AU615649B2

AU615649B2 – Stable hydrogen peroxide dental gel containing fumed silicas
– Google Patents

AU615649B2 – Stable hydrogen peroxide dental gel containing fumed silicas
– Google Patents
Stable hydrogen peroxide dental gel containing fumed silicas

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Info

Publication number
AU615649B2

AU615649B2
AU14680/88A
AU1468088A
AU615649B2
AU 615649 B2
AU615649 B2
AU 615649B2
AU 14680/88 A
AU14680/88 A
AU 14680/88A
AU 1468088 A
AU1468088 A
AU 1468088A
AU 615649 B2
AU615649 B2
AU 615649B2
Authority
AU
Australia
Prior art keywords
weight
hydrogen peroxide
dental gel
phase
gel according
Prior art date
1987-04-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Application number
AU14680/88A
Other versions

AU1468088A
(en

Inventor
Denise-Marie Ditomasso
Shirley Mei-King Ng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Colgate Palmolive Co

Original Assignee
Colgate Palmolive Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1987-04-17
Filing date
1988-04-15
Publication date
1991-10-10

1988-04-15
Application filed by Colgate Palmolive Co
filed
Critical
Colgate Palmolive Co

1988-10-20
Publication of AU1468088A
publication
Critical
patent/AU1468088A/en

1991-10-10
Application granted
granted
Critical

1991-10-10
Publication of AU615649B2
publication
Critical
patent/AU615649B2/en

2008-04-15
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

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Hydrogen peroxide
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Silicium dioxide
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water
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polyethylene glycol
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fumed silica
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quinolin-8-ol
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L-tryptophane
Chemical compound

C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1
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0.000
description
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Magnesium peroxide
Chemical compound

[Mg+2].[O-][O-]
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0.000
description
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Mannitol
Natural products

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Mentha pulegium
Species

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Mentha pulegium
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Mucosal infection
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N-Vinyl-2-pyrrolidone
Chemical compound

C=CN1CCCC1=O
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description
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Ocotea pretiosa
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Oral herpes
Diseases

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PO4
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Human genes

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Phenethylamine
Chemical compound

NCCC1=CC=CC=C1
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0.000
description
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Poloxamer
Chemical compound

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229920002582
Polyethylene Glycol 600
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Povidone-iodine
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Silicon
Chemical compound

[Si]
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Sokalan®
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235000016639
Syzygium aromaticum
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244000223014
Syzygium aromaticum
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Tragacanth
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Triethanolamine
Chemical compound

OCCN(CCO)CCO
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0.000
description
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QIVBCDIJIAJPQS-UHFFFAOYSA-N
Tryptophan
Natural products

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Chemical compound

[Zn]
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acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium
Chemical compound

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aluminium oxide
Inorganic materials

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aluminium phosphate
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aspartame
Chemical compound

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calcium carbonate
Inorganic materials

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calcium peroxide
Chemical compound

[Ca+2].[O-][O-]
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0.000
description
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calcium peroxide
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239000001506
calcium phosphate
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carbamide peroxide
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carboxypolymethylene
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chemical reaction product
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cinnamon
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cleaning agent
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Chemical compound

[Ca+2].[Ca+2].[O-]P([O-])([O-])=O
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Chemical compound

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disodium ethylene diamine tetraacetate
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disodium;dioxido(oxo)tin
Chemical compound

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Chemical group

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gamma-tocopherol
Natural products

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glycols
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hectorite
Chemical compound

[Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2
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hectorite
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description
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235000010299
hexamethylene tetramine
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description
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239000004312
hexamethylene tetramine
Substances

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description
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hexamethylenetetramine
Chemical compound

C1N(C2)CN3CN1CN2C3
VKYKSIONXSXAKP-UHFFFAOYSA-N
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description
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238000009775
high-speed stirring
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hortel pimenta
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hydrogen
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hydrogen peroxide oral gel
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hydrolysis reaction
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improvement
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iodine
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iodine
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latex
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lozenge
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magnesium carbonate
Chemical compound

[Mg+2].[O-]C([O-])=O
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description
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magnesium carbonate
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magnesium carbonate
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magnesium peroxide
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mannitol
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mannitol
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manufacturing process
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menthol
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metal
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metal
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methyl group
Chemical group

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methyl salicylate
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natural gum
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neutralizing effect
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oleic acid
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oleic acids
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oral product
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oral solution
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organic material
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palmitic acid group
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papa-hydroxy-benzoic acid
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periodontitis
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peroxidase activity proteins
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pharmaceutical gel
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phenyldehydroalanine
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phosphate
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phosphate
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polyvinylpyrrolidone
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salicylic acid
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Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K8/00—Cosmetics or similar toiletry preparations

A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form

A61K8/04—Dispersions; Emulsions

A61K8/042—Gels

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K8/00—Cosmetics or similar toiletry preparations

A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition

A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients

A61K8/22—Peroxides; Oxygen; Ozone

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K8/00—Cosmetics or similar toiletry preparations

A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition

A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients

A61K8/25—Silicon; Compounds thereof

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K8/00—Cosmetics or similar toiletry preparations

A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition

A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds

A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen

A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups

Description

By: _’f Registered Patent Attorney I Sydn~ To: The Commissioner of Patents ‘COMMONWEALTH OF AUSTRALIA
A
COMIMONWEALTH OF AUSTR71LIA Patent Act 1952 615649 C OM P LE TE SPECIFICATION
(ORIGINAL)
Class Int. Class Application Number Lodged Complete Specification Lodged Accepted Published 9r 4.
6 9 9@ 9 Priority 17 April 1987 Related Art Name of Applicant COLGATE-PALMOLIVE
COMPANY
f 0 9 Address of Applicant Actual Inventor/s 300 Park Avenue, New York New York 10022, U.S.A.
Shirley Mei-King Ng Denise-Marie DiTomasso .A 9 4. r 9 Address for Service F.B. RICE CO., Patent Attorneys, 28A Montague Street, BALMAIN 2041.
Complete Specification for the invention entitled: STABLE HYDROGEN PEROXIDE DENTAL GEL CONTAINING FUMED SILICAS The following statement is a full description of this invention including the best method of performing it known to us/=e:rdiI~ tat.
(c r C tt t t c ttrt *t 4 i La S IL a’ -2- Background and Prior Art The present invention relates to the formation of a cosmetic and chemically stable hydrogen peroxide-containing dental gel having an acid pH of about 3-6 comprising a compatible system of specified amounts of specific dental components, desirably prepared by a specific order of addition of the various ingredients.
Until now it has been difficult to formulate a cosmetic and chemically stable hydrogen peroxide gel with appropriate thickening/gelling agents, humectant, surfactants and flavor for oral application. However, after extensive experimentation on various mixtures of components in the hydrogen-peroxide dental gel product, a compatible system of water, a combination of hydrophilic 15 and hydrophobic fumed silica as gelling agent, polyethylene glycol humectant, nonionic surfactant, sweetening agent, sodium benzoate, and flavor has been discovered. It has also been found that the order of addition of these ingredients is important in the formation of a stable gel.
Accordingly, it has been discovered that by using a specific sequential step process, stable formulations of a hydrogen peroxide dental gel containing a combination of hydrophilic and hydrophobic fumed silica as gelling agent, a polyethylene glycol hymectant, a nonionic surfactant, sweetening agent, sodium benzoate, and flavor can be made.
The stable hydrogen peroxide gel is prepared by homogenizing the fumed silicas in the polyethylene glycol and water phases and the sequential addition of the 30 premixed homogenized hydrophobic fumed silica in the polyethylene glycol (Phase A) to the premixed homogenized hydrophilic fumed silica in water containing hydrogen peroxide (Phase B) and mixing for about 30 minutes while maintaining the temperature at room temperature, adding the predissolved sodium saccharin and sodium benzoate in 3 water (Phase C) with mixing which effects immediate gellation, adding the presolubilized flavor in the nonionic surfactant and water (Phase D) and mixing for about 5-10 minutes until a clear, homogeneous rigid stable dental gel is obtained.
The finished oral product is a stable rigid gel having improved chemcial and cosmetic stability and improved taste.
It has long been recognized in the art that hydrogen peroxide and other peroxygen-containing agents are effective in curative and/or prophylactic treatments with respect to caries, dental plaque, gingivitis, periodontitis, mouth odor, tooth stains, recurrent aphthous ulcers, denture irritations, orthodontic 15 appliance lesions, postextraction and postperiodontal surgery, traumatic oral lesions and mucosal infections, S. herpetic stomatitis and the like. Peroxide-containing agents in the oral cavity exert a chemomethanical action generating thousands of tiny oxygen bubbles produced by S 20 interaction with tissue and salivary enzymes.
Peroxide mouthrinses and other oral preparations prevent colonization and multiplication of anaerobic bacteria known to be associated with periodontal disease.
00 Peroxygen-containing gels or pastes are indicated and/or 0 00 25 desirable where it is required to selectively treat areas for more than a few seconds, such gels and pastes tending to remain at the site of application for a time sufficient for the peroxide to manifest its maximum effectiveness.
It is also known that most peroxy compounds such as I 30 hydrogen peroxide in oral compositions tend to he unstable in storage due to incompatability with and/or interaction with other common ingredients in the composition, and lose the capacity to release active or nascent oxygen over relatively short periods of time. This adversely affects both the chemical stability of the composition as well as 4 the cosmetic stability of the final product, particularly in the gel containing hydrogen peroxide.
The prior art has attempted to solve said problems by using a variety of stabilizers for dental compositions in assorted forms such as tablets, chewing gum, mouthwashes, toothpastes, or powder containing a hydrogen peroxide as shown in U.S. Patent No. 4,226,851 wherein is disclosed an aqueous mouthwash containing hydrogen peroxide, flavor, zinc chorlide and water soluble Vitamin E which stabilizers the hydrogen peroxide in the mouthwash. U.S.
Patent No. 4,302,441 discloses solid oral products (tablets and chewing gum) containing urea hydrogen peroxide in gum bases such as jelutong, rubber latex, vinylite resins, etc., and in methyl, ethyl and sodium t 15 carboxymethyl cellulose carriers, free of glycerol, also T tr r ,1 containing sweeteners such as sodium saccharinate xylitol, t, sorbitol, and mannitol and flavors. U.S. Patent No.
St, 4,476,108 discloses an admixture of peroxidase, a peroxide and a donor molecule such as phenylethylamine tyrosie, t 20 tryptophan, benzoic acid, salicylic acid, hydroquinone, dehydrophenyl-alanine, vanillan and para-aminobenzoic acid, in a carrier such as water (mouthwash) or in the tt form of a paste, gel or powder U.S. Patent No. 4,431,631 discloses an aqueous oral solution hydrogen peroxide, glycerin and/or sorbitol humectant, 0.5-3% pluronic-type o. surfactant, polyoxyethylenated sorbitol monofatty acid ester surfactant, sweetener and flavor.
The prior art also discloses dental compositions containing a hydrogen peroxide and an additional component to effect stabilization, such as ascorbic acid in U.S.
Patent No. 3,886,265, wherein is disclosed tablets, lozenges, chewing gum or an aerosol or spray form containing a peroxide such as hydrogen peroxide and an ene-diol compound such as ascorbic acid, effective against bad breath.
1 .1,1, ii i 5 U.S. Patent No. 4,521,403 discloses a method of controlling and treating periodontal diseases by washing the teeth with an aqueous or aqueous alcoholic solution of a hydrogen peroxide and a povidone-iodine complex (complex of iodine with 1-vinyl-2-pyrrolidone polymers). These two ingredients are mixed only prior to use. U.S. Patent No.
4,592,487 discloses an antiplaque dentifrice in the form of a toothpaste or gel containing the two components, a peroxide and povidone-iodone complex, each separately mixed with conventional dentifrice components, and kept separated until admixed and dispensed from a special dual compartment container/mixer/dispenser device. U.S. Patent No. 4,592,488 discloses an oral mouthwash containing an iodophor or quaternary ammonium compound and a peroxy 15 compound such as hydrogen peroxide in the form of an o* *o aqueous or aqueous alcoholic solution prior to combining Sa. the two components into an oral mouthwash. U.S. Patent No. 4,592,489 discloses a two-part container for dispensing an oral mouthwash containing the eoooo 20 providone-iodine complex solution separate from the hydrogen peroxide solution and mixing prior to dispensing.
Dental compositions containing other oxidizing agents o. in lieu of the hydrogen peroxide are also disclosed in the prior art. U.S. Patent No. 4,405,599 discloses toothpaste 25 containing an oxidizing agent such as carbamide peroxide ‘o (urea peroxide) which dissociates into urea and hydrogen peroxide in the oral cavity, in a paste carrier comprising an anionic detergent, sorbitol and glycerin humectant and a thickening agent such as gum tragacanth, sodium alginate or sodium carboxymethyl cellulose. U.S. Patent No.
l 4,405,599 discloses toothpaste containing calcium peroxide and sodium perborate oxidizing agents; dicalcium phosphate, calcium carbonate and magnesium carbonate cleaning agents; sorbitol humectant; cornstarch and cellulose gum thickening agents; and an anionic detergent.
I
6 0000 *000 4 it 00 i to I 40c 4 1 044 000I 4 0000i 0 However, none of the aforesaid patents disclose the preparation of hydrogen peroxide gels containing the essential specific components of a polyethylene glycol humectant, a nonionic surfactant, flavor, sodium saccharin, sodium benzoate and a combination of hydrophilic and hydrophobic fumed silica gelling/thickening agent in the formation of a stable dental gel.
The prior art also discloses processes of preparing peroxide gels as shown in U.S. Patent No. 3,657,413 and the article by Assasy et al, «Stability of Hydrogen Peroxide in Certain Pharmaceutical Gels» Cosmetics and Toiletries 54-56, 91, September 1976. The patent discloses a clear gel comprising urea peroxide, glycerol, 15 a carboxypolymethylene polymer and flavor; prepared by dispensing the polymer into the glycerol with high speed stirring at reduced pressure and then dissolving the urea peroxide and other ingredients in the thickened polymer/glycerol solution yielding a viscous gel. The article discloses methyl cellulose gels for treating surface cuts, bleaching hair and for deodorant pruposes containing 0.1% oxine as stabilizer for the hydrogen peroxide; prepared by dispersing the methyl cellulose in water using an electric stirrer and then neutralizing the 25 triethanolamine to yield a gel; or dispersing in hot water until well hydrated, refrigerating until solidified and stirring until a gel is obtained, adding the stabilizer oxine to the gel, followed by the addition of the hydrogen peroxide. Other stabilizers which are not as effective as 30 oxine include hexamine, benzoic acid or urea.
Hydrogen peroxide gels containing polyoxyethylene polyoxypropylene block copolymers as the gelling/thickening agent is disclosed in U.S. Patent No.
3,639,574 which discloses a stable hydrogen peroxide gel for use in hair bleaching and treating surface cuts, using P #0 00 0 00 04
P
4 00 o .0 04 *0a 0 0 00 0 &r 0 S SO 0 4010(0
-A
I I 7 polyoxyethylene polyoxypropylene block copolymers as gelling agents in amounts of 22-79% of the total compositions, which may be prepared by dissolving the copolymers in water cooled to a temperature of 35-50°F and slowly adding the hydrogen peroxide to the cool polymer solution, allowing the solution to warm up to room temperature which forms a clear gel. This method may be varied by first adding the H 2 0 2 to cold water and then adding the copolymer to the cold aqueous solution and mixing until completely dissolved, follwed by standing at room temperature until it gels. This is not a dental gel, does not contain the polyethylene glycol humecatant, sodium saccharine sweetener, or flavor which are essential ingredients in the dental gel.
15 Denture cleansers containing 0.5-1.0% CAB-O-Sil, a t»t colloidal, submicroscopic, pyrogenic silica, to maintain a re mixture of solid ingredients in a free-flowing state and t to prevent lumping is disclosed in U.S. Patent No.
3,372,125.
U.S. Patent No. 4,223,003 discloses toothpaste and powder dentifrices con-taining a dye, a high foaming surfactant (anionic) to produce colored foam when brushing the teeth, a peroxide-containing compound such as J magnesium peroxide, and conventional dental constituents t. 25 which include carboxymethyl cellulose thickeners, So, pyrogenic silica, humectants, polishing agents, flavors, fluorides, etc.
U.S. Patent No. 4,537,765 discloses a toothpaste having a pH of 9.2-10.5 containing a peroxydiphoshpate 30 salt, a polyethylene glycol humectant, a thickener such as i colloidal silica, carboxyvinyl polymer, cellulose gums, or hectorite, a polishing agent such as silica or hydrated alumina and anionic or nonionic surfactants such as Pluronic F108.
However, the prior art does not disclose a cosmetic i i x and chemically stable aqueous hydrogen peroxide dental gel having a pH 3-6 containing as the essential ingredients a combination of hydrophilic and hydrophobic fumed silica gelling agent, a polyethylene glycol humectant, a nonionic surfactant, sweetening agent, sodium benzoate, and flavor prepared by a novel process utilizing a specific sequence of steps, which comprises the sequential addition with mixing of Phase A, a premixed homogenized hydrophobic fumed silica in polyethylene glycol; to Phase B, of premixed homogenized-hydrophilic fumed silica in water containing hydrogen peroxide, and mixing for about minutes at room temperature; adding Phase C, predissolved sodium saccharin and sodium benzoate in water to Phase AB to effect gelation; adding Phase D, pre-solubilized flavor rrt ‘,tt 15 in the nonionic surfactant and water to Phase ABC and e mixing for about 5-10 minutes until a clear, and homogeneous rigid gel is obtained.
SSummary of the Invention It has now been found that an aqueous hydrogen peroxide dental gel can be stabilized in the presence of polyethylene glycol, sodium saccharin, sodium benzoate, nonionic surfactant and flavor when using a combination of hydrophilic and hydrophobic fumed silica at a level of about 8-10% by weight hydrophilic fumed silica and 1 25 0.5-1.5% by weight hydrophobic fumed silica as the gelling agent. The fumed silica gelling agents are compatible awith the aqueous hydrogen peroxide, whereas the natural gums derived from organic material such as alignates, methyl cellulose and the like, are degraded by the hydrogen peroxide resulting in unstable gels. Similarly, Ssynthetic organic polymers such as polyvinyl pyrrolidone form a stringy gel, which is not the clear homogenous rigid gel in accordance with the present novel dental gel product. The presence of stabilizers such as sodium stannate, sodiun pyrophosphate, oxine EDTA and calcium 9 disodium EDTA have been found to be unnecessary and undesirable because their presence provide no advantages to the composition. Their presence tend to adversely affect the chemical stability of the H202 The combination of polyethylene glycol hymectant and the fumed silicas gelling agent has been found to yield a more stable rigid gel than a gel prepared in the absence of the polyethylene glycol. The presence of nonionic surfactants have been found to have acceptable stability in an aqueous peroxide environment. The anionic surfactants do not have acceptable stability in the presence of hydrogen peroxide. Accordingly, the formulation of present novel stable hydrogen peroxide dental gel is based on the specifically of compatible ingredients.
15 It has additionally been found that a novel process bs of preparing the hydrogen peroxide gel further assists in o* the obtention of a stable H 2 0 2 gel. The process utilizes a specific sequence of steps which comprises the formation of four separate phases: Phase A comprising hydrophobic fumed silica dispersed in polyethylene glycol by mixing until homogeneous, Phase B comprising hydrophilic fumed silica and hydrogen peroxide dissolved in water, Phase C comprising sodium saccharin and sodium 25 benzoate dissolved in water, and Phase D comprising flavor solubilized in nonionic °surfactant and water; and sequentially adding Phase A to 1Phase B and mixing until a homogeneous translucent liquid is obtained, and further homogenizing this mixture at room temperature for about thrity minutes; admixing Phase C with Phases AB which forms a gel; adding Phase D to Phase ABC and mixing for about 5-10 minutes to form a rigid clear homogeneous stable dental gel. The stable gel product may be acidified to a pH of about 3-6 with an appropriate acid such as citric acid or phosphate acid, if e r t I It Itr *i *4 4) 4 1 ar £4U needed. The final product may be packaged in any suitable container compatible with the hydrogen peroxide, such as plastic or metal tubes; or in a dual compartment container or kit with a bicarbonate dentifrice.
Accordingly, a primary object of the present invention is to formulate a cosmetically and chemically stable hydrogen peroxide oral gel having a pH of about 3-6 and preferably 4.5-5 containing a combination of hydrophilic and hydrophobic fumed silica as gelling agent in amounts of about 8-10% by weight hydrophilic fumed silica and about 0.5-1.5% by weight hydrophobic fumed silica which is compatible with the H202.
Another object of this invention is to provide a cosmetically stable H20 2 -combined hydrophilic and 15 hydrophobic fumed silica gel containing polyethylene glycol humectant which is compatible with the other dental ingredients.
Still another object of this invention is to provide a cosmetically and chemically stable aqueous H 2 02 dental gel having improved taste containing a compatible formulation of the fumed silica gelling agent, polyethylene glycol humectant, nonionic surfactant, flavor, sweetening agent such as sodium saccharin and sodium benzoate.
25 Another object of this invention is to formulate a stable H 2 0, dental gel based on the hydrophilic and hydrophobic fumed silica gelling agent, with improved compatability of all components by using a novel process comprising a specific order of addition of the various ingredients.
Additional objects, advantages and novel features of the invention will be set forth in part in the description which follows, and in part will become apparent to those skilled in the art upon examination of the following or may be learned by practice of the invention. The objects i: 1: i 11 and advantages of the invention may be realized and attained by means of the instrumentalities and combination particularly pointed out in the appended claims.
To achieve the foregoing and other objects and in accordance with the present invention, as embodied and broadly described herein, the novel stable aqueous hydrogen peroxide dental gel of this invention comprises about 1.5-3.5% by weight H 2 0 2 as the sole chemically active agent, about 8-10% by weight hydrophilic fumed silica and 0.5-1.5% by weight hydrophobic fumed silica as gelling agent, about 20-40% by weight polyethylene glycol humectant, a nonionic surfactant, sweetener, flavor and sodium benzoate, said gel having an acid pH or about 3-6.
Sodium saccharin is the preferred sweetener. Sodium :c t 15 benzoate is an essential additive in the gellation of the prefe- rably formulation. The water content in the gel^constitutes about 20-40% by weight of the dental composition.
1 Distilled or deionized water is preferred to prevent minimal contamination.
The stable hydrogen peroxide dental gel of this invention is prepared by a novel process comprising separately homogenizing the hydrophobic fumed silica in S the polyethylene glycol forming Phase A; and the Shdrbphcbic- fumed silica in the formula amount of water r 25 containing the hydrogen peroxide, Phase B; and mixing the two phases to form a translucent liquid; sequentially admixing Phase C consisting of sodium saccharin and sodium benzoate dissolved in water, with the translucent liquid of Phase AB to form a gel; and admixing Phase D consisting i II of flavors solubilized in the nonionic surfactant and
S
l water, with the gel of Phase ABC to obtain a clear, homogeneous, rigid, stable dental gel.
This order of addition of the specific ingredients is essential to the formation of a stable hydrogen peroxide dental gel. No gellation occurs if sodium benzoate is _1( i: i i 12 eliminated from the formulations. Likewise, if Phase D is added to Phase AB prior to Phase C, no gellation is observed.
More specifically, present invention relates to a novel process of preparing a cosmetic and chemically stablke aqueous H 2 0 2 dental gel comprising a combination of hydrophilic and hydrophobic fumed silica gelling/thickening agent, polyethylene glycol humectant, a nonionic surfactant, a sweetener, sodium benzoate, and a flavor, consisting essentailly of homogenizing the fumed silicas in the polyethylene glycol and water phases by the t sequential addition of the premixed homogenized hydrophobic fumed silica in the polyethylene glycol (Phase A) to the premixed homogenized hydrophilic fumed silica in 15 water containing hydrogen peroxide (Phase B) and mixing for about 30 minutes while maintaining the temperature at room temperature, adding the predissolved sodium saccharin and sodium benzoate in water (Phase C) with mixing which effects immediate gellation, adding the presolubilized flavor in the nonionic surfactant and water (Phase D) and mixing for about 5-10 minutes until a clear, homogeneous rigid stable dental gel is obtained.
The hydrogren peroxide formulation of present invention contains an effective amount of hydrogen peroxide for oral antigingivitis application, preferably about 1.5-3.5% by weight of the composition. Hydrogen 0* peroxide is usually supplied as 30-35% aqueous solutions containing 1.5-3.5% active ingredient. The hydrogen peroxide is stable in the presence of polyethylene glycol, sodium saccharin, nonionic surfactant, flavor, and the fumed silica gelling agent.
An essential ingredient in present H 2 0 2 gel dentifrice is a compatible peroxide-stable thickening and gelling agent which is a combination of hydrophilic and hydrophobic fumed silica in amounts of about 8-10% by 13 weight hydrophilic fumed silica and about 0.5-1.5% by weight of hydrophobic fumed silica. The preferred weight ratio of the fumed silica mixture in present dentifrice gel is within the range of 16:1 to 6:1 hydrophilic to hydrophobic fumed silica. The combination of hydrophilic and hydrophobic fumed silica provides greater stability properties to the hydrogen peroxide gel than with the use of a single fumed silica or other type of colloidal silica. This combination passes the freeze/thaw cycle without showing separation. Three weeks of aging of several formulations showed significant improvement in the ,aI cosmetic stability of the hydrogen peroixde gel. Fumed SI silica is a coagulated silicon dioxide of extremely small particle size, produced by the hydrolysis of silicon t 15 tetrachloride vapor in a flame of hydrogen and oxygen; and is described in Cosmetic Technology, March 1980 pp 35-39, by John Hardy and William F. Moll Jr. in an article entitled «The Use of Fumed Silica in Cosmetics». In this combustion process, molten spheres of silica are formed 20 having average diameters of 7 to 14 millimicrons and final surface areas ranging from 400 square meters per gram (m2/g) to 200 m 2 The molten spheres fuse with one another to form bLr.nched three-dimensional, chainlike aggregates. During the formation of fumed silica, three types of hydroxyl groups are produced, isolated hydroxyls, hydrogen-bonded hydroxyls and siloxane (Si-0-Si). The S» °isolated and the hydrogen-bonded hydroxyl groups are sites of hydrophilicity, whereas the siloxane is nonpolar and hydrophobic. Fumed silica is a dry powder obtainable as «Aerosil» from Degussa. Various types of Aerosils are available depending on the variations in the manufacturing process. Aerosil 200 is a hydrophilic fumed silica, having a surface area of 200+ 25 square meters per gram, an average particle size of about 10-12 nanometers and a compacted apparent density of about 50g/l. Aerosil with i~i i- -i :1 14 surface areas greater than 200 m 2 /g such as Aerosil 300 and Aerosol 380 may also be used. Aerosil R972 is a hydrophobic fumed silica having a surface area of 110+ m 2 /g and an average particle size of 16 nanometers and a compacted apparent density of about 50 g/l.
Another essential ingredient in the H 2 0 gel formulation of present invention is the polyethylene glycol humectant which is compatible with the hydrogen peroxide, the nonionic surfactant, flavor and the fumed silica gelling agent.
Polyethylene glycols known by the trademark CARBOWAX are nonionic polymers of ethylene oxide having the general Sformula:
HOCH
2
(CH
2
CH
2 15 wherein n represents the average number of oxyethylene groups. The Carbowax polyethylene glycols are designated by a number such as 400,600, etc. which represents the approximate average molecular weight. The polyethylene qlycols 200, 300, 400 and 600 are clear viscous liquids at room temperature. They are less hygroscopic than glycerin and simple glycols, are water soluble and form a clear aqueous solution. The polyethylene glycols provide a different and better feel and taste to the dental product than the glycerin or sorbitol. It has been found that the polyethylene glycol humectant aids in making a superior S, stable rigid H202 gel compared to the gel with glycerin. The polyethylene glycol humectant constitutes S about 20-40% by weight of the H202 gel compared to the Sgel with glycerin. The polyethylene glycol humectant constitutes about 20-40% by weight of the H 2 0 2 gel formulation. Typically, the average molecular weight of polyethylene glycol humectant is up to about 1000, preferably about 400-600 and most preferably about 600.
Another essential ingredient in the aqueous gel formulation of this invention is the nonionic I» l 15 surfactant which is compatible with the H 2 0 2 and is peroxide-stable. The nonionic surfactant serves as a solubilizing, dispersing, emulsifying and wetting agent and is especially effective to solubilize the flavor. A particularly useful nonionic surfactant is a water soluble polyoxyethylene monoester of sorbitol with a C 10 to
C
18 fatty acid, known under the Tween Trademark. The Tween surfactants are mixtures of C10-C18 fatty acid esters of sorbitol (and sorbitol anhydrides), consisting predominantly of the monoester, condensed with about 10-30, preferably about 20, moles of ethyleneoxide. The fatty acid (aliphatic hydrocarbon monocarboxylic acid) may S..be saturated or unsaturated, e.g. lauric, palmitic, ‘.stearic, oleic acids. Polysorbate 20 Tween 20) is 15 especially preferred and is commonly referred to as polyoxyethylene (20) sorbitan monolaurate. The nonionic surfactant constitutes about 0.5-5.0% by weight and preferably 0.5-3% by weight of the gel composition.
Another essential ingredient of present aqueous
H
2 0 2 gel dentifrice is a flavor compatible with and stable in the presence of hydrogen peroxide. The flavor ingredient preferably constitutes about 0.5-2% by weight of the composition. Suitable flavoring constituents are Sflavoring oils, e.g. oils of spearment, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, majoram, cinnamon and methyl salicylate and menthol.
A sweetening material is also employed as a complement to the flavoring material. Suitable sweetening agents are water soluble and include sodium saccharin, sodium cyclamate, xylitol, perillartime, D-tryptopham, aspartame, dihydrochalcones and the like, preferably in concentrations of about .01 to 1.0% by weight. Sodium saccharin is preferred.
The pH of the H 2 0 2 gel dentifrice of the 16 invention ranges from 3-6, preferably about 4.5 to 5 for optimum use in the oral cavity A pH less than 4.5 may be too acid for optimum use in oral cavity and at a greater than 5 the stability of the gel is diminished. The pH of the prepared composition is generally adjusted to 5.0 with an appropriate acid such as phosphoric acid or citric acid. The acidic pH affords greater stability to the gel product of present invention. The lower the pH, the greater the stability.
The hydrogen peroxide gel dentifrice of this invention may also contain conventional additional ingredients such as coloring or whitening agents, or o0 preservatives in minimal amounts of up to 5% by weight and preferably up to provided they do not interfere with the chemical and cosmetic (physical) stability properties of the finished product.
It has been found that by specifically utilizing the specific combination of ingredients of nonionic surfactant, polyethylene glycol humectant, the combination of hydrophilic and hydrophobic fumed silica gelling agent, etcsweetening agent, sodium benzoate and flavor, a cosmetic and chemically stable aqueous hydrogen peroxide gel dentifrice having improved taste can be formulated.
oIt has additionally been found that the new formulation method of homogenizing the fumed silicas in r the polyethylene glycol and water phases and the lt sequential addition of Phase A, B, C and D, using the specific ingredient of gelling agent, humectant, nonionic surfactant, sodium benzoate, sweetening agent (sodium saccharin) and flavor provides superior chemical and cosmetic stability to an aqueous hydrogen peroxide gel dentifrice having improved taste.
The final product is a rigid ringing gel which may be described as gels that have a firm jelly-like consistency; that is, when said gel is packaged in a jar type container
J
21 17 and the sides of said container are tapped lightly, the gel vibrates but retains its original configuration. The dental gel product cf present invention is a dentifrice and not a mouthrinse, and will dissolve in the oral cavity only upon brushing.
In the practice of this invention to promote oral hygiene, the gel dentifrice according to this invention is applied regularly to dental enamel by brushing the teeth for 30-90 seconds at least once daily.
DETAILED DESCRIPTION OF THE INVENTION The following examples are further illustrative of the nature of the present invention, but it is understood that the invention is not limited thereto. The compositions are prepared in the usual manner and all 15 amounts and proportions referred to herein and in the appended claims are by weight unless otherwise indicated.
Examples 1 and 2 Ir
I
I I Ct Phases Ingredients S 20 A Polyethylene glycol 600 (Union Carbide) C 4 Aerosil R972 (Degussa) B Distilled, deionized water Aerosil 200 (Degussa) H202 (35% Aqueous Solu) to C Distilled, deionized water Sodium Saccharin i Sodium Benzoate D Distilled, deionized water Polyoxyethylene (20) Sorbitan monolaurate Flavor pH: app. 4.5-5 Procedure: Steps: Percentage EX1 40.0 0.5 33.65 8.0 8.6 1.5 0.2 0.35 5.0 1.2 1.0 EX2 40.0 11.00 28.6 0.2 1.2 bad breath.
1 ‘1 S 18 1. Aerosil R972 (hydrophobic fumed silica) is dispersed in PEG-600 with a lightnin mixer until homogeneous.
2. Phase A is added to Phase B and pre-mixed in the Hobart mixer or Ross mixer until homogeneous (translucent liquid).
3. The above mixture is further homogenized with a Homomixer for an additional 30 minutes while the temperature was maintained at room temperature.
4. The pre-dissolved sodium saccharin and sodium benzoate (Phase C) are added to Phase AB while homomixing. Gel.ation is immediate.
Phase ABC is transferred to a Ross or Hobart mixer.
The pre-solubilized flavor (Phase D) is then added, and mixed for an additional 5-10 minutes. A stable gel is formed.
Example 3 Example 1 is repeated except that polyethylene glycol 400 is substituted for the polyethylene glycol 600. The end product is equally effective against gingivitis related bacteria, and also exhibits excellent chemical and cosmetic stability properties.
Examples 4 and Ingredients t *r tpp 4cr tesr 4 4* 4 44 C 4 4 Ct 4 4.
J;
‘-4 Polyethylene glycol 600 (Union Carbide) Aerosil 200 (Degussa) Aerosil R972 (Degussa) Hydrogen peroxide (35% aqueous solu) Sodium Saccharin Sodium Benzoate Polyoxyethy (20) Sorbitan Monolaurate Flavor Distilled, deionized water pH: app. 4.5-5.0 Example 4 20.0 8.0 0.5 8.6 0.2 0.35 1.0 1.0 60.35 Example 4 0 10.0 8.6 0.2 1.2 37.0 1 i
L
I
19 The above dental hydrogen peroxide gel formulations are prepared by the same procedure outlined in Example i.
The final dentifrice products of Examples 4 and 5 also exhibit excellent storage stability and are in the form of a stable rigid clear gel.
From the foregoing description, it should be clear that the invention may be embodied in other specific forms without departing from the spirit or the essential characteristics thereof. The disclosed embodiments are therefore, to be considered in all respects as illustrative and not restrictive.
*te.
I t c Cr
C
CC :-i C a C S o .AL I r r 1 v

Claims (13)

1. A stable aqueous hydrogen peroxide dental gel comprising 1.5-3.5% by weight hydrogen peroxide as the sole chemically active agent, a combination of 8-10% by weight hydrophilic and 0.5-1.5% by weight hydrophobic fumed silica gelling agents, 20 to 40% by weight of ,a polyethylene glycol humectant, 0.5-5% by weight nonionic surfactant, sweetening agent, sodium benzoate and a flavor, said gel having an acid pH of 3-6.

2. The dental gel according to claim 1, wherein sweetening agent is sodium saccharin in an amount of 0.2-1% by weight.

3. The dental gel according to Claim 1, wherein the S, nonionic surfactant is a polyoxyethylene monoester of sorbitol with a C10 to C18 fatty acid.

4. The dental gel according to Claim 1, wherein the aqueous content constitutes 20-40% by weight of deionized water. ot 5. The dental gel according to Claim 4, wherein the 20 flavor content is 0.5-2% by weight.

6. The dental gel according to Claim 3 wherein the nonionic surfactant is polyethylene sorbitan monolaurate.

7. The dental gel according the Claim 5 wherein the sodium benzoate constitutes 0.35 to 0.5% by weight of the composition.

8. The dental gel according to Claim 1 having a pH of 4.5-5.

9. The dental gel according to Claim 1, wherein the polyethylene glycol has an average molecular weight of 200-1000. The dental gel according to Claim 9, wherein the molecular weight of the polyethylene glycol is 400-600.

11. The hydrogen peroxide gel according to Claim 7, prepared by a process comprising separately homogenizing the hydrophobic fumed silica in the polyethylene glycol 21 forming Phase A, and the hydrophilic fumed silica in the formula amount of water containing the hydrogen peroxide, Phase B; and mixing the two phases to form a translucent liquid, sequentially admixing Phase C consisting of sodium saccharin and sodium benzoate dissolved in water, with the translucent liquid of Phase AB to form a gel; and admixing phase D consisting of flavors solubilized in the nonionic surfactant and water, with the gel of Phase ABC to obtain a clear, homogeneous, rigid, stable dental gel.

12. A cosmetic and chemically stable aqueous hydrogen peroxide dental gel having a pH between 3-6, comprising hydrogen peroxide as the sole chemically active agent in an amount of 1.5-3.5% by weight, a combination of 8-10% by weight hydrophilic and 0.5-1.5% by weight hydrophobic 15 fumed silica gelling agent, 20-40% by weight of a polyethylene glycol humectant, 0.5-5% by weight nonionic surfactant, a sweetener, sodium benzoate and a flavor prepared by homogenizing the fumed silicas in the polyethylene glycol and water phases and the sequential 1 20 addition of the premixed homogenized hydrophobic fumed silica in the polyethylene glycol (Phase A) to the premixed homogenized hydrophilic fumed silica in water Scontaining hydrogen peroxide (Phase B) and mixing for about 30 minutes while maintaining the temperature at room temperature, adding the predissolved sodium saccharin and sodium benzoate in water (Phase C) with mixing which effects immediate gellation adding the pre-solubilized flavor in the nonionic surfactant and water (Phase D) and mixing for 5-10 minutes until a clear, homogeneous rigid stable dental gel is obtained.

13. The dental gel according to Claim 12, wherein the pH is adjusted to 4.5-5 with an acid.

14. The dental gel according to Claim 12, wherein the polyethylene glycol humectant has a molecular weight of

600. 22 The dental gel according to Claim 12 wherein the nonionic surfactant is a polyoxyethylene monoester or sorbitol with a C 10 to C 18 fatty acid in an amount of 0.5-3% by weight. 16. The dental gel according to Claim 12, wherein the sodium benzoate constitutes 0.35 to 0.5% by weight. 17. The dental gel according to Claim 13, wherein the sweetening agent is sodium saccharine and the nonionic surfactant is polyethylene sorbitan monolaurate. DATED this 30 day of July 1991 9 t So° COLGATE-PALMOLIVE COMPANY Patent Attorneys for the Applicant: r F,B. RICE CO. 0099c0 04 0 rr 4: r

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Dentifrice gels containing sodium bicarbonate

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Dunhall Pharmaceuticals, Inc.
Method and material for brightening teeth

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patent/US4788052A/en
not_active
Expired – Lifetime

1988

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EP
EP88730084A
patent/EP0288419B1/en
not_active
Expired

1988-04-15
CA
CA000564242A
patent/CA1327754C/en
not_active
Expired – Fee Related

1988-04-15
DE
DE8888730084T
patent/DE3872577T2/en
not_active
Expired – Fee Related

1988-04-15
AU
AU14680/88A
patent/AU615649B2/en
not_active
Ceased

1988-04-18
JP
JP63095351A
patent/JPH01110614A/en
active
Pending

Also Published As

Publication number
Publication date

US4788052A
(en)

1988-11-29

JPH01110614A
(en)

1989-04-27

EP0288419A1
(en)

1988-10-26

EP0288419B1
(en)

1992-07-08

CA1327754C
(en)

1994-03-15

DE3872577D1
(en)

1992-08-13

DE3872577T2
(en)

1993-02-04

AU1468088A
(en)

1988-10-20

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