AU1050892A – Intermediates in the preparation of quinolone carboxylic acids
– Google Patents
AU1050892A – Intermediates in the preparation of quinolone carboxylic acids
– Google Patents
Intermediates in the preparation of quinolone carboxylic acids
Info
Publication number
AU1050892A
AU1050892A
AU10508/92A
AU1050892A
AU1050892A
AU 1050892 A
AU1050892 A
AU 1050892A
AU 10508/92 A
AU10508/92 A
AU 10508/92A
AU 1050892 A
AU1050892 A
AU 1050892A
AU 1050892 A
AU1050892 A
AU 1050892A
Authority
AU
Australia
Prior art keywords
preparation
intermediates
carboxylic acids
quinolone carboxylic
fluoro
Prior art date
1988-11-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU10508/92A
Other versions
AU637944B2
(en
Inventor
Brian Thomas O’neill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-11-23
Filing date
1992-01-28
Publication date
1992-03-19
1992-01-28
Application filed by Pfizer Inc
filed
Critical
Pfizer Inc
1992-03-19
Publication of AU1050892A
publication
Critical
patent/AU1050892A/en
1993-06-10
Application granted
granted
Critical
1993-06-10
Publication of AU637944B2
publication
Critical
patent/AU637944B2/en
2009-11-21
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
239000000543
intermediate
Substances
0.000
title
abstract
2
-1
quinolone carboxylic acids
Chemical class
0.000
title
abstract
2
XOQQVKDBGLYPGH-UHFFFAOYSA-N
2-oxo-1h-quinoline-3-carboxylic acid
Chemical compound
C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1
XOQQVKDBGLYPGH-UHFFFAOYSA-N
0.000
abstract
1
230000000844
anti-bacterial effect
Effects
0.000
abstract
1
125000001246
bromo group
Chemical group
Br*
0.000
abstract
1
125000001309
chloro group
Chemical group
Cl*
0.000
abstract
1
150000002148
esters
Chemical class
0.000
abstract
1
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D215/20—Oxygen atoms
C07D215/22—Oxygen atoms attached in position 2 or 4
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
C07C63/70—Monocarboxylic acids
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C2601/00—Systems containing only non-condensed rings
C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Abstract
Quinolonecarboxylic acid intermediates useful in the preparation of antibacterial 6-fluoro-7-substituted-quinolonecarboxylic acids are prepared from 2-(iodo, bromo or chloro)-3-fluoro-4-(fluoro or chloro)-phenyl carboxylic acid or ester.
AU10508/92A
1988-11-23
1992-01-28
Intermediates in the preparation of quinolone carboxylic acids
Ceased
AU637944B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US275449
1988-11-23
US07/275,449
US4939290A
(en)
1988-11-23
1988-11-23
Benzoic acid derivatives
Related Parent Applications (1)
Application Number
Title
Priority Date
Filing Date
AU45382/89A
Division
AU619361B2
(en)
1988-11-23
1989-11-21
A process for preparing a substituted benzoic acid intermediate
Publications (2)
Publication Number
Publication Date
AU1050892A
true
AU1050892A
(en)
1992-03-19
AU637944B2
AU637944B2
(en)
1993-06-10
Family
ID=23052333
Family Applications (2)
Application Number
Title
Priority Date
Filing Date
AU45382/89A
Ceased
AU619361B2
(en)
1988-11-23
1989-11-21
A process for preparing a substituted benzoic acid intermediate
AU10508/92A
Ceased
AU637944B2
(en)
1988-11-23
1992-01-28
Intermediates in the preparation of quinolone carboxylic acids
Family Applications Before (1)
Application Number
Title
Priority Date
Filing Date
AU45382/89A
Ceased
AU619361B2
(en)
1988-11-23
1989-11-21
A process for preparing a substituted benzoic acid intermediate
Country Status (23)
Country
Link
US
(1)
US4939290A
(en)
EP
(1)
EP0370686B1
(en)
JP
(1)
JPH0639446B2
(en)
KR
(1)
KR910008797B1
(en)
CN
(1)
CN1022183C
(en)
AT
(1)
ATE99283T1
(en)
AU
(2)
AU619361B2
(en)
CA
(1)
CA2003446A1
(en)
DE
(1)
DE68911879T2
(en)
DK
(1)
DK587089A
(en)
EG
(1)
EG18943A
(en)
ES
(1)
ES2062037T3
(en)
FI
(1)
FI91856C
(en)
HU
(1)
HU208529B
(en)
IE
(1)
IE61737B1
(en)
MY
(1)
MY105874A
(en)
NO
(1)
NO176315C
(en)
NZ
(1)
NZ231459A
(en)
PH
(1)
PH27224A
(en)
PL
(1)
PL162203B1
(en)
PT
(1)
PT92366B
(en)
YU
(1)
YU47003B
(en)
ZA
(1)
ZA898902B
(en)
Families Citing this family (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE4200512C2
(en)
*
1992-01-11
1994-09-15
Riedel De Haen Ag
Process for the preparation of halogenanthranilic acids and aromatic bromine compounds as precursors
PE20011349A1
(en)
2000-06-16
2002-01-19
Upjohn Co
1-ARIL-4-OXO-1,4-DIHYDRO-3-QUINOLINE CARBOXAMIDES AS ANTIVIRAL AGENTS
CN103450107B
(en)
*
2013-09-13
2016-05-25
陕西嘉禾生物科技股份有限公司
A kind of preparation method of N-methyl-isatin acid anhydrides
CN109053486B
(en)
*
2018-08-16
2022-12-30
江苏中旗科技股份有限公司
Synthesis method of N-methyl-2-fluoroaniline
CN112094586B
(en)
*
2020-09-22
2021-11-09
丹阳市精通眼镜技术创新服务中心有限公司
High-wear-resistance hydrophobic coating and preparation method thereof
Family Cites Families (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3598823A
(en)
*
1969-05-28
1971-08-10
Sandoz Ag
Tricyclic quinazolinones
FR2436781A1
(en)
*
1978-09-19
1980-04-18
Berri Balzac
3-Amino-(1h,3h)-quinazoline-2,4-di:one derivs. – useful as anxiolytics and sedatives to treat hypertension
US4521616A
(en)
*
1980-12-29
1985-06-04
Occidental Chemical Corporation
Method for the preparation of fluoroanthranilic acids
DE3248507A1
(en)
*
1982-12-29
1984-07-05
Bayer Ag, 5090 Leverkusen
MICROBICIDE AGENTS BASED ON CHINOLONIC CARBONIC ACID
US4623650A
(en)
*
1984-12-06
1986-11-18
Pfizer Inc.
Antibiotic derivatives of 7-phenyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
1988
1988-11-23
US
US07/275,449
patent/US4939290A/en
not_active
Expired – Lifetime
1989
1989-11-15
EP
EP89311819A
patent/EP0370686B1/en
not_active
Expired – Lifetime
1989-11-15
ES
ES89311819T
patent/ES2062037T3/en
not_active
Expired – Lifetime
1989-11-15
DE
DE89311819T
patent/DE68911879T2/en
not_active
Expired – Fee Related
1989-11-15
AT
AT89311819T
patent/ATE99283T1/en
not_active
IP Right Cessation
1989-11-20
MY
MYPI89001612A
patent/MY105874A/en
unknown
1989-11-21
NZ
NZ231459A
patent/NZ231459A/en
unknown
1989-11-21
CA
CA002003446A
patent/CA2003446A1/en
not_active
Abandoned
1989-11-21
PT
PT92366A
patent/PT92366B/en
active
IP Right Grant
1989-11-21
AU
AU45382/89A
patent/AU619361B2/en
not_active
Ceased
1989-11-21
HU
HU896037A
patent/HU208529B/en
not_active
IP Right Cessation
1989-11-21
KR
KR1019890016870A
patent/KR910008797B1/en
not_active
IP Right Cessation
1989-11-22
CN
CN89108800A
patent/CN1022183C/en
not_active
Expired – Fee Related
1989-11-22
DK
DK587089A
patent/DK587089A/en
not_active
Application Discontinuation
1989-11-22
IE
IE372989A
patent/IE61737B1/en
not_active
IP Right Cessation
1989-11-22
ZA
ZA898902A
patent/ZA898902B/en
unknown
1989-11-22
JP
JP1304566A
patent/JPH0639446B2/en
not_active
Expired – Lifetime
1989-11-22
EG
EG57589A
patent/EG18943A/en
active
1989-11-22
NO
NO894642A
patent/NO176315C/en
not_active
IP Right Cessation
1989-11-22
YU
YU222089A
patent/YU47003B/en
unknown
1989-11-22
PL
PL89282412A
patent/PL162203B1/en
unknown
1989-11-22
FI
FI895571A
patent/FI91856C/en
not_active
IP Right Cessation
1989-11-23
PH
PH39580A
patent/PH27224A/en
unknown
1992
1992-01-28
AU
AU10508/92A
patent/AU637944B2/en
not_active
Ceased
Also Published As
Publication number
Publication date
CN1022183C
(en)
1993-09-22
DE68911879T2
(en)
1994-04-07
FI91856B
(en)
1994-05-13
EP0370686B1
(en)
1993-12-29
YU222089A
(en)
1991-08-31
ZA898902B
(en)
1991-06-26
YU47003B
(en)
1994-11-15
PH27224A
(en)
1993-05-04
KR910008797B1
(en)
1991-10-21
ATE99283T1
(en)
1994-01-15
NO176315C
(en)
1995-03-15
CA2003446A1
(en)
1990-05-23
IE61737B1
(en)
1994-11-30
AU637944B2
(en)
1993-06-10
AU619361B2
(en)
1992-01-23
KR900007807A
(en)
1990-06-02
ES2062037T3
(en)
1994-12-16
PT92366A
(en)
1990-05-31
EP0370686A3
(en)
1990-12-12
HUT56072A
(en)
1991-07-29
US4939290A
(en)
1990-07-03
PL162203B1
(en)
1993-09-30
DK587089A
(en)
1990-05-24
FI91856C
(en)
1994-08-25
NZ231459A
(en)
1991-08-27
AU4538289A
(en)
1990-05-31
NO894642D0
(en)
1989-11-22
FI895571A0
(en)
1989-11-22
CN1042906A
(en)
1990-06-13
DK587089D0
(en)
1989-11-22
EP0370686A2
(en)
1990-05-30
NO894642L
(en)
1990-05-25
HU896037D0
(en)
1990-02-28
JPH0639446B2
(en)
1994-05-25
MY105874A
(en)
1995-02-28
HU208529B
(en)
1993-11-29
IE893729L
(en)
1990-05-23
JPH02231451A
(en)
1990-09-13
NO176315B
(en)
1994-12-05
PT92366B
(en)
1996-04-30
DE68911879D1
(en)
1994-02-10
EG18943A
(en)
1994-07-30
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Legal Events
Date
Code
Title
Description
2003-06-26
MK14
Patent ceased section 143(a) (annual fees not paid) or expired
