AU6978687A – Hybrid interferons
– Google Patents
AU6978687A – Hybrid interferons
– Google Patents
Hybrid interferons
Info
Publication number
AU6978687A
AU6978687A
AU69786/87A
AU6978687A
AU6978687A
AU 6978687 A
AU6978687 A
AU 6978687A
AU 69786/87 A
AU69786/87 A
AU 69786/87A
AU 6978687 A
AU6978687 A
AU 6978687A
AU 6978687 A
AU6978687 A
AU 6978687A
Authority
AU
Australia
Prior art keywords
interferons
novel
hybrid
omega
preparation
Prior art date
1986-03-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU69786/87A
Other versions
AU600702B2
(en
Inventor
Gunther Adolf
Gerhard Bodo
Edgar Falkner
Rudolf Hauptmann
Ingrid Maurer-Fogy
Peter Meindl
Peter Swetly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1986-03-10
Filing date
1987-03-06
Publication date
1987-09-17
1987-03-06
Application filed by Boehringer Ingelheim International GmbH
filed
Critical
Boehringer Ingelheim International GmbH
1987-09-17
Publication of AU6978687A
publication
Critical
patent/AU6978687A/en
1990-08-23
Application granted
granted
Critical
1990-08-23
Publication of AU600702B2
publication
Critical
patent/AU600702B2/en
2007-03-06
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C12N15/09—Recombinant DNA-technology
C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C12N15/70—Vectors or expression systems specially adapted for E. coli
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
C07K14/52—Cytokines; Lymphokines; Interferons
C07K14/555—Interferons [IFN]
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
C07K14/52—Cytokines; Lymphokines; Interferons
C07K14/555—Interferons [IFN]
C07K14/56—IFN-alpha
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
C07K16/249—Interferons
C—CHEMISTRY; METALLURGY
C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C12N15/09—Recombinant DNA-technology
C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K38/00—Medicinal preparations containing peptides
Abstract
The invention relates to novel hybrid interferons comprising part of an alpha -interferon and part of an omega-interferon, the N-terminal Met- or N-formyl-Met derivatives of these interferons and, if the peptide sequence of the hybrid interferon contains a glycosylation site, the N-glycosylated derivatives of these interferons, their use as medicaments and as intermediates for the immunisation of test animals and the preparation of these interferons, novel monoclonal antibodies and their use for the purification of alpha – and omega-interferons, the hybrid cell lines secreting them, and the preparation of these hybrid cell lines, a novel purification procedure for alpha – and omega-interferons with the aid of a novel antibody affinity column containing the abovementioned novel monoclonal antibodies, and the preparation of these antibodies, novel hybrid plasmids for improving the expression of the omega-interferons, and novel intermediate plasmids for preparing the novel plasmids, and their preparation.
AU69786/87A
1986-03-10
1987-03-06
Hybrid interferons
Ceased
AU600702B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
DE3607835
1986-03-10
DE19863607835
DE3607835A1
(en)
1986-03-10
1986-03-10
HYBRID INTERFERONS, THEIR USE AS MEDICINAL PRODUCTS AND AS INTERMEDIATE PRODUCTS FOR THE PRODUCTION OF ANTIBODIES AND THE USE THEREOF AND METHOD FOR THEIR PRODUCTION
Publications (2)
Publication Number
Publication Date
AU6978687A
true
AU6978687A
(en)
1987-09-17
AU600702B2
AU600702B2
(en)
1990-08-23
Family
ID=6295926
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU69786/87A
Ceased
AU600702B2
(en)
1986-03-10
1987-03-06
Hybrid interferons
Country Status (21)
Country
Link
US
(1)
US4917887A
(en)
EP
(1)
EP0236920B1
(en)
JP
(1)
JPS62282595A
(en)
KR
(1)
KR950008191B1
(en)
AT
(1)
ATE81671T1
(en)
AU
(1)
AU600702B2
(en)
DD
(2)
DD276493A5
(en)
DE
(2)
DE3607835A1
(en)
DK
(1)
DK120387A
(en)
ES
(1)
ES2052502T3
(en)
FI
(2)
FI871012A
(en)
GR
(1)
GR3006844T3
(en)
HU
(1)
HU206896B
(en)
IE
(2)
IE940131L
(en)
IL
(1)
IL81832A0
(en)
NO
(1)
NO870967L
(en)
NZ
(1)
NZ219549A
(en)
PH
(1)
PH27060A
(en)
PT
(1)
PT84427B
(en)
SU
(1)
SU1604164A3
(en)
ZA
(1)
ZA871679B
(en)
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NEW MONOCLONAL ANTIBODIES AGAINST IFN-OMEGA, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CLEANING AND DETECTING IFN-OMEGA
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1986-12-10
1988-06-16
Boehringer Ingelheim Int
HORSE (GAMMA) INTERFERON
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1987-10-22
1989-11-27
Boehringer Ingelheim Int
Novel hybridoma cell lines which produce novel monoclonal antibodies against IFN-omega, process for their preparation and the use of the novel monoclonal antibodies for the purification and for the detection of IFN-omega
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Raw hide containing an inorganic pyrophosphate
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BOEHRINGER INGELHEIM INTERNATIONAL GmbH
Process for preparing and purifying alpha-interferon
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1995-05-10
1999-08-17
University Of Florida
Hybrid interferon tau/alpha polypeptides, their recombinant production, and methods using them
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1996-04-12
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Pepgen Corporation And University Of Florida
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Vical, Inc.
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1998-07-28
2004-02-03
The United States Of America As Represented By The Department Of Health And Human Services
Interferon α hybrids
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2000-11-03
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インターシア セラピューティクス，インコーポレイティド
Method for short and long term drug dosage determination
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2001-03-01
2003-05-16
Genodyssee
NOVEL POLYNUCLEOTIDES COMPRISING FUNCTIONAL SNP-TYPE POLYMORPHISM IN THE NUCLEOTIDE SEQUENCE OF THE IFN-ALPHA-2 GENE AS WELL AS NEW POLYPEPTIDES ENCODED BY THESE POLYNUCLEOTIDES AND THEIR THERAPEUTIC USES
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2001-04-04
2003-12-12
Genodyssee
NOVEL ERYTHROPOIETIN (EPO) POLYNUCLEOTIDES AND POLYPEPTIDES
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Pepgen Corporation
Hybrid interferon/interferon tau proteins, compositions and methods of use
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2008-12-03
精达制药公司
Method for treating diseases with omega interferon
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2003-11-17
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Intarcia Therapeutics, Inc.
Composition and dosage form comprising an interferon particle formulation and suspending vehicle
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Neose Technologies Inc
Glycopegylation methods and proteins/peptides produced by the methods
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Alza Corporation
Solvent/polymer solutions as suspension vehicles
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Intarcia Therapeutics, Inc.
Suspension formulation comprising an insulinotropic peptide
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Suspension formulations of insulinotropic peptides and uses thereof
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Intarcia Therapeutics Inc
Devices, formulations and methods for the delivery of several beneficial agents
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Interferon alpha and omega antibody antagonists
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Implant installation and removal system
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1989-05-10
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Process for the preparation and purification of human Le-shaped interferon protein.
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1994-01-19
ゲネンテツク・インコ−ポレ−テツド
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Hybrid human leukocyte interferons
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DNA SEQUENCES, THEIR PRODUCTION, PLASMIDES CONTAINING THESE SEQUENCES AND THE USE THEREOF FOR THE SYNTHESIS OF EUKARYOTIC GENE PRODUCTS IN PROKARYOTS
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GENE TECHNOLOGICAL PROCESS FOR PRODUCING HUMAN GAMMA INTERFERON AND MEANS FOR CARRYING OUT THIS PROCESS
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Genentech Inc
MISCELLANEOUS FAMILY OF HUMAN WBC INTERFERONS, COMPOSITIONS CONTAINING THEM, METHODS FOR THEIR PRODUCTION, AND DNA AND TRANSFECTED HOSTS THEREOF.
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Hybrid lymphoblastoid-leukocyte human interferons
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Hybrid interferons
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*
1985-12-02
1990-06-19
G. D. Searle And Company
Covalently linked polypeptide cell modulators
1986
1986-03-10
DE
DE19863607835
patent/DE3607835A1/en
not_active
Withdrawn
1987
1987-03-04
ES
ES87103030T
patent/ES2052502T3/en
not_active
Expired – Lifetime
1987-03-04
EP
EP87103030A
patent/EP0236920B1/en
not_active
Expired – Lifetime
1987-03-04
AT
AT87103030T
patent/ATE81671T1/en
not_active
IP Right Cessation
1987-03-04
DE
DE8787103030T
patent/DE3782259D1/en
not_active
Expired – Fee Related
1987-03-06
AU
AU69786/87A
patent/AU600702B2/en
not_active
Ceased
1987-03-09
NO
NO870967A
patent/NO870967L/en
unknown
1987-03-09
JP
JP62053911A
patent/JPS62282595A/en
active
Pending
1987-03-09
DK
DK120387A
patent/DK120387A/en
not_active
Application Discontinuation
1987-03-09
US
US07/023,634
patent/US4917887A/en
not_active
Expired – Fee Related
1987-03-09
IE
IE940131A
patent/IE940131L/en
unknown
1987-03-09
FI
FI871012A
patent/FI871012A/en
not_active
Application Discontinuation
1987-03-09
PT
PT84427A
patent/PT84427B/en
not_active
IP Right Cessation
1987-03-09
IE
IE59187A
patent/IE60573B1/en
not_active
IP Right Cessation
1987-03-09
IL
IL81832A
patent/IL81832A0/en
not_active
IP Right Cessation
1987-03-09
ZA
ZA871679A
patent/ZA871679B/en
unknown
1987-03-09
NZ
NZ219549A
patent/NZ219549A/en
unknown
1987-03-09
DD
DD32350187A
patent/DD276493A5/en
not_active
IP Right Cessation
1987-03-09
HU
HU87995A
patent/HU206896B/en
unknown
1987-03-09
SU
SU874202086A
patent/SU1604164A3/en
active
1987-03-09
DD
DD87300598A
patent/DD266118A5/en
not_active
IP Right Cessation
1987-03-10
KR
KR1019870002106A
patent/KR950008191B1/en
active
IP Right Grant
1987-03-10
PH
PH34995A
patent/PH27060A/en
unknown
1992
1992-12-11
FI
FI925631A
patent/FI925631A/en
not_active
Application Discontinuation
1993
1993-01-21
GR
GR930400095T
patent/GR3006844T3/el
unknown
Also Published As
Publication number
Publication date
AU600702B2
(en)
1990-08-23
DD266118A5
(en)
1989-03-22
IE60573B1
(en)
1994-07-27
IE940131L
(en)
1987-09-10
KR950008191B1
(en)
1995-07-26
DD276493A5
(en)
1990-02-28
FI925631A0
(en)
1992-12-11
IE870591L
(en)
1987-09-10
FI871012A
(en)
1987-09-11
ZA871679B
(en)
1988-11-30
PT84427B
(en)
1989-10-04
GR3006844T3
(en)
1993-06-30
DE3607835A1
(en)
1987-09-24
IL81832A0
(en)
1987-10-20
US4917887A
(en)
1990-04-17
FI871012A0
(en)
1987-03-09
EP0236920A3
(en)
1988-03-02
HUT44074A
(en)
1988-01-28
JPS62282595A
(en)
1987-12-08
ES2052502T3
(en)
1994-07-16
PT84427A
(en)
1987-04-01
KR870009020A
(en)
1987-10-22
DK120387A
(en)
1987-09-11
NO870967D0
(en)
1987-03-09
NZ219549A
(en)
1990-07-26
PH27060A
(en)
1993-02-01
SU1604164A3
(en)
1990-10-30
DK120387D0
(en)
1987-03-09
FI925631A
(en)
1992-12-11
DE3782259D1
(en)
1992-11-26
EP0236920B1
(en)
1992-10-21
NO870967L
(en)
1987-09-11
HU206896B
(en)
1993-01-28
EP0236920A2
(en)
1987-09-16
ATE81671T1
(en)
1992-11-15
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