AU585196B2 – Oxazolidin-2-one derivatives as hypoglycemic agents
– Google Patents
AU585196B2 – Oxazolidin-2-one derivatives as hypoglycemic agents
– Google Patents
Oxazolidin-2-one derivatives as hypoglycemic agents
Info
Publication number
AU585196B2
AU585196B2
AU17534/88A
AU1753488A
AU585196B2
AU 585196 B2
AU585196 B2
AU 585196B2
AU 17534/88 A
AU17534/88 A
AU 17534/88A
AU 1753488 A
AU1753488 A
AU 1753488A
AU 585196 B2
AU585196 B2
AU 585196B2
Authority
AU
Australia
Prior art keywords
oxazolidin
pharmaceutically
derivatives
salt
hypoglycemic agents
Prior art date
1987-06-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU17534/88A
Other versions
AU1753488A
(en
Inventor
David Alan Clark
Michael Ross Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1987-06-10
Filing date
1988-06-09
Publication date
1989-06-08
1988-06-09
Application filed by Pfizer Inc
filed
Critical
Pfizer Inc
1988-12-15
Publication of AU1753488A
publication
Critical
patent/AU1753488A/en
1989-06-08
Application granted
granted
Critical
1989-06-08
Publication of AU585196B2
publication
Critical
patent/AU585196B2/en
2008-06-09
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D263/18—Oxygen atoms
C07D263/20—Oxygen atoms attached in position 2
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P3/00—Drugs for disorders of the metabolism
A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D263/18—Oxygen atoms
C07D263/20—Oxygen atoms attached in position 2
C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D263/48—Nitrogen atoms not forming part of a nitro radical
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
Oxazolidin-2-one derivs. of formula (I), corresp. pharmaceutically-acceptable acid addn. salt or pharmaceutically-acceptable cationic salt are new. Rb is (i), (ii) (iii) or (iv), W is S or O; X, X’ is H, Cl, F or CF3; Y is -COOR1, -CON(R1)CH2CONR3R3, gp. (v) or vi), Ra, R1, R2, R3 are H, CH3, R4 is CH3 or CF3. For pharmaceutically-acceptable acid addn. salt, Y is gp. (v) or Rb is gp. (iii). For pharmaceutically-acceptable cationic salt y is -COOH or gp. (vi). – Also claimed is an optically active cpd. of formula (I) and use of cpd. (I) as a medicament for the treatment of hyperglycemia.
AU17534/88A
1987-06-10
1988-06-09
Oxazolidin-2-one derivatives as hypoglycemic agents
Ceased
AU585196B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
PCT/US1987/001356
WO1988009661A1
(en)
1987-06-10
1987-06-10
Oxazolidin-2-one derivatives as hypoglycemic agents
WOUS8701356
1987-06-10
Publications (2)
Publication Number
Publication Date
AU1753488A
AU1753488A
(en)
1988-12-15
AU585196B2
true
AU585196B2
(en)
1989-06-08
Family
ID=22202413
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU17534/88A
Ceased
AU585196B2
(en)
1987-06-10
1988-06-09
Oxazolidin-2-one derivatives as hypoglycemic agents
Country Status (21)
Country
Link
US
(1)
US4968707A
(en)
EP
(1)
EP0294995B1
(en)
JP
(1)
JPS649979A
(en)
KR
(1)
KR900007313B1
(en)
AT
(1)
ATE82284T1
(en)
AU
(1)
AU585196B2
(en)
CA
(1)
CA1305152C
(en)
DE
(1)
DE3875806T2
(en)
DK
(1)
DK313588A
(en)
ES
(1)
ES2045116T3
(en)
FI
(1)
FI89479C
(en)
GR
(1)
GR3007059T3
(en)
HU
(1)
HU203330B
(en)
IE
(1)
IE62029B1
(en)
IL
(1)
IL86603A
(en)
MY
(1)
MY103297A
(en)
NO
(1)
NO171978C
(en)
NZ
(1)
NZ224957A
(en)
PT
(1)
PT87702B
(en)
WO
(1)
WO1988009661A1
(en)
ZA
(1)
ZA884114B
(en)
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Assignee
Title
JPH02167224A
(en)
*
1988-09-13
1990-06-27
Tanabe Seiyaku Co Ltd
Antilipemic agent
US5356908A
(en)
*
1989-04-21
1994-10-18
E. I. Du Pont De Nemours And Company
Fungicidal oxazolidinones
WO1991003474A1
(en)
*
1989-08-29
1991-03-21
Pfizer Inc.
Hypoglycemic thiazolidinedione derivatives
US5068342A
(en)
*
1989-10-27
1991-11-26
American Home Products Corporation
5-[(1- and 2-naphthalenyl)thio and sulfonyl]-2,4-thiazolidinediones and derivatives thereof
CA2083891A1
(en)
*
1991-12-03
1993-06-04
Angus Murray Macleod
Heterocyclic compounds, compositions containing them and their use in therapy
US5747501A
(en)
*
1992-04-07
1998-05-05
Pfizer, Inc.
Indole derivatives
ATE185564T1
(en)
1992-08-31
1999-10-15
Sankyo Co
OXAZOLIDINE DERIVATIVES HAVING ANTIDIABETIC AND ANTI-OBESITY PROPERTIES, THEIR PREPARATION AND THERAPEUTIC USE
KR0173145B1
(en)
*
1993-04-07
1999-02-01
고바야시 유키오
Thiazolidine derivative and pharmaceutical composition containing the same
US5629200A
(en)
1993-11-18
1997-05-13
Daicel Chemical Industries, Ltd.
Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation
CA2145257A1
(en)
*
1994-03-23
1995-09-24
Takashi Fujita
Thiazolidine and oxazolidine derivatives, their preparation and their medical use
JP5082033B2
(en)
2001-12-21
2012-11-28
エグゼリクシス パテント カンパニー エルエルシー
LXR modulator
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2001-12-21
2009-01-27
X-Ceptor Therapeutics, Inc.
Modulators of LXR
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*
2004-07-02
2011-07-15
Merck Sharp & Dohme
CETP INHIBITORS
WO2006069193A2
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2004-12-21
2006-06-29
Gilead Sciences, Inc.
Imidazo[4,5-c]pyridine compound and method of antiviral treatment
TW200732313A
(en)
2005-12-15
2007-09-01
Astrazeneca Ab
Oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators
BRPI0620752A2
(en)
*
2005-12-30
2011-11-22
Merck & Co Inc
pharmaceutically acceptable salt or compound thereof, pharmaceutical composition, and use of the compound or a pharmaceutically acceptable salt thereof
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Priority date
Publication date
Assignee
Title
US2909467A
(en)
*
1958-07-09
1959-10-20
Us Vitamin Pharm Corp
3-(d-alpha-methylphenethyl)-5-methyl-1, 3-oxazolidine-2, 4-dione
JPS5522636A
(en)
*
1978-08-04
1980-02-18
Takeda Chem Ind Ltd
Thiazoliding derivative
DD153682A1
(en)
*
1978-10-19
1982-01-27
Horst Bercher
PROCESS FOR PRODUCING NEW ALKANOLAMINE
DE3162756D1
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*
1980-05-22
1984-04-26
Beecham Group Plc
Arylethanolamine derivatives, their preparation and use in pharmaceutical compositions
SG56656G
(en)
*
1980-07-28
1987-03-27
Pfizer
Hypoglycemic 5-substituted oxazolidine-2, 4-diones
US4407811A
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*
1981-01-02
1983-10-04
Pfizer Inc.
Hypoglycemic 5-substituted oxazolidine-2,4-diones
ES8400116A1
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*
1981-10-13
1983-10-16
Pfizer
Oxazolidinedione derivatives.
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(en)
*
1982-03-01
1984-09-26
Pfizer
JPS58183676A
(en)
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1982-04-19
1983-10-26
Takeda Chem Ind Ltd
Oxazole derivative
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*
1982-06-23
1984-02-07
Pfizer Inc.
Alicyclic substituted oxazolidine-2,4-diones having hypoglycemic activity
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*
1983-01-17
1986-10-14
Pfizer Inc.
Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
EP0140359B1
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*
1983-11-02
1989-01-25
Beecham Group Plc
Morpholine derivatives
DE3466387D1
(en)
*
1983-11-04
1987-10-29
Beecham Group Plc
Tertiary amines
CA1249992A
(en)
*
1983-11-10
1989-02-14
Marcel Muller
Oxazolidines
GB8412862D0
(en)
*
1984-05-19
1984-06-27
Beecham Group Plc
Compounds
GB8418657D0
(en)
*
1984-07-21
1984-08-22
Beecham Group Plc
Compounds
WO1986002073A1
(en)
*
1984-10-03
1986-04-10
Takeda Chemical Industries, Ltd.
Thiazolidinedione derivatives, process for their preparation, and pharmaceutical composition containing same
DE3438839A1
(en)
*
1984-10-19
1986-04-24
Schering AG, 1000 Berlin und 4709 Bergkamen
PHARMACEUTICAL PREPARATIONS
AR240698A1
(en)
*
1985-01-19
1990-09-28
Takeda Chemical Industries Ltd
Process for the preparation of 5-(4-(2-(5-ethyl-2-pyridil)-ethoxy)benzyl)-2,4-thiazolodinedione and their salts
US4738972A
(en)
*
1985-05-21
1988-04-19
Pfizer Inc.
Hypoglycemic thiazolidinediones
JPH06779B2
(en)
*
1985-06-10
1994-01-05
武田薬品工業株式会社
Thiazolidione derivative and pharmaceutical composition comprising the same
US4812570A
(en)
*
1986-07-24
1989-03-14
Takeda Chemical Industries, Ltd.
Method for producing thiazolidinedione derivatives
US4873255A
(en)
*
1987-02-04
1989-10-10
Sankyo Company Limited
Thiazolidinone derivatives, their preparation and their use
EP0295828A1
(en)
*
1987-06-13
1988-12-21
Beecham Group Plc
Novel compounds
US4791125A
(en)
*
1987-12-02
1988-12-13
Pfizer Inc.
Thiazolidinediones as hypoglycemic and anti-atherosclerosis agents
1987
1987-06-10
US
US07/460,848
patent/US4968707A/en
not_active
Expired – Fee Related
1987-06-10
HU
HU874223A
patent/HU203330B/en
not_active
IP Right Cessation
1987-06-10
WO
PCT/US1987/001356
patent/WO1988009661A1/en
active
IP Right Grant
1988
1988-06-01
EP
EP88304976A
patent/EP0294995B1/en
not_active
Expired – Lifetime
1988-06-01
ES
ES88304976T
patent/ES2045116T3/en
not_active
Expired – Lifetime
1988-06-01
AT
AT88304976T
patent/ATE82284T1/en
active
1988-06-01
DE
DE8888304976T
patent/DE3875806T2/en
not_active
Expired – Fee Related
1988-06-02
IL
IL86603A
patent/IL86603A/en
not_active
IP Right Cessation
1988-06-06
MY
MYPI88000601A
patent/MY103297A/en
unknown
1988-06-07
JP
JP63139787A
patent/JPS649979A/en
active
Granted
1988-06-08
CA
CA000568902A
patent/CA1305152C/en
not_active
Expired – Fee Related
1988-06-09
IE
IE173488A
patent/IE62029B1/en
not_active
IP Right Cessation
1988-06-09
ZA
ZA884114A
patent/ZA884114B/en
unknown
1988-06-09
PT
PT87702A
patent/PT87702B/en
not_active
IP Right Cessation
1988-06-09
NZ
NZ224957A
patent/NZ224957A/en
unknown
1988-06-09
KR
KR1019880006908A
patent/KR900007313B1/en
not_active
IP Right Cessation
1988-06-09
AU
AU17534/88A
patent/AU585196B2/en
not_active
Ceased
1988-06-09
DK
DK313588A
patent/DK313588A/en
not_active
Application Discontinuation
1989
1989-02-08
NO
NO89890529A
patent/NO171978C/en
unknown
1989-12-05
FI
FI895815A
patent/FI89479C/en
not_active
IP Right Cessation
1993
1993-02-11
GR
GR930400291T
patent/GR3007059T3/el
unknown
Also Published As
Publication number
Publication date
FI895815A0
(en)
1989-12-05
ES2045116T3
(en)
1994-01-16
DK313588D0
(en)
1988-06-09
JPH0448791B2
(en)
1992-08-07
GR3007059T3
(en)
1993-07-30
MY103297A
(en)
1993-05-29
ZA884114B
(en)
1990-02-28
ATE82284T1
(en)
1992-11-15
CA1305152C
(en)
1992-07-14
EP0294995B1
(en)
1992-11-11
NO171978B
(en)
1993-02-15
KR890000447A
(en)
1989-03-14
DK313588A
(en)
1989-02-10
WO1988009661A1
(en)
1988-12-15
NZ224957A
(en)
1990-03-27
EP0294995A1
(en)
1988-12-14
KR900007313B1
(en)
1990-10-08
IL86603A
(en)
1992-09-06
FI89479C
(en)
1993-10-11
DE3875806D1
(en)
1992-12-17
HUT53623A
(en)
1990-11-28
DE3875806T2
(en)
1993-04-08
NO890529L
(en)
1989-02-08
IL86603A0
(en)
1988-11-30
PT87702B
(en)
1992-10-30
AU1753488A
(en)
1988-12-15
HU203330B
(en)
1991-07-29
NO890529D0
(en)
1989-02-08
PT87702A
(en)
1988-07-01
FI89479B
(en)
1993-06-30
JPS649979A
(en)
1989-01-13
IE62029B1
(en)
1994-12-14
IE881734L
(en)
1988-12-10
US4968707A
(en)
1990-11-06
NO171978C
(en)
1993-05-26
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