AU538928B2 - Creación de Inventos y Patentes con Inteligencia Artificial

AU538928B2 – Substituted propenylamine derivatives
– Google Patents

AU538928B2 – Substituted propenylamine derivatives
– Google Patents
Substituted propenylamine derivatives

Info

Publication number
AU538928B2

AU538928B2
AU61592/80A
AU6159280A
AU538928B2
AU 538928 B2
AU538928 B2
AU 538928B2
AU 61592/80 A
AU61592/80 A
AU 61592/80A
AU 6159280 A
AU6159280 A
AU 6159280A
AU 538928 B2
AU538928 B2
AU 538928B2
Authority
AU
Australia
Prior art keywords
formula
propenylamine
derivatives
substituted
radical
Prior art date
1979-08-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired, expires 2005-08-20

Application number
AU61592/80A
Other versions

AU6159280A
(en

Inventor
Anton Stutz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1979-08-22
Filing date
1980-08-20
Publication date
1984-09-06
Family has litigation

First worldwide family litigation filed
litigation
Critical
https://patents.darts-ip.com/?family=4328536&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU538928(B2)
«Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1980-08-20
Application filed by Sandoz AG
filed
Critical
Sandoz AG

1981-04-16
Publication of AU6159280A
publication
Critical
patent/AU6159280A/en

1984-09-06
Application granted
granted
Critical

1984-09-06
Publication of AU538928B2
publication
Critical
patent/AU538928B2/en

1997-10-16
Assigned to NOVARTIS AG
reassignment
NOVARTIS AG
Request to Amend Deed and Register
Assignors: SANDOZ LTD.

2005-08-20
Adjusted expiration
legal-status
Critical

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members

C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms

C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms

C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

A61P31/04—Antibacterial agents

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

A61P31/10—Antimycotics

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms

C07C33/04—Acyclic alcohols with carbon-to-carbon triple bonds

C07C33/048—Acyclic alcohols with carbon-to-carbon triple bonds with double and triple bonds

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms

C07C33/05—Alcohols containing rings other than six-membered aromatic rings

C07C33/12—Alcohols containing rings other than six-membered aromatic rings containing five-membered rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems

C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans

C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom

C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms

C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes

C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

C07D333/58—Radicals substituted by nitrogen atoms

Abstract

A compound of the formula: I wherein the double bond is in the trans configuration and R1 is a radical of formula IIa, IIa R2, R3, R5, R7 and R8 are each hydrogen, R4 is methyl, and R6 is a radical of formula IIIa -C 3BOND C-R11 IIIa where R11 is n-butyl, tertiary butyl or phenyl or a chemotherapeutically acceptable acid addition salt thereof; processes for their production, their use as pharmaceuticals and pharmaceutical compositions containing them.

AU61592/80A
1979-08-22
1980-08-20
Substituted propenylamine derivatives

Expired

AU538928B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

CH765679

1979-08-22

CH765679

1979-08-22

Publications (2)

Publication Number
Publication Date

AU6159280A

AU6159280A
(en)

1981-04-16

AU538928B2
true

AU538928B2
(en)

1984-09-06

Family
ID=4328536
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU61592/80A
Expired

AU538928B2
(en)

1979-08-22
1980-08-20
Substituted propenylamine derivatives

Country Status (24)

Country
Link

US
(1)

US4755534A
(en)

EP
(1)

EP0024587B1
(en)

JP
(2)

JPS5632440A
(en)

AT
(1)

ATE10272T1
(en)

AU
(1)

AU538928B2
(en)

CA
(1)

CA1157023A
(en)

CY
(1)

CY1410A
(en)

DE
(3)

DE19975055I1
(en)

DK
(1)

DK153470C
(en)

ES
(1)

ES8105694A1
(en)

FI
(1)

FI65775C
(en)

HK
(1)

HK21588A
(en)

IE
(1)

IE50878B1
(en)

IL
(1)

IL60877A
(en)

KE
(1)

KE3775A
(en)

LU
(1)

LU88343I2
(en)

MY
(1)

MY8600181A
(en)

NL
(1)

NL930136I2
(en)

NZ
(1)

NZ194714A
(en)

PH
(1)

PH22166A
(en)

PT
(1)

PT71717B
(en)

SG
(1)

SG89287G
(en)

YU
(1)

YU41513B
(en)

ZA
(1)

ZA805185B
(en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US5132459A
(en)

1979-08-22
1992-07-21
Sandoz Ltd.
Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals

CH653028A5
(en)

1982-02-03
1985-12-13
Sandoz Ag

BENZTHIOPHENALLYLAMINE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF.

FR2526423B1
(en)

1982-05-07
1987-07-10
Sandoz Sa

NOVEL UNSATURATED AMINES, THEIR PREPARATION AND THEIR USE AS MEDICINES

JPS6145A
(en)

1984-06-09
1986-01-06
Kaken Pharmaceut Co Ltd
Naphthylmethylamine derivative and antifungal containing the same

DE3582060D1
(en)

1984-11-22
1991-04-11
Sandoz Ag

HOMOPROPARGYLAMINE.

CH672311A5
(en)

1985-09-14
1989-11-15
Sandoz Ag

NL8700083A
(en)

1986-01-29
1987-08-17
Sandoz Ag

AMINES ACTING AGAINST FUNGI, METHODS FOR THE PREPARATION THEREOF AND THEIR USE

US4751245A
(en)

1986-06-25
1988-06-14
E. R. Squibb & Sons, Inc.
Antifungal derivatives of N-(6,6-dimethyl-2-hepten-4-ynyl)-1-naphthalenemethanamine and method of using same

EP0254677A1
(en)

1986-07-08
1988-01-27
Sandoz Ag
Antimycotic 6-phenyl-2-hexen-4-ynamines

JPS63238060A
(en)

1987-03-26
1988-10-04
Maruho Kk
Quinoline derivative

ZA885824B
(en)

1987-08-14
1989-04-26
Merrell Dow Pharma
Novel antidepressants

US5149714A
(en)

1987-08-14
1992-09-22
Merrell Dow Pharmaceuticals Inc.
Antidepressants

US5234946A
(en)

1987-11-27
1993-08-10
Banyu Pharmaceutical Co., Ltd.
Substituted alkylamine derivatives

NZ227042A
(en)

1987-11-27
1991-05-28
Banyu Pharma Co Ltd
Substituted alkylamine derivatives and pharmaceutical compositions

EP0363326A3
(en)

1988-10-07
1991-10-09
Sandoz Ag
Fungicidal amines

DE69011139T2
(en)

1989-01-12
1995-03-09
Sumitomo Chemical Co

Aromatic allylanim containing thermosetting resin composition.

JP3116364B2
(en)

1989-10-02
2000-12-11
萬有製薬株式会社

Method for producing enyne derivatives

FR2673537B1
(en)

1991-03-08
1993-06-11
Oreal

USE OF HYDROPHILIC PENETRATION AGENTS IN DERMATOLOGICAL COMPOSITIONS FOR THE TREATMENT OF ONYCHOMYCOSES, AND CORRESPONDING COMPOSITIONS.

HU223343B1
(en)

1991-05-20
2004-06-28
Novartis Ag.
Compositions comprising allylamine derivatives, and process for their preparation

HU219480B
(en)

1991-05-23
2001-04-28
Novartis Ag.
Process for producing locally applicable pharmaceutical compositions comprising allylamine derivative against fungus infection of nails

GB9111611D0
(en)

1991-05-30
1991-07-24
Sandoz Ltd
Liposomes

JPH04138020U
(en)

1991-06-14
1992-12-24

GB9513750D0
(en)

1995-07-06
1995-09-06
Sandoz Ltd
Use of allylamines

NZ280065A
(en)

1995-09-20
1998-04-27
Apotex Inc
Preparation of n-alkyl-n-(1-naphthylmethyl)alk-2-en-4-ynylamine derivatives

US6075056A
(en)

1997-10-03
2000-06-13
Penederm, Inc.
Antifungal/steroid topical compositions

SK5202000A3
(en)

2000-04-07
2001-12-03
Slovakofarma As
Method for the preparation of (e)-n-(6,6-dimethyl-2-hepten-4- inyl)-n-methyl-1-naphthalenemethylamine (terbinaphin)

MXPA02012113A
(en)

2000-06-09
2003-04-25
Aventis Cropscience Sa
Process for the preparation of pesticidal compounds.

IL137364A
(en)

2000-07-18
2005-08-31
Chemagis Ltd
Process for the preparation of 6,6-dimethylhept-1-en-4-yn-3-ol

GB0103046D0
(en)

2001-02-07
2001-03-21
Novartis Ag
Organic Compounds

US7244703B2
(en)

2001-06-22
2007-07-17
Bentley Pharmaceuticals, Inc.
Pharmaceutical compositions and methods for peptide treatment

KR100459275B1
(en)

2001-12-28
2004-12-03
주식회사유한양행
A PROCESS FOR THE PREPARATION OF TERBINAFINE OR HCl SALT THEREOF

BG65097B1
(en)

2002-03-15
2007-02-28
Richter Gedeon Vegyeszeti Gyar Rt.
Process for preparing a substituted allylamine derivative and the salts thereof

US8404751B2
(en)

2002-09-27
2013-03-26
Hallux, Inc.
Subunguicide, and method for treating onychomycosis

AU2004224326B2
(en)

2003-03-21
2010-04-22
Nexmed Holdings, Inc.
Antifungal nail coat and method of use

GB0503942D0
(en)

2005-02-25
2005-04-06
Novartis Ag
Purification process

GB0320312D0
(en)

2003-08-29
2003-10-01
Novartis Ag
Purification process

US20050197512A1
(en)

2003-08-29
2005-09-08
Ulrich Beutler
Purification process

EA010885B1
(en)

2003-12-08
2008-12-30
Бентли Фармасьютикалз, Инк.
Pharmaceutical compositions and methods for insulin treatment

ES2245596B1
(en)

2004-06-10
2007-07-01
Ercros Industrial, S.A.
Production of terbinaphin hydrochlorate (TH) comprises reaction of chlorinated and methylamine derivatives with reflux of isopropanol increasing performance

US20060004230A1
(en)

2004-06-30
2006-01-05
Joseph Kaspi
Process for the preparation of terbinafine and salts thereof

AU2005258903A1
(en)

2004-07-02
2006-01-12
Warner-Lambert Company Llc
Compositions and methods for treating pathological infections

US7740875B2
(en)

2004-10-08
2010-06-22
Mediquest Therapeutics, Inc.
Organo-gel formulations for therapeutic applications

US20060078580A1
(en)

2004-10-08
2006-04-13
Mediquest Therapeutics, Inc.
Organo-gel formulations for therapeutic applications

CN1293037C
(en)

2004-11-03
2007-01-03
浙江海正药业股份有限公司
Process for preparing terbinafine hydrochliride

US20090118721A1
(en)

2005-07-21
2009-05-07
Eric Bornstein
Near Infrared Microbial Elimination Laser System (NIMELS)

JP2010512343A
(en)

2006-12-08
2010-04-22
オースペックス・ファーマシューティカルズ・インコーポレイテッド

Preparation and utility of substituted allylamines

US20080176908A1
(en)

2007-01-18
2008-07-24
Mcanally Weylan R
Method of using squalene monooxygenase inhibitors to treat acne

US20090082469A1
(en)

2007-09-26
2009-03-26
Protia, Llc
Deuterium-enriched terbinafine

EP2317993A2
(en)

2008-07-23
2011-05-11
Tdt, Ltd
Methods of administering topical antifungal formulations for the treatment of fungal infections

EP2730271B1
(en)

2012-11-11
2018-01-24
Symrise AG
Aqeuous compositions

US8697753B1
(en)

2013-02-07
2014-04-15
Polichem Sa
Method of treating onychomycosis

EP2772245B1
(en)

2013-02-27
2018-08-22
Symrise AG
Ginger extract for the protection of stem cells

BR112015022025A8
(en)

2013-03-14
2019-12-10
Hallux Inc

composition and use of an active agent

EP2862852B1
(en)

2013-10-18
2018-07-04
Symrise AG
Urea derivatives for the protection of stem cells

EP2921157B1
(en)

2014-03-18
2017-08-16
Symrise AG
Coated titanium dioxide to reduce whitening effect on skin

EP2939710B1
(en)

2014-04-29
2020-06-17
Symrise AG
Active Mixtures

EP3045161A1
(en)

2015-01-18
2016-07-20
Symrise AG
Active compositions comprising 1,2-hexanediol and 1,2-octanediol

CN104725240B
(en)

2015-02-12
2017-05-24
吉林修正药业新药开发有限公司
Method for preparing terbinafine hydrochloride Z-shaped isomer

CN108084125B
(en)

2016-11-23
2020-08-18
华东理工大学
Benzoheterocyclylalkylamines and their use

CN114727689B
(en)

2019-11-12
2023-11-03
Ykk株式会社
Zipper fastener

Family Cites Families (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

BE623609A
(en)

1961-10-27

DE2716943C2
(en)

1976-04-28
1986-08-14
Sandoz-Patent-GmbH, 7850 Lörrach

N- (3-Phenyl-2-propenyl) -N- (1-naphthylmethyl) amines, their use and preparation

EP0000896B1
(en)

1977-08-19
1982-10-13
Sandoz Ag
Propenyl amines, processes for their production and pharmaceutical compositions containing them

1980

1980-08-06
DE
DE1999175055
patent/DE19975055I1/en
active
Pending

1980-08-06
DE
DE8080104623T
patent/DE3069633D1/en
not_active
Expired

1980-08-06
EP
EP80104623A
patent/EP0024587B1/en
not_active
Expired

1980-08-06
CY
CY141080A
patent/CY1410A/en
unknown

1980-08-06
AT
AT80104623T
patent/ATE10272T1/en
active

1980-08-06
DE
DE1993175084
patent/DE19375084I2/en
active
Active

1980-08-15
FI
FI802583A
patent/FI65775C/en
not_active
IP Right Cessation

1980-08-19
IL
IL60877A
patent/IL60877A/en
unknown

1980-08-20
CA
CA000358656A
patent/CA1157023A/en
not_active
Expired

1980-08-20
DK
DK357980A
patent/DK153470C/en
not_active
IP Right Cessation

1980-08-20
AU
AU61592/80A
patent/AU538928B2/en
not_active
Expired

1980-08-20
NZ
NZ194714A
patent/NZ194714A/en
unknown

1980-08-21
JP
JP11578880A
patent/JPS5632440A/en
active
Granted

1980-08-21
YU
YU2096/80A
patent/YU41513B/en
unknown

1980-08-21
PT
PT71717A
patent/PT71717B/en
unknown

1980-08-21
PH
PH24470A
patent/PH22166A/en
unknown

1980-08-21
IE
IE1770/80A
patent/IE50878B1/en
not_active
IP Right Cessation

1980-08-21
ES
ES494408A
patent/ES8105694A1/en
not_active
Expired

1980-08-22
ZA
ZA00805185A
patent/ZA805185B/en
unknown

1984

1984-09-04
US
US06/646,724
patent/US4755534A/en
not_active
Expired – Lifetime

1986

1986-12-30
MY
MY181/86A
patent/MY8600181A/en
unknown

1987

1987-10-06
KE
KE3775A
patent/KE3775A/en
unknown

1987-10-13
SG
SG892/87A
patent/SG89287G/en
unknown

1988

1988-01-27
JP
JP63016755A
patent/JPS63313753A/en
active
Granted

1988-03-24
HK
HK215/88A
patent/HK21588A/en
not_active
IP Right Cessation

1993

1993-06-30
LU
LU88343C
patent/LU88343I2/en
unknown

1993-07-02
NL
NL930136C
patent/NL930136I2/en
unknown

Also Published As

Publication number
Publication date

DK357980A
(en)

1981-02-23

DE19375084I2
(en)

2000-11-16

CA1157023A
(en)

1983-11-15

YU209680A
(en)

1983-10-31

NZ194714A
(en)

1984-11-09

PH22166A
(en)

1988-06-28

DE3069633D1
(en)

1984-12-20

MY8600181A
(en)

1986-12-31

ES494408A0
(en)

1981-06-16

CY1410A
(en)

1988-04-22

JPH0415216B2
(en)

1992-03-17

FI802583A
(en)

1981-02-23

IL60877A
(en)

1984-08-31

YU41513B
(en)

1987-08-31

DK153470B
(en)

1988-07-18

NL930136I1
(en)

1993-11-01

DE19975055I1
(en)

2000-01-27

FI65775B
(en)

1984-03-30

ATE10272T1
(en)

1984-11-15

IL60877A0
(en)

1980-10-26

ZA805185B
(en)

1982-03-31

JPS6342612B2
(en)

1988-08-24

ES8105694A1
(en)

1981-06-16

LU88343I2
(en)

1994-05-04

IE50878B1
(en)

1986-08-06

IE801770L
(en)

1981-02-22

AU6159280A
(en)

1981-04-16

EP0024587B1
(en)

1984-11-14

EP0024587A1
(en)

1981-03-11

JPS63313753A
(en)

1988-12-21

DK153470C
(en)

1988-11-28

JPS5632440A
(en)

1981-04-01

NL930136I2
(en)

1998-10-01

KE3775A
(en)

1987-11-27

HK21588A
(en)

1988-03-31

SG89287G
(en)

1988-09-30

FI65775C
(en)

1984-07-10

PT71717B
(en)

1981-09-24

PT71717A
(en)

1980-09-01

US4755534A
(en)

1988-07-05

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