AU7865481A

AU7865481A – 2-acylaminomethyl-1,4-benzodiazepine
– Google Patents

AU7865481A – 2-acylaminomethyl-1,4-benzodiazepine
– Google Patents
2-acylaminomethyl-1,4-benzodiazepine

Info

Publication number
AU7865481A

AU7865481A
AU78654/81A
AU7865481A
AU7865481A
AU 7865481 A
AU7865481 A
AU 7865481A
AU 78654/81 A
AU78654/81 A
AU 78654/81A
AU 7865481 A
AU7865481 A
AU 7865481A
AU 7865481 A
AU7865481 A
AU 7865481A
Authority
AU
Australia
Prior art keywords
amino
substituent
lower alkyl
alkyl
mono
Prior art date
1980-12-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU78654/81A
Other versions

AU543172B2
(en

Inventor
Werner Benson
Hans Liepmann
Wolfgang Milkowski
Dietmar Romer
Horst Zeugner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Products GmbH

Original Assignee
Kali Chemie Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1980-12-20
Filing date
1981-12-18
Publication date
1982-07-01

1981-12-18
Application filed by Kali Chemie Pharma GmbH
filed
Critical
Kali Chemie Pharma GmbH

1982-07-01
Publication of AU7865481A
publication
Critical
patent/AU7865481A/en

1985-04-04
Application granted
granted
Critical

1985-04-04
Publication of AU543172B2
publication
Critical
patent/AU543172B2/en

2001-12-18
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 – C07D459/00, C07D463/00, C07D477/00 or C07D489/00

C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 – C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings

C07D491/04—Ortho-condensed systems

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P25/00—Drugs for disorders of the nervous system

A61P25/04—Centrally acting analgesics, e.g. opioids

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms

C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4

C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems

C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Abstract

Novel 2-acyl amino methyl-5-phenyl-1H-2,3-dihydro-1,4-benzo diazepine compounds of the following Formula I I which have valuable pharmacological properties are provided. In said Formula I the acyl group -CO-R3 represents a benzoyl group or a phenyl alkanoyl group which may be unsubstituted or mono- or di-substituted in the phenyl ring. The substituent R1 in said compounds indicates lower alkyl, lower alkenyl, or cyclopropyl methyl, and the substituent R2 indicates hydrogen, lower alkyl, or lower alkenyl, while the substituent R6 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, lower alkylthio, nitro, trifluoro methyl, cyano, amino, mono- or di-lower alkyl amino, lower mono-alkanoyl amino, lower N-alkyl-N-alkanoyl amino, or lower alkanoyloxy, and the substituent R7 indicates hydrogen, halogen, lower alkyl, lower alkoxy, hydroxyl, or lower alkanoyloxy, whereby R6 and R7, when attached to adjacent carbon atoms, may form together the methylene dioxy or the ethylene dioxy group. The substituents R8 and R9 designate the same substituents as indicated for the substituents R6 and R7. The compounds of Formula I have a surprising analgesic activity.

AU78654/81A
1980-12-20
1981-12-18
2-acylaminomethyl-1,4-benzodiazepine

Ceased

AU543172B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE30482645

1980-12-20

DE19803048264

DE3048264A1
(en)

1980-12-20
1980-12-20

2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINE AND ITS SALTS AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Publications (2)

Publication Number
Publication Date

AU7865481A
true

AU7865481A
(en)

1982-07-01

AU543172B2

AU543172B2
(en)

1985-04-04

Family
ID=6119800
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU78654/81A
Ceased

AU543172B2
(en)

1980-12-20
1981-12-18
2-acylaminomethyl-1,4-benzodiazepine

Country Status (20)

Country
Link

US
(1)

US4533662A
(en)

EP
(1)

EP0054839B1
(en)

JP
(1)

JPS57123171A
(en)

AT
(1)

ATE13883T1
(en)

AU
(1)

AU543172B2
(en)

CA
(1)

CA1173440A
(en)

DD
(1)

DD201789A5
(en)

DE
(2)

DE3048264A1
(en)

DK
(1)

DK563681A
(en)

ES
(1)

ES508113A0
(en)

FI
(1)

FI68046C
(en)

GR
(1)

GR82268B
(en)

HU
(1)

HU187397B
(en)

IE
(1)

IE51799B1
(en)

IL
(1)

IL64584A
(en)

NO
(1)

NO157376C
(en)

NZ
(1)

NZ199318A
(en)

PH
(1)

PH21646A
(en)

PT
(1)

PT74115B
(en)

ZA
(1)

ZA818775B
(en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

EP0170024A3
(en)

*

1984-06-26
1990-01-31
Merck & Co. Inc.
Use of 2-acylaminomethyl-1,4-benzodiazepine derivatives for the production of pharmaceutical compositions and process for the preparation for pharmaceutical compositions

US4684646A
(en)

*

1984-06-26
1987-08-04
Merck & Co., Inc.
2-acylaminomethyl-1,4-benzodiazepine derivatives as CCK-antagonists

US4724237A
(en)

*

1984-06-26
1988-02-09
Merck & Co., Inc.
2-substituted-aminomethyl-1,4-benzodiazepines

US5439906A
(en)

*

1993-11-22
1995-08-08
Merck & Co., Inc.
Antiarrhythmic benzodiazepines

US5426185A
(en)

*

1993-11-22
1995-06-20
Merck & Co., Inc.
Antiarrhythmic benzodiazepines

JP2006522794A
(en)

*

2003-04-10
2006-10-05
ファイザー株式会社

Bicyclic compounds as NR2B receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE2221558C2
(en)

*

1972-05-03
1982-12-02
Kali-Chemie Ag, 3000 Hannover

5-Phenyl-2,3-dihydro-1H-1,4-benzodiazepines and their acid addition salts, processes for their preparation and pharmaceuticals containing these compounds

DE2353187A1
(en)

*

1973-05-02
1974-11-14
Kali Chemie Ag
2-(Subst. aminomethyl)-1,4-benzodiazepines – useful as tranquillisers with only slight musculotropic effect

US3925358A
(en)

*

1973-07-27
1975-12-09
Hoffmann La Roche
1-Lower alkyl-2-substituted-1,4-benzodiazepines

BE839365R
(en)

*

1976-03-09
1976-09-09

DIAZEPINE DERIVATIVES

JPS6045875B2
(en)

*

1979-12-07
1985-10-12
エフ・ホフマン・ラ・ロツシユ・ウント・カンパニ−・アクチエンゲゼルシヤフト

Imidazole derivative

DE2952279A1
(en)

*

1979-12-24
1981-06-25
Kali-Chemie Pharma Gmbh, 3000 Hannover

NEW 2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINE AND ITS SALTS AND METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

1980

1980-12-20
DE
DE19803048264
patent/DE3048264A1/en
not_active
Withdrawn

1981

1981-12-09
DE
DE8181110275T
patent/DE3171071D1/en
not_active
Expired

1981-12-09
AT
AT81110275T
patent/ATE13883T1/en
active

1981-12-09
EP
EP81110275A
patent/EP0054839B1/en
not_active
Expired

1981-12-11
PT
PT74115A
patent/PT74115B/en
unknown

1981-12-14
US
US06/330,324
patent/US4533662A/en
not_active
Expired – Fee Related

1981-12-15
PH
PH26630A
patent/PH21646A/en
unknown

1981-12-16
FI
FI814032A
patent/FI68046C/en
not_active
IP Right Cessation

1981-12-17
JP
JP56202628A
patent/JPS57123171A/en
active
Granted

1981-12-18
ES
ES508113A
patent/ES508113A0/en
active
Granted

1981-12-18
DK
DK563681A
patent/DK563681A/en
not_active
Application Discontinuation

1981-12-18
CA
CA000392654A
patent/CA1173440A/en
not_active
Expired

1981-12-18
DD
DD81235957A
patent/DD201789A5/en
unknown

1981-12-18
NO
NO814356A
patent/NO157376C/en
unknown

1981-12-18
IL
IL64584A
patent/IL64584A/en
unknown

1981-12-18
NZ
NZ199318A
patent/NZ199318A/en
unknown

1981-12-18
HU
HU813849A
patent/HU187397B/en
unknown

1981-12-18
ZA
ZA818775A
patent/ZA818775B/en
unknown

1981-12-18
AU
AU78654/81A
patent/AU543172B2/en
not_active
Ceased

1981-12-18
IE
IE2989/81A
patent/IE51799B1/en
unknown

1981-12-18
GR
GR66843A
patent/GR82268B/el
unknown

Also Published As

Publication number
Publication date

ES8300721A1
(en)

1982-11-01

GR82268B
(en)

1984-12-13

PT74115A
(en)

1982-01-01

JPS57123171A
(en)

1982-07-31

JPH0155271B2
(en)

1989-11-22

ZA818775B
(en)

1982-11-24

DD201789A5
(en)

1983-08-10

ATE13883T1
(en)

1985-07-15

NO157376B
(en)

1987-11-30

PH21646A
(en)

1988-01-13

IE51799B1
(en)

1987-04-01

DK563681A
(en)

1982-06-21

IL64584A
(en)

1985-05-31

DE3171071D1
(en)

1985-07-25

NO157376C
(en)

1988-03-09

PT74115B
(en)

1983-05-11

NO814356L
(en)

1982-06-21

US4533662A
(en)

1985-08-06

HU187397B
(en)

1985-12-28

FI68046B
(en)

1985-03-29

NZ199318A
(en)

1983-06-17

FI814032L
(en)

1982-06-21

DE3048264A1
(en)

1982-09-09

EP0054839B1
(en)

1985-06-19

EP0054839A3
(en)

1983-01-05

CA1173440A
(en)

1984-08-28

EP0054839A2
(en)

1982-06-30

IL64584A0
(en)

1982-03-31

AU543172B2
(en)

1985-04-04

IE812989L
(en)

1982-06-20

FI68046C
(en)

1985-07-10

ES508113A0
(en)

1982-11-01

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