AU551236B2 – Process for the preparation of 6-bromo-, 6-ronhch2- substituted and 6-unsubstituted penicillins
– Google Patents
AU551236B2 – Process for the preparation of 6-bromo-, 6-ronhch2- substituted and 6-unsubstituted penicillins
– Google Patents
Process for the preparation of 6-bromo-, 6-ronhch2- substituted and 6-unsubstituted penicillins
Info
Publication number
AU551236B2
AU551236B2
AU29079/84A
AU2907984A
AU551236B2
AU 551236 B2
AU551236 B2
AU 551236B2
AU 29079/84 A
AU29079/84 A
AU 29079/84A
AU 2907984 A
AU2907984 A
AU 2907984A
AU 551236 B2
AU551236 B2
AU 551236B2
Authority
AU
Australia
Prior art keywords
ronhch2
penicillins
bromo
unsubstituted
substituted
Prior art date
1983-06-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU29079/84A
Other versions
AU2907984A
(en
Inventor
Donald Klein Pirie
Paul Douglas Weeks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1983-06-06
Filing date
1984-06-05
Publication date
1986-04-24
1984-06-05
Application filed by Pfizer Inc
filed
Critical
Pfizer Inc
1984-12-13
Publication of AU2907984A
publication
Critical
patent/AU2907984A/en
1986-04-24
Application granted
granted
Critical
1986-04-24
Publication of AU551236B2
publication
Critical
patent/AU551236B2/en
2004-06-05
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P31/04—Antibacterial agents
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
Y02P20/00—Technologies relating to chemical industry
Y02P20/50—Improvements relating to the production of bulk chemicals
Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
A process for the debromination of 6-monobromo- and 6,6-dibromopenicillanic acid, and various derivatives thereof, by the action of a bisulfite salt. The debrominated compounds produced find various utilities, as beta-lactamase inhibitors useful in therapy in combination with known beta-lactam antibiotics, or as intermediates in the further synthesis of useful beta-lactam compounds.
AU29079/84A
1983-06-06
1984-06-05
Process for the preparation of 6-bromo-, 6-ronhch2- substituted and 6-unsubstituted penicillins
Ceased
AU551236B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US06/501,731
US4468351A
(en)
1983-06-06
1983-06-06
Process for debromination of dibromopenicillanic acid and derivatives
US501731
1983-06-06
Publications (2)
Publication Number
Publication Date
AU2907984A
AU2907984A
(en)
1984-12-13
AU551236B2
true
AU551236B2
(en)
1986-04-24
Family
ID=23994800
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU29079/84A
Ceased
AU551236B2
(en)
1983-06-06
1984-06-05
Process for the preparation of 6-bromo-, 6-ronhch2- substituted and 6-unsubstituted penicillins
Country Status (22)
Country
Link
US
(1)
US4468351A
(en)
EP
(1)
EP0129360B1
(en)
JP
(1)
JPS608293A
(en)
KR
(1)
KR870000324B1
(en)
AT
(1)
ATE29722T1
(en)
AU
(1)
AU551236B2
(en)
CA
(1)
CA1210388A
(en)
DE
(1)
DE3466220D1
(en)
DK
(1)
DK275684A
(en)
ES
(1)
ES8602807A1
(en)
FI
(1)
FI82938C
(en)
GR
(1)
GR81625B
(en)
HU
(1)
HU193931B
(en)
IE
(1)
IE57561B1
(en)
IL
(1)
IL72004A
(en)
NO
(1)
NO162722C
(en)
NZ
(1)
NZ208379A
(en)
PH
(1)
PH20990A
(en)
PL
(1)
PL143370B1
(en)
PT
(1)
PT78691A
(en)
YU
(1)
YU44872B
(en)
ZA
(1)
ZA844185B
(en)
Families Citing this family (10)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4588527A
(en)
*
1983-06-06
1986-05-13
Pfizer Inc.
Process for preparing penicillanic acid 1,1-dioxide derivatives
EP0139048A1
(en)
*
1983-10-18
1985-05-02
Gist-Brocades N.V.
Process for the dehalogenation of 6,6-dibromopenicillanic acid 1,1-dioxide
US4596677A
(en)
*
1984-04-06
1986-06-24
Bristol-Myers Company
Anhydropenicillin intermediates
US4816580A
(en)
*
1986-04-10
1989-03-28
Leo Pharmaceutical Products Ltd. A/S
Improved method for preparing penicillanic acid derivatives
US4885370A
(en)
*
1987-03-11
1989-12-05
Pfizer Inc.
Synthetic method for indol-2(3H)-ones
GB8808701D0
(en)
*
1988-04-13
1988-05-18
Erba Carlo Spa
Beta-lactam derivatives
GB2343676A
(en)
1998-11-12
2000-05-17
Merck & Co Inc
Selective mono-debromination of polybromoalkyl aryl ketones
EP1666482B1
(en)
*
2003-09-03
2009-12-23
Otsuka Chemical Co., Ltd.
Process for producing penicillanic acid compound
CN102702228A
(en)
*
2012-06-26
2012-10-03
齐鲁天和惠世制药有限公司
Method for preparing sulbactam
CN104910184B
(en)
*
2015-04-27
2017-03-29
齐鲁天和惠世制药有限公司
A kind of preparation method of 6,6 dibromo penicillanic acid
Family Cites Families (7)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4180506A
(en)
*
1978-01-18
1979-12-25
Rex Pratt
6β-Bromo penicillanic acid
DE3068390D1
(en)
*
1979-01-10
1984-08-09
Beecham Group Plc
Penicillin derivatives, process for their preparation and pharmaceutical compositions containing certain of these compounds
US4420426A
(en)
*
1979-03-05
1983-12-13
Pfizer Inc.
6-Alpha-halopenicillanic acid 1,1-dioxides
GB2051046B
(en)
*
1979-05-21
1984-03-28
Leo Pharm Prod Ltd
Penicillanic acid derivatives
US4432970A
(en)
*
1979-11-23
1984-02-21
Pfizer Inc.
6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4427678A
(en)
*
1982-01-11
1984-01-24
Pfizer Inc.
6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors
PT76527B
(en)
*
1982-04-19
1985-12-09
Gist Brocades Nv
A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof
1983
1983-06-06
US
US06/501,731
patent/US4468351A/en
not_active
Expired – Fee Related
1984
1984-06-04
GR
GR74908A
patent/GR81625B/el
unknown
1984-06-04
AT
AT84303735T
patent/ATE29722T1/en
not_active
IP Right Cessation
1984-06-04
IL
IL72004A
patent/IL72004A/en
unknown
1984-06-04
PH
PH30764A
patent/PH20990A/en
unknown
1984-06-04
EP
EP84303735A
patent/EP0129360B1/en
not_active
Expired
1984-06-04
PL
PL1984248046A
patent/PL143370B1/en
unknown
1984-06-04
DK
DK275684A
patent/DK275684A/en
not_active
Application Discontinuation
1984-06-04
PT
PT78691A
patent/PT78691A/en
not_active
IP Right Cessation
1984-06-04
CA
CA000455814A
patent/CA1210388A/en
not_active
Expired
1984-06-04
DE
DE8484303735T
patent/DE3466220D1/en
not_active
Expired
1984-06-05
ZA
ZA844185A
patent/ZA844185B/en
unknown
1984-06-05
FI
FI842253A
patent/FI82938C/en
not_active
IP Right Cessation
1984-06-05
IE
IE1392/84A
patent/IE57561B1/en
not_active
IP Right Cessation
1984-06-05
HU
HU842179A
patent/HU193931B/en
not_active
IP Right Cessation
1984-06-05
AU
AU29079/84A
patent/AU551236B2/en
not_active
Ceased
1984-06-05
NZ
NZ208379A
patent/NZ208379A/en
unknown
1984-06-05
NO
NO842250A
patent/NO162722C/en
unknown
1984-06-05
ES
ES533149A
patent/ES8602807A1/en
not_active
Expired
1984-06-05
YU
YU972/84A
patent/YU44872B/en
unknown
1984-06-05
KR
KR1019840003124A
patent/KR870000324B1/en
not_active
IP Right Cessation
1984-06-06
JP
JP59116338A
patent/JPS608293A/en
active
Granted
Also Published As
Publication number
Publication date
DE3466220D1
(en)
1987-10-22
GR81625B
(en)
1984-12-11
CA1210388A
(en)
1986-08-26
NO162722C
(en)
1990-02-07
HU193931B
(en)
1987-12-28
KR850000452A
(en)
1985-02-27
ZA844185B
(en)
1986-01-29
EP0129360A1
(en)
1984-12-27
YU44872B
(en)
1991-04-30
NO162722B
(en)
1989-10-30
ATE29722T1
(en)
1987-10-15
EP0129360B1
(en)
1987-09-16
PL248046A1
(en)
1985-10-22
NZ208379A
(en)
1987-05-29
US4468351A
(en)
1984-08-28
HUT34204A
(en)
1985-02-28
PH20990A
(en)
1987-06-18
FI82938B
(en)
1991-01-31
FI842253A0
(en)
1984-06-05
YU97284A
(en)
1986-10-31
FI842253A
(en)
1984-12-07
DK275684A
(en)
1984-12-07
IE57561B1
(en)
1992-12-16
PT78691A
(en)
1984-07-01
IL72004A
(en)
1988-07-31
ES533149A0
(en)
1985-12-01
IE841392L
(en)
1984-12-06
DK275684D0
(en)
1984-06-04
ES8602807A1
(en)
1985-12-01
AU2907984A
(en)
1984-12-13
KR870000324B1
(en)
1987-02-27
PL143370B1
(en)
1988-02-29
IL72004A0
(en)
1984-10-31
FI82938C
(en)
1991-05-10
JPH0342277B2
(en)
1991-06-26
NO842250L
(en)
1984-12-07
JPS608293A
(en)
1985-01-17
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