AU5439990A – Nucleoside derivatives and their use as medicaments
– Google Patents
AU5439990A – Nucleoside derivatives and their use as medicaments
– Google Patents
Nucleoside derivatives and their use as medicaments
Info
Publication number
AU5439990A
AU5439990A
AU54399/90A
AU5439990A
AU5439990A
AU 5439990 A
AU5439990 A
AU 5439990A
AU 54399/90 A
AU54399/90 A
AU 54399/90A
AU 5439990 A
AU5439990 A
AU 5439990A
AU 5439990 A
AU5439990 A
AU 5439990A
Authority
AU
Australia
Prior art keywords
nhr4
mono
alkoxy
halogen
alkyl
Prior art date
1989-07-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU54399/90A
Inventor
Werner Bourgeois
Reiner Gumbiowski
Edith Koch
Bernhard Konig
Alfred Mertens
Angelika Roling
Helmut Rosemeyer
Frank Seela
Harald Zilch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1989-07-24
Filing date
1990-04-23
Publication date
1991-02-22
1990-04-23
Application filed by Boehringer Mannheim GmbH
filed
Critical
Boehringer Mannheim GmbH
1991-02-22
Publication of AU5439990A
publication
Critical
patent/AU5439990A/en
Status
Abandoned
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P31/12—Antivirals
Abstract
Nucleosides of formula (I), their anomers, N7 and N9 regioisomeric tautomers and salts, and nucleic acids based on them are new, where Ba= a gp. of formula (A), (B), (C), (D), (E) or (F). R1-3= H, halogen, alkyl, OH, SH, NO2, NH2, thioalkyl, alkoxy, aralkyl, aralkoxy, aminoalkyl, (di)alkylaminoalkyl, NHR4, N(R4)2 or N=CHR4. R4= alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, alkoxyalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, mono- or di- alkylaminoalkyl or aralkyl or heteroarylalkyl both opt. substd. with alkyl, alkoxy, halogen or OH; and when R4 occurs in NHR4 or N=CHR4 it may also be NH2, mono- or di-alkylamino or alkoxy. Y=H, alkylcarbonyl or mono-, di- or tri- phosphate. R5-R8= H or 1-2 of R5-R8 are OH, halogen, CN, N3, NHR4, N(R4)2, or R5 and R7 together form an additional bond between C2′ and C3′. Provided that: (a) when Ba=(B) R6 is not H, N3 or NH2. (b) when Ba=(D) and R2=H then R1 is not Cl or NH2 and R6 is not H or Cl. (c) when Ba=(E) then R5 and R7 do not form a bond. Prepn. of (I), their use in DNA sequencing and antiviral compsns. contg. new and known (I) are also claime
AU54399/90A
1989-07-24
1990-04-23
Nucleoside derivatives and their use as medicaments
Abandoned
AU5439990A
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
DE3924424
1989-07-24
DE3924424A
DE3924424A1
(en)
1989-07-24
1989-07-24
NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINAL PRODUCT AND THEIR USE IN THE SEQUENCING OF NUCLEIC ACID
Publications (1)
Publication Number
Publication Date
AU5439990A
true
AU5439990A
(en)
1991-02-22
Family
ID=6385699
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU54399/90A
Abandoned
AU5439990A
(en)
1989-07-24
1990-04-23
Nucleoside derivatives and their use as medicaments
Country Status (13)
Country
Link
US
(1)
US5446139A
(en)
EP
(2)
EP0666269A3
(en)
JP
(1)
JPH04507086A
(en)
AT
(1)
ATE130306T1
(en)
AU
(1)
AU5439990A
(en)
CA
(1)
CA2064024A1
(en)
DD
(1)
DD296687A5
(en)
DE
(2)
DE3924424A1
(en)
IE
(1)
IE902665A1
(en)
IL
(1)
IL95128A0
(en)
PT
(1)
PT94788A
(en)
WO
(1)
WO1991001325A1
(en)
ZA
(1)
ZA905760B
(en)
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Methods for modulation and inhibition of telomerase
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1995-07-06
1997-02-05
Board Of Regents, The University Of Texas System
Methods and compositions for modulation and inhibition of teomerase
AU2253297A
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1996-01-23
1997-08-20
Regents Of The University Of Michigan, The
Imidazo{1,2-a}pyridine c-nucleosides as antiviral agents
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1996-02-01
2000-08-09
Amersham Int Plc
Nucleoside analogues
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Nucleoside analogues
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1997-07-22
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Astra Pharma Prod
Triazolo [4,5-d]pyrimidine compounos and their use and process for preparation
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1999-11-12
2003-04-15
アンジオテック ファーマシューティカルズ，インコーポレイテッド
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2002-09-25
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Brigham Young University
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2004-07-21
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Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives
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2004-09-14
2013-08-30
Gilead Pharmasset Llc
2-deoxy-2-fluoro-2-c-methyl-ribono lactones, and preparation thereof and 1,3-dioxolanes
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2004-12-17
2006-12-28
Schroth Gary P
ID-tag complexes, arrays, and methods of use thereof
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2009-11-24
Chemocentryx, Inc.
Heteroaryl sulfonamides and CCR2
WO2008147454A1
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*
2006-11-16
2008-12-04
Case Western Reserve University
Selective inhibitors of translesion dna replication
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(en)
2005-03-16
2012-02-14
Case Western Reserve University
Selective inhibitors of translesion DNA replication
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2005-06-20
2006-12-21
Applera Corporation.
Cis-regulatory modules
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2005-07-19
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Glaxo Group Ltd
Compounds
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2006-03-15
2019-05-29
Siemens Healthcare Diagnostics Inc.
Degenerate nucleobase analogs
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Chemocentryx, Inc.
Heteroaryl sulfonamides and CCR2/CCR9
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2006-12-26
2013-03-19
Siemens Healthcare Diagnostics Inc.
Heteropolynucleotide duplexes with purine—purine base pairing
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(en)
2007-08-29
2014-08-05
Adam Lubin
Therapy of tumors and infectious agents deficient in methylthioadenosine phosphorylase
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2009-05-21
2012-06-07
Siemens Healthcare Diagnostics Inc.
Universal Tags With Non-Natural Nucleobases
WO2013033705A2
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2011-09-01
2013-03-07
Case Western Reserve University
Non-natural nucleosides as theranostic agents
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2011-12-22
2016-06-27
Alios Biopharma Inc
Substituted nucleosides, nucleotides and analogs thereof
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Janssen Biopharma, Inc.
Substituted nucleosides, nucleotides and analogs thereof
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2016-09-13
Alios Biopharma, Inc.
Substituted nucleosides, nucleotides and analogs thereof
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(en)
2013-02-08
2017-11-21
Case Western Reserve University
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2020-07-08
ChemoCentryx, Inc.
Method of treating focal segmental glomerulosclerosis
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Chemocentryx Inc
Treatment of focal segmental glomerulosclerosis with ccr2 antagonists
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Publication number
Priority date
Publication date
Assignee
Title
GB696952A
(en)
*
1950-05-19
1953-09-09
British Drug Houses Ltd
Improvements in or relating to the manufacture of heterocyclic compounds
CH477470A
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1966-05-04
1969-08-31
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Process for the preparation of ribofuranosides
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1974-06-18
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2{40 ,3{40 -unsaturated nucleosides and method of making
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3-deazaguanine and derivatives thereof
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1981-01-20
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Deazapurine nucleosides, formulations and preparation thereof
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β-D-Arabinofuranosylimidazo(4,5-c)pyridine compounds and methods for their production
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(en)
*
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Naeem Botros Hanna
Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds
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*
1988-03-25
1991-02-26
Merrell Dow Pharmaceuticals Inc.
Derivatives with unsaturated substitutions for the 5′-hydroxymethyl group
1989
1989-07-24
DE
DE3924424A
patent/DE3924424A1/en
not_active
Withdrawn
1990
1990-04-23
DE
DE59009888T
patent/DE59009888D1/en
not_active
Expired – Fee Related
1990-04-23
AT
AT90906204T
patent/ATE130306T1/en
not_active
IP Right Cessation
1990-04-23
WO
PCT/EP1990/000650
patent/WO1991001325A1/en
active
IP Right Grant
1990-04-23
EP
EP95106043A
patent/EP0666269A3/en
not_active
Withdrawn
1990-04-23
EP
EP90906204A
patent/EP0484333B1/en
not_active
Expired – Lifetime
1990-04-23
JP
JP2506235A
patent/JPH04507086A/en
active
Pending
1990-04-23
CA
CA2064024A
patent/CA2064024A1/en
not_active
Abandoned
1990-04-23
US
US07/809,506
patent/US5446139A/en
not_active
Expired – Fee Related
1990-04-23
AU
AU54399/90A
patent/AU5439990A/en
not_active
Abandoned
1990-07-19
IL
IL95128A
patent/IL95128A0/en
unknown
1990-07-23
DD
DD90342998A
patent/DD296687A5/en
not_active
IP Right Cessation
1990-07-23
PT
PT94788A
patent/PT94788A/en
not_active
Application Discontinuation
1990-07-23
ZA
ZA905760A
patent/ZA905760B/en
unknown
1990-07-23
IE
IE266590A
patent/IE902665A1/en
unknown
Also Published As
Publication number
Publication date
WO1991001325A1
(en)
1991-02-07
IE902665A1
(en)
1991-02-27
DE3924424A1
(en)
1991-01-31
IL95128A0
(en)
1991-06-10
EP0484333A1
(en)
1992-05-13
CA2064024A1
(en)
1991-02-07
EP0484333B1
(en)
1995-11-15
JPH04507086A
(en)
1992-12-10
ZA905760B
(en)
1991-06-26
DE59009888D1
(en)
1995-12-21
PT94788A
(en)
1991-03-20
DD296687A5
(en)
1991-12-12
EP0666269A2
(en)
1995-08-09
US5446139A
(en)
1995-08-29
ATE130306T1
(en)
1995-12-15
EP0666269A3
(en)
1996-04-24
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