AU528825B2 – (3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
– Google Patents
AU528825B2 – (3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
– Google Patents
(3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
Info
Publication number
AU528825B2
AU528825B2
AU50279/79A
AU5027979A
AU528825B2
AU 528825 B2
AU528825 B2
AU 528825B2
AU 50279/79 A
AU50279/79 A
AU 50279/79A
AU 5027979 A
AU5027979 A
AU 5027979A
AU 528825 B2
AU528825 B2
AU 528825B2
Authority
AU
Australia
Prior art keywords
pyridazinyl
dihydro
oxo
benzimidazole derivatives
benzimidazole
Prior art date
1978-08-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU50279/79A
Other versions
AU5027979A
(en
Inventor
Volkhard Austel
Willi Diederen
Wolfgang Eberlein
Walter Haarmann
Joachim Heider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1978-08-25
Filing date
1979-08-24
Publication date
1983-05-12
1978-08-25
Priority claimed from DE19782837161
external-priority
patent/DE2837161A1/en
1979-06-01
Priority claimed from DE19792922336
external-priority
patent/DE2922336A1/en
1979-08-24
Application filed by Dr Karl Thomae GmbH
filed
Critical
Dr Karl Thomae GmbH
1980-02-28
Publication of AU5027979A
publication
Critical
patent/AU5027979A/en
1983-05-12
Application granted
granted
Critical
1983-05-12
Publication of AU528825B2
publication
Critical
patent/AU528825B2/en
1999-08-24
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/33—Heterocyclic compounds
A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
A61K31/50—Pyridazines; Hydrogenated pyridazines
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
AU50279/79A
1978-08-25
1979-08-24
(3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
Expired
AU528825B2
(en)
Applications Claiming Priority (4)
Application Number
Priority Date
Filing Date
Title
DE28371611
1978-08-25
DE19782837161
DE2837161A1
(en)
1978-08-25
1978-08-25
5-Alkyl:pyridazinyl substd. benzimidazole derivs. – useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors
DE19792922336
DE2922336A1
(en)
1979-06-01
1979-06-01
5-Alkyl:pyridazinyl substd. benzimidazole derivs. – useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors
DE29223367
1979-06-01
Publications (2)
Publication Number
Publication Date
AU5027979A
AU5027979A
(en)
1980-02-28
AU528825B2
true
AU528825B2
(en)
1983-05-12
Family
ID=25775527
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU50279/79A
Expired
AU528825B2
(en)
1978-08-25
1979-08-24
(3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
Country Status (17)
Country
Link
US
(1)
US4361563A
(en)
EP
(1)
EP0008391B1
(en)
AU
(1)
AU528825B2
(en)
BG
(1)
BG60428B2
(en)
CA
(1)
CA1134362A
(en)
CS
(1)
CS410191A3
(en)
DE
(1)
DE2962051D1
(en)
DK
(1)
DK152496C
(en)
ES
(2)
ES8101067A1
(en)
FI
(1)
FI66372C
(en)
GR
(1)
GR69998B
(en)
HK
(1)
HK50585A
(en)
IE
(1)
IE48814B1
(en)
MX
(1)
MX9202731A
(en)
NL
(1)
NL980035I2
(en)
PH
(1)
PH17515A
(en)
SG
(1)
SG285G
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU586852B2
(en)
*
1985-02-19
1989-07-27
Merck Patent Gesellschaft Mit Beschrankter Haftung
Benzimidazolylpyridazinones
Families Citing this family (59)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE3129447A1
(en)
*
1981-07-25
1983-02-10
Dr. Karl Thomae Gmbh, 7950 Biberach
«NEW BENZTRIAZOLES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS»
US4699909A
(en)
*
1981-07-25
1987-10-13
Dr. Karl Thomae Gmbh
Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones
US4353905A
(en)
*
1981-09-17
1982-10-12
Warner-Lambert Company
Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones
IT1172270B
(en)
*
1982-06-21
1987-06-18
Wellcome Found
INTERFERON PRODUCTION PROCEDURE
US4734415A
(en)
*
1982-08-13
1988-03-29
Warner-Lambert Company
Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones
US4717730A
(en)
*
1982-12-03
1988-01-05
Warner-Lambert Company
4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components
US4521416A
(en)
*
1983-03-22
1985-06-04
Warner-Lambert Company
4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones
GB8320005D0
(en)
*
1983-07-25
1983-08-24
Fujisawa Pharmaceutical Co
Benzothiazoline derivatives
US4591591A
(en)
*
1984-03-08
1986-05-27
Eli Lilly And Company
Pyridazinone derivatives as inotropic agents
IL75122A
(en)
*
1984-05-14
1989-02-28
Lilly Co Eli
3-methyl-5-(tetrahydro-6-oxopyridazin-3-yl)indoline derivatives,their preparation and use
US4647564A
(en)
*
1984-05-14
1987-03-03
Eli Lilly And Company
Inotropic agents
US4816454A
(en)
*
1984-09-21
1989-03-28
Cassella Aktiengesellschaft
4,5-dihydro-3(2H)-pyridazinones and their pharmacological use
US4617302A
(en)
*
1984-10-15
1986-10-14
Eli Lilly And Company
Inotropic agents
DE3511110A1
(en)
*
1985-03-27
1986-10-02
Dr. Karl Thomae Gmbh, 7950 Biberach
NEW PYRIDAZINONE, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4725686A
(en)
*
1985-11-22
1988-02-16
William H. Rorer, Inc.
Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4868300A
(en)
*
1985-11-22
1989-09-19
Rorer Pharmaceutical Corporation
Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses
US4785101A
(en)
*
1985-11-22
1988-11-15
Rorer Pharmaceutical Corporation
Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses
US4906630A
(en)
*
1985-11-22
1990-03-06
Rorer Pharmaceutical Corporation
Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds
DE3623944A1
(en)
*
1986-07-16
1988-02-11
Thomae Gmbh Dr K
NEW BENZOLSULFONAMIDO INDANYL COMPOUNDS, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
US4859672A
(en)
*
1986-10-29
1989-08-22
Rorer Pharmaceutical Corporation
Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone
DE3704879A1
(en)
*
1987-02-17
1988-08-25
Merck Patent Gmbh
PYRIDAZINE DERIVATIVES
DE3734083A1
(en)
*
1987-10-08
1989-04-20
Heumann Pharma Gmbh & Co
BENZIMIDAZOLES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
ATE110071T1
(en)
*
1988-01-23
1994-09-15
Kyowa Hakko Kogyo Kk
PYRIDAZINONE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
DE3805635A1
(en)
*
1988-02-24
1989-09-07
Thomae Gmbh Dr K
USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT WITH ANTI-MIXIC EFFECTS ON THE HEART AND ITS COMBINATIONS WITH SS-BLOCKERS OR BRADYCARDICA
DE3814057A1
(en)
*
1988-04-26
1989-11-09
Heumann Pharma Gmbh & Co
6-OXO-PYRIDAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5338743A
(en)
*
1988-06-06
1994-08-16
Fujisawa Pharmaceutical Co., Ltd.
New use of the adenosine antagonist
EP0350990B1
(en)
*
1988-07-11
1995-09-20
Akzo Nobel N.V.
Pyridazinone derivatives
DE3830054A1
(en)
*
1988-09-03
1990-03-15
Boehringer Mannheim Gmbh
PHENYLAMIDES – PROCESS FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3908531A1
(en)
*
1989-03-16
1990-09-20
Thomae Gmbh Dr K
MEDICAMENT WITH A POSITIVE INOTROPIC EFFECT, CONTAINING A SYNERGISTIC MIXTURE CONSISTING OF A BENZIMIDAZOLE AND AN SS BLOCKER, THEIR PREPARATION AND THEIR USE
DE3934436A1
(en)
*
1989-06-01
1991-04-18
Thomae Gmbh Dr K
2-HYDROXY-N-PROPYLAMINES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE4001622A1
(en)
*
1990-01-20
1991-07-25
Thomae Gmbh Dr K
ORAL DRUGS OF PIMOBENDAN
US5364646A
(en)
*
1990-01-10
1994-11-15
Dr. Karl Thomae Gmbh
Oral pharmaceutical forms of pimobendan
EP0497258B1
(en)
*
1991-01-29
2002-01-02
Fujisawa Pharmaceutical Co., Ltd.
Use of adenosine antagonists in the prevention and treatment of pancreatitis and ulcer
PT994890E
(en)
1997-06-10
2003-11-28
Glaxo Group Ltd
BENZIMIDAZOLE DERIVATIVES
US6162804A
(en)
*
1997-09-26
2000-12-19
Merck & Co., Inc.
Tyrosine kinase inhibitors
US6465484B1
(en)
1997-09-26
2002-10-15
Merck & Co., Inc.
Angiogenesis inhibitors
KR100515918B1
(en)
1998-10-23
2005-09-20
토레이가부시끼가이샤
Pharmaceutical composition for modulating immunity
TWI225488B
(en)
*
1999-12-21
2004-12-21
Janssen Pharmaceutica Nv
Derivatives of homopiperidinyl substituted benzimidazole analogues
AU2002226602A1
(en)
*
2000-07-31
2002-04-08
Carl Ernest Alexander
Personal oral hygiene composition and device
AU2002345796A1
(en)
*
2001-06-26
2003-03-03
Beth Israel Deaconess Medical Center
Compositions and methods for inhibiting platelet activation and thrombosis
DE10203086A1
(en)
*
2002-01-28
2003-07-31
Bayer Ag
5-ring heterocycles
DE102004011512B4
(en)
2004-03-08
2022-01-13
Boehringer Ingelheim Vetmedica Gmbh
Pharmaceutical preparation containing pimobendan
US8980894B2
(en)
2004-03-25
2015-03-17
Boehringer Ingelheim Vetmedica Gmbh
Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1
(en)
*
2004-03-25
2005-09-28
Boehringer Ingelheim Vetmedica Gmbh
Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
JP4714921B2
(en)
*
2005-02-14
2011-07-06
トーアエイヨー株式会社
Production method of pimobendan and its intermediate
CN101282929A
(en)
*
2005-08-15
2008-10-08
Irm责任有限公司
Compounds and compositions as tpo mimetics
CN101309685A
(en)
*
2005-11-14
2008-11-19
贝林格尔·英格海姆维特梅迪卡有限公司
Use of pde iii inhibitors or calcium sensitizers for the treatment of asymptomatic (occult) heart failure
EP1920785A1
(en)
*
2006-11-07
2008-05-14
Boehringer Ingelheim Vetmedica Gmbh
Liquid preparation comprising a complex of pimobendan and cyclodextrin
FR2917975B1
(en)
2007-06-26
2009-10-16
Ceva Sante Animale Sa
COMPOSITIONS AND TREATMENT OF CARDIAC INSUFFICIENCY IN NON-HUMAN MAMMAL ANIMALS
NZ592927A
(en)
2008-11-25
2013-07-26
Boehringer Ingelheim Vetmed
PHOSPHODIESTERASE TYPE III (PDE III) INHIBITORS OR CA2+-SENSITIZING AGENTS such as pimobendan FOR THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY
NL1037569C2
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2009-12-18
2011-06-21
Eurovet Animal Health B V
Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
CA2843100A1
(en)
2011-08-12
2013-02-21
Boehringer Ingelheim Vetmedica Gmbh
Funny current (if) inhibitors for use in a method of treating and preventing heart failure in feline
EP2825159B1
(en)
2012-03-15
2022-06-22
Boehringer Ingelheim Vetmedica GmbH
Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
DK3021832T3
(en)
2013-07-19
2021-05-25
Boehringer Ingelheim Vetmedica Gmbh
PRESERVED ETHERIFIED CYCLODEXTRINE DERIVATIVES CONTAINING LIQUID AQUATIC PHARMACEUTICAL COMPOSITION
ES2593210T3
(en)
2013-12-04
2016-12-07
Boehringer Ingelheim Vetmedica Gmbh
Improved pharmaceutical compositions of pimobendan
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(en)
2016-04-06
2020-01-21
Boehringer Ingelheim Vetmedica Gmbh
Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106432095B
(en)
*
2016-09-09
2019-04-16
东南大学
The preparation of -3 (2H) -one of pimobendan key intermediate 6- (3,4- diamino-phenyl) -5- methyl -4,5- dihydrogen dazin
CN106518850B
(en)
*
2016-11-15
2019-04-09
青岛农业大学
A kind of chemical synthesis process of pimobendan
WO2022073954A1
(en)
2020-10-08
2022-04-14
Boehringer Ingelheim Vetmedica Gmbh
Use of pimobendan in the anaesthesia of non-human mammals
Family Cites Families (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE2427943C2
(en)
*
1974-06-10
1984-08-02
Dr. Karl Thomae Gmbh, 7950 Biberach
Benzimidazoles, processes for their preparation and pharmaceuticals containing them
DE2516040C2
(en)
*
1974-06-10
1984-12-20
Dr. Karl Thomae Gmbh, 7950 Biberach
Benzimidazoles, processes for their preparation and pharmaceuticals containing them
JPS5416485A
(en)
*
1977-07-08
1979-02-07
Yoshitomi Pharmaceut Ind Ltd
Pyridazinone derivatives and their preparation
1979
1979-07-24
ES
ES482789A
patent/ES8101067A1/en
not_active
Expired
1979-07-25
GR
GR59689A
patent/GR69998B/el
unknown
1979-08-01
DE
DE7979102758T
patent/DE2962051D1/en
not_active
Expired
1979-08-01
EP
EP79102758A
patent/EP0008391B1/en
not_active
Expired
1979-08-23
CA
CA000334357A
patent/CA1134362A/en
not_active
Expired
1979-08-23
FI
FI792628A
patent/FI66372C/en
not_active
IP Right Cessation
1979-08-24
AU
AU50279/79A
patent/AU528825B2/en
not_active
Expired
1979-08-24
IE
IE1629/79A
patent/IE48814B1/en
not_active
IP Right Cessation
1979-08-24
DK
DK354279A
patent/DK152496C/en
not_active
IP Right Cessation
1980
1980-05-29
ES
ES491970A
patent/ES8105001A1/en
not_active
Expired
1981
1981-05-01
US
US06/259,537
patent/US4361563A/en
not_active
Expired – Lifetime
1981-05-26
PH
PH25674A
patent/PH17515A/en
unknown
1985
1985-01-03
SG
SG2/85A
patent/SG285G/en
unknown
1985-07-04
HK
HK505/85A
patent/HK50585A/en
not_active
IP Right Cessation
1991
1991-12-27
CS
CS914101A
patent/CS410191A3/en
unknown
1992
1992-06-08
MX
MX9202731A
patent/MX9202731A/en
unknown
1994
1994-01-25
BG
BG98420A
patent/BG60428B2/en
unknown
1998
1998-11-19
NL
NL980035C
patent/NL980035I2/en
unknown
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU586852B2
(en)
*
1985-02-19
1989-07-27
Merck Patent Gesellschaft Mit Beschrankter Haftung
Benzimidazolylpyridazinones
Also Published As
Publication number
Publication date
FI66372C
(en)
1984-10-10
BG60428B2
(en)
1995-03-31
NL980035I1
(en)
1999-02-01
SG285G
(en)
1985-11-15
DK354279A
(en)
1980-02-26
MX9202731A
(en)
1992-06-30
EP0008391B1
(en)
1982-02-03
ES491970A0
(en)
1981-05-16
IE791629L
(en)
1980-02-25
GR69998B
(en)
1982-07-23
HK50585A
(en)
1985-07-12
FI66372B
(en)
1984-06-29
IE48814B1
(en)
1985-05-29
DK152496C
(en)
1988-07-25
DK152496B
(en)
1988-03-07
PH17515A
(en)
1984-09-13
US4361563A
(en)
1982-11-30
DE2962051D1
(en)
1982-03-11
FI792628A
(en)
1980-02-26
EP0008391A1
(en)
1980-03-05
CA1134362A
(en)
1982-10-26
CS410191A3
(en)
1992-05-13
AU5027979A
(en)
1980-02-28
ES482789A0
(en)
1980-12-01
NL980035I2
(en)
1999-03-01
ES8105001A1
(en)
1981-05-16
ES8101067A1
(en)
1980-12-01
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Date
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Title
Description
2000-03-30
MK14
Patent ceased section 143(a) (annual fees not paid) or expired
