AU5193379A

AU5193379A – 6-arylpyridazin-3-ones
– Google Patents

AU5193379A – 6-arylpyridazin-3-ones
– Google Patents
6-arylpyridazin-3-ones

Info

Publication number
AU5193379A

AU5193379A
AU51933/79A
AU5193379A
AU5193379A
AU 5193379 A
AU5193379 A
AU 5193379A
AU 51933/79 A
AU51933/79 A
AU 51933/79A
AU 5193379 A
AU5193379 A
AU 5193379A
AU 5193379 A
AU5193379 A
AU 5193379A
Authority
AU
Australia
Prior art keywords
alkyl
biphenylyl
arylpyridazin
ones
phenoxyphenyl
Prior art date
1978-10-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU51933/79A
Other versions

AU532749B2
(en

Inventor
Joachim Gante
Hans-Adolf Kurmeier
Reinhard Lissner
Guido Melzer
Dieter Orth
Erich Schacht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1978-10-19
Filing date
1979-10-18
Publication date
1980-04-24

1979-10-18
Application filed by Merck Patent GmbH
filed
Critical
Merck Patent GmbH

1980-04-24
Publication of AU5193379A
publication
Critical
patent/AU5193379A/en

1983-10-13
Application granted
granted
Critical

1983-10-13
Publication of AU532749B2
publication
Critical
patent/AU532749B2/en

1999-10-18
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings

C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems

C07D237/30—Phthalazines

C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P25/00—Drugs for disorders of the nervous system

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P25/00—Drugs for disorders of the nervous system

A61P25/04—Centrally acting analgesics, e.g. opioids

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P3/00—Drugs for disorders of the metabolism

A61P3/06—Antihyperlipidemics

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P3/00—Drugs for disorders of the metabolism

A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P7/00—Drugs for disorders of the blood or the extracellular fluid

A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings

C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings

C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings

C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings

C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members

C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D237/14—Oxygen atoms

Abstract

Compounds of the formula wherein R1 is 4-biphenylyl, 4-phenoxyphenyl or 4-biphenylyl or 4-phenoxyphenyl substituted in the 4′-position by F, Cl, Br or I; R2 is H, C1-4-alkyl, hydroxy-C1-4-alkyl or pyridyl; R3 and R6 are each H or alkyl of 1-4 carbon atoms, or together are-(CH2)4-; and R4 and R5 are each H or together are a C-C bond; at least one of the radicals R2, R3 and R6 being other than hydrogen, possess valuable pharmacological properties, e.g., lower lipid levels and are anti-thrombotic.

AU51933/79A
1978-10-19
1979-10-18
6-arylpyridazin-3-ones

Ceased

AU532749B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE28454560

1978-10-19

DE19782845456

DE2845456A1
(en)

1978-10-19
1978-10-19

6-ARYLPYRIDAZIN-3-ONE AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number
Publication Date

AU5193379A
true

AU5193379A
(en)

1980-04-24

AU532749B2

AU532749B2
(en)

1983-10-13

Family
ID=6052528
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU51933/79A
Ceased

AU532749B2
(en)

1978-10-19
1979-10-18
6-arylpyridazin-3-ones

Country Status (12)

Country
Link

US
(1)

US4289774A
(en)

EP
(1)

EP0010156B1
(en)

JP
(1)

JPS5557570A
(en)

AT
(1)

ATE1624T1
(en)

AU
(1)

AU532749B2
(en)

CA
(1)

CA1134826A
(en)

DE
(2)

DE2845456A1
(en)

ES
(1)

ES485153A1
(en)

HU
(1)

HU180264B
(en)

IL
(1)

IL58473A
(en)

YU
(1)

YU252479A
(en)

ZA
(1)

ZA795561B
(en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE3124699A1
(en)

*

1981-06-24
1983-01-13
Basf Ag, 6700 Ludwigshafen

NEW 2-ARYL-3,4-DIAZA-BICYCLO (4.N.0.) ALKEN- (2) -ONE- (5), METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

DE3321012A1
(en)

*

1983-06-10
1984-12-13
A. Nattermann & Cie GmbH, 5000 Köln

SUBSTITUTED 4,5-DIHYDRO-6- (THIEN-2-YL) -3 (2H) -PYRIDAZINONE AND 6- (THIEN-2-YL) -3 (2H) -PYRIDAZINONE AND METHOD FOR THE PRODUCTION THEREOF

US4631279A
(en)

*

1984-10-15
1986-12-23
Eli Lilly And Company
6-(pyridinylphenyl)dihydropyridazinones as inotropic agents

EP0210530A1
(en)

*

1985-07-27
1987-02-04
MERCK PATENT GmbH
6-Arylalkenyl pyridazinones

US4806535A
(en)

*

1987-07-22
1989-02-21
Rorer Pharmaceutical Corporation
Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility

GB8824458D0
(en)

*

1988-10-19
1988-11-23
Orion Yhtymae Oy
Substituted pyridazinones

DE19514568A1
(en)

1995-04-20
1996-10-24
Merck Patent Gmbh

Arylalkyl pyridazinones

US6103718A
(en)

*

1997-01-15
2000-08-15
Byk Gulden Lomberg Chemische Fabrik Gmbh
Phthalazinones

US7074959B2
(en)

*

2002-08-01
2006-07-11
New Mexico Highlands University
Methods and systems for remediating hydrazine-contaminated equipment and/or surfaces

WO2013097052A1
(en)

2011-12-30
2013-07-04
Abbott Laboratories
Bromodomain inhibitors

WO2013185284A1
(en)

2012-06-12
2013-12-19
Abbott Laboratories
Pyridinone and pyridazinone derivatives

SG11201808003RA
(en)

2016-04-15
2018-10-30
Abbvie Inc
Bromodomain inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE1670683A1
(en)

*

1966-03-31
1970-01-02
Bayer Ag

Process for the production of novel aryl ethers

FR1604863A
(en)

*

1967-11-22
1972-04-17

US3689652A
(en)

*

1970-10-09
1972-09-05
William Vincent Curran
Method of lowering blood pressure in mammals

US3822260A
(en)

*

1970-10-09
1974-07-02
American Cyanamid Co
6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones

US4088762A
(en)

*

1971-02-22
1978-05-09
Bdh Pharmaceuticals Limited
6-(P-PIPERAZINO)-PHENYL-4,5-DIHYDRO-3(2H)pyridazinones

GB1383906A
(en)

*

1971-02-22
1974-02-12
Bdh Pharmaceuticals Ltd
Pyridazinones

US3812256A
(en)

*

1971-06-08
1974-05-21
American Cyanamid Co
Novel method for lowering blood pressure in mammals

US3840662A
(en)

*

1971-08-05
1974-10-08
Shimamoto Takio
Method of treating atherosclerosis using 4-hydroxymethyl-1-keto-1,2-dihydrophthalazine or acid salts thereof

GB1488330A
(en)

*

1973-12-19
1977-10-12
Smith Kline French Lab
Dihydropyridazinones

JPS6037101B2
(en)

*

1977-03-09
1985-08-24
三共株式会社

Method for producing phenylpyridazinone derivatives

1978

1978-10-19
DE
DE19782845456
patent/DE2845456A1/en
not_active
Withdrawn

1979

1979-09-12
DE
DE7979103396T
patent/DE2963814D1/en
not_active
Expired

1979-09-12
EP
EP79103396A
patent/EP0010156B1/en
not_active
Expired

1979-09-12
AT
AT79103396T
patent/ATE1624T1/en
not_active
IP Right Cessation

1979-10-16
IL
IL58473A
patent/IL58473A/en
unknown

1979-10-17
YU
YU02524/79A
patent/YU252479A/en
unknown

1979-10-18
CA
CA000337906A
patent/CA1134826A/en
not_active
Expired

1979-10-18
ZA
ZA00795561A
patent/ZA795561B/en
unknown

1979-10-18
ES
ES485153A
patent/ES485153A1/en
not_active
Expired

1979-10-18
AU
AU51933/79A
patent/AU532749B2/en
not_active
Ceased

1979-10-19
HU
HU79ME2311A
patent/HU180264B/en
unknown

1979-10-19
US
US06/086,604
patent/US4289774A/en
not_active
Expired – Lifetime

1979-10-19
JP
JP13428379A
patent/JPS5557570A/en
active
Pending

Also Published As

Publication number
Publication date

IL58473A0
(en)

1980-01-31

IL58473A
(en)

1985-07-31

ATE1624T1
(en)

1982-10-15

EP0010156A1
(en)

1980-04-30

US4289774A
(en)

1981-09-15

HU180264B
(en)

1983-02-28

ZA795561B
(en)

1980-09-24

YU252479A
(en)

1983-01-21

CA1134826A
(en)

1982-11-02

DE2845456A1
(en)

1980-08-14

AU532749B2
(en)

1983-10-13

DE2963814D1
(en)

1982-11-11

ES485153A1
(en)

1980-05-16

EP0010156B1
(en)

1982-10-06

JPS5557570A
(en)

1980-04-28

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