AU3243289A – Hydrogenated isoquinoline or benzazepine derivatives and intermediates thereof
– Google Patents
AU3243289A – Hydrogenated isoquinoline or benzazepine derivatives and intermediates thereof
– Google Patents
Hydrogenated isoquinoline or benzazepine derivatives and intermediates thereof
Info
Publication number
AU3243289A
AU3243289A
AU32432/89A
AU3243289A
AU3243289A
AU 3243289 A
AU3243289 A
AU 3243289A
AU 32432/89 A
AU32432/89 A
AU 32432/89A
AU 3243289 A
AU3243289 A
AU 3243289A
AU 3243289 A
AU3243289 A
AU 3243289A
Authority
AU
Australia
Prior art keywords
intermediates
treatment
same
neuronal death
benzazepine derivatives
Prior art date
1988-04-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU32432/89A
Other versions
AU624128B2
(en
Inventor
Atsushi Kuno
Mitsuru Ohkubo
Hisashi Takasugi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-04-05
Filing date
1989-04-04
Publication date
1989-10-12
1989-04-04
Application filed by Fujisawa Pharmaceutical Co Ltd
filed
Critical
Fujisawa Pharmaceutical Co Ltd
1989-10-12
Publication of AU3243289A
publication
Critical
patent/AU3243289A/en
1992-06-04
Application granted
granted
Critical
1992-06-04
Publication of AU624128B2
publication
Critical
patent/AU624128B2/en
2009-04-04
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
C07D223/16—Benzazepines; Hydrogenated benzazepines
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/08—Antiepileptics; Anticonvulsants
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
Y02P20/00—Technologies relating to chemical industry
Y02P20/50—Improvements relating to the production of bulk chemicals
Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
The present invention relates to novel bicyclic amine compound and a pharmaceutically acceptable salt thereof, which is an N-methyl-D-aspartate (an excitatory amino acid) receptor antagonist and useful as an anticonvulsant and a drug for treatment of the delayed neuronal death induced, for instance, by cerebral ischemia, for example, in case of cardiac arrest, to a process for the preparation thereof, to a pharmaceutical composition comprising the same, and to a use of the same as a medicament in treatment of convulsion and delayed neuronal death in human being or animal.
AU32432/89A
1988-04-05
1989-04-04
Hydrogenated isoquinoline or benzazepine derivatives and intermediates thereof
Ceased
AU624128B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
GB888807922A
GB8807922D0
(en)
1988-04-05
1988-04-05
Isoquinoline compound & process for preparation thereof
GB8807922
1988-04-05
Publications (2)
Publication Number
Publication Date
AU3243289A
true
AU3243289A
(en)
1989-10-12
AU624128B2
AU624128B2
(en)
1992-06-04
Family
ID=10634575
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU32432/89A
Ceased
AU624128B2
(en)
1988-04-05
1989-04-04
Hydrogenated isoquinoline or benzazepine derivatives and intermediates thereof
Country Status (16)
Country
Link
US
(1)
US5059608A
(en)
EP
(1)
EP0336228B1
(en)
JP
(1)
JP2674199B2
(en)
KR
(1)
KR890016013A
(en)
CN
(1)
CN1036758A
(en)
AT
(1)
ATE113937T1
(en)
AU
(1)
AU624128B2
(en)
DE
(1)
DE68919252T2
(en)
DK
(1)
DK161889A
(en)
FI
(1)
FI891582A
(en)
GB
(1)
GB8807922D0
(en)
HU
(1)
HU206681B
(en)
IL
(1)
IL89736A0
(en)
NO
(1)
NO891390L
(en)
PH
(1)
PH26281A
(en)
ZA
(1)
ZA892230B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU619744B2
(en)
*
1987-03-27
1992-02-06
Schering Corporation
Substituted benzazepines, their preparation and pharmaceutical compositions containing them
Families Citing this family (12)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4902695A
(en)
*
1989-02-13
1990-02-20
Eli Lilly And Company
Excitatory amino acid receptor antagonists
US5837808A
(en)
*
1991-08-20
1998-11-17
Baxter International Inc.
Analogs of hirudin
US5246943A
(en)
*
1992-05-19
1993-09-21
Warner-Lambert Company
Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
US5236934A
(en)
*
1992-08-26
1993-08-17
E. I. Du Pont De Nemours And Company
1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
US5360569A
(en)
*
1993-11-12
1994-11-01
Lever Brothers Company, Division Of Conopco, Inc.
Activation of bleach precursors with catalytic imine quaternary salts
DE69405407T2
(en)
*
1993-11-12
1998-01-08
Unilever Nv
IMINIUM SALES AS A FASTENER CATALYST
US5360568A
(en)
*
1993-11-12
1994-11-01
Lever Brothers Company, Division Of Conopco, Inc.
Imine quaternary salts as bleach catalysts
DZ2446A1
(en)
*
1997-03-18
2003-01-11
Smithkline Beecham Plc
New compounds
EP1023269A4
(en)
*
1997-09-30
2001-06-27
Molecular Design Int
Beta3-adrenoreceptor agonists, agonist compositions and methods of using
US6593341B2
(en)
2001-03-29
2003-07-15
Molecular Design International, Inc.
β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6596734B1
(en)
2002-10-11
2003-07-22
Molecular Design International, Inc.
Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
KR100812843B1
(en)
*
2005-06-01
2008-03-11
한화석유화학 주식회사
3,4-dihydroisoquinolinium salt derivatives
Family Cites Families (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US3963725A
(en)
*
1973-07-20
1976-06-15
Fujisawa Pharmaceutical Co., Ltd.
1,2,3,4-Tetrahydroisoquinoline derivatives and the preparation thereof
JPS5734275B2
(en)
*
1973-07-30
1982-07-22
AR204327A1
(en)
*
1973-07-20
1975-12-22
Fujisawa Pharmaceutical Co
PROCEDURE FOR THE PREPARATION OF 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES
US4755218A
(en)
*
1985-12-31
1988-07-05
Monsanto Company
Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8800397D0
(en)
*
1988-01-08
1988-02-10
Sandoz Ltd
Improvements in/relating to organic compounds
1988
1988-04-05
GB
GB888807922A
patent/GB8807922D0/en
active
Pending
1989
1989-03-23
EP
EP89105218A
patent/EP0336228B1/en
not_active
Expired – Lifetime
1989-03-23
ZA
ZA892230A
patent/ZA892230B/en
unknown
1989-03-23
US
US07/327,813
patent/US5059608A/en
not_active
Expired – Fee Related
1989-03-23
DE
DE68919252T
patent/DE68919252T2/en
not_active
Expired – Fee Related
1989-03-23
AT
AT89105218T
patent/ATE113937T1/en
not_active
IP Right Cessation
1989-03-24
IL
IL89736A
patent/IL89736A0/en
unknown
1989-03-29
PH
PH38390A
patent/PH26281A/en
unknown
1989-04-03
NO
NO89891390A
patent/NO891390L/en
unknown
1989-04-03
FI
FI891582A
patent/FI891582A/en
not_active
IP Right Cessation
1989-04-04
AU
AU32432/89A
patent/AU624128B2/en
not_active
Ceased
1989-04-04
KR
KR1019890004528A
patent/KR890016013A/en
not_active
Application Discontinuation
1989-04-04
DK
DK161889A
patent/DK161889A/en
not_active
Application Discontinuation
1989-04-04
JP
JP1085172A
patent/JP2674199B2/en
not_active
Expired – Fee Related
1989-04-04
CN
CN89102133A
patent/CN1036758A/en
active
Pending
1989-04-05
HU
HU891646A
patent/HU206681B/en
not_active
IP Right Cessation
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU619744B2
(en)
*
1987-03-27
1992-02-06
Schering Corporation
Substituted benzazepines, their preparation and pharmaceutical compositions containing them
Also Published As
Publication number
Publication date
JP2674199B2
(en)
1997-11-12
ZA892230B
(en)
1989-11-29
NO891390D0
(en)
1989-04-03
AU624128B2
(en)
1992-06-04
PH26281A
(en)
1992-04-10
FI891582A0
(en)
1989-04-03
US5059608A
(en)
1991-10-22
HUT50782A
(en)
1990-03-28
DK161889D0
(en)
1989-04-04
DE68919252D1
(en)
1994-12-15
KR890016013A
(en)
1989-11-27
EP0336228B1
(en)
1994-11-09
JPH01294664A
(en)
1989-11-28
DK161889A
(en)
1989-10-06
IL89736A0
(en)
1989-09-28
EP0336228A1
(en)
1989-10-11
NO891390L
(en)
1989-10-06
ATE113937T1
(en)
1994-11-15
GB8807922D0
(en)
1988-05-05
HU206681B
(en)
1992-12-28
DE68919252T2
(en)
1995-03-23
CN1036758A
(en)
1989-11-01
FI891582A
(en)
1989-10-06
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