AU3054384A – Imidazoliums, intermediates thereto and method of use
– Google Patents
AU3054384A – Imidazoliums, intermediates thereto and method of use
– Google Patents
Imidazoliums, intermediates thereto and method of use
Info
Publication number
AU3054384A
AU3054384A
AU30543/84A
AU3054384A
AU3054384A
AU 3054384 A
AU3054384 A
AU 3054384A
AU 30543/84 A
AU30543/84 A
AU 30543/84A
AU 3054384 A
AU3054384 A
AU 3054384A
AU 3054384 A
AU3054384 A
AU 3054384A
Authority
AU
Australia
Prior art keywords
imidazoliums
intermediates
imidazolium salts
refractoriness
useful
Prior art date
1983-07-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU30543/84A
Other versions
AU582538B2
(en
Inventor
Julius Diamond
William Carl Lumma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1983-07-12
Filing date
1984-07-12
Publication date
1985-01-17
1984-07-12
Application filed by Schering AG
filed
Critical
Schering AG
1985-01-17
Publication of AU3054384A
publication
Critical
patent/AU3054384A/en
1989-04-06
Application granted
granted
Critical
1989-04-06
Publication of AU582538B2
publication
Critical
patent/AU582538B2/en
2004-07-12
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C17/00—Preparation of halogenated hydrocarbons
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/06—Antiarrhythmics
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C17/00—Preparation of halogenated hydrocarbons
C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C17/00—Preparation of halogenated hydrocarbons
C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C17/00—Preparation of halogenated hydrocarbons
C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
C07C17/2635—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving a phosphorus compound, e.g. Wittig synthesis
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
C07C309/01—Sulfonic acids
C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
C07C33/40—Halogenated unsaturated alcohols
C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
C07C33/483—Monocyclic
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
C07C33/40—Halogenated unsaturated alcohols
C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
The imidazolium salts described are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided as well as pharmaceutical formulations containing such imidazolium salts.
AU30543/84A
1983-07-12
1984-07-12
Imidazoliums, intermediates thereto and method of use
Ceased
AU582538B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US513143
1983-07-12
US06/513,143
US4581370A
(en)
1983-07-12
1983-07-12
Antiarrhythmic imidazoliums
Publications (2)
Publication Number
Publication Date
AU3054384A
true
AU3054384A
(en)
1985-01-17
AU582538B2
AU582538B2
(en)
1989-04-06
Family
ID=24042059
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU30543/84A
Ceased
AU582538B2
(en)
1983-07-12
1984-07-12
Imidazoliums, intermediates thereto and method of use
Country Status (15)
Country
Link
US
(2)
US4581370A
(en)
EP
(1)
EP0131302B1
(en)
JP
(1)
JPH08815B2
(en)
AT
(1)
ATE72238T1
(en)
AU
(1)
AU582538B2
(en)
CA
(1)
CA1289563C
(en)
DE
(1)
DE3485488D1
(en)
DK
(1)
DK339184A
(en)
FI
(1)
FI90232C
(en)
GR
(1)
GR82282B
(en)
IE
(1)
IE59337B1
(en)
IL
(1)
IL72354A
(en)
NO
(1)
NO168300C
(en)
NZ
(1)
NZ208831A
(en)
ZA
(1)
ZA845410B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU569135B2
(en)
*
1983-12-30
1988-01-21
Ciba-Geigy Ag
1-phenyl-alkyl-2-alkylimidazoles
Families Citing this family (25)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4609670A
(en)
*
1984-11-13
1986-09-02
Eli Lilly And Company
Imidazolium hypoglycemic agents
DE3674054D1
(en)
*
1985-04-26
1990-10-18
Hoffmann La Roche
1,3-DISUBSTITUTED IMIDAZOLI SALTS.
US4978672A
(en)
*
1986-03-07
1990-12-18
Ciba-Geigy Corporation
Alpha-heterocyclc substituted tolunitriles
US4937250A
(en)
*
1988-03-07
1990-06-26
Ciba-Geigy Corporation
Alpha-heterocycle substituted tolunitriles
GB8609331D0
(en)
*
1986-04-16
1986-05-21
Pfizer Ltd
Anti-arrythmia agents
GB8707120D0
(en)
*
1987-03-25
1987-04-29
Pfizer Ltd
Antiarrhythmic agents
US4918080A
(en)
*
1987-04-14
1990-04-17
Glaxo Group Limited
Imidazollyl containing ketone derivatives
GB8720693D0
(en)
*
1987-09-03
1987-10-07
Glaxo Group Ltd
Chemical compounds
SK282656B6
(en)
*
1991-08-14
2002-11-06
Procter And Gamble Pharmaceuticals
4-Oxocyclic ureas useful as antiarrhythmic and antifibrillatory a gents and pharmaceutical composition comprising the same
CA2115426C
(en)
*
1991-08-14
2001-09-11
Stanford Salvatore Pelosi Jr.
Novel cyclic ureas useful as antiarrhythmic and antifibrillatory agents
JPH06510285A
(en)
*
1991-08-14
1994-11-17
プロクター、エンド、ギャンブル、ファーマスーティカルズ、インコーポレーテッド
Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents
US5635521A
(en)
*
1991-09-23
1997-06-03
Sandoz Ltd.
Imidazolylmethyl-pyridines
DK0618913T3
(en)
*
1991-12-18
1996-10-14
Schering Corp
Imidazolyl or imidazoylalkyl substituted with a 4- or 5-membered nitrogen-containing heterocyclic ring
GB9127304D0
(en)
*
1991-12-23
1992-02-19
Boots Co Plc
Therapeutic agents
US5183813A
(en)
*
1992-02-19
1993-02-02
Sterling Winthrop Inc.
Antiarrhythmic agents
US6031109A
(en)
*
1993-06-22
2000-02-29
Knoll Aktiengesellschaft
Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents
GB9312893D0
(en)
*
1993-06-22
1993-08-04
Boots Co Plc
Therapeutic agents
FR2766178B1
(en)
*
1997-07-16
2000-03-17
Oreal
NOVEL CATIONIC OXIDATION BASES, THEIR USE FOR OXIDATION DYEING OF KERATINIC FIBERS, TINCTORIAL COMPOSITIONS AND DYEING METHODS
FR2766179B1
(en)
*
1997-07-16
2000-03-17
Oreal
NOVEL CATIONIC OXIDATION BASES, THEIR USE FOR OXIDATION DYEING OF KERATINIC FIBERS, TINCTORIAL COMPOSITIONS AND DYEING METHODS
FR2782718B1
(en)
*
1998-09-02
2000-11-10
Oreal
NOVEL CATIONIC COMPOUNDS, THEIR USE FOR OXIDATION DYEING OF KERATINIC FIBERS, TINCTORIAL COMPOSITIONS AND DYEING METHODS
FR2782719B1
(en)
*
1998-09-02
2000-11-10
Oreal
NOVEL CATIONIC ORTHOPHENYLENEDIAMINES, THEIR USE FOR OXIDATION DYEING OF KERATINIC FIBERS, TINCTORIAL COMPOSITIONS AND DYEING METHODS
JP4620286B2
(en)
*
2001-06-05
2011-01-26
富士フイルム株式会社
Electrolyte composition, photoelectric conversion element and photoelectrochemical cell
AR039391A1
(en)
2002-04-08
2005-02-16
Glaxo Group Ltd
CYCLOPENTENE COMPOUND, PHARMACEUTICAL COMPOSITION THAT INCLUDES IT AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
GB0225548D0
(en)
2002-11-01
2002-12-11
Glaxo Group Ltd
Compounds
JP2008133248A
(en)
*
2006-10-24
2008-06-12
Sanyo Chem Ind Ltd
Method for producing imidazolium salt
Family Cites Families (11)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US2493318A
(en)
*
1945-07-14
1950-01-03
Lilly Co Eli
Imidazolium compounds
FR8357M
(en)
*
1966-09-08
1971-02-08
SE7600674L
(en)
*
1975-02-05
1976-08-06
Rohm & Haas
FUNGICIDER
DE2510525C3
(en)
*
1975-03-11
1978-03-30
Th. Goldschmidt Ag, 4300 Essen
2-alkyl imidazolium quaternary salts
JPS5488268A
(en)
*
1977-10-19
1979-07-13
Wellcome Found
Novel imidazole derivatives*their manufacture and medical composition
JPS5479278A
(en)
*
1977-12-05
1979-06-25
Nippon Soda Co Ltd
Imidazolium halide
IT1097314B
(en)
*
1978-07-26
1985-08-31
Recordati Chem Pharm
DERIVATIVES OF IMIDAZOLE WITH ANTI-CONVULSIVE ACTIVITY
FR2486079A1
(en)
*
1980-07-07
1982-01-08
Rhone Poulenc Agrochimie
1,3-Alkyl or benzyl substd. imidazolium phosphite derivs. – are fungicides active against basidiomycetes, ascomycetes, phycomycetes and fungi imperfecti
JPS5838261A
(en)
*
1981-08-29
1983-03-05
Kissei Pharmaceut Co Ltd
Novel 1,3-disubstituted imidazole derivative and its preparation
JPS5855466A
(en)
*
1981-09-28
1983-04-01
Kissei Pharmaceut Co Ltd
Novel 1,3-disubstituted imidazole derivative and its preparation
DE3319845A1
(en)
*
1983-06-01
1984-12-06
Basf Ag, 6700 Ludwigshafen
ARYLALKYLIMIDAZOLIUM AND TRIAZOLI SALTS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MICROCIDES
1983
1983-07-12
US
US06/513,143
patent/US4581370A/en
not_active
Expired – Fee Related
1984
1984-07-09
IL
IL72354A
patent/IL72354A/en
not_active
IP Right Cessation
1984-07-09
NZ
NZ208831A
patent/NZ208831A/en
unknown
1984-07-09
EP
EP84108015A
patent/EP0131302B1/en
not_active
Expired – Lifetime
1984-07-09
AT
AT84108015T
patent/ATE72238T1/en
not_active
IP Right Cessation
1984-07-09
DE
DE8484108015T
patent/DE3485488D1/en
not_active
Expired – Lifetime
1984-07-10
FI
FI842760A
patent/FI90232C/en
not_active
IP Right Cessation
1984-07-10
DK
DK339184A
patent/DK339184A/en
not_active
Application Discontinuation
1984-07-11
IE
IE177484A
patent/IE59337B1/en
not_active
IP Right Cessation
1984-07-11
NO
NO842835A
patent/NO168300C/en
unknown
1984-07-11
CA
CA000458676A
patent/CA1289563C/en
not_active
Expired – Lifetime
1984-07-11
GR
GR75280A
patent/GR82282B/el
unknown
1984-07-12
AU
AU30543/84A
patent/AU582538B2/en
not_active
Ceased
1984-07-12
ZA
ZA845410A
patent/ZA845410B/en
unknown
1984-07-12
JP
JP59143414A
patent/JPH08815B2/en
not_active
Expired – Lifetime
1986
1986-07-03
US
US06/881,760
patent/US4689341A/en
not_active
Expired – Fee Related
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU569135B2
(en)
*
1983-12-30
1988-01-21
Ciba-Geigy Ag
1-phenyl-alkyl-2-alkylimidazoles
Also Published As
Publication number
Publication date
DK339184D0
(en)
1984-07-10
NO168300C
(en)
1992-02-05
DE3485488D1
(en)
1992-03-12
NO168300B
(en)
1991-10-28
EP0131302A2
(en)
1985-01-16
AU582538B2
(en)
1989-04-06
IE841774L
(en)
1985-01-12
DK339184A
(en)
1985-01-13
ZA845410B
(en)
1985-02-27
EP0131302A3
(en)
1987-06-16
ATE72238T1
(en)
1992-02-15
FI90232C
(en)
1994-01-10
NO842835L
(en)
1985-01-14
FI90232B
(en)
1993-09-30
IE59337B1
(en)
1994-02-09
JPH08815B2
(en)
1996-01-10
FI842760A
(en)
1985-01-13
CA1289563C
(en)
1991-09-24
IL72354A0
(en)
1984-11-30
NZ208831A
(en)
1988-09-29
EP0131302B1
(en)
1992-01-29
GR82282B
(en)
1984-12-13
JPS6038366A
(en)
1985-02-27
US4581370A
(en)
1986-04-08
US4689341A
(en)
1987-08-25
IL72354A
(en)
1988-11-30
FI842760A0
(en)
1984-07-10
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None