AU6627781A – Octapeptide esters with angiotensin-02 antagonizing effects
– Google Patents
AU6627781A – Octapeptide esters with angiotensin-02 antagonizing effects
– Google Patents
Octapeptide esters with angiotensin-02 antagonizing effects
Info
Publication number
AU6627781A
AU6627781A
AU66277/81A
AU6627781A
AU6627781A
AU 6627781 A
AU6627781 A
AU 6627781A
AU 66277/81 A
AU66277/81 A
AU 66277/81A
AU 6627781 A
AU6627781 A
AU 6627781A
AU 6627781 A
AU6627781 A
AU 6627781A
Authority
AU
Australia
Prior art keywords
group
tyr
arg
moiety
general formula
Prior art date
1980-01-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU66277/81A
Other versions
AU541526B2
(en
Inventor
Egon Karpati
Lajos Kisfaludy
Olga Nyeki
Laszlo Szporny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Nyrt
Original Assignee
Richter Gedeon Nyrt
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1980-01-18
Filing date
1981-01-16
Publication date
1981-07-23
1981-01-16
Application filed by Richter Gedeon Nyrt, Richter Gedeon Vegyeszeti Gyar RT
filed
Critical
Richter Gedeon Nyrt
1981-07-23
Publication of AU6627781A
publication
Critical
patent/AU6627781A/en
1985-01-10
Application granted
granted
Critical
1985-01-10
Publication of AU541526B2
publication
Critical
patent/AU541526B2/en
2001-01-16
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
C07K7/04—Linear peptides containing only normal peptide links
C07K7/14—Angiotensins: Related peptides
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/12—Antihypertensives
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K38/00—Medicinal preparations containing peptides
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
Y02P20/00—Technologies relating to chemical industry
Y02P20/50—Improvements relating to the production of bulk chemicals
Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
Y10S530/80—Antihypertensive peptides
Abstract
New octapeptides of the general formula (I), X-Arg-Val-Tyr-Ile-His-Pro-Y-OA (I) wherein X stands for the acyl group of an N-methylamino acid or the acyl group of an aliphatic alpha -hydroxy- or alpha -aminooxycarboxylic acid, Y is the residue of an aliphatic amino acid, and A is a C1-5 alkyl group, are prepared so that the protecting groups of a protected octapeptide derivative of the general formula (II), B-X-Arg(C)-Val-Tyr(D)-Ile-His(E)-Pro-Y-OA (II) wherein B is a group removable by acidolysis or catalytic hydrogenation, C is a group for the temporary protection of the guanidino group on the Arg moiety, D is a group for the temporary protection of the aromatic hydroxy group on the Tyr moiety, E is a group for the temporary protection of the imidazole group on the His moiety, and A, X and Y are as defined above, are removed either stepwise or in a single step. If desired, a compound of the general formula (I) is converted into its acid addition salt or pharmaceutically acceptable complex. The new compounds according to the invention possess angiotensin-II antagonizing effects, and can be used in the therapy to diagnose or treat hypertensive states.
AU66277/81A
1980-01-18
1981-01-16
Octapeptide esters with angiotensin-02 antagonizing effects
Ceased
AU541526B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
HU8080101A
HU181009B
(en)
1980-01-18
1980-01-18
Process for preparing angiotensin-ii analogues with antagonictic activity containing in position 1 sarcosyl,hydroxyacetyl or l-alpha-aminoxy-propionyl group and in positiona 8 esteric group
HU10180
1980-01-18
Publications (2)
Publication Number
Publication Date
AU6627781A
true
AU6627781A
(en)
1981-07-23
AU541526B2
AU541526B2
(en)
1985-01-10
Family
ID=10947913
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU66277/81A
Ceased
AU541526B2
(en)
1980-01-18
1981-01-16
Octapeptide esters with angiotensin-02 antagonizing effects
Country Status (19)
Country
Link
US
(1)
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(en)
EP
(1)
EP0034259B1
(en)
JP
(1)
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AT
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AU
(1)
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CA
(1)
CA1156222A
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CS
(1)
CS217987B2
(en)
DD
(1)
DD156968A5
(en)
DE
(1)
DE3170906D1
(en)
ES
(1)
ES8205754A1
(en)
FI
(1)
FI72732C
(en)
HU
(1)
HU181009B
(en)
IL
(1)
IL61923A
(en)
IN
(1)
IN153212B
(en)
NO
(1)
NO155100C
(en)
PH
(1)
PH16791A
(en)
PL
(1)
PL126240B1
(en)
SU
(1)
SU1041030A3
(en)
YU
(1)
YU41959B
(en)
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(en)
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1971-12-27
1975-09-23
Univ Sherbrooke
Angiotensin{hd II {B position 8 analogs
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1975-12-02
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{8 N-Me-Ile{40 ,Ile{hu 8{b {9 -Angiotensin II as an angiotensin antagonist
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1981-07-28
Richter Gedeon Vegyeszet
Process for preparing angiotensin ii analogues containing alpha-hydroxy-acid in position 1 with angiotensin ii antagonist activity
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1977-07-18
1981-07-28
Richter Gedeon Vegyeszet
Process for preparing angiotensin ii analogues containing alpha- amino-oxy-acid in position 1 with angiotensin ii antagonist activity
1980
1980-01-18
HU
HU8080101A
patent/HU181009B/en
not_active
IP Right Cessation
1981
1981-01-08
CS
CS81173A
patent/CS217987B2/en
unknown
1981-01-13
PH
PH25082A
patent/PH16791A/en
unknown
1981-01-14
US
US06/225,048
patent/US4388304A/en
not_active
Expired – Fee Related
1981-01-16
SU
SU813226301A
patent/SU1041030A3/en
active
1981-01-16
NO
NO810150A
patent/NO155100C/en
unknown
1981-01-16
CA
CA000368682A
patent/CA1156222A/en
not_active
Expired
1981-01-16
PL
PL1981229244A
patent/PL126240B1/en
unknown
1981-01-16
AU
AU66277/81A
patent/AU541526B2/en
not_active
Ceased
1981-01-16
ES
ES498582A
patent/ES8205754A1/en
not_active
Expired
1981-01-16
IL
IL61923A
patent/IL61923A/en
unknown
1981-01-16
IN
IN47/CAL/81A
patent/IN153212B/en
unknown
1981-01-16
FI
FI810122A
patent/FI72732C/en
not_active
IP Right Cessation
1981-01-16
DD
DD81227055A
patent/DD156968A5/en
unknown
1981-01-16
YU
YU92/81A
patent/YU41959B/en
unknown
1981-01-17
JP
JP463281A
patent/JPS56138155A/en
active
Pending
1981-01-19
AT
AT81100356T
patent/ATE13740T1/en
not_active
IP Right Cessation
1981-01-19
DE
DE8181100356T
patent/DE3170906D1/en
not_active
Expired
1981-01-19
EP
EP81100356A
patent/EP0034259B1/en
not_active
Expired
Also Published As
Publication number
Publication date
AU541526B2
(en)
1985-01-10
CS217987B2
(en)
1983-02-25
YU41959B
(en)
1988-04-30
JPS56138155A
(en)
1981-10-28
ATE13740T1
(en)
1985-06-15
NO810150L
(en)
1981-07-20
YU9281A
(en)
1983-09-30
DE3170906D1
(en)
1985-07-18
HU181009B
(en)
1983-05-30
IL61923A
(en)
1984-01-31
NO155100C
(en)
1987-02-11
PH16791A
(en)
1984-02-28
DD156968A5
(en)
1982-10-06
CA1156222A
(en)
1983-11-01
EP0034259A1
(en)
1981-08-26
US4388304A
(en)
1983-06-14
ES498582A0
(en)
1982-07-01
FI810122L
(en)
1981-07-19
SU1041030A3
(en)
1983-09-07
EP0034259B1
(en)
1985-06-12
IN153212B
(en)
1984-06-16
FI72732C
(en)
1987-07-10
IL61923A0
(en)
1981-02-27
PL229244A1
(en)
1981-10-30
FI72732B
(en)
1987-03-31
ES8205754A1
(en)
1982-07-01
NO155100B
(en)
1986-11-03
PL126240B1
(en)
1983-07-30
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