AU5241490A

AU5241490A – Platinum complexes and antitumor agents containing them as an active ingredient
– Google Patents

AU5241490A – Platinum complexes and antitumor agents containing them as an active ingredient
– Google Patents
Platinum complexes and antitumor agents containing them as an active ingredient

Info

Publication number
AU5241490A

AU5241490A
AU52414/90A
AU5241490A
AU5241490A
AU 5241490 A
AU5241490 A
AU 5241490A
AU 52414/90 A
AU52414/90 A
AU 52414/90A
AU 5241490 A
AU5241490 A
AU 5241490A
AU 5241490 A
AU5241490 A
AU 5241490A
Authority
AU
Australia
Prior art keywords
antitumor agents
platinum complexes
active ingredient
agents containing
murine leukemia
Prior art date
1989-03-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU52414/90A
Other versions

AU623986B2
(en

Inventor
Yoshihiro Muraoka
Osamu Shiratori
Tetsushi Totani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shionogi and Co Ltd

Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1989-03-30
Filing date
1990-03-30
Publication date
1990-10-04

1990-03-30
Application filed by Shionogi and Co Ltd
filed
Critical
Shionogi and Co Ltd

1990-10-04
Publication of AU5241490A
publication
Critical
patent/AU5241490A/en

1992-05-28
Application granted
granted
Critical

1992-05-28
Publication of AU623986B2
publication
Critical
patent/AU623986B2/en

2010-03-30
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups

C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P35/00—Antineoplastic agents

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C211/00—Compounds containing amino groups bound to a carbon skeleton

C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings

C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton

C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups

C07C62/02—Saturated compounds containing hydroxy or O-metal groups

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups

C07C62/02—Saturated compounds containing hydroxy or O-metal groups

C07C62/04—Saturated compounds containing hydroxy or O-metal groups with a six-membered ring

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System

C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group

C07F15/0086—Platinum compounds

C07F15/0093—Platinum compounds without a metal-carbon linkage

Abstract

Novel platinum complexes of the formula: wherein R<1> and R<2> are identical or different lower alkyl groups, or R<1> and R<2> taken together form a -(CH2)m- bridge, and m is an integer from 2 to 5, and antitumor agents comprising the compounds (I) are disclosed, which are effective against cisplatin-resistant ascitic murine leukemia, murine leukemia, and solid tumors with only slight hemotoxicity and nephrotoxicity.

AU52414/90A
1989-03-30
1990-03-30
Platinum complexes and antitumor agents containing them as an active ingredient

Ceased

AU623986B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

JP1080917A

JP2740919B2
(en)

1989-03-30
1989-03-30

Platinum complexes and antitumor agents containing these as active ingredients

JP1-80917

1989-03-30

Publications (2)

Publication Number
Publication Date

AU5241490A
true

AU5241490A
(en)

1990-10-04

AU623986B2

AU623986B2
(en)

1992-05-28

Family
ID=13731759
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU52414/90A
Ceased

AU623986B2
(en)

1989-03-30
1990-03-30
Platinum complexes and antitumor agents containing them as an active ingredient

Country Status (10)

Country
Link

US
(1)

US4968826A
(en)

EP
(1)

EP0390138B1
(en)

JP
(1)

JP2740919B2
(en)

KR
(1)

KR950004896B1
(en)

AT
(1)

ATE99666T1
(en)

AU
(1)

AU623986B2
(en)

CA
(1)

CA2012155C
(en)

DE
(1)

DE69005676T2
(en)

DK
(1)

DK0390138T3
(en)

ES
(1)

ES2062146T3
(en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US5206400A
(en)

*

1986-07-07
1993-04-27
Ohio State University
Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof

IT1216687B
(en)

*

1988-04-01
1990-03-08
Boehringer Biochemia Srl

PLATINUM (II) COMPLEXES, THEIR PREPARATION AND USE AS ANTI-CANCER PRODUCTS.

US5393909A
(en)

*

1988-11-22
1995-02-28
Board Of Regents, The University Of Texas System
Diamine platinum complexes as antitumor agents

US5130450A
(en)

*

1990-04-25
1992-07-14
Nippon Kayaku Kabushiki Kaisha
Platinum complexes

JPH08176176A
(en)

*

1994-12-26
1996-07-09
Ss Pharmaceut Co Ltd
Platinum complex and malignant tumor-thrapeutic agent containing the same

WO2006091790A1
(en)

*

2005-02-23
2006-08-31
Xenoport, Inc.
Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

JPS5829957B2
(en)

*

1977-09-12
1983-06-25
喜徳 喜谷

Novel platinum complex

JPS59112995A
(en)

*

1982-12-21
1984-06-29
Shionogi & Co Ltd
Novel glycolic acid platinum complex

JPS617283A
(en)

*

1984-06-20
1986-01-13
Shionogi & Co Ltd
Novel platinum complex and anti-malignant tumor agent

EP0169645A1
(en)

*

1984-06-27
1986-01-29
Johnson Matthey Public Limited Company
Platinum co-ordination compounds

US4808730A
(en)

*

1987-06-23
1989-02-28
American Cyanamid Company
Synthesis of cisplatin analogs

1989

1989-03-30
JP
JP1080917A
patent/JP2740919B2/en
not_active
Expired – Fee Related

1990

1990-03-14
CA
CA002012155A
patent/CA2012155C/en
not_active
Expired – Fee Related

1990-03-16
US
US07/495,169
patent/US4968826A/en
not_active
Expired – Lifetime

1990-03-29
DK
DK90106012.9T
patent/DK0390138T3/en
active

1990-03-29
AT
AT90106012T
patent/ATE99666T1/en
not_active
IP Right Cessation

1990-03-29
DE
DE69005676T
patent/DE69005676T2/en
not_active
Expired – Fee Related

1990-03-29
EP
EP90106012A
patent/EP0390138B1/en
not_active
Expired – Lifetime

1990-03-29
ES
ES90106012T
patent/ES2062146T3/en
not_active
Expired – Lifetime

1990-03-30
AU
AU52414/90A
patent/AU623986B2/en
not_active
Ceased

1990-03-30
KR
KR1019900004351A
patent/KR950004896B1/en
not_active
IP Right Cessation

Also Published As

Publication number
Publication date

ATE99666T1
(en)

1994-01-15

ES2062146T3
(en)

1994-12-16

CA2012155A1
(en)

1990-09-30

DE69005676T2
(en)

1994-06-01

KR900014415A
(en)

1990-10-23

JP2740919B2
(en)

1998-04-15

EP0390138B1
(en)

1994-01-05

DE69005676D1
(en)

1994-02-17

EP0390138A1
(en)

1990-10-03

US4968826A
(en)

1990-11-06

KR950004896B1
(en)

1995-05-15

CA2012155C
(en)

1995-11-07

JPH02258790A
(en)

1990-10-19

DK0390138T3
(en)

1994-02-14

AU623986B2
(en)

1992-05-28

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Legal Events

Date
Code
Title
Description

2003-10-30
MK14
Patent ceased section 143(a) (annual fees not paid) or expired

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