979218993A
patent/PL119174B1/en
unknown

1979-10-16
PL
PL1979227124A
patent/PL123430B1/en
unknown

1979-10-16
GR
GR60275A
patent/GR73819B/el
unknown

1979-10-17
NO
NO793344A
patent/NO793344L/en
unknown

1979-10-17
DK
DK438379A
patent/DK154297C/en
active

1979-10-17
IE
IE1969/79A
patent/IE48852B1/en
unknown

1979-10-17
CA
CA337,796A
patent/CA1130805A/en
not_active
Expired

1979-10-17
IL
IL58474A
patent/IL58474A0/en
unknown

1979-10-17
PT
PT70329A
patent/PT70329A/en
unknown

1979-10-17
SU
SU792832051A
patent/SU1001857A3/en
active

1979-10-18
FI
FI793229A
patent/FI793229A/en
not_active
Application Discontinuation

1979-10-18
ES
ES485162A
patent/ES8103745A1/en
not_active
Expired

1979-10-18
GB
GB7936147A
patent/GB2034705B/en
not_active
Expired

1979-10-18
CS
CS797083A
patent/CS216512B2/en
unknown

1979-10-18
EG
EG624/79A
patent/EG14028A/en
active

1979-10-18
ZA
ZA00795559A
patent/ZA795559B/en
unknown

1979-10-18
FR
FR7925883A
patent/FR2439199A1/en
not_active
Withdrawn

1979-10-18
JP
JP13363479A
patent/JPS5557588A/en
active
Granted

1982

1982-12-22
US
US06/452,009
patent/US4457927A/en
not_active
Expired – Fee Related

Also Published As

Publication number
Publication date

EP0011142B1
(en)

1982-12-29

DD147242A5
(en)

1981-03-25

IL58474A0
(en)

1980-01-31

FR2439199A1
(en)

1980-05-16

SU1001857A3
(en)

1983-02-28

DE2964431D1
(en)

1983-02-03

CS216512B2
(en)

1982-11-26

DK438379A
(en)

1980-04-19

ZA795559B
(en)

1980-09-24

ES485162A0
(en)

1981-03-16

NZ191828A
(en)

1983-03-15

DE2845766A1
(en)

1980-04-30

US4457927A
(en)

1984-07-03

ES8103745A1
(en)

1981-03-16

JPS5557588A
(en)

1980-04-28

DK154297B
(en)

1988-10-31

PT70329A
(en)

1979-11-01

EP0011142A1
(en)

1980-05-28

IE791969L
(en)

1980-04-18

RO78339A
(en)

1982-04-12

PL218993A1
(en)

1980-06-16

PL123430B1
(en)

1982-10-30

PL119174B1
(en)

1981-12-31

NO793344L
(en)

1980-04-21

CA1130805A
(en)

1982-08-31

IE48852B1
(en)

1985-05-29

ATE2146T1
(en)

1983-01-15

GB2034705A
(en)

1980-06-11

GR73819B
(en)

1984-05-03

AU529643B2
(en)

1983-06-16

GB2034705B
(en)

1982-12-08

EG14028A
(en)

1982-09-30

JPS634537B2
(en)

1988-01-29

PL123075B1
(en)

1982-09-30

FI793229A
(en)

1980-04-19

DK154297C
(en)

1989-03-28

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