AU7872181A – Guanine derivatives
– Google Patents
AU7872181A – Guanine derivatives
– Google Patents
Guanine derivatives
Info
Publication number
AU7872181A
AU7872181A
AU78721/81A
AU7872181A
AU7872181A
AU 7872181 A
AU7872181 A
AU 7872181A
AU 78721/81 A
AU78721/81 A
AU 78721/81A
AU 7872181 A
AU7872181 A
AU 7872181A
AU 7872181 A
AU7872181 A
AU 7872181A
Authority
AU
Australia
Prior art keywords
fluoro
hydroxy
hydrogen
methods
different
Prior art date
1980-12-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU78721/81A
Other versions
AU542373B2
(en
Inventor
Curt-Erik Hagberg
Karl Nils-Gunnar Johansson
Zsuzsanna Maria Ilona Kovacs
Goran Bertil Stening
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Lakemedel AB
Original Assignee
Astra Lakemedel AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1980-12-22
Filing date
1981-12-21
Publication date
1982-07-01
1981-12-21
Application filed by Astra Lakemedel AB
filed
Critical
Astra Lakemedel AB
1982-07-01
Publication of AU7872181A
publication
Critical
patent/AU7872181A/en
1985-02-21
Application granted
granted
Critical
1985-02-21
Publication of AU542373B2
publication
Critical
patent/AU542373B2/en
2001-12-21
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D307/32—Oxygen atoms
C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P31/12—Antivirals
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D473/00—Heterocyclic compounds containing purine ring systems
Abstract
Novel derivatives of guanine, viz. antiviral compounds of the formula
wherein each of R1 and R2, which are the same or different is hydrogen, hydroxy or fluoro; provided that R1 or R2 is hydrogen when R1 and R2 are different, and provided that R1 and R2 are hydroxy or fluoro when R1 and R2 are the same; or a physiologically acceptable salt of an optical isomer thereof, methods for their preparation, pharmaceutical preparations containing the compounds, and methods for the treatment of virus infections and other diseases causes by viruses.
AU78721/81A
1980-12-22
1981-12-21
Guanine derivatives
Ceased
AU542373B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
SE8009040
1980-12-22
SE8009040
1980-12-22
Publications (2)
Publication Number
Publication Date
AU7872181A
true
AU7872181A
(en)
1982-07-01
AU542373B2
AU542373B2
(en)
1985-02-21
Family
ID=20342543
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU78721/81A
Ceased
AU542373B2
(en)
1980-12-22
1981-12-21
Guanine derivatives
Country Status (17)
Country
Link
US
(1)
US4495190A
(en)
EP
(1)
EP0055239B1
(en)
JP
(1)
JPS57501963A
(en)
AT
(1)
ATE20748T1
(en)
AU
(1)
AU542373B2
(en)
CA
(1)
CA1172633A
(en)
DE
(1)
DE3174948D1
(en)
DK
(1)
DK148279C
(en)
FI
(1)
FI68054C
(en)
GR
(1)
GR76971B
(en)
IL
(1)
IL64501A
(en)
NO
(1)
NO822712L
(en)
NZ
(1)
NZ199334A
(en)
RO
(1)
RO85288B
(en)
SU
(2)
SU1272991A3
(en)
WO
(1)
WO1982002202A1
(en)
ZA
(1)
ZA818781B
(en)
Families Citing this family (33)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
SE8203855D0
(en)
*
1982-06-21
1982-06-21
Astra Laekemedel Ab
NOVEL DERIVATIVES OF GUANINE I
SE8203856D0
(en)
*
1982-06-21
1982-06-21
Astra Laekemedel Ab
NOVEL DERIVATIVES OF GUANINE II
US5047533A
(en)
*
1983-05-24
1991-09-10
Sri International
Acyclic purine phosphonate nucleotide analogs
HUT36464A
(en)
*
1983-05-24
1985-09-30
Newport Pharmaceuticals
Process for producing erythro-4-amino-3-/2-hydroxy-3-alkyl/-imidazol-5-carboxamide
GB8320308D0
(en)
*
1983-07-28
1983-09-01
Wellcome Found
Antiviral combinations
US5684153A
(en)
1984-08-16
1997-11-04
Beecham Group Plc
Process for the preparation of purine derivatives
DE3485225D1
(en)
*
1983-08-18
1991-12-05
Beecham Group Plc
ANTIVIRAL GUANINE DERIVATIVES.
IL73682A
(en)
*
1983-12-20
1991-08-16
Medivir Ab
Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4579849A
(en)
*
1984-04-06
1986-04-01
Merck & Co., Inc.
N-alkylguanine acyclonucleosides as antiviral agents
US4801710A
(en)
*
1984-10-26
1989-01-31
Merck & Co., Inc.
Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives
YU45690B
(en)
*
1984-12-22
1992-07-20
Krka Tovarna Zdraviln.Sol.O.
PROCEDURE FOR PREPARING 9- (2-HYDROXYETHOXYMETHYL) -GUANINE
EP0193454A1
(en)
*
1985-02-25
1986-09-03
Merck & Co. Inc.
8-Substituted-9-hydroxyalkyl and hydroxyalkoxymethyl-guanines and pharmaceutical compositions containing them
EP0219838A3
(en)
*
1985-10-22
1988-04-06
Takeda Chemical Industries, Ltd.
Carbocyclic purine nucleosides, their production and use
US5578468A
(en)
*
1987-08-10
1996-11-26
Duke University
Site-specific RNA cleavage
US5443964A
(en)
*
1987-08-10
1995-08-22
Duke University
Poxvirus insertion/expression vector
US4935427A
(en)
*
1987-12-31
1990-06-19
The United States Of America As Represented By The Department Of Health And Human Services
Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
US4966895A
(en)
*
1989-02-02
1990-10-30
Merck & Co. Inc.
Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
US5352669A
(en)
*
1990-03-13
1994-10-04
The Of The United States Of America As Represented By The Department Of Health And Human Services
O6 -benzylated guanine, guanosine and 2′-deoxyguanosine compounds possessing O6 -alkylguanine-DNA alkyltransferase depleting activity
US5091432A
(en)
*
1990-03-28
1992-02-25
Glasky Alvin J
9-substituted hypoxanthine bi-functional compounds and their neuroimmunological methods of use
SK280313B6
(en)
*
1990-04-24
1999-11-08
�Stav Organick� Chemie A Biochemie Av �R
N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, process for their preparation and their use
US5368853A
(en)
*
1990-05-11
1994-11-29
The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services
Leukoregulin anti-viral therapy
JP2939646B2
(en)
*
1990-07-17
1999-08-25
チッソ株式会社
4-Substituted-2-hydroxybutanoic acid esters and production method
US5874578A
(en)
*
1992-07-13
1999-02-23
Bristol-Myers Squibb
Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
US5525606A
(en)
1994-08-01
1996-06-11
The United States Of America As Represented By The Department Of Health And Human Services
Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
US6359114B1
(en)
*
1995-06-07
2002-03-19
Aphton Corp.
System for method for the modification and purification of proteins
US6060458A
(en)
*
1998-02-13
2000-05-09
The United States Of America As Represented By The Department Of Health And Human Services
Oligodeoxyribonucleotides comprising O6 -benzylguanine and their use
US20070129334A1
(en)
*
2001-10-30
2007-06-07
Conforma Therapeutics Corporation
Orally Active Purine-Based Inhibitors of Heat Shock Protein 90
EP2336133A1
(en)
2001-10-30
2011-06-22
Conforma Therapeutics Corporation
Purine analogs having HSP90-inhibiting activity
US7148228B2
(en)
2003-09-18
2006-12-12
Conforma Therapeutics Corporation
Pyrazolopyrimidines and related analogs as HSP90-inhibitors
BRPI0609509A2
(en)
2005-03-30
2010-04-13
Conforma Therapeutics Corp
pharmaceutically acceptable compound or a polymorph, solvate, tautomer, enantiomer, prodrug or salt thereof, pharmaceutical composition, and, use of the pharmaceutically acceptable compound, polymorph, solvate, tautomer, enantiomer, prodrug or salt
AU2006259431B2
(en)
*
2005-06-14
2011-09-29
Brigham Young University
Methods for selective N-9 glycosylation of purines
EP1937258A2
(en)
*
2005-09-23
2008-07-02
Conforma Therapeutics Corporation
Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors
CN108912055B
(en)
*
2018-08-20
2020-06-30
河南师范大学
Method for synthesizing antiviral drug cidofovir intermediate and bucyclovir intermediate
Family Cites Families (8)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
IL34188A
(en)
*
1969-04-09
1972-12-29
Seiyaku T Co
4-(9-adenyl)-2,3-dihydroxy butyric acid and the preparation thereof
US3836656A
(en)
*
1972-02-07
1974-09-17
Sandoz Ag
Substituted purines as hypolipidemics
US4199574A
(en)
*
1974-09-02
1980-04-22
Burroughs Wellcome Co.
Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4230708A
(en)
*
1977-10-20
1980-10-28
Stichting Rega V.Z.W.
Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents
CS199093B1
(en)
*
1977-10-20
1980-07-31
Antonin Holy
Antiviral agent
US4221910A
(en)
*
1978-09-15
1980-09-09
Newport Pharmaceuticals International, Inc.
9-(Hydroxy alkyl)purines
US4423050A
(en)
*
1981-05-21
1983-12-27
Syntex (U.S.A.) Inc.
9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4451478A
(en)
*
1982-03-12
1984-05-29
Newport Pharmaceuticals International, Inc.
Imidazole compounds
1981
1981-12-10
IL
IL64501A
patent/IL64501A/en
unknown
1981-12-18
ZA
ZA818781A
patent/ZA818781B/en
unknown
1981-12-21
CA
CA000392782A
patent/CA1172633A/en
not_active
Expired
1981-12-21
GR
GR66864A
patent/GR76971B/el
unknown
1981-12-21
AU
AU78721/81A
patent/AU542373B2/en
not_active
Ceased
1981-12-21
NZ
NZ199334A
patent/NZ199334A/en
unknown
1981-12-22
DE
DE8181850250T
patent/DE3174948D1/en
not_active
Expired
1981-12-22
JP
JP57500239A
patent/JPS57501963A/ja
active
Pending
1981-12-22
EP
EP81850250A
patent/EP0055239B1/en
not_active
Expired
1981-12-22
WO
PCT/SE1981/000389
patent/WO1982002202A1/en
active
IP Right Grant
1981-12-22
AT
AT81850250T
patent/ATE20748T1/en
not_active
IP Right Cessation
1982
1982-08-09
NO
NO822712A
patent/NO822712L/en
unknown
1982-08-18
DK
DK369982A
patent/DK148279C/en
not_active
IP Right Cessation
1982-08-19
FI
FI822891A
patent/FI68054C/en
not_active
IP Right Cessation
1982-08-20
SU
SU823480213A
patent/SU1272991A3/en
active
1982-08-21
RO
RO108498A
patent/RO85288B/en
unknown
1982-10-25
US
US06/436,522
patent/US4495190A/en
not_active
Expired – Fee Related
1983
1983-10-31
SU
SU833657074A
patent/SU1272992A3/en
active
Also Published As
Publication number
Publication date
NZ199334A
(en)
1985-09-13
DE3174948D1
(en)
1986-08-21
AU542373B2
(en)
1985-02-21
FI68054C
(en)
1985-07-10
NO822712L
(en)
1982-08-09
GR76971B
(en)
1984-09-04
DK148279C
(en)
1986-02-17
DK148279B
(en)
1985-05-28
FI68054B
(en)
1985-03-29
US4495190A
(en)
1985-01-22
FI822891L
(en)
1982-08-19
DK369982A
(en)
1982-08-18
EP0055239A1
(en)
1982-06-30
JPS57501963A
(en)
1982-11-04
RO85288A
(en)
1984-11-25
IL64501A0
(en)
1982-03-31
WO1982002202A1
(en)
1982-07-08
ATE20748T1
(en)
1986-08-15
ZA818781B
(en)
1982-11-24
RO85288B
(en)
1984-11-30
EP0055239B1
(en)
1986-07-16
FI822891A0
(en)
1982-08-19
IL64501A
(en)
1985-07-31
CA1172633A
(en)
1984-08-14
SU1272992A3
(en)
1986-11-23
SU1272991A3
(en)
1986-11-23
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