AU538362B2

AU538362B2 – 1-(acylamino-aryloxy)-3-alkylamino propan-2-ols-nitrite compounds
– Google Patents

AU538362B2 – 1-(acylamino-aryloxy)-3-alkylamino propan-2-ols-nitrite compounds
– Google Patents
1-(acylamino-aryloxy)-3-alkylamino propan-2-ols-nitrite compounds

Info

Publication number
AU538362B2

AU538362B2
AU69804/81A
AU6980481A
AU538362B2
AU 538362 B2
AU538362 B2
AU 538362B2
AU 69804/81 A
AU69804/81 A
AU 69804/81A
AU 6980481 A
AU6980481 A
AU 6980481A
AU 538362 B2
AU538362 B2
AU 538362B2
Authority
AU
Australia
Prior art keywords
linear
carbon atoms
treatment
branched alkyl
compounds
Prior art date
1980-04-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Application number
AU69804/81A
Other versions

AU6980481A
(en

Inventor
Herbert Koppe
Werner Kummer
Gojko Muacevic
Helmut Stahle
Werner Traunecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim International GmbH

Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1980-04-25
Filing date
1981-04-24
Publication date
1984-08-09

1981-04-24
Application filed by Boehringer Ingelheim International GmbH
filed
Critical
Boehringer Ingelheim International GmbH

1981-10-29
Publication of AU6980481A
publication
Critical
patent/AU6980481A/en

1984-08-09
Application granted
granted
Critical

1984-08-09
Publication of AU538362B2
publication
Critical
patent/AU538362B2/en

2001-04-24
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C253/00—Preparation of carboxylic acid nitriles

C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C255/00—Carboxylic acid nitriles

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/08—Vasodilators for multiple indications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/12—Antihypertensives

Abstract

This invention relates to compounds of the formula (I) wherein R1 represents a linear or branched alkyl of from 1 to 20 carbon atoms; R2 represents a hydrogen or halogen atom, a linear or branched alkyl or alkoxy of from 1 to 4 carbon atoms, or a divalent group -CH=CH-CH=CH- or -(CH2)n-, in which n is an integer of from 3 to 5, with the free valences bonded in the o-position relative to one another; and R3 represents a linear or branched alkyl of from 3 to 10 carbon atoms, with the provisos that R3 is not tert.butyl when R1 is ethyl or propyl and R2 is a hydrogen atom and that R3 is not isopropyl when R1 is propyl and R2 is a hydrogen atom, or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of Formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.

AU69804/81A
1980-04-25
1981-04-24
1-(acylamino-aryloxy)-3-alkylamino propan-2-ols-nitrite compounds

Ceased

AU538362B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE30159912

1980-04-25

DE19803015991

DE3015991A1
(en)

1980-04-25
1980-04-25

NEW 1-ARYLOXY-3-ALKYLAMINO-2-PROPANOLS AND METHOD FOR THE PRODUCTION THEREOF

Publications (2)

Publication Number
Publication Date

AU6980481A

AU6980481A
(en)

1981-10-29

AU538362B2
true

AU538362B2
(en)

1984-08-09

Family
ID=6100942
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU69804/81A
Ceased

AU538362B2
(en)

1980-04-25
1981-04-24
1-(acylamino-aryloxy)-3-alkylamino propan-2-ols-nitrite compounds

Country Status (20)

Country
Link

US
(1)

US4438143A
(en)

EP
(1)

EP0038936B1
(en)

JP
(1)

JPS56167651A
(en)

KR
(1)

KR840001840B1
(en)

AT
(1)

ATE3146T1
(en)

AU
(1)

AU538362B2
(en)

CA
(1)

CA1147751A
(en)

DE
(2)

DE3015991A1
(en)

DK
(1)

DK181781A
(en)

ES
(3)

ES8207502A1
(en)

FI
(1)

FI74273C
(en)

GB
(1)

GB2074576B
(en)

GR
(1)

GR75601B
(en)

IE
(1)

IE51832B1
(en)

IL
(1)

IL62715A
(en)

NO
(1)

NO150555C
(en)

NZ
(1)

NZ196928A
(en)

PH
(1)

PH18942A
(en)

PT
(1)

PT72891B
(en)

ZA
(1)

ZA812702B
(en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4559359A
(en)

*

1981-06-23
1985-12-17
American Hospital Supply Corporation
Method for treating glaucoma by the topical administration of selectively metabolized beta-blocking agents

DE3133678A1
(en)

*

1981-08-26
1983-03-17
Boehringer Ingelheim KG, 6507 Ingelheim

NEW L-ARYLOXY-3-ALKYLAMINO-2-PROPANOLS AND METHOD FOR THEIR PRODUCTION

EP0179808B1
(en)

*

1984-04-09
1991-10-30
The Du Pont Merck Pharmaceutical Company
Pharmaceutical composition suitable for treatment or prophylaxis of cardiac disorders

DE3443998A1
(en)

*

1984-12-01
1986-06-05
Boehringer Mannheim Gmbh, 6800 Mannheim

AMINO-PROPANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND INTERMEDIATE PRODUCTS

DE4032531C1
(en)

*

1990-10-13
1992-01-30
Rudolf Wittner Gmbh U. Co, 7972 Isny, De
Square-shaped container for records and audio or video cassettes – uses coupling plugs with four cross-arranged shanks fitting complementary profiled grooves to connect holder boxes

Family Cites Families (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB1199037A
(en)

1967-09-27
1970-07-15
Ici Ltd
Alkanolamine Derivatives

CH516509A
(en)

*

1964-09-30
1971-12-15
Ici Ltd
Alkanolamine derivatives b-adrenergic blocking agents

DE2503222A1
(en)

*

1975-01-27
1976-07-29
Boehringer Sohn Ingelheim

PROCESS FOR THE PREPARATION OF 1-ARYL-OXY-3-N-SUBSTITUTED AMINOPROPAN DERIVATIVES

JPS5220459A
(en)

*

1975-08-08
1977-02-16
Mitsubishi Heavy Ind Ltd
Air heater with flushing space

JPS5537544A
(en)

*

1978-09-08
1980-03-15
Yamaha Motor Co Ltd
Run-on preventive device of engine

1980

1980-04-25
DE
DE19803015991
patent/DE3015991A1/en
not_active
Withdrawn

1981

1981-03-26
EP
EP81102294A
patent/EP0038936B1/en
not_active
Expired

1981-03-26
DE
DE8181102294T
patent/DE3160202D1/en
not_active
Expired

1981-03-26
AT
AT81102294T
patent/ATE3146T1/en
not_active
IP Right Cessation

1981-04-20
PT
PT72891A
patent/PT72891B/en
unknown

1981-04-22
GR
GR64775A
patent/GR75601B/el
unknown

1981-04-22
NO
NO811366A
patent/NO150555C/en
unknown

1981-04-23
DK
DK181781A
patent/DK181781A/en
not_active
Application Discontinuation

1981-04-23
FI
FI811277A
patent/FI74273C/en
not_active
IP Right Cessation

1981-04-23
KR
KR1019810001406A
patent/KR840001840B1/en
active

1981-04-24
GB
GB8112695A
patent/GB2074576B/en
not_active
Expired

1981-04-24
NZ
NZ196928A
patent/NZ196928A/en
unknown

1981-04-24
ES
ES501600A
patent/ES8207502A1/en
not_active
Expired

1981-04-24
IE
IE928/81A
patent/IE51832B1/en
unknown

1981-04-24
ZA
ZA00812702A
patent/ZA812702B/en
unknown

1981-04-24
ES
ES501594A
patent/ES8207515A1/en
not_active
Expired

1981-04-24
ES
ES501601A
patent/ES8207503A1/en
not_active
Expired

1981-04-24
AU
AU69804/81A
patent/AU538362B2/en
not_active
Ceased

1981-04-24
IL
IL62715A
patent/IL62715A/en
unknown

1981-04-24
CA
CA000376193A
patent/CA1147751A/en
not_active
Expired

1981-04-24
JP
JP6233581A
patent/JPS56167651A/en
active
Pending

1982

1982-09-21
US
US06/420,796
patent/US4438143A/en
not_active
Expired – Fee Related

1982-10-01
PH
PH27946A
patent/PH18942A/en
unknown

Also Published As

Publication number
Publication date

FI74273C
(en)

1988-01-11

ATE3146T1
(en)

1983-05-15

GR75601B
(en)

1984-08-01

IE810928L
(en)

1981-10-25

US4438143A
(en)

1984-03-20

ES501601A0
(en)

1982-09-16

ZA812702B
(en)

1983-02-23

PT72891A
(en)

1981-05-01

GB2074576A
(en)

1981-11-04

IE51832B1
(en)

1987-04-15

IL62715A
(en)

1985-04-30

NO811366L
(en)

1981-10-26

ES501594A0
(en)

1982-09-16

FI74273B
(en)

1987-09-30

FI811277L
(en)

1981-10-26

DE3160202D1
(en)

1983-06-01

ES501600A0
(en)

1982-09-16

NO150555B
(en)

1984-07-30

IL62715A0
(en)

1981-06-29

NO150555C
(en)

1984-11-07

AU6980481A
(en)

1981-10-29

DK181781A
(en)

1981-10-26

DE3015991A1
(en)

1981-11-05

PT72891B
(en)

1983-01-10

JPS56167651A
(en)

1981-12-23

KR830005122A
(en)

1983-07-23

NZ196928A
(en)

1983-12-16

CA1147751A
(en)

1983-06-07

ES8207503A1
(en)

1982-09-16

EP0038936B1
(en)

1983-04-27

EP0038936A1
(en)

1981-11-04

ES8207515A1
(en)

1982-09-16

ES8207502A1
(en)

1982-09-16

KR840001840B1
(en)

1984-10-22

PH18942A
(en)

1985-11-14

GB2074576B
(en)

1984-02-15

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1-(acylamino-aryloxy)-3-alkylamino propan-2-ols-nitrite compounds

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