AU528825B2

AU528825B2 – (3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
– Google Patents

AU528825B2 – (3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives
– Google Patents
(3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives

Info

Publication number
AU528825B2

AU528825B2
AU50279/79A
AU5027979A
AU528825B2
AU 528825 B2
AU528825 B2
AU 528825B2
AU 50279/79 A
AU50279/79 A
AU 50279/79A
AU 5027979 A
AU5027979 A
AU 5027979A
AU 528825 B2
AU528825 B2
AU 528825B2
Authority
AU
Australia
Prior art keywords
pyridazinyl
dihydro
oxo
benzimidazole derivatives
benzimidazole
Prior art date
1978-08-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
AU50279/79A
Other versions

AU5027979A
(en

Inventor
Volkhard Austel
Willi Diederen
Wolfgang Eberlein
Walter Haarmann
Joachim Heider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1978-08-25
Filing date
1979-08-24
Publication date
1983-05-12

1978-08-25
Priority claimed from DE19782837161
external-priority
patent/DE2837161A1/en

1979-06-01
Priority claimed from DE19792922336
external-priority
patent/DE2922336A1/en

1979-08-24
Application filed by Dr Karl Thomae GmbH
filed
Critical
Dr Karl Thomae GmbH

1980-02-28
Publication of AU5027979A
publication
Critical
patent/AU5027979A/en

1983-05-12
Application granted
granted
Critical

1983-05-12
Publication of AU528825B2
publication
Critical
patent/AU528825B2/en

1999-08-24
Anticipated expiration
legal-status
Critical

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings

C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings

C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines

A61K31/50—Pyridazines; Hydrogenated pyridazines

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings

C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems

C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles

C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2

AU50279/79A
1978-08-25
1979-08-24
(3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives

Expired

AU528825B2
(en)

Applications Claiming Priority (4)

Application Number
Priority Date
Filing Date
Title

DE28371611

1978-08-25

DE19782837161

DE2837161A1
(en)

1978-08-25
1978-08-25
5-Alkyl:pyridazinyl substd. benzimidazole derivs. – useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors

DE19792922336

DE2922336A1
(en)

1979-06-01
1979-06-01
5-Alkyl:pyridazinyl substd. benzimidazole derivs. – useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors

DE29223367

1979-06-01

Publications (2)

Publication Number
Publication Date

AU5027979A

AU5027979A
(en)

1980-02-28

AU528825B2
true

AU528825B2
(en)

1983-05-12

Family
ID=25775527
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU50279/79A
Expired

AU528825B2
(en)

1978-08-25
1979-08-24
(3-oxo-4,5-dihydro-2h-6-pyridazinyl)-benzimidazole derivatives

Country Status (17)

Country
Link

US
(1)

US4361563A
(en)

EP
(1)

EP0008391B1
(en)

AU
(1)

AU528825B2
(en)

BG
(1)

BG60428B2
(en)

CA
(1)

CA1134362A
(en)

CS
(1)

CS410191A3
(en)

DE
(1)

DE2962051D1
(en)

DK
(1)

DK152496C
(en)

ES
(2)

ES8101067A1
(en)

FI
(1)

FI66372C
(en)

GR
(1)

GR69998B
(en)

HK
(1)

HK50585A
(en)

IE
(1)

IE48814B1
(en)

MX
(1)

MX9202731A
(en)

NL
(1)

NL980035I2
(en)

PH
(1)

PH17515A
(en)

SG
(1)

SG285G
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU586852B2
(en)

*

1985-02-19
1989-07-27
Merck Patent Gesellschaft Mit Beschrankter Haftung
Benzimidazolylpyridazinones

Families Citing this family (59)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE3129447A1
(en)

*

1981-07-25
1983-02-10
Dr. Karl Thomae Gmbh, 7950 Biberach

“NEW BENZTRIAZOLES, THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS”

US4699909A
(en)

*

1981-07-25
1987-10-13
Dr. Karl Thomae Gmbh
Benzotriazolyl-4,5-dihydro-3(2H)-pyridazinones

US4353905A
(en)

*

1981-09-17
1982-10-12
Warner-Lambert Company
Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones

IT1172270B
(en)

*

1982-06-21
1987-06-18
Wellcome Found

INTERFERON PRODUCTION PROCEDURE

US4734415A
(en)

*

1982-08-13
1988-03-29
Warner-Lambert Company
Substituted 4,5-dihydro-6-(substituted)-phenyl-3(2H)-pyridazinones and 6-(substituted) phenyl-3(2H)-pyridazinones

US4717730A
(en)

*

1982-12-03
1988-01-05
Warner-Lambert Company
4,5-dihydro-6-(substituted)phenyl-5-methyl-3-(2H)-pyridazinones and pharmaceutical compositions containing the compounds as active components

US4521416A
(en)

*

1983-03-22
1985-06-04
Warner-Lambert Company
4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones

GB8320005D0
(en)

*

1983-07-25
1983-08-24
Fujisawa Pharmaceutical Co
Benzothiazoline derivatives

US4591591A
(en)

*

1984-03-08
1986-05-27
Eli Lilly And Company
Pyridazinone derivatives as inotropic agents

IL75122A
(en)

*

1984-05-14
1989-02-28
Lilly Co Eli
3-methyl-5-(tetrahydro-6-oxopyridazin-3-yl)indoline derivatives,their preparation and use

US4647564A
(en)

*

1984-05-14
1987-03-03
Eli Lilly And Company
Inotropic agents

US4816454A
(en)

*

1984-09-21
1989-03-28
Cassella Aktiengesellschaft
4,5-dihydro-3(2H)-pyridazinones and their pharmacological use

US4617302A
(en)

*

1984-10-15
1986-10-14
Eli Lilly And Company
Inotropic agents

DE3511110A1
(en)

*

1985-03-27
1986-10-02
Dr. Karl Thomae Gmbh, 7950 Biberach

NEW PYRIDAZINONE, THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

US4725686A
(en)

*

1985-11-22
1988-02-16
William H. Rorer, Inc.
Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses

US4868300A
(en)

*

1985-11-22
1989-09-19
Rorer Pharmaceutical Corporation
Benzodiazinone-pyridazinone and hydroxy-pyrazolyl compounds, cardiotonic compositions including the same, and their uses

US4785101A
(en)

*

1985-11-22
1988-11-15
Rorer Pharmaceutical Corporation
Benzodiazinone-hydroxypyrazolyl compounds, cardiotonic compositions including the same and their uses

US4906630A
(en)

*

1985-11-22
1990-03-06
Rorer Pharmaceutical Corporation
Method of increasing cardiac contractility using pharmaceutical compositions comprising benzodiazinone- pyridazinone or hydroxy-pyrazolyl compounds

DE3623944A1
(en)

*

1986-07-16
1988-02-11
Thomae Gmbh Dr K

NEW BENZOLSULFONAMIDO INDANYL COMPOUNDS, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

US4859672A
(en)

*

1986-10-29
1989-08-22
Rorer Pharmaceutical Corporation
Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone

DE3704879A1
(en)

*

1987-02-17
1988-08-25
Merck Patent Gmbh

PYRIDAZINE DERIVATIVES

DE3734083A1
(en)

*

1987-10-08
1989-04-20
Heumann Pharma Gmbh & Co

BENZIMIDAZOLES, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

ATE110071T1
(en)

*

1988-01-23
1994-09-15
Kyowa Hakko Kogyo Kk

PYRIDAZINONE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

DE3805635A1
(en)

*

1988-02-24
1989-09-07
Thomae Gmbh Dr K

USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT WITH ANTI-MIXIC EFFECTS ON THE HEART AND ITS COMBINATIONS WITH SS-BLOCKERS OR BRADYCARDICA

DE3814057A1
(en)

*

1988-04-26
1989-11-09
Heumann Pharma Gmbh & Co

6-OXO-PYRIDAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

US5338743A
(en)

*

1988-06-06
1994-08-16
Fujisawa Pharmaceutical Co., Ltd.
New use of the adenosine antagonist

EP0350990B1
(en)

*

1988-07-11
1995-09-20
Akzo Nobel N.V.
Pyridazinone derivatives

DE3830054A1
(en)

*

1988-09-03
1990-03-15
Boehringer Mannheim Gmbh

PHENYLAMIDES – PROCESS FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

DE3908531A1
(en)

*

1989-03-16
1990-09-20
Thomae Gmbh Dr K

MEDICAMENT WITH A POSITIVE INOTROPIC EFFECT, CONTAINING A SYNERGISTIC MIXTURE CONSISTING OF A BENZIMIDAZOLE AND AN SS BLOCKER, THEIR PREPARATION AND THEIR USE

DE3934436A1
(en)

*

1989-06-01
1991-04-18
Thomae Gmbh Dr K

2-HYDROXY-N-PROPYLAMINES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF

DE4001622A1
(en)

*

1990-01-20
1991-07-25
Thomae Gmbh Dr K

ORAL DRUGS OF PIMOBENDAN

US5364646A
(en)

*

1990-01-10
1994-11-15
Dr. Karl Thomae Gmbh
Oral pharmaceutical forms of pimobendan

EP0497258B1
(en)

*

1991-01-29
2002-01-02
Fujisawa Pharmaceutical Co., Ltd.
Use of adenosine antagonists in the prevention and treatment of pancreatitis and ulcer

PT994890E
(en)

1997-06-10
2003-11-28
Glaxo Group Ltd

BENZIMIDAZOLE DERIVATIVES

US6162804A
(en)

*

1997-09-26
2000-12-19
Merck & Co., Inc.
Tyrosine kinase inhibitors

US6465484B1
(en)

1997-09-26
2002-10-15
Merck & Co., Inc.
Angiogenesis inhibitors

KR100515918B1
(en)

1998-10-23
2005-09-20
토레이가부시끼가이샤
Pharmaceutical composition for modulating immunity

TWI225488B
(en)

*

1999-12-21
2004-12-21
Janssen Pharmaceutica Nv
Derivatives of homopiperidinyl substituted benzimidazole analogues

AU2002226602A1
(en)

*

2000-07-31
2002-04-08
Carl Ernest Alexander
Personal oral hygiene composition and device

AU2002345796A1
(en)

*

2001-06-26
2003-03-03
Beth Israel Deaconess Medical Center
Compositions and methods for inhibiting platelet activation and thrombosis

DE10203086A1
(en)

*

2002-01-28
2003-07-31
Bayer Ag

5-ring heterocycles

DE102004011512B4
(en)

2004-03-08
2022-01-13
Boehringer Ingelheim Vetmedica Gmbh

Pharmaceutical preparation containing pimobendan

US8980894B2
(en)

2004-03-25
2015-03-17
Boehringer Ingelheim Vetmedica Gmbh
Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure

EP1579862A1
(en)

*

2004-03-25
2005-09-28
Boehringer Ingelheim Vetmedica Gmbh
Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure

JP4714921B2
(en)

*

2005-02-14
2011-07-06
トーアエイヨー株式会社

Production method of pimobendan and its intermediate

CN101282929A
(en)

*

2005-08-15
2008-10-08
Irm责任有限公司
Compounds and compositions as tpo mimetics

CN101309685A
(en)

*

2005-11-14
2008-11-19
贝林格尔·英格海姆维特梅迪卡有限公司
Use of pde iii inhibitors or calcium sensitizers for the treatment of asymptomatic (occult) heart failure

EP1920785A1
(en)

*

2006-11-07
2008-05-14
Boehringer Ingelheim Vetmedica Gmbh
Liquid preparation comprising a complex of pimobendan and cyclodextrin

FR2917975B1
(en)

2007-06-26
2009-10-16
Ceva Sante Animale Sa

COMPOSITIONS AND TREATMENT OF CARDIAC INSUFFICIENCY IN NON-HUMAN MAMMAL ANIMALS

NZ592927A
(en)

2008-11-25
2013-07-26
Boehringer Ingelheim Vetmed
PHOSPHODIESTERASE TYPE III (PDE III) INHIBITORS OR CA2+-SENSITIZING AGENTS such as pimobendan FOR THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY

NL1037569C2
(en)

*

2009-12-18
2011-06-21
Eurovet Animal Health B V
Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.

CA2843100A1
(en)

2011-08-12
2013-02-21
Boehringer Ingelheim Vetmedica Gmbh
Funny current (if) inhibitors for use in a method of treating and preventing heart failure in feline

EP2825159B1
(en)

2012-03-15
2022-06-22
Boehringer Ingelheim Vetmedica GmbH
Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof

DK3021832T3
(en)

2013-07-19
2021-05-25
Boehringer Ingelheim Vetmedica Gmbh

PRESERVED ETHERIFIED CYCLODEXTRINE DERIVATIVES CONTAINING LIQUID AQUATIC PHARMACEUTICAL COMPOSITION

ES2593210T3
(en)

2013-12-04
2016-12-07
Boehringer Ingelheim Vetmedica Gmbh

Improved pharmaceutical compositions of pimobendan

US10537570B2
(en)

2016-04-06
2020-01-21
Boehringer Ingelheim Vetmedica Gmbh
Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease

CN106432095B
(en)

*

2016-09-09
2019-04-16
东南大学
The preparation of -3 (2H) -one of pimobendan key intermediate 6- (3,4- diamino-phenyl) -5- methyl -4,5- dihydrogen dazin

CN106518850B
(en)

*

2016-11-15
2019-04-09
青岛农业大学
A kind of chemical synthesis process of pimobendan

WO2022073954A1
(en)

2020-10-08
2022-04-14
Boehringer Ingelheim Vetmedica Gmbh
Use of pimobendan in the anaesthesia of non-human mammals

Family Cites Families (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE2427943C2
(en)

*

1974-06-10
1984-08-02
Dr. Karl Thomae Gmbh, 7950 Biberach

Benzimidazoles, processes for their preparation and pharmaceuticals containing them

DE2516040C2
(en)

*

1974-06-10
1984-12-20
Dr. Karl Thomae Gmbh, 7950 Biberach

Benzimidazoles, processes for their preparation and pharmaceuticals containing them

JPS5416485A
(en)

*

1977-07-08
1979-02-07
Yoshitomi Pharmaceut Ind Ltd
Pyridazinone derivatives and their preparation

1979

1979-07-24
ES
ES482789A
patent/ES8101067A1/en
not_active
Expired

1979-07-25
GR
GR59689A
patent/GR69998B/el
unknown

1979-08-01
DE
DE7979102758T
patent/DE2962051D1/en
not_active
Expired

1979-08-01
EP
EP79102758A
patent/EP0008391B1/en
not_active
Expired

1979-08-23
CA
CA000334357A
patent/CA1134362A/en
not_active
Expired

1979-08-23
FI
FI792628A
patent/FI66372C/en
not_active
IP Right Cessation

1979-08-24
AU
AU50279/79A
patent/AU528825B2/en
not_active
Expired

1979-08-24
IE
IE1629/79A
patent/IE48814B1/en
not_active
IP Right Cessation

1979-08-24
DK
DK354279A
patent/DK152496C/en
not_active
IP Right Cessation

1980

1980-05-29
ES
ES491970A
patent/ES8105001A1/en
not_active
Expired

1981

1981-05-01
US
US06/259,537
patent/US4361563A/en
not_active
Expired – Lifetime

1981-05-26
PH
PH25674A
patent/PH17515A/en
unknown

1985

1985-01-03
SG
SG2/85A
patent/SG285G/en
unknown

1985-07-04
HK
HK505/85A
patent/HK50585A/en
not_active
IP Right Cessation

1991

1991-12-27
CS
CS914101A
patent/CS410191A3/en
unknown

1992

1992-06-08
MX
MX9202731A
patent/MX9202731A/en
unknown

1994

1994-01-25
BG
BG98420A
patent/BG60428B2/en
unknown

1998

1998-11-19
NL
NL980035C
patent/NL980035I2/en
unknown

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU586852B2
(en)

*

1985-02-19
1989-07-27
Merck Patent Gesellschaft Mit Beschrankter Haftung
Benzimidazolylpyridazinones

Also Published As

Publication number
Publication date

FI66372C
(en)

1984-10-10

BG60428B2
(en)

1995-03-31

NL980035I1
(en)

1999-02-01

SG285G
(en)

1985-11-15

DK354279A
(en)

1980-02-26

MX9202731A
(en)

1992-06-30

EP0008391B1
(en)

1982-02-03

ES491970A0
(en)

1981-05-16

IE791629L
(en)

1980-02-25

GR69998B
(en)

1982-07-23

HK50585A
(en)

1985-07-12

FI66372B
(en)

1984-06-29

IE48814B1
(en)

1985-05-29

DK152496C
(en)

1988-07-25

DK152496B
(en)

1988-03-07

PH17515A
(en)

1984-09-13

US4361563A
(en)

1982-11-30

DE2962051D1
(en)

1982-03-11

FI792628A
(en)

1980-02-26

EP0008391A1
(en)

1980-03-05

CA1134362A
(en)

1982-10-26

CS410191A3
(en)

1992-05-13

AU5027979A
(en)

1980-02-28

ES482789A0
(en)

1980-12-01

NL980035I2
(en)

1999-03-01

ES8105001A1
(en)

1981-05-16

ES8101067A1
(en)

1980-12-01

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2000-03-30
MK14
Patent ceased section 143(a) (annual fees not paid) or expired

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