AU5948080A

AU5948080A – Synthesis of vincaminic acid derivatives
– Google Patents

AU5948080A – Synthesis of vincaminic acid derivatives
– Google Patents
Synthesis of vincaminic acid derivatives

Info

Publication number
AU5948080A

AU5948080A
AU59480/80A
AU5948080A
AU5948080A
AU 5948080 A
AU5948080 A
AU 5948080A
AU 59480/80 A
AU59480/80 A
AU 59480/80A
AU 5948080 A
AU5948080 A
AU 5948080A
AU 5948080 A
AU5948080 A
AU 5948080A
Authority
AU
Australia
Prior art keywords
acid derivatives
synthesis
vincaminic acid
ethyl
vincaminic
Prior art date
1979-06-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU59480/80A
Other versions

AU529996B2
(en

Inventor
Guy Rossey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Synthelabo SA

Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1979-06-22
Filing date
1980-06-20
Publication date
1981-01-08

1980-06-20
Application filed by Synthelabo SA
filed
Critical
Synthelabo SA

1981-01-08
Publication of AU5948080A
publication
Critical
patent/AU5948080A/en

1983-06-30
Application granted
granted
Critical

1983-06-30
Publication of AU529996B2
publication
Critical
patent/AU529996B2/en

2000-06-20
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00

C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains three hetero rings

C07D471/14—Ortho-condensed systems

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE

Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

Y02P20/00—Technologies relating to chemical industry

Y02P20/50—Improvements relating to the production of bulk chemicals

Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Vincaminic acid derivatives of formula (A) (A) useful in treating cerebral insufficiency, are prepared by reacting 1-ethyl-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizine with the 2,4-DNP hydrazone of ethyl or methyl bromopyruvate followed by (i) reduction of the C=N bond and (ii) simultaneous cyclization with removal of the ketone-protecting group in either order.

AU59480/80A
1979-06-22
1980-06-20
Synthesis of vincaminic acid derivatives

Ceased

AU529996B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

FR7916030A

FR2459799A1
(en)

1979-06-22
1979-06-22

SYNTHESIS OF () -VINCAMINE

FR7916030

1979-06-22

Publications (2)

Publication Number
Publication Date

AU5948080A
true

AU5948080A
(en)

1981-01-08

AU529996B2

AU529996B2
(en)

1983-06-30

Family
ID=9226959
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU59480/80A
Ceased

AU529996B2
(en)

1979-06-22
1980-06-20
Synthesis of vincaminic acid derivatives

Country Status (19)

Country
Link

US
(1)

US4316029A
(en)

EP
(1)

EP0021923B1
(en)

JP
(1)

JPS567783A
(en)

AT
(1)

ATE4575T1
(en)

AU
(1)

AU529996B2
(en)

CA
(1)

CA1143735A
(en)

DE
(1)

DE3064745D1
(en)

DK
(1)

DK265480A
(en)

ES
(1)

ES492626A0
(en)

FI
(1)

FI67546C
(en)

FR
(1)

FR2459799A1
(en)

GR
(1)

GR69293B
(en)

HU
(1)

HU183155B
(en)

IE
(1)

IE49920B1
(en)

IL
(1)

IL60368A
(en)

NO
(1)

NO153728C
(en)

NZ
(1)

NZ194105A
(en)

PT
(1)

PT71437A
(en)

ZA
(1)

ZA803691B
(en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

HU182411B
(en)

*

1981-11-03
1984-01-30
Richter Gedeon Vegyeszet
Process for preparing eburnamonine derivatives

HU186891B
(en)

*

1981-06-12
1985-10-28
Richter Gedeon Vegyeszet
Process for producing esters of apovincaminic acid

HU182380B
(en)

*

1981-09-30
1983-12-28
Richter Gedeon Vegyeszet
Process for producing esters of vincaminic acid

AU562731B2
(en)

*

1985-02-01
1987-06-18
Nippon Steel Corporation
Preventtion of casting defects in continuous casting

JPH0790343B2
(en)

*

1986-10-31
1995-10-04
住友金属工業株式会社

Breakout prediction method in continuous casting

US4949777A
(en)

*

1987-10-02
1990-08-21
Kawasaki Steel Corp.
Process of and apparatus for continuous casting with detection of possibility of break out

ES2052449B1
(en)

*

1992-12-22
1995-02-16
Covex Sa

NEW PROCEDURE FOR THE PREPARATION OF THE ETHYL APOVINCAMINATE.

CN102558170B
(en)

*

2010-12-13
2015-03-18
辽宁海德制药有限公司
Method for preparing optically pure cis apovincaminic acid ester

CN103554102A
(en)

*

2013-11-22
2014-02-05
长沙理工大学
Simple synthetic method of vinpocetine

Family Cites Families (6)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

HU163143B
(en)

*

1971-05-07
1973-06-28

US4033969A
(en)

*

1972-06-19
1977-07-05
Agence Nationale De Valorisation De La Recherche (Anvar)
Vincamine derivatives

FR2190113A5
(en)

*

1972-06-19
1974-01-25
Anvar

FR2259612B1
(en)

*

1974-01-31
1977-09-09
Synthelabo

CH586698A5
(en)

*

1975-07-10
1977-04-15
Sandoz Ag

GB1565804A
(en)

*

1975-10-28
1980-04-23
Inverni Della Beffa Spa
Alkaloid derivatives

1979

1979-06-22
FR
FR7916030A
patent/FR2459799A1/en
active
Granted

1980

1980-06-06
EP
EP80400807A
patent/EP0021923B1/en
not_active
Expired

1980-06-06
DE
DE8080400807T
patent/DE3064745D1/en
not_active
Expired

1980-06-06
AT
AT80400807T
patent/ATE4575T1/en
active

1980-06-19
FI
FI801969A
patent/FI67546C/en
not_active
IP Right Cessation

1980-06-20
NZ
NZ194105A
patent/NZ194105A/en
unknown

1980-06-20
IL
IL60368A
patent/IL60368A/en
unknown

1980-06-20
NO
NO801853A
patent/NO153728C/en
unknown

1980-06-20
DK
DK265480A
patent/DK265480A/en
not_active
Application Discontinuation

1980-06-20
HU
HU801538A
patent/HU183155B/en
unknown

1980-06-20
PT
PT71437A
patent/PT71437A/en
unknown

1980-06-20
AU
AU59480/80A
patent/AU529996B2/en
not_active
Ceased

1980-06-20
IE
IE1284/80A
patent/IE49920B1/en
unknown

1980-06-20
US
US06/161,359
patent/US4316029A/en
not_active
Expired – Lifetime

1980-06-20
CA
CA000354458A
patent/CA1143735A/en
not_active
Expired

1980-06-20
ES
ES492626A
patent/ES492626A0/en
active
Granted

1980-06-20
ZA
ZA00803691A
patent/ZA803691B/en
unknown

1980-06-20
JP
JP8451280A
patent/JPS567783A/en
active
Pending

1980-06-21
GR
GR62278A
patent/GR69293B/el
unknown

Also Published As

Publication number
Publication date

FR2459799B1
(en)

1982-04-30

NZ194105A
(en)

1983-05-10

FR2459799A1
(en)

1981-01-16

FI801969A
(en)

1980-12-23

NO801853L
(en)

1980-12-23

HU183155B
(en)

1984-04-28

EP0021923A1
(en)

1981-01-07

IL60368A
(en)

1983-03-31

IE49920B1
(en)

1986-01-08

IE801284L
(en)

1980-12-22

DK265480A
(en)

1980-12-23

ES8201170A1
(en)

1981-11-01

FI67546B
(en)

1984-12-31

JPS567783A
(en)

1981-01-27

EP0021923B1
(en)

1983-09-07

PT71437A
(en)

1980-07-01

DE3064745D1
(en)

1983-10-13

ZA803691B
(en)

1981-06-24

NO153728B
(en)

1986-02-03

GR69293B
(en)

1982-05-13

AU529996B2
(en)

1983-06-30

IL60368A0
(en)

1980-09-16

NO153728C
(en)

1986-05-14

ATE4575T1
(en)

1983-09-15

ES492626A0
(en)

1981-11-01

US4316029A
(en)

1982-02-16

FI67546C
(en)

1985-04-10

CA1143735A
(en)

1983-03-29

Similar Documents

Publication
Publication Date
Title

IE781878L
(en)

1979-03-19

Imidazole derivatives

ES8500242A1
(en)

1984-10-01

Imidazole derivatives, their preparation and medicines containing these compounds.

FI93447B
(en)

1994-12-30

Analogous process for the preparation of therapeutically useful 3- (tetrahydropyrido, dihydropyrrolo and tetrahydropyrazino [1,2-a] indol-10-yl) pyrrole-2,5-dione derivatives

DE3750443D1
(en)

1994-10-06

Cephalosporin compounds, process for their preparation and antibacterial agents.

AU7535087A
(en)

1988-01-14

The process for the manufacture of spiro-linked pyrrolidine-2,5-dione derivatives

HU9301366D0
(en)

1993-09-28

Benzo-pyridone derivatives and pyrido-pyridone ones substituted with sulfonyl-benzyl group

AU529996B2
(en)

1983-06-30

Synthesis of vincaminic acid derivatives

AU6587896A
(en)

1996-12-12

Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives

IE38979L
(en)

1974-09-16

Tetrazolyl – quinoxalinecarboxamide derivatives

AU7147287A
(en)

1988-03-31

Five-membered N-heterocyclic derivatives of N'-substituted-N,N'-diacylhydrazines

AU4820679A
(en)

1980-01-03

Derivatives of 1,3,5-triazacycloheptane-2,4-dione

AU658175B2
(en)

1995-04-06

Use of 2-iminothiazolidin-4-one derivatives as novel pharmaceutical active ingredients

CA2120229A1
(en)

1993-04-15

Methylpiperazinoazepine derivatives, their preparation and their use

IE893578L
(en)

1990-05-08

Phenyloxypropanolamine derivatives, their preparation and¹their application in therapeutics

IE39800L
(en)

1974-12-14

4-amino-3-hydrazino-1,2,4-triazole derivatives

IE791438L
(en)

1980-01-31

Oxadiazolotriazines

IE780849L
(en)

1978-11-05

Thienamycin derivatives

IE812722L
(en)

1982-05-21

Naphthyridine derivatives

IE780829L
(en)

1978-10-29

(3,4-dichlorophenylsulphinyl)-acetamideoxime and its¹addition salts, cns therapeutic.

FI930300A
(en)

1993-01-25

5-Amino-1,2,4-thiadiazol-3-yl-iminokarbonylförening

AU492123B2
(en)

1977-12-08

6[&-amino-w-(2,3-methylene-dioxyphenyl)-acylamido] penicillanic acid derivatives

AU1463676A
(en)

1977-12-08

6[&-amino-w-(2,3-methylene-dioxyphenyl)-acylamido] penicillanic acid derivatives

CA2177602A1
(en)

1995-06-08

N-substituted azabicycloalkane derivatives, their preparation and use

JPS5353665A
(en)

1978-05-16

Thioxanthene derivatives

Download PDF in English