AU3015289A - Creation of Inventions and Patents with Artificial Intelligence

AU3015289A – 2′-deoxy-5-fluorouridine derivatives
– Google Patents

AU3015289A – 2′-deoxy-5-fluorouridine derivatives
– Google Patents
2′-deoxy-5-fluorouridine derivatives

Info

Publication number
AU3015289A

AU3015289A
AU30152/89A
AU3015289A
AU3015289A
AU 3015289 A
AU3015289 A
AU 3015289A
AU 30152/89 A
AU30152/89 A
AU 30152/89A
AU 3015289 A
AU3015289 A
AU 3015289A
AU 3015289 A
AU3015289 A
AU 3015289A
Authority
AU
Australia
Prior art keywords
group
deoxy
chem
formula
acyl
Prior art date
1988-02-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU30152/89A
Other versions

AU610344B2
(en

Inventor
Tsutomu Kawai
Fumio Mori
Hitoshi Saito
Setsuo Takeda
Norio Unemi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Taiho Pharmaceutical Co Ltd

Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-02-29
Filing date
1989-02-21
Publication date
1989-08-31

1989-02-21
Application filed by Taiho Pharmaceutical Co Ltd
filed
Critical
Taiho Pharmaceutical Co Ltd

1989-08-31
Publication of AU3015289A
publication
Critical
patent/AU3015289A/en

1991-05-16
Application granted
granted
Critical

1991-05-16
Publication of AU610344B2
publication
Critical
patent/AU610344B2/en

1993-02-18
Assigned to TAIHO PHARMACEUTICAL CO., LTD.
reassignment
TAIHO PHARMACEUTICAL CO., LTD.
Alteration of Name(s) in Register under S187
Assignors: KURARAY CO., LTD., TAIHO PHARMACEUTICAL CO., LTD.

2009-02-21
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS

C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof

C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

C07H19/06—Pyrimidine radicals

C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS

C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof

C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

C07H19/06—Pyrimidine radicals

C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

2 min -Deoxy-5-fluorouridine derivatives of the formula wherein, R<1> is hydrogen atom or an acyl group and R<2> and R<3> are respectively hydrogen atom, an acyl group or a group of the formula wherein X<1> and X<2> are respectively oxygen atom or sulfur atom; R<4> is a phenyl group, a benzyl group or a naphthyl group each of which may be substituted by an alkyl group, an alkoxyl group, an alkoxycarbonyl group, an alkylthio group, an acyl group, a halogen atom, trifluoromethyl group, nitro group, cyano group, carboxyl group and/or methylenedioxy group and R<5> is an alkyl group, an alkenyl group or one of the groups represented by R<4> which is the same as or different from R<4>, at least one of R<2> and R<3> being a group of the formula which exhibit excellent antitumour activities and have lower toxicity, methods of the production thereof and antitumour compositions containing said 2 min -deoxy-5-fluorouridine derivatives.

AU30152/89A
1988-02-29
1989-02-21
2′-deoxy-5-fluorouridine derivatives

Ceased

AU610344B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

JP63-47864

1988-02-29

JP4786488

1988-02-29

Publications (2)

Publication Number
Publication Date

AU3015289A
true

AU3015289A
(en)

1989-08-31

AU610344B2

AU610344B2
(en)

1991-05-16

Family
ID=12787236
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU30152/89A
Ceased

AU610344B2
(en)

1988-02-29
1989-02-21
2′-deoxy-5-fluorouridine derivatives

Country Status (9)

Country
Link

US
(1)

US5032680A
(en)

EP
(1)

EP0331032B1
(en)

KR
(1)

KR890013009A
(en)

CN
(1)

CN1024349C
(en)

AT
(1)

ATE88714T1
(en)

AU
(1)

AU610344B2
(en)

CA
(1)

CA1313661C
(en)

DE
(1)

DE68906183T2
(en)

ES
(1)

ES2054899T3
(en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US5250673A
(en)

1983-05-23
1993-10-05
Taiho Pharmaceutical Company, Ltd.
2′-deoxy-5-substituted uridine derivatives

GB8823319D0
(en)

1988-10-05
1988-11-09
Nycomed As
Chemical compounds

DE4015715A1
(en)

1990-05-16
1991-11-21
Bayer Ag

NEW OLIGOPHOSPHATES WITH ANTIVIRAL EFFECT

US5627165A
(en)

1990-06-13
1997-05-06
Drug Innovation & Design, Inc.
Phosphorous prodrugs and therapeutic delivery systems using same

DK0533833T3
(en)

1990-06-13
1996-04-22
Arnold Glazier

Phosphorus prodrugs

US5272152A
(en)

1990-07-02
1993-12-21
E. R. Squibb & Sons, Inc.
Purinyl and pyrimidinyl tetrahydrofurans

EP0481214B1
(en)

1990-09-14
1998-06-24
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Prodrugs of phosphonates

US5233031A
(en)

1991-09-23
1993-08-03
University Of Rochester
Phosphoramidate analogs of 2′-deoxyuridine

US5314893A
(en)

1993-01-25
1994-05-24
Bristol-Myers Squibb Co.
Antiviral tetrahydropyrans

JP2526414B2
(en)

1994-05-20
1996-08-21
工業技術院長

Anticancer drug ester compound and method for producing the same

US6232465B1
(en)

1994-09-02
2001-05-15
Andrew C. Hiatt
Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides

US5990300A
(en)

1994-09-02
1999-11-23
Andrew C. Hiatt
Enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides

US6214987B1
(en)

1994-09-02
2001-04-10
Andrew C. Hiatt
Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides

US5808045A
(en)

1994-09-02
1998-09-15
Andrew C. Hiatt
Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides

US5872244A
(en)

1994-09-02
1999-02-16
Andrew C. Hiatt
3′ protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds

US5763594A
(en)

1994-09-02
1998-06-09
Andrew C. Hiatt
3′ protected nucleotides for enzyme catalyzed template-independent creation of phosphodiester bonds

US6319908B1
(en)

1996-07-03
2001-11-20
Inspire Pharmaceuticals, Inc.
Method for large-scale production of di(uridine 5′-tetraphosphate) and salts thereof

TW593331B
(en)

1997-07-25
2004-06-21
Inspire Pharmaceuticals Inc
Method for large-scale production of di(uridine 5′)-tetraphosphate and salts thereof

US6872710B2
(en)

1997-07-25
2005-03-29
Inspire Pharmaceuticals, Inc.
Di(uridine 5′)-tetraphosphate and salts thereof

AU5107600A
(en)

1999-06-11
2001-01-02
Fuji Photo Film Co., Ltd.
Aryl phosphates

DE10313035A1
(en)

2003-03-24
2004-10-07
Resprotect Gmbh

Method to increase the apoptotic effect of cytostatics without increasing toxic side effects

CN101765369A
(en)

2007-03-19
2010-06-30
俄勒冈州由俄勒冈州立大学代表州高等教育委员会行使
Mannich base N-oxide drugs

WO2009042064A2
(en)

2007-09-21
2009-04-02
Nektar Therapeutics Al, Corporation
Oligomer-nucleoside phosphate conjugates

CN101440111B
(en)

2008-12-22
2011-06-22
西安交通大学
Anti-tumor compound and preparation thereof

CN104151360B
(en)

2013-05-14
2019-02-22
北京美倍他药物研究有限公司
Phosphoric acid/phosphonate derivative and its medical usage

CN110678473A
(en)

2017-04-25
2020-01-10
大原药品工业株式会社
5′ -dibenzyl monophosphate derivatives of nucleoside anticancer or antiviral drugs

Family Cites Families (12)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

JPS5535057A
(en)

1978-09-05
1980-03-11
Funai Corp
2′-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it

JPS56115799A
(en)

1980-02-15
1981-09-11
Funai Corp
2′-deoxy-3′,5′-di-o-alkylcarbonyl-5-fluorouridine derivative, its preparation, and antitumor agnet containing the same

JPS57128699A
(en)

1981-02-03
1982-08-10
Tokyo Kinzoku Kogyo Kk
5-fluorouracil derivative and its medical composition

JPS5899499A
(en)

1981-12-09
1983-06-13
Teijin Ltd
5-fluoro-2′-deoxyuridine derivative and its preparation

JPS5970699A
(en)

1982-10-13
1984-04-21
Teijin Ltd
5-fluoro-2′-deoxyuridine derivative and its preparation

DE3263939D1
(en)

1981-12-09
1985-07-04
Teijin Ltd
5-fluoro-2′-deoxyuridine derivatives and a process for the preparation thereof

JPS5993096A
(en)

1982-11-19
1984-05-29
Teijin Ltd
5-fluoro-2′-deoxyuridine derivative and its preparation

US4684631A
(en)

1984-10-09
1987-08-04
Toyama Chemical Co., Ltd.
Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same

JPS6191196A
(en)

1984-10-09
1986-05-09
Toyama Chem Co Ltd
Novel 5-fluoro-2′-deoxyuridine 5′-phosphate derivative and its salt

JPS6191195A
(en)

1984-10-12
1986-05-09
Toyama Chem Co Ltd
Novel 5-fluoro-2′-deoxyuridine-5′-phosphate derivative and its salt

JPS61152694A
(en)

1984-12-27
1986-07-11
Toyama Chem Co Ltd
Novel 5-fluoro-2′-deoxyuridine-5′-phosphate derivative and its salt

JPS61236793A
(en)

1985-04-15
1986-10-22
Toyo Jozo Co Ltd
Novel phospholipid nucleoside derivative

1989

1989-02-21
AU
AU30152/89A
patent/AU610344B2/en
not_active
Ceased

1989-02-24
EP
EP89103261A
patent/EP0331032B1/en
not_active
Expired – Lifetime

1989-02-24
US
US07/314,924
patent/US5032680A/en
not_active
Expired – Fee Related

1989-02-24
ES
ES89103261T
patent/ES2054899T3/en
not_active
Expired – Lifetime

1989-02-24
AT
AT89103261T
patent/ATE88714T1/en
not_active
IP Right Cessation

1989-02-24
DE
DE8989103261T
patent/DE68906183T2/en
not_active
Expired – Fee Related

1989-02-27
CA
CA000592229A
patent/CA1313661C/en
not_active
Expired – Fee Related

1989-02-28
CN
CN89101035A
patent/CN1024349C/en
not_active
Expired – Fee Related

1989-02-28
KR
KR1019890002397A
patent/KR890013009A/en
not_active
Application Discontinuation

Also Published As

Publication number
Publication date

CN1045395A
(en)

1990-09-19

DE68906183T2
(en)

1993-09-02

CA1313661C
(en)

1993-02-16

AU610344B2
(en)

1991-05-16

US5032680A
(en)

1991-07-16

CN1024349C
(en)

1994-04-27

EP0331032A1
(en)

1989-09-06

EP0331032B1
(en)

1993-04-28

ES2054899T3
(en)

1994-08-16

KR890013009A
(en)

1989-09-20

DE68906183D1
(en)

1993-06-03

ATE88714T1
(en)

1993-05-15

Contact information