AU557068B2 – 1-aroyl-5-oxo-2-pyrrolidine propanoic acids and esters
– Google Patents
AU557068B2 – 1-aroyl-5-oxo-2-pyrrolidine propanoic acids and esters
– Google Patents
1-aroyl-5-oxo-2-pyrrolidine propanoic acids and esters
Info
Publication number
AU557068B2
AU557068B2
AU20871/83A
AU2087183A
AU557068B2
AU 557068 B2
AU557068 B2
AU 557068B2
AU 20871/83 A
AU20871/83 A
AU 20871/83A
AU 2087183 A
AU2087183 A
AU 2087183A
AU 557068 B2
AU557068 B2
AU 557068B2
Authority
AU
Australia
Prior art keywords
esters
aroyl
oxo
amnesia
reversal
Prior art date
1982-11-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU20871/83A
Other versions
AU2087183A
(en
Inventor
Donald Eugene Butler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1982-11-15
Filing date
1983-11-01
Publication date
1986-12-04
1983-11-01
Application filed by Warner Lambert Co LLC
filed
Critical
Warner Lambert Co LLC
1984-05-24
Publication of AU2087183A
publication
Critical
patent/AU2087183A/en
1986-12-04
Application granted
granted
Critical
1986-12-04
Publication of AU557068B2
publication
Critical
patent/AU557068B2/en
2003-11-01
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D207/24—Oxygen or sulfur atoms
C07D207/26—2-Pyrrolidones
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer’s disease or other forms of dementia
Abstract
1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids, salts, and esters which are useful as pharmacological agents, especially as agents for the reversal of amnesia, enhancing performance in poorly motivated subjects and treatment of senility and methods for their preparations are disclosed. Pharmaceutical compositions containing said compounds, salts, and esters and methods for using said compositions in treating senility, improving motivation and reversal of amnesia are also taught. The novel compounds have the formula:where R, X and Y are hydrogen atoms or various substituents, but R, X and Y are not simultaneously all hydrogen atoms.
AU20871/83A
1982-11-15
1983-11-01
1-aroyl-5-oxo-2-pyrrolidine propanoic acids and esters
Ceased
AU557068B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US06/441,335
US4452990A
(en)
1982-11-15
1982-11-15
1-Aroyl-5-oxo-2-pyrrolidinepropanoic acids and related esters
US441335
1982-11-15
Publications (2)
Publication Number
Publication Date
AU2087183A
AU2087183A
(en)
1984-05-24
AU557068B2
true
AU557068B2
(en)
1986-12-04
Family
ID=23752490
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU20871/83A
Ceased
AU557068B2
(en)
1982-11-15
1983-11-01
1-aroyl-5-oxo-2-pyrrolidine propanoic acids and esters
Country Status (20)
Country
Link
US
(1)
US4452990A
(en)
EP
(1)
EP0110575B1
(en)
JP
(1)
JPS59101461A
(en)
KR
(1)
KR900005018B1
(en)
AT
(1)
ATE27272T1
(en)
AU
(1)
AU557068B2
(en)
CA
(1)
CA1215977A
(en)
DE
(1)
DE3371628D1
(en)
DK
(1)
DK519783D0
(en)
ES
(1)
ES527241A0
(en)
FI
(1)
FI77443C
(en)
GR
(1)
GR78737B
(en)
HU
(1)
HU190916B
(en)
IE
(1)
IE56126B1
(en)
IL
(1)
IL70082A
(en)
NO
(1)
NO161491C
(en)
NZ
(1)
NZ206256A
(en)
PH
(1)
PH20393A
(en)
PT
(1)
PT77653B
(en)
ZA
(1)
ZA838126B
(en)
Families Citing this family (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US5173489A
(en)
*
1986-04-10
1992-12-22
The Dupont Merck Pharmaceutical Co.
α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US4760083A
(en)
*
1986-04-10
1988-07-26
E. I. Dupont De Nemours & Company
3,3-disubstituted indolines
US4876259A
(en)
*
1987-01-05
1989-10-24
E. I. Du Pont De Nemours And Company
3,3-disubstituted indolines
EP0367393A3
(en)
*
1988-10-31
1991-03-27
Takeda Chemical Industries, Ltd.
New heterocyclic compounds, production and use thereof
AT391692B
(en)
*
1989-04-24
1990-11-12
Fleischhacker Wilhelm Dr
ENANTIOMER-PURE, POSITION 1 ALKYLATED 5-OXO-2-PYRROLIDINE PROPANIC ACIDS AND THEIR ESTERS, THEIR PRODUCTION AND USE
Family Cites Families (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
JPS535158A
(en)
*
1976-07-05
1978-01-18
Teijin Ltd
Preparation of optical active alpha-alkylvenzylalcohol and its intermediates
1982
1982-11-15
US
US06/441,335
patent/US4452990A/en
not_active
Expired – Fee Related
1983
1983-10-21
IE
IE2475/83A
patent/IE56126B1/en
not_active
IP Right Cessation
1983-10-24
CA
CA000439583A
patent/CA1215977A/en
not_active
Expired
1983-10-28
IL
IL70082A
patent/IL70082A/en
unknown
1983-10-31
EP
EP83306607A
patent/EP0110575B1/en
not_active
Expired
1983-10-31
ZA
ZA838126A
patent/ZA838126B/en
unknown
1983-10-31
DE
DE8383306607T
patent/DE3371628D1/en
not_active
Expired
1983-10-31
AT
AT83306607T
patent/ATE27272T1/en
not_active
IP Right Cessation
1983-11-01
AU
AU20871/83A
patent/AU557068B2/en
not_active
Ceased
1983-11-07
KR
KR1019830005266A
patent/KR900005018B1/en
not_active
IP Right Cessation
1983-11-10
GR
GR72941A
patent/GR78737B/el
unknown
1983-11-11
FI
FI834136A
patent/FI77443C/en
not_active
IP Right Cessation
1983-11-11
PT
PT77653A
patent/PT77653B/en
not_active
IP Right Cessation
1983-11-14
PH
PH29831A
patent/PH20393A/en
unknown
1983-11-14
HU
HU833897A
patent/HU190916B/en
not_active
IP Right Cessation
1983-11-14
JP
JP58212636A
patent/JPS59101461A/en
active
Pending
1983-11-14
ES
ES527241A
patent/ES527241A0/en
active
Granted
1983-11-14
DK
DK5197/83A
patent/DK519783D0/en
not_active
Application Discontinuation
1983-11-14
NZ
NZ206256A
patent/NZ206256A/en
unknown
1983-11-14
NO
NO834149A
patent/NO161491C/en
unknown
Also Published As
Publication number
Publication date
IE832475L
(en)
1984-05-15
PT77653A
(en)
1983-12-01
KR840006622A
(en)
1984-12-01
PH20393A
(en)
1986-12-12
FI77443C
(en)
1989-03-10
ATE27272T1
(en)
1987-06-15
IL70082A
(en)
1987-07-31
AU2087183A
(en)
1984-05-24
EP0110575B1
(en)
1987-05-20
EP0110575A1
(en)
1984-06-13
ES8600238A1
(en)
1985-04-16
DK519783D0
(en)
1983-11-14
FI834136A
(en)
1984-05-16
NO161491C
(en)
1989-08-23
KR900005018B1
(en)
1990-07-18
NO834149L
(en)
1984-05-16
CA1215977A
(en)
1986-12-30
ES527241A0
(en)
1985-04-16
NO161491B
(en)
1989-05-16
IE56126B1
(en)
1991-04-24
GR78737B
(en)
1984-10-02
FI77443B
(en)
1988-11-30
US4452990A
(en)
1984-06-05
IL70082A0
(en)
1984-01-31
JPS59101461A
(en)
1984-06-12
HU190916B
(en)
1986-12-28
ZA838126B
(en)
1985-06-26
NZ206256A
(en)
1985-09-13
FI834136A0
(en)
1983-11-11
DE3371628D1
(en)
1987-06-25
PT77653B
(en)
1986-04-17
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