AU3662697A

AU3662697A – Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
– Google Patents

AU3662697A – Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process
– Google Patents
Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process

Info

Publication number
AU3662697A

AU3662697A
AU36626/97A
AU3662697A
AU3662697A
AU 3662697 A
AU3662697 A
AU 3662697A
AU 36626/97 A
AU36626/97 A
AU 36626/97A
AU 3662697 A
AU3662697 A
AU 3662697A
AU 3662697 A
AU3662697 A
AU 3662697A
Authority
AU
Australia
Prior art keywords
interrupting
synthesis
blocking
amplification process
dna shuffling
Prior art date
1996-07-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU36626/97A
Other versions

AU724521B2
(en

Inventor
Jay M. Short
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BP Corp North America Inc

Original Assignee
BP Corp North America Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1996-07-09
Filing date
1997-07-09
Publication date
1998-02-02

1997-07-09
Application filed by BP Corp North America Inc
filed
Critical
BP Corp North America Inc

1998-02-02
Publication of AU3662697A
publication
Critical
patent/AU3662697A/en

1999-03-11
Assigned to DIVERSA CORPORATION
reassignment
DIVERSA CORPORATION
Amend patent request/document other than specification (104)
Assignors: RECOMBINANT BIOCATALYSIS, INC.

2000-09-21
Application granted
granted
Critical

2000-09-21
Publication of AU724521B2
publication
Critical
patent/AU724521B2/en

2007-10-04
Assigned to VERENIUM CORPORATION
reassignment
VERENIUM CORPORATION
Request to Amend Deed and Register
Assignors: DIVERSA CORPORATION

2011-03-10
Assigned to BP CORPORATION NORTH AMERICA INC.
reassignment
BP CORPORATION NORTH AMERICA INC.
Alteration of Name(s) in Register under S187
Assignors: VERENIUM CORPORATION

2017-07-09
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING

C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES

C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions

C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules

C—CHEMISTRY; METALLURGY

C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING

C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA

C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor

C12N15/09—Recombinant DNA-technology

C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA

C12N15/102—Mutagenizing nucleic acids

C12N15/1027—Mutagenizing nucleic acids by DNA shuffling, e.g. RSR, STEP, RPR

AU36626/97A
1996-07-09
1997-07-09
Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process

Ceased

AU724521B2
(en)

Applications Claiming Priority (3)

Application Number
Priority Date
Filing Date
Title

US08/677112

1996-07-09

US08/677,112

US5965408A
(en)

1996-07-09
1996-07-09
Method of DNA reassembly by interrupting synthesis

PCT/US1997/012239

WO1998001581A1
(en)

1996-07-09
1997-07-09
Method of dna shuffling with polynucleotides produced by blockingor interrupting a synthesis or amplification process

Related Child Applications (1)

Application Number
Title
Priority Date
Filing Date

AU72417/00A
Division

AU7241700A
(en)

1996-07-09
2000-12-21
Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process

Publications (2)

Publication Number
Publication Date

AU3662697A
true

AU3662697A
(en)

1998-02-02

AU724521B2

AU724521B2
(en)

2000-09-21

Family
ID=24717384
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU36626/97A
Ceased

AU724521B2
(en)

1996-07-09
1997-07-09
Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process

Country Status (7)

Country
Link

US
(2)

US5965408A
(en)

EP
(1)

EP1007727A4
(en)

JP
(1)

JP2000514651A
(en)

AU
(1)

AU724521B2
(en)

CA
(1)

CA2259628A1
(en)

IL
(1)

IL127972A0
(en)

WO
(1)

WO1998001581A1
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU741834B2
(en)

*

1997-03-18
2001-12-13
Novozymes A/S
An (in vitro) method for construction of a dna library

Families Citing this family (282)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US5837458A
(en)

1994-02-17
1998-11-17
Maxygen, Inc.
Methods and compositions for cellular and metabolic engineering

US6117679A
(en)

1994-02-17
2000-09-12
Maxygen, Inc.
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

US6165793A
(en)

*

1996-03-25
2000-12-26
Maxygen, Inc.
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

US6995017B1
(en)

1994-02-17
2006-02-07
Maxygen, Inc.
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

US6395547B1
(en)

1994-02-17
2002-05-28
Maxygen, Inc.
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

US6406855B1
(en)

1994-02-17
2002-06-18
Maxygen, Inc.
Methods and compositions for polypeptide engineering

US6309883B1
(en)

*

1994-02-17
2001-10-30
Maxygen, Inc.
Methods and compositions for cellular and metabolic engineering

US5605793A
(en)

1994-02-17
1997-02-25
Affymax Technologies N.V.
Methods for in vitro recombination

US20060257890A1
(en)

*

1996-05-20
2006-11-16
Maxygen, Inc.
Methods and compositions for cellular and metabolic engineering

US6335160B1
(en)

1995-02-17
2002-01-01
Maxygen, Inc.
Methods and compositions for polypeptide engineering

US20020028443A1
(en)

*

1999-09-27
2002-03-07
Jay M. Short
Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process

US6238884B1
(en)

1995-12-07
2001-05-29
Diversa Corporation
End selection in directed evolution

US7018793B1
(en)

1995-12-07
2006-03-28
Diversa Corporation
Combinatorial screening of mixed populations of organisms

US20020164580A1
(en)

*

1995-12-07
2002-11-07
Diversa Corporation
Combinatorial screening of mixed populations of organisms

US6740506B2
(en)

1995-12-07
2004-05-25
Diversa Corporation
End selection in directed evolution

US6939689B2
(en)

1995-12-07
2005-09-06
Diversa Corporation
Exonuclease-mediated nucleic acid reassembly in directed evolution

US6537776B1
(en)

1999-06-14
2003-03-25
Diversa Corporation
Synthetic ligation reassembly in directed evolution

US6352842B1
(en)

1995-12-07
2002-03-05
Diversa Corporation
Exonucease-mediated gene assembly in directed evolution

US6713279B1
(en)

1995-12-07
2004-03-30
Diversa Corporation
Non-stochastic generation of genetic vaccines and enzymes

US5830696A
(en)

1996-12-05
1998-11-03
Diversa Corporation
Directed evolution of thermophilic enzymes

US5965408A
(en)

*

1996-07-09
1999-10-12
Diversa Corporation
Method of DNA reassembly by interrupting synthesis

US6361974B1
(en)

*

1995-12-07
2002-03-26
Diversa Corporation
Exonuclease-mediated nucleic acid reassembly in directed evolution

US20030219752A1
(en)

*

1995-12-07
2003-11-27
Diversa Corporation
Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof

US6358709B1
(en)

1995-12-07
2002-03-19
Diversa Corporation
End selection in directed evolution

US6096548A
(en)

1996-03-25
2000-08-01
Maxygen, Inc.
Method for directing evolution of a virus

US6506602B1
(en)

1996-03-25
2003-01-14
Maxygen, Inc.
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

PT938584E
(en)

1996-07-10
2008-08-29
Lonza Ag
Method of preparing (s) – or (r) -3,3,3-trifluoro-2-hydroxy-2- methylpropionic acid

US20070009930A1
(en)

*

1996-12-18
2007-01-11
Maxygen, Inc.
Methods and compositions for polypeptide engineering

US7148054B2
(en)

1997-01-17
2006-12-12
Maxygen, Inc.
Evolution of whole cells and organisms by recursive sequence recombination

KR100568008B1
(en)

1997-01-17
2006-04-07
맥시겐, 인크.
Evolution of whole cells and organisms by recursive sequence recombination

US6326204B1
(en)

1997-01-17
2001-12-04
Maxygen, Inc.
Evolution of whole cells and organisms by recursive sequence recombination

US6159687A
(en)

1997-03-18
2000-12-12
Novo Nordisk A/S
Methods for generating recombined polynucleotides

US6159688A
(en)

*

1997-03-18
2000-12-12
Novo Nordisk A/S
Methods of producing polynucleotide variants

US6153410A
(en)

*

1997-03-25
2000-11-28
California Institute Of Technology
Recombination of polynucleotide sequences using random or defined primers

CA2307016A1
(en)

1997-10-24
1999-05-06
Life Technologies, Inc.
Recombinational cloning using nucleic acids having recombination sites

EP1030861A4
(en)

1997-10-31
2001-09-05
Maxygen Inc
Modification of virus tropism and host range by viral genome shuffling

KR20010032861A
(en)

1997-12-08
2001-04-25
캘리포니아 인스티튜트 오브 테크놀로지
Method for creating polynucleotide and polypeptide sequences

US6541011B2
(en)

1998-02-11
2003-04-01
Maxygen, Inc.
Antigen library immunization

US7390619B1
(en)

1998-02-11
2008-06-24
Maxygen, Inc.
Optimization of immunomodulatory properties of genetic vaccines

KR20010082543A
(en)

1998-05-01
2001-08-30
추후제출
Optimization of pest resistance genes using dna shuffling

US6902918B1
(en)

1998-05-21
2005-06-07
California Institute Of Technology
Oxygenase enzymes and screening method

US20030207345A1
(en)

*

1998-05-21
2003-11-06
California Institute Of Technology
Oxygenase enzymes and screening method

US7153655B2
(en)

*

1998-06-16
2006-12-26
Alligator Bioscience Ab
Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence

US6365408B1
(en)

1998-06-19
2002-04-02
Maxygen, Inc.
Methods of evolving a polynucleotides by mutagenesis and recombination

US6846655B1
(en)

1998-06-29
2005-01-25
Phylos, Inc.
Methods for generating highly diverse libraries

AU766498B2
(en)

1998-07-23
2003-10-16
President And Fellows Of Harvard College, The
Synthetic peptides and methods of use for autoimmune disease therapies

US20030153042A1
(en)

*

1998-07-28
2003-08-14
California Institute Of Technology
Expression of functional eukaryotic proteins

JP2002522089A
(en)

*

1998-08-12
2002-07-23
マキシジェン, インコーポレイテッド

DNA shuffling to produce herbicide-selective crops

WO2000009682A1
(en)

1998-08-12
2000-02-24
Maxygen, Inc.
Dna shuffling of monooxygenase genes for production of industrial chemicals

US20060242731A1
(en)

*

1998-08-12
2006-10-26
Venkiteswaran Subramanian
DNA shuffling to produce herbicide selective crops

EP1119616A2
(en)

1998-10-07
2001-08-01
Maxygen, Inc.
Dna shuffling to produce nucleic acids for mycotoxin detoxification

WO2000028018A1
(en)

1998-11-10
2000-05-18
Maxygen, Inc.
Modified adp-glucose pyrophosphorylase for improvement and optimization of plant phenotypes

US6438561B1
(en)

*

1998-11-19
2002-08-20
Navigation Technologies Corp.
Method and system for using real-time traffic broadcasts with navigation systems

WO2000040715A2
(en)

*

1999-01-05
2000-07-13
Trustees Of Boston University
Improved nucleic acid cloning

US20040005673A1
(en)

*

2001-06-29
2004-01-08
Kevin Jarrell
System for manipulating nucleic acids

US6376246B1
(en)

1999-02-05
2002-04-23
Maxygen, Inc.
Oligonucleotide mediated nucleic acid recombination

US20030054390A1
(en)

*

1999-01-19
2003-03-20
Maxygen, Inc.
Oligonucleotide mediated nucleic acid recombination

US6917882B2
(en)

*

1999-01-19
2005-07-12
Maxygen, Inc.
Methods for making character strings, polynucleotides and polypeptides having desired characteristics

US6436675B1
(en)

1999-09-28
2002-08-20
Maxygen, Inc.
Use of codon-varied oligonucleotide synthesis for synthetic shuffling

EP1151409A1
(en)

*

1999-01-18
2001-11-07
Maxygen, Inc.
Methods of populating data stuctures for use in evolutionary simulations

US7024312B1
(en)

1999-01-19
2006-04-04
Maxygen, Inc.
Methods for making character strings, polynucleotides and polypeptides having desired characteristics

JP2002534966A
(en)

*

1999-01-19
2002-10-22
マキシジェン, インコーポレイテッド

Oligonucleotide-mediated nucleic acid recombination

US20070065838A1
(en)

*

1999-01-19
2007-03-22
Maxygen, Inc.
Oligonucleotide mediated nucleic acid recombination

US6961664B2
(en)

1999-01-19
2005-11-01
Maxygen
Methods of populating data structures for use in evolutionary simulations

US20090130718A1
(en)

*

1999-02-04
2009-05-21
Diversa Corporation
Gene site saturation mutagenesis

JP2003524394A
(en)

1999-02-11
2003-08-19
マキシジェン, インコーポレイテッド

High-throughput mass spectrometry

JP3399518B2
(en)

*

1999-03-03
2003-04-21
インターナショナル・ビジネス・マシーンズ・コーポレーション

Semiconductor structure and method of manufacturing the same

US6531316B1
(en)

1999-03-05
2003-03-11
Maxyag, Inc.
Encryption of traits using split gene sequences and engineered genetic elements

EP1165757A1
(en)

1999-03-05
2002-01-02
Maxygen, Inc.
Encryption of traits using split gene sequences

EP1161529A2
(en)

*

1999-03-09
2001-12-12
Diversa Corporation
End selection in directed evolution

JP2004500019A
(en)

*

1999-03-26
2004-01-08
ディベルサ コーポレーション

Exonuclease-mediated nucleic acid reassembly in directed evolution

US7332308B1
(en)

1999-05-21
2008-02-19
The Penn State Research Foundation
Incrementally truncated nucleic acids and methods of making same

AU5805500A
(en)

*

1999-07-07
2001-01-30
Maxygen Aps
A method for preparing modified polypeptides

US20040002474A1
(en)

*

1999-10-07
2004-01-01
Maxygen Inc.
IFN-alpha homologues

US7430477B2
(en)

1999-10-12
2008-09-30
Maxygen, Inc.
Methods of populating data structures for use in evolutionary simulations

WO2001032829A2
(en)

*

1999-11-05
2001-05-10
Novozymes A/S
Methods to screen microorganisms or gene libraries for products secreted from a cell

US6686515B1
(en)

1999-11-23
2004-02-03
Maxygen, Inc.
Homologous recombination in plants

US7115712B1
(en)

1999-12-02
2006-10-03
Maxygen, Inc.
Cytokine polypeptides

WO2001051663A2
(en)

*

2000-01-11
2001-07-19
Maxygen, Inc.
Integrated systems and methods for diversity generation and screening

WO2001064864A2
(en)

*

2000-02-28
2001-09-07
Maxygen, Inc.
Single-stranded nucleic acid template-mediated recombination and nucleic acid fragment isolation

EP1276861A2
(en)

*

2000-03-24
2003-01-22
Maxygen, Inc.
Methods for modulating cellular and organismal phenotypes

US6534292B1
(en)

*

2000-05-08
2003-03-18
Genencor International, Inc.
Methods for forming recombined nucleic acids

US7115403B1
(en)

2000-05-16
2006-10-03
The California Institute Of Technology
Directed evolution of galactose oxidase enzymes

US7074590B2
(en)

*

2000-06-23
2006-07-11
Maxygen, Inc.
Chimeric promoters

JP2004513878A
(en)

*

2000-06-23
2004-05-13
マキシジェン, インコーポレイテッド

Novel costimulatory molecules

EP2287296A1
(en)

2000-06-26
2011-02-23
Novozymes A/S
Lipolytic enzyme

AU2001271912A1
(en)

*

2000-07-07
2002-01-21
Maxygen, Inc.
Molecular breeding of transposable elements

US6994963B1
(en)

*

2000-07-10
2006-02-07
Ambion, Inc.
Methods for recombinatorial nucleic acid synthesis

US6858422B2
(en)

*

2000-07-13
2005-02-22
Codexis, Inc.
Lipase genes

AU2001273559A1
(en)

*

2000-07-18
2002-01-30
Enchira Biotechnology Corporation
Methods of ligation mediated chimeragenesis utilizing populations of scaffold and donor nucleic acids

WO2002010750A2
(en)

*

2000-07-31
2002-02-07
Maxygen, Inc.
Biosensors, reagents and diagnostic applications of directed evolution

AU2001280968A1
(en)

*

2000-07-31
2002-02-13
Menzel, Rolf
Compositions and methods for directed gene assembly

US7198924B2
(en)

2000-12-11
2007-04-03
Invitrogen Corporation
Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites

AU2001284997A1
(en)

*

2000-08-24
2002-03-04
Maxygen, Inc.
Constructs and their use in metabolic pathway engineering

JP2002083691A
(en)

*

2000-09-06
2002-03-22
Sharp Corp
Active matrix driven organic led display unit and its manufacturing method

CA2422749A1
(en)

*

2000-09-21
2002-03-28
Merck & Co., Inc.
Method for generating recombinant polynucleotides

US7202070B2
(en)

*

2000-10-31
2007-04-10
Biocatalytics, Inc.
Method for reductive amination of a ketone using a mutated enzyme

US6955879B2
(en)

*

2000-11-10
2005-10-18
Amicogen, Inc.
Method for generating recombinant DNA library using unidirectional single-stranded DNA fragments

US6958213B2
(en)

*

2000-12-12
2005-10-25
Alligator Bioscience Ab
Method for in vitro molecular evolution of protein function

DE10062086A1
(en)

*

2000-12-13
2002-07-04
Wella Ag

Agent and method of dyeing keratin fibers

US20020086292A1
(en)

2000-12-22
2002-07-04
Shigeaki Harayama
Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules

US20020150895A1
(en)

*

2000-12-22
2002-10-17
Raymond Wheeler
Method and apparatus for filtering and extending RNA alignment coverage

US20030036854A1
(en)

*

2001-02-06
2003-02-20
The Penn State Research Foundation
Apparatus and method for designing proteins and protein libraries

EP3305894A1
(en)

2001-02-21
2018-04-11
BASF Enzymes LLC
Enzymes having alpha amylase activity and methods of use thereof

US7465567B2
(en)

*

2001-04-16
2008-12-16
California Institute Of Technology
Peroxide-driven cytochrome P450 oxygenase variants

CA2444020A1
(en)

*

2001-05-03
2002-11-14
Rensselaer Polytechnic Institute
Novel methods of directed evolution

AU2002342955A1
(en)

*

2001-05-17
2002-11-25
Proteus
Method of preparing polynucleotide fragments for use in shuffling, and shuffling of same

KR100430534B1
(en)

*

2001-05-23
2004-05-10
주식회사 마이크로아이디
Method for constructing a chimeric dna library using a single strand specific dnase

DK2327765T3
(en)

2001-06-21
2015-07-13
Basf Enzymes Llc
nitrilases

WO2003000941A2
(en)

2001-06-26
2003-01-03
Novozymes A/S
Polypeptides having cellobiohydrolase i activity and polynucleotides encoding same

WO2003008563A2
(en)

2001-07-20
2003-01-30
California Institute Of Technology
Improved cytochrome p450 oxygenases

DE60202478T3
(en)

2001-07-23
2010-01-07
Dsm Ip Assets B.V.

METHOD FOR PRODUCING POLYNUCLEOTIDE VARIANTS

DE60232523D1
(en)

*

2001-07-26
2009-07-16
Stratagene California

MULTI-JOBS Mutagenesis

US7364890B2
(en)

*

2001-07-28
2008-04-29
Midwest Research Institute
Thermal tolerant avicelase from Acidothermus cellulolyticus

US6943001B2
(en)

*

2001-08-03
2005-09-13
Diversa Corporation
Epoxide hydrolases, nucleic acids encoding them and methods for making and using them

CA2456229A1
(en)

*

2001-08-03
2003-02-13
Diversa Corporation
Epoxide hydrolases, nucleic acids encoding them and methods for making and using them

US6987079B2
(en)

*

2001-08-14
2006-01-17
W.R. Grace & Co.-Conn.
Supported catalyst systems

DK2279753T3
(en)

2001-10-10
2015-11-23
Novo Nordisk As
The conversion of peptides and glycokonjugering

BRPI0213207B1
(en)

2001-10-10
2021-06-15
Novo Nordisk A/S

IN VITRO CELL FREE PROCESS FOR THE RENOVATION OF A PEPTIDE AND PROCESSES TO FORM A CONJUGATE BETWEEN PEPTIDES AND A MODIFICATION GROUP

CA2468710A1
(en)

*

2001-12-03
2003-06-12
Diversa Corporation
Chromosomal saturation mutagenesis

AU2002366523A1
(en)

*

2001-12-05
2003-06-23
E-Tenna Corporation
Capacitively-loaded bent-wire monopole on an artificial magnetic conductor

GB0202206D0
(en)

*

2002-01-31
2002-03-20
Bioinvent Int Ab
Method of making libraries of anti-ligands

AU2002306484A1
(en)

2002-02-13
2003-09-04
Dow Global Technologies Inc.
Over-expression of extremozyme genes in pseudomonads and closely related bacteria

CA2476362A1
(en)

*

2002-02-15
2003-08-28
Diversa Corporation
Chimeric cannulae proteins, nucleic acids encoding them and methods for making and using them

WO2003072054A2
(en)

*

2002-02-25
2003-09-04
Cabot Corporation
Custom ligand design for biomolecular filtration and purification for bioseperation

CA2475547A1
(en)

*

2002-02-26
2003-09-04
E.I. Du Pont De Nemours And Company
Method for the recombination of genetic elements

US20040132101A1
(en)

2002-09-27
2004-07-08
Xencor
Optimized Fc variants and methods for their generation

BRPI0309391B1
(en)

2002-04-19
2018-10-30
Dsm Food Specialties B V

vector comprising nucleic acid encoding phospholipase activity polypeptide, transformed cell, protein preparation, preparation method and related methods

US7226771B2
(en)

2002-04-19
2007-06-05
Diversa Corporation
Phospholipases, nucleic acids encoding them and methods for making and using them

US7405062B2
(en)

*

2002-05-14
2008-07-29
San Diego Antibody
Method for cloning variable domain sequences of immunological gene repertoire

ES2285118T5
(en)

*

2002-05-17
2012-09-21
Alligator Bioscience Ab

A METHOD FOR IN VITRO MOLECULAR DEVELOPMENT OF A PROTEIC FUNCTION.

WO2004009761A2
(en)

2002-07-18
2004-01-29
Monsanto Technology Llc
Methods for using artificial polynucleotides and compositions thereof to reduce transgene silencing

EP1527173A1
(en)

*

2002-07-23
2005-05-04
Nuevolution A/S
Gene shuffing by template switching

AU2003256731A1
(en)

*

2002-08-02
2004-02-23
Aromagen Corporation
Methods for making (-) -menthol and oxygenated menthane compounds

CA2494798A1
(en)

2002-08-06
2005-01-13
Verdia, Inc.
Ap1 amine oxidase variants

WO2004029207A2
(en)

2002-09-27
2004-04-08
Xencor Inc.
Optimized fc variants and methods for their generation

ATE438711T1
(en)

2002-12-20
2009-08-15
Novozymes As

POLYPEPTIDES WITH CELLOBIOHYDROLASE II ACTIVITY AND POLYNUCLEOTIDES CODING THEREFOR

EP3023498B1
(en)

2003-03-06
2018-11-28
BASF Enzymes LLC
Amylases, nucleic acids encoding them and methods for making and using them

US8298799B2
(en)

2003-03-07
2012-10-30
Dsm Ip Assets B. V.
Hydrolases, nucleic acids encoding them and methods for making and using them

EP2390352A1
(en)

2003-03-18
2011-11-30
Quantum Genetics Ireland Limited
Systems and methods for improving protein and milk production of dairy herds

MXPA05010681A
(en)

2003-04-04
2005-12-15
Diversa Corp
Pectate lyases, nucleic acids encoding them and methods for making and using them.

EP2338333B1
(en)

2003-04-09
2017-09-06
ratiopharm GmbH
Glycopegylation methods and proteins/peptides produced by the methods

JP2007500514A
(en)

2003-04-29
2007-01-18
パイオニア ハイ−ブレッド インターナショナル, インコーポレイテッド

Novel glyphosate N-acetyltransferase (GAT) gene

US20050009772A1
(en)

*

2003-05-06
2005-01-13
The Regents Of The University Of California
Methods and compositions for the treatment of glaucoma and other retinal diseases

WO2005017105A2
(en)

2003-06-17
2005-02-24
California University Of Technology
Regio- and enantioselective alkane hydroxylation with modified cytochrome p450

EP2404931A1
(en)

2003-07-02
2012-01-11
Verenium Corporation
Glucanases, nucleic acids encoding them and methods for making and using them

US7435570B2
(en)

*

2003-08-11
2008-10-14
California Institute Of Technology
Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use

CA2535526C
(en)

2003-08-11
2015-09-29
Diversa Corporation
Laccases, nucleic acids encoding them and methods for making and using them

DK1664343T3
(en)

2003-09-09
2014-08-11
Integrigen Inc

METHODS AND COMPOSITIONS FOR GENERATING CHIMELY HUMAN ANTIBODY GENES

EP1704246A4
(en)

*

2003-09-30
2007-11-28
Perkinelmer Las Inc
Compositions and processes for genotyping single nucleotide polymorphisms

US20050084868A1
(en)

*

2003-10-16
2005-04-21
Wolfgang Aehle
Generation of stabilized proteins by combinatorial consensus mutagenesis

CA2546698A1
(en)

*

2003-11-20
2005-06-02
Agency For Science, Technology And Research
Method

DE602004027538D1
(en)

2003-12-01
2010-07-15
Life Technologies Corp

NUCLEIC ACID MOLECULES AND RECOMBINATION AGENTS CONTAINED THEREOF

BRPI0507929A
(en)

2004-02-19
2007-07-17
Univ Alberta

leptin promoter polymorphisms and their uses

US7208474B2
(en)

2004-02-25
2007-04-24
Pioneer Hi-Bred International, Inc.
Bacillus thuringiensis crystal polypeptides, polynucleotides, and compositions thereof

AU2005215852B2
(en)

2004-02-25
2010-04-22
Novozymes A/S
Fungal cell wall degrading enzyme

AR049214A1
(en)

2004-06-09
2006-07-05
Pioneer Hi Bred Int

PEPTIDES OF TRANSIT TO PLASTIDES

WO2006009676A2
(en)

2004-06-16
2006-01-26
Diversa Corporation
Compositions and methods for enzymatic decolorization of chlorophyll

JP2008507282A
(en)

2004-07-20
2008-03-13
アイソジェニス・インコーポレイテッド

Specific inhibition of diseases related to autoimmunity and self-antigen

US20080176790A1
(en)

2004-10-29
2008-07-24
Defrees Shawn
Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)

US9489496B2
(en)

*

2004-11-12
2016-11-08
Apple Inc.
Secure software updates

EP2886658A1
(en)

2005-03-10
2015-06-24
BASF Enzymes LLC
Lyase enzymes, nucleic acids encoding them and methods for making and using them

CA2611859C
(en)

2005-03-15
2015-03-31
Verenium Corporation
Cellulases, nucleic acids encoding them and methods for making and using them

EP2360256B1
(en)

*

2005-03-25
2014-12-31
National Research Council of Canada
Method for isolation of soluble polypeptides

US8715988B2
(en)

2005-03-28
2014-05-06
California Institute Of Technology
Alkane oxidation by modified hydroxylases

US11214817B2
(en)

2005-03-28
2022-01-04
California Institute Of Technology
Alkane oxidation by modified hydroxylases

WO2006121569A2
(en)

2005-04-08
2006-11-16
Neose Technologies, Inc.
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants

CA2612760C
(en)

2005-06-21
2015-05-12
Xoma Technology Ltd.
Il-1.beta. binding antibodies and fragments thereof

GB2432366B
(en)

*

2005-11-19
2007-11-21
Alligator Bioscience Ab
A method for in vitro molecular evolution of protein function

EP1987142A4
(en)

2006-02-02
2009-07-15
Verenium Corp
Esterases and related nucleic acids and methods

EP2447363B1
(en)

2006-02-10
2014-02-12
Verenium Corporation
Cellucloytic enzymes, nucleic acids encoding them and methods for making and using them

EP2548956A1
(en)

2006-02-14
2013-01-23
Verenium Corporation
Xylanases, nucleic acids encoding them and methods for making and using them

AU2007223913B2
(en)

2006-03-07
2013-06-13
Cargill, Incorporated
Aldolases, nucleic acids encoding them and methods for making and using them

BR122017003017B1
(en)

2006-03-07
2018-10-23
Basf Enzymes Llc

NUCLEIC ACID, EXPRESSION CASSETTE, VECTOR, CLONING VEHICLE, MOTRANSGENIC MICROORGANISM, POLYPEPTIDE, SIGNAL PEPTIDE, COMPOSITION, AND METHODS TO PRODUCE A RECOMBINANT CARIAN CARD A NON-CARBONIZED LIP FOR A NERCARIOUS CARBON TO FORM A CARBON-CARBON CONNECTION, TO MAKE A FOOD, FEED OR DRINK, AND TO CONVERT A BIOMASS ANY LIGNOCELLULOSTIC MATERIAL INTO A FUEL

US7846712B2
(en)

*

2006-06-01
2010-12-07
Alliance For Sustainable Energy, Llc
L-arabinose fermenting yeast

US8252559B2
(en)

*

2006-08-04
2012-08-28
The California Institute Of Technology
Methods and systems for selective fluorination of organic molecules

BRPI0714876B1
(en)

2006-08-04
2022-04-19
Verenium Corporation

Isolated, synthetic or recombinant nucleic acid, expression cassette, cloning vector or vehicle, transformed bacterial, fungal or yeast cell, isolated, synthetic or recombinant polypeptide, composition, as well as production methods and uses thereof

WO2008016709A2
(en)

*

2006-08-04
2008-02-07
California Institute Of Technology
Methods and systems for selective fluorination of organic molecules

PT2397486E
(en)

2006-09-21
2015-03-23
Basf Enzymes Llc
Phytases, nucleic acids encoding them and methods for making and using them

KR20090068266A
(en)

2006-09-21
2009-06-25
베레늄 코포레이션
Phospholipases, nucleic acids encoding them and methods for making and using them

DK2479267T3
(en)

2006-12-21
2017-03-27
Basf Enzymes Llc

Amylases and Glucoamylases, Nucleic Acids Encoding Them, and Methods for Preparing and Using Them

AR065544A1
(en)

2007-01-30
2009-06-17
Verenium Corp

ENZYMES FOR THE TREATMENT OF NUCLEIC ACID LIGNOCELLULOSICS THAT CODE AND METHODS TO PREPARE AND USE THEM

EP2115153B1
(en)

2007-03-01
2013-06-05
BP Corporation North America Inc.
Nitrilases, nucleic acids encoding them and methods for making and using them

US8802401B2
(en)

*

2007-06-18
2014-08-12
The California Institute Of Technology
Methods and compositions for preparation of selectively protected carbohydrates

EP3031919B1
(en)

*

2007-07-31
2018-09-19
BASF Enzymes LLC
Tailored multi-site combinational assembly

US8486680B2
(en)

2007-10-03
2013-07-16
Bp Corporation North America Inc.
Xylanases, nucleic acids encoding them and methods for making and using them

US8497127B2
(en)

2007-12-03
2013-07-30
Syngenta Participations Ag
Engineering enzymatically susceptible proteins

CN104651381A
(en)

2008-01-03
2015-05-27
巴斯夫酶有限责任公司
Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them

US8541220B2
(en)

2008-01-03
2013-09-24
Verenium Corporation
Isomerases, nucleic acids encoding them and methods for making and using them

CN102027109B
(en)

2008-05-16
2016-01-06
Reg生命科学有限责任公司
Produce the method and composition of hydrocarbon polymer

US20090312196A1
(en)

*

2008-06-13
2009-12-17
Codexis, Inc.
Method of synthesizing polynucleotide variants

US8383346B2
(en)

*

2008-06-13
2013-02-26
Codexis, Inc.
Combined automated parallel synthesis of polynucleotide variants

US8153391B2
(en)

2008-08-29
2012-04-10
Bunge Oils, Inc.
Hydrolases, nucleic acids encoding them and methods for making and using them

US8198062B2
(en)

2008-08-29
2012-06-12
Dsm Ip Assets B.V.
Hydrolases, nucleic acids encoding them and methods for making and using them

US8357503B2
(en)

2008-08-29
2013-01-22
Bunge Oils, Inc.
Hydrolases, nucleic acids encoding them and methods for making and using them

EP2975122B1
(en)

2008-10-07
2018-06-06
REG Life Sciences, LLC
Method and compositions for producing fatty aldehydes

CN105154380B
(en)

2008-10-28
2018-11-09
Reg生命科学有限责任公司
Method and composition for generating fatty alcohol

JP5882058B2
(en)

2008-11-07
2016-03-09
ファブラス エルエルシー

Combination antibody library and use thereof

BRPI1011160A8
(en)

2009-05-21
2018-01-02
Verenium Corp

PHYTASES, PROTEIN PREPARATION INCLUDING THEM, AND THEIR USES

US9133406B2
(en)

2009-09-25
2015-09-15
REG Life Sciences, LLC
Production of fatty acid derivatives

UA109884C2
(en)

2009-10-16
2015-10-26

A POLYPEPTIDE THAT HAS THE ACTIVITY OF THE PHOSPHATIDYLINOSYTOL-SPECIFIC PHOSPHOLIPASE C, NUCLEIC ACID, AND METHOD OF METHOD

UA111708C2
(en)

2009-10-16
2016-06-10
Бандж Ойлз, Інк.

METHOD OF OIL REFINING

US9267148B2
(en)

2009-11-02
2016-02-23
Plant Sensory Systems, Llc
Methods for the biosynthesis of taurine or hypotaurine in cells

EP2496600A1
(en)

2009-11-04
2012-09-12
Fabrus LLC
Methods for affinity maturation-based antibody optimization

WO2011089574A2
(en)

2010-01-22
2011-07-28
Proteus
Methods of generating modified polynucleotide libraries and methods of using the same for directed protein evolution

WO2011100667A1
(en)

2010-02-14
2011-08-18
Ls9, Inc.
Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols

WO2011116396A2
(en)

2010-03-19
2011-09-22
The Board Of Trustees Of The Leland Stanford Junior University
Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists

AU2011230633B2
(en)

2010-03-26
2015-01-22
Mayo Foundation For Medical Education And Research
Methods and materials for detecting colorectal neoplasm

AR084377A1
(en)

2010-04-08
2013-05-15
Ls9 Inc

METHODS AND COMPOSITIONS RELATED TO BIOSYNTHETIC ALCOHOL FAT ENZYMES

US9068017B2
(en)

2010-04-08
2015-06-30
Ibis Biosciences, Inc.
Compositions and methods for inhibiting terminal transferase activity

WO2012009660A2
(en)

2010-07-15
2012-01-19
The Procter & Gamble Company
Detergent compositions comprising microbially produced fatty alcohols and derivatives thereof

AU2011289283B2
(en)

2010-08-13
2015-04-30
Pioneer Hi-Bred International, Inc.
Chimeric promoters and methods of use

WO2012051055A2
(en)

2010-10-06
2012-04-19
Bp Corporation North America Inc.
Variant cbh i polypeptides

WO2012054730A1
(en)

2010-10-22
2012-04-26
Oslo Universitetssykehus Hf
Methods and kits for detection of 5-hydroxymethylcytosine

ES2829198T3
(en)

2011-02-02
2021-05-31
Exact Sciences Dev Co Llc

Digital sequence analysis of DNA methylation

WO2012106579A1
(en)

2011-02-03
2012-08-09
Bristol-Myers Squibb Company
Amino acid dehydrogenase and its use in preparing amino acids from keto acids

US20140031257A1
(en)

2011-03-10
2014-01-30
Oslo Universitetssykehus Hf
Methods and biomarkers for detection of gastrointestinal cancers

CA2869144A1
(en)

2011-03-30
2012-10-04
Ls9, Inc.
Compositions comprising and methods for producing beta-hydroxy fatty acid esters

SI2906587T1
(en)

2011-04-01
2020-12-31
Genomatica, Inc.
Methods and compositions for improved production of fatty acids and derivatives thereof

US8993341B2
(en)

2011-05-12
2015-03-31
Exact Sciences Corporation
Removal of PCR inhibitors

US8808990B2
(en)

2011-05-12
2014-08-19
Exact Sciences Corporation
Serial isolation of multiple DNA targets from stool

US9000146B2
(en)

2011-05-12
2015-04-07
Exact Sciences Corporation
Isolation of nucleic acids

WO2013019647A1
(en)

2011-08-03
2013-02-07
Ls9, Inc.
Production of fatty acids and derivatives thereof having improved aliphatic chain length and saturation characteristics

WO2013064908A1
(en)

2011-11-04
2013-05-10
Oslo Universitetssykehus Hf
Methods and biomarkers for analysis of colorectal cancer

EP3425065B1
(en)

2011-12-13
2021-04-21
Oslo Universitetssykehus HF
Methods and kits for detection of methylation status

US9822417B2
(en)

2012-01-09
2017-11-21
Oslo Universitetssykehus Hf
Methods and biomarkers for analysis of colorectal cancer

US9506117B2
(en)

2012-02-21
2016-11-29
Oslo Universitetssykehus Hf
Methods and biomarkers for detection and prognosis of cervical cancer

WO2013138339A1
(en)

*

2012-03-15
2013-09-19
Codexis, Inc.
Gene shuffling methods

WO2013152051A2
(en)

2012-04-02
2013-10-10
Ls9, Inc.
Improved production of fatty acid derivatives

BR112014024674B1
(en)

2012-04-02
2022-06-07
Genomatica, Inc

Variant carboxylic acid reductase (car) polypeptide, recombinant escherichia coli host cell, cell culture, and method of producing a fatty alcohol composition with high titer, yield, or productivity

CN104411823A
(en)

2012-05-04
2015-03-11
纳幕尔杜邦公司
Compositions and methods comprising sequences having meganuclease activity

WO2013177191A1
(en)

2012-05-21
2013-11-28
The Scripps Research Institute
Ribosomal polynucleotides and related expression systems

DK2885407T3
(en)

2012-08-16
2018-07-16
Bangladesh Jute Res Institute

DESTROYING ENZYMES FROM MACROPHOMINA PHASEOLINA AND ITS APPLICATIONS

MY175956A
(en)

2012-08-16
2020-07-16
Bangladesh Jute Res Institute
Cellulose and/or hemicelluloses degrading enzymes from macrophomina phaseolina and uses thereof

BR112015005782A2
(en)

2012-09-14
2017-08-08
Reg Life Sciences Llc

Enzyme variants with enhanced ester synthase properties

US9212392B2
(en)

2012-09-25
2015-12-15
Exact Sciences Corporation
Normalization of polymerase activity

AU2013204200B2
(en)

2012-10-11
2016-10-20
Brandeis University
Treatment of amyotrophic lateral sclerosis

US9710596B2
(en)

2012-11-21
2017-07-18
Exact Sciences Corporation
Methods for quantifying nucleic acid variations

MX2015007361A
(en)

2012-12-12
2015-09-10
Reg Life Sciences Llc
Acp-mediated production of fatty acid derivatives.

CN105051189B
(en)

2013-01-16
2019-08-06
Reg生命科学有限责任公司
With the acyl-acp reductase for improving characteristic

GB201308828D0
(en)

2013-03-12
2013-07-03
Verenium Corp
Phytase

EP2970995A1
(en)

2013-03-14
2016-01-20
Pioneer Hi-Bred International, Inc.
Compositions having dicamba decarboxylase activity and methods of use

GB201308843D0
(en)

2013-03-14
2013-07-03
Verenium Corp
Phytase formulation

WO2014159650A2
(en)

2013-03-14
2014-10-02
Mayo Foundation For Medical Education And Research
Detecting neoplasm

CA2904537A1
(en)

2013-03-14
2014-09-25
Pioneer Hi-Bred International, Inc.
Compositions having dicamba decarboxylase activity and methods of use

WO2014184684A2
(en)

2013-05-16
2014-11-20
Oslo Universitetssykehus Hf
Methods and biomarkers for detection of hematological cancers

KR20220053681A
(en)

2013-06-14
2022-04-29
게노마티카 인코포레이티드
Methods of producing omega-hydroxylated fatty acid derivatives

US10093909B2
(en)

2013-07-25
2018-10-09
Basf Enzymes Llc
Phytase

AU2014318531B2
(en)

2013-09-13
2020-10-08
Genomatica, Inc.
Improved acetyl-CoA carboxylase variants

CA2924669C
(en)

2013-09-20
2023-03-21
The Regents Of The University Of Michigan
Compositions and methods for the analysis of radiosensitivity

WO2015066695A1
(en)

2013-11-04
2015-05-07
Exact Sciences Corporation
Multiple-control calibrators for dna quantitation

US10138524B2
(en)

2013-12-19
2018-11-27
Exact Sciences Development Company, Llc
Synthetic nucleic acid control molecules

WO2015107430A2
(en)

2014-01-16
2015-07-23
Oslo Universitetssykehus Hf
Methods and biomarkers for detection and prognosis of cervical cancer

EP3839071A1
(en)

2014-03-31
2021-06-23
Mayo Foundation for Medical Education and Research
Detecting colorectal neoplasm

SI3087179T1
(en)

2014-06-16
2020-10-30
Genomatica, Inc.
Omega-hydroxylase-related fusion polypeptides with improved properties

CN113981057A
(en)

2014-12-12
2022-01-28
精密科学公司
Compositions and methods for performing methylation detection assays

CN107208135B
(en)

2014-12-12
2021-10-15
精密科学公司
Compositions and methods for performing methylation detection assays

US10435755B2
(en)

2015-03-27
2019-10-08
Exact Sciences Development Company, Llc
Detecting esophageal disorders

EP3280818A2
(en)

2015-04-07
2018-02-14
Novozymes A/S
Methods for selecting enzymes having lipase activity

EP3280817A2
(en)

2015-04-07
2018-02-14
Novozymes A/S
Methods for selecting enzymes having enhanced activity

KR20180068985A
(en)

2015-10-30
2018-06-22
이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨

Detection of complex amplification and separation and detection of DNA from plasma

WO2017101987A1
(en)

2015-12-15
2017-06-22
REG Life Sciences, LLC
Omega-hydroxylase-related fusion polypeptide variants with improved properties

CN109312333A
(en)

2016-04-07
2019-02-05
诺维信公司
The method for selecting that there is the enzyme of proteinase activity

AU2017260630B2
(en)

2016-05-05
2023-07-13
Exact Sciences Corporation
Detection of lung neoplasia by analysis of methylated DNA

US20170321286A1
(en)

2016-05-05
2017-11-09
Exact Sciences Corporation
Detection of lung neoplasia by amplification of rna sequences

EP3488003B1
(en)

2016-07-19
2023-10-25
Exact Sciences Corporation
Nucleic acid control molecules from non-human organisms

EP3488004B1
(en)

2016-07-19
2021-10-06
Exact Sciences Development Company, LLC
Methylated control dna

KR20190045188A
(en)

2016-09-02
2019-05-02
메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치

Hepatocellular carcinoma detection

MX2019007402A
(en)

2016-12-21
2019-11-05
Creatus Biosciences Inc
Method and organism expressing metschnikowia xylose transporters for increased xylose uptake.

CA3047841A1
(en)

2016-12-21
2018-06-28
Creatus Biosciences Inc.
Xylitol producing metschnikowia species

WO2018127786A1
(en)

2017-01-06
2018-07-12
Oslo Universitetssykehus Hf
Compositions and methods for determining a treatment course of action

EP3574110A4
(en)

2017-01-27
2021-01-13
Exact Sciences Development Company, LLC
Detection of colon neoplasia by analysis of methylated dna

US11667952B2
(en)

*

2017-08-24
2023-06-06
Takara Bio Usa, Inc.
Methods of producing nucleic acids using oligonucleotides modified by a stimulus

US10648025B2
(en)

2017-12-13
2020-05-12
Exact Sciences Development Company, Llc
Multiplex amplification detection assay II

WO2020099938A2
(en)

2018-11-16
2020-05-22
Oslo Universitetssykehus Hf
Methods and compositions for characterizing bladder cancer

KR20220092561A
(en)

2019-10-31
2022-07-01
메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치

Ovarian Cancer Detection

US20230063705A1
(en)

2020-01-21
2023-03-02
Qingdao Navid Biotechnology Co., Ltd.
Methods and kits for amplification and detection of nucleic acids

WO2021253115A1
(en)

2020-06-15
2021-12-23
Melio Peptide Systems Inc.
Microorganisms and methods for reducing bacterial contamination

AU2021329899A1
(en)

2020-08-19
2023-03-09
Exact Sciences Corporation
Detecting non-hodgkin lymphoma

WO2023021330A1
(en)

2021-08-16
2023-02-23
University Of Oslo
Compositions and methods for determining a treatment course of action

WO2023081167A2
(en)

2021-11-02
2023-05-11
The Regents Of The University Of California
P-selectin mutants and modulation of integrin-mediated signaling

WO2023146807A1
(en)

2022-01-25
2023-08-03
The Regents Of The University Of California
Vegf mutants and modulation of integrin-mediated signaling

Family Cites Families (22)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4965188A
(en)

*

1986-08-22
1990-10-23
Cetus Corporation
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme

US5333675C1
(en)

*

1986-02-25
2001-05-01
Perkin Elmer Corp
Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps

US4683202A
(en)

*

1985-03-28
1987-07-28
Cetus Corporation
Process for amplifying nucleic acid sequences

US5176995A
(en)

*

1985-03-28
1993-01-05
Hoffmann-La Roche Inc.
Detection of viruses by amplification and hybridization

DE3590766T
(en)

1985-03-30
1987-04-23

US4638202A
(en)

1985-09-11
1987-01-20
Resinoid Engineering Corporation
Commutator and method of making same

US4800159A
(en)

*

1986-02-07
1989-01-24
Cetus Corporation
Process for amplifying, detecting, and/or cloning nucleic acid sequences

US5354656A
(en)

*

1989-10-02
1994-10-11
Stratagene
Method of DNA sequencing

EP0528881A4
(en)

*

1990-04-24
1993-05-26
Stratagene
Methods for phenotype creation from multiple gene populations

US5234824A
(en)

*

1990-11-13
1993-08-10
Specialty Laboratories, Inc.
Rapid purification of DNA

US5187083A
(en)

*

1990-11-13
1993-02-16
Specialty Laboratories, Inc.
Rapid purification of DNA

US5645988A
(en)

*

1991-05-08
1997-07-08
The United States Of America As Represented By The Department Of Health And Human Services
Methods of identifying drugs with selective effects against cancer cells

DE4343591A1
(en)

*

1993-12-21
1995-06-22
Evotec Biosystems Gmbh

Process for the evolutionary design and synthesis of functional polymers based on shape elements and shape codes

WO1995021270A2
(en)

*

1994-02-04
1995-08-10
Beckman Instruments, Inc.
Method, reagent and kit for the detection and amplification of nucleic acid sequences

US5605793A
(en)

*

1994-02-17
1997-02-25
Affymax Technologies N.V.
Methods for in vitro recombination

US6117679A
(en)

1994-02-17
2000-09-12
Maxygen, Inc.
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination

US5837458A
(en)

*

1994-02-17
1998-11-17
Maxygen, Inc.
Methods and compositions for cellular and metabolic engineering

JPH08217620A
(en)

*

1995-02-15
1996-08-27
Meiji Milk Prod Co Ltd
Melanogenesis inhibitor and skin cosmetic

US5965408A
(en)

*

1996-07-09
1999-10-12
Diversa Corporation
Method of DNA reassembly by interrupting synthesis

US6096548A
(en)

*

1996-03-25
2000-08-01
Maxygen, Inc.
Method for directing evolution of a virus

CA2386090A1
(en)

1999-10-27
2001-05-03
California Institute Of Technology
Production of functional hybrid genes and proteins

US20020051998A1
(en)

1999-12-08
2002-05-02
California Institute Of Technology
Directed evolution of biosynthetic and biodegradation pathways

1996

1996-07-09
US
US08/677,112
patent/US5965408A/en
not_active
Expired – Lifetime

1997

1997-07-09
EP
EP97933438A
patent/EP1007727A4/en
not_active
Withdrawn

1997-07-09
CA
CA002259628A
patent/CA2259628A1/en
not_active
Abandoned

1997-07-09
AU
AU36626/97A
patent/AU724521B2/en
not_active
Ceased

1997-07-09
WO
PCT/US1997/012239
patent/WO1998001581A1/en
not_active
Application Discontinuation

1997-07-09
JP
JP10505366A
patent/JP2000514651A/en
not_active
Ceased

1997-07-09
IL
IL12797297A
patent/IL127972A0/en
unknown

1999

1999-08-17
US
US09/376,727
patent/US6440668B1/en
not_active
Expired – Lifetime

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU741834B2
(en)

*

1997-03-18
2001-12-13
Novozymes A/S
An (in vitro) method for construction of a dna library

Also Published As

Publication number
Publication date

EP1007727A1
(en)

2000-06-14

WO1998001581A1
(en)

1998-01-15

JP2000514651A
(en)

2000-11-07

IL127972A0
(en)

1999-11-30

US6440668B1
(en)

2002-08-27

EP1007727A4
(en)

2000-08-23

AU724521B2
(en)

2000-09-21

CA2259628A1
(en)

1998-01-15

US5965408A
(en)

1999-10-12

Similar Documents

Publication
Publication Date
Title

AU3662697A
(en)

1998-02-02

Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process

AU1824697A
(en)

1997-08-01

A water vapor annealing process

AU4635597A
(en)

1998-05-05

Gene synthesis method

AU7551594A
(en)

1995-02-28

Method for recognition of the nucleotide sequence of a purified dna segment

IL130308A0
(en)

2000-06-01

Salting-out process of crystallizing 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo¬5.5.0.0.5,903,11¾-dodecane

AU3890795A
(en)

1996-05-06

Improved method for nucleotide sequence amplification

AU2171497A
(en)

1997-10-22

Process for the purification of butane-1,4-diol

EP0807657A4
(en)

1998-10-21

Process for producing polycarbonate

AU4149197A
(en)

1998-03-19

Method for production of magnesium

AU3447597A
(en)

1998-02-02

Method for the production of a therapeutic DNA

AU7817994A
(en)

1995-05-08

Catalytic process

AU6886991A
(en)

1991-06-13

A method of synthesizing double-stranded dna molecules

AU6614198A
(en)

1998-08-07

Purification process

AU6039394A
(en)

1994-08-29

Process for making 1,3-diols and 3-hydroxyaldehydes

AU7959994A
(en)

1995-05-22

Perchlorate removal process

AU4265997A
(en)

1998-06-10

Hoop earring

AU7440596A
(en)

1997-04-30

Sewage process method

AU2781597A
(en)

1997-12-05

Improved process for the production of scratch-off cards

AU1640997A
(en)

1997-10-02

Process for passivating surgical needles

AU3827393A
(en)

1993-11-11

Improved prilling process

EP0974647A4
(en)

2002-10-23

Process for producing target substances by fermentation

AUPN564495A0
(en)

1995-10-19

Recovery of vanadium

AU4222996A
(en)

1996-08-22

Process for growing virus

AU1118797A
(en)

1997-05-29

Process

AU1879397A
(en)

1997-09-16

A process for the preparation of copolymers

Legal Events

Date
Code
Title
Description

2001-01-25
FGA
Letters patent sealed or granted (standard patent)

Download PDF in English

None