AU5847890A – Process for producing pressed, moulded, delayed release dose units and dose units thus produced
– Google Patents
AU5847890A – Process for producing pressed, moulded, delayed release dose units and dose units thus produced
– Google Patents
Process for producing pressed, moulded, delayed release dose units and dose units thus produced
Info
Publication number
AU5847890A
AU5847890A
AU58478/90A
AU5847890A
AU5847890A
AU 5847890 A
AU5847890 A
AU 5847890A
AU 58478/90 A
AU58478/90 A
AU 58478/90A
AU 5847890 A
AU5847890 A
AU 5847890A
AU 5847890 A
AU5847890 A
AU 5847890A
Authority
AU
Australia
Prior art keywords
release
unit
dose units
dosage forms
particles
Prior art date
1990-07-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU58478/90A
Other versions
AU651316B2
(en
AU651316C
(en
Inventor
Klaus Budde
Fritz Demmer
Berthold Stemmle
Alexander Wirl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Group PTC ehf
Original Assignee
Actavis Group PTC ehf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1990-07-02
Filing date
1990-07-02
Publication date
1992-01-23
1990-07-02
Application filed by Actavis Group PTC ehf
filed
Critical
Actavis Group PTC ehf
1992-01-23
Publication of AU5847890A
publication
Critical
patent/AU5847890A/en
1994-07-21
Publication of AU651316B2
publication
Critical
patent/AU651316B2/en
1995-01-27
Application granted
granted
Critical
1995-01-27
Publication of AU651316C
publication
Critical
patent/AU651316C/en
2009-01-08
Assigned to ACTAVIS GROUP PTC EHF.
reassignment
ACTAVIS GROUP PTC EHF.
Alteration of Name(s) in Register under S187
Assignors: BOEHRINGER MANNHEIM GMBH
2010-07-02
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K9/00—Medicinal preparations characterised by special physical form
A61K9/20—Pills, tablets, discs, rods
A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K9/00—Medicinal preparations characterised by special physical form
A61K9/20—Pills, tablets, discs, rods
A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P3/00—Drugs for disorders of the metabolism
A61P3/06—Antihyperlipidemics
Abstract
Process for the preparation of shaped, compressed controlled-release unit-dosage forms from a therapeutic active substance exhibiting a self-retarding release that depends on the magnitude of the force used for the compression. The process gives unit-dosage forms for which the release of the active substance is highly uniform, reproducibly identical and largely linear. To achieve this, the active substance and an additive charge that inhibits or compensates for the self-retardation of its release are processed into particles in the first stage of production, so that the preliminary compressed objects made from these particles without any further additives exhibit a rapid release (in comparison with the required controlled release) over the range of the force of compression envisaged for the production of the unit-dosage form in question, after which the particles are compressed in the second stage of production with a release-retarding agent to obtain the unit-dosage forms. The invention also relates to the unit-dosage forms thus obtained.
AU58478/90A
1990-07-02
Process for producing pressed, moulded, delayed release dose units and dose units thus produced
Expired
AU651316C
(en)
Applications Claiming Priority (3)
Application Number
Priority Date
Filing Date
Title
CA002085231A
CA2085231C
(en)
1990-07-02
1990-07-02
Process for the preparation of shaped, compressed controlled-release unit-dosage forms, and the compressed unit-dosage forms thus obtained
PCT/DE1990/000498
WO1992000064A1
(en)
1990-07-02
1990-07-02
Process for producing pressed, moulded, delayed release dose units and dose units thus produced
US95570592A
1992-12-18
1992-12-18
Publications (3)
Publication Number
Publication Date
AU5847890A
true
AU5847890A
(en)
1992-01-23
AU651316B2
AU651316B2
(en)
1994-07-21
AU651316C
AU651316C
(en)
1995-01-27
Family
ID=
Also Published As
Publication number
Publication date
FI103179B
(en)
1999-05-14
FI925984A0
(en)
1992-12-31
EP0537139B1
(en)
1994-05-18
HU219341B
(en)
2001-03-28
DE59005781D1
(en)
1994-06-23
HUT74904A
(en)
1997-03-28
ES2056470T3
(en)
1994-10-01
HU9204151D0
(en)
1993-04-28
IL98632A
(en)
1996-12-05
WO1992000064A1
(en)
1992-01-09
NZ238702A
(en)
1992-10-28
ATE105710T1
(en)
1994-06-15
FI103179B1
(en)
1999-05-14
CA2085231A1
(en)
1992-01-03
ZA915047B
(en)
1992-04-29
DK0537139T3
(en)
1994-08-22
US5840330A
(en)
1998-11-24
EP0537139A1
(en)
1993-04-21
AU651316B2
(en)
1994-07-21
FI925984A
(en)
1992-12-31
CA2085231C
(en)
1997-12-30
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Process for producing pressed, moulded, delayed release dose units and dose units thus produced
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