AU530060B2 - Creation of Inventions and Patents with Artificial Intelligence

AU530060B2 – Amino pyridine derivatives
– Google Patents

AU530060B2 – Amino pyridine derivatives
– Google Patents
Amino pyridine derivatives

Info

Publication number
AU530060B2

AU530060B2
AU54397/80A
AU5439780A
AU530060B2
AU 530060 B2
AU530060 B2
AU 530060B2
AU 54397/80 A
AU54397/80 A
AU 54397/80A
AU 5439780 A
AU5439780 A
AU 5439780A
AU 530060 B2
AU530060 B2
AU 530060B2
Authority
AU
Australia
Prior art keywords
alkyl
carbon atoms
group
halogen
radical
Prior art date
1979-01-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Application number
AU54397/80A
Other versions

AU5439780A
(en

Inventor
Hiristos Anagnostopoulos
Wilfried Greve
Heinzgeorg Von Schuh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1979-01-08
Filing date
1980-01-07
Publication date
1983-06-30

1980-01-07
Application filed by Hoechst AG
filed
Critical
Hoechst AG

1980-07-17
Publication of AU5439780A
publication
Critical
patent/AU5439780A/en

1983-06-30
Application granted
granted
Critical

1983-06-30
Publication of AU530060B2
publication
Critical
patent/AU530060B2/en

2000-01-07
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

150000003927
aminopyridines
Chemical class

0.000
title
1

125000004432
carbon atom
Chemical group

0.000
abstract
9

125000000217
alkyl group
Chemical group

0.000
abstract
7

229910052736
halogen
Inorganic materials

0.000
abstract
4

150000002367
halogens
Chemical class

0.000
abstract
4

-1
phenyl-sulfoxy
Chemical group

0.000
abstract
4

229910052739
hydrogen
Inorganic materials

0.000
abstract
3

239000001257
hydrogen
Substances

0.000
abstract
3

150000003254
radicals
Chemical class

0.000
abstract
3

IJGRMHOSHXDMSA-UHFFFAOYSA-N
Atomic nitrogen
Chemical compound

N#N
IJGRMHOSHXDMSA-UHFFFAOYSA-N
0.000
abstract
2

125000003545
alkoxy group
Chemical group

0.000
abstract
2

150000001350
alkyl halides
Chemical class

0.000
abstract
2

125000005842
heteroatom
Chemical group

0.000
abstract
2

125000004435
hydrogen atom
Chemical group

[H]*

0.000
abstract
2

125000002887
hydroxy group
Chemical group

[H]O*

0.000
abstract
2

125000000449
nitro group
Chemical group

[O-][N+](*)=O

0.000
abstract
2

229910052757
nitrogen
Inorganic materials

0.000
abstract
2

125000001997
phenyl group
Chemical group

[H]C1=C([H])C([H])=C(*)C([H])=C1[H]

0.000
abstract
2

150000003928
4-aminopyridines
Chemical class

0.000
abstract
1

LFQSCWFLJHTTHZ-UHFFFAOYSA-N
Ethanol
Chemical compound

CCO
LFQSCWFLJHTTHZ-UHFFFAOYSA-N
0.000
abstract
1

UFHFLCQGNIYNRP-UHFFFAOYSA-N
Hydrogen
Chemical compound

[H][H]
UFHFLCQGNIYNRP-UHFFFAOYSA-N
0.000
abstract
1

NINIDFKCEFEMDL-UHFFFAOYSA-N
Sulfur
Chemical compound

[S]
NINIDFKCEFEMDL-UHFFFAOYSA-N
0.000
abstract
1

BQIKRTGTPBOIMK-UHFFFAOYSA-N
[O]C[O]
Chemical compound

[O]C[O]
BQIKRTGTPBOIMK-UHFFFAOYSA-N
0.000
abstract
1

125000004414
alkyl thio group
Chemical group

0.000
abstract
1

125000004397
aminosulfonyl group
Chemical group

NS(=O)(=O)*

0.000
abstract
1

QVGXLLKOCUKJST-UHFFFAOYSA-N
atomic oxygen
Chemical compound

[O]
QVGXLLKOCUKJST-UHFFFAOYSA-N
0.000
abstract
1

150000001875
compounds
Chemical class

0.000
abstract
1

125000004093
cyano group
Chemical group

*C#N

0.000
abstract
1

125000004663
dialkyl amino group
Chemical group

0.000
abstract
1

239000003814
drug
Substances

0.000
abstract
1

125000002485
formyl group
Chemical group

[H]C(*)=O

0.000
abstract
1

125000000623
heterocyclic group
Chemical group

0.000
abstract
1

125000004433
nitrogen atom
Chemical group

0.000
abstract
1

229910052760
oxygen
Inorganic materials

0.000
abstract
1

239000001301
oxygen
Substances

0.000
abstract
1

125000004430
oxygen atom
Chemical group

0.000
abstract
1

125000003884
phenylalkyl group
Chemical group

0.000
abstract
1

125000003356
phenylsulfanyl group
Chemical group

[*]SC1=C([H])C([H])=C([H])C([H])=C1[H]

0.000
abstract
1

150000003839
salts
Chemical class

0.000
abstract
1

125000001424
substituent group
Chemical group

0.000
abstract
1

125000001174
sulfone group
Chemical group

0.000
abstract
1

229910052717
sulfur
Inorganic materials

0.000
abstract
1

239000011593
sulfur
Substances

0.000
abstract
1

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members

C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D213/72—Nitrogen atoms

C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P11/00—Drugs for disorders of the respiratory system

A61P11/14—Antitussive agents

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals

C07D213/84—Nitriles

C07D213/85—Nitriles in position 3

Abstract

4-Aminopyridines of the formula in which R1 is hydrogen or alkyl of up to 6 carbon atoms and R2 represents (a) alkyl of up to 6 carbon atoms substituted up to three times with at least one radical from the group of halogen and hydroxyl, with formyl acetalized with an alcohol of up to 3 carbon atoms, alkylthio of up to 3 carbon atoms, phenylthio or the corresponding alkyl- and phenyl-sulfoxy and sulfone groups, the phenyl ring optionally carrying in each case up to three substituents from the group of alkyl, alkyl halide, alkoxy, mono- or dialkylamino having each up to 4 carbon atoms in each alkyl radical, halogen, nitro, amino and hydroxy, or (b) phenylalkyl or diphenyl-alkyl of up to 6 carbon atoms in the linear or branched alkyl moiety, the phenyl rings optionally being substituted up to three times with at least one radical from the group of alkyl, alkoxy, alkyl halide with up to 4 carbon atoms each, halogen, amino, hydroxy, nitro, the sulfamoyl group and the methylene dioxy radical, or R1 and R2, together with the nitrogen atom present in the 4-position, form a five- to seven-membered heterocyclic ring optionally substituted with alkyl of up to 2 carbon atoms and including up to two hetero-atoms, the second hetero-atom being oxygen, sulfur optionally carrying up to two oxygen atoms, or nitrogen, and R3 and R4 which may be identical or different, each represent alkyl of up to 9 carbon atoms, one of the two radicals optionally also being hydrogen, Y is a nitro or a cyano group, and Z stands for hydrogen or halogen, and the physiologically acceptable salts of these compounds, processes for their preparation and medicaments made thereof.

AU54397/80A
1979-01-08
1980-01-07
Amino pyridine derivatives

Ceased

AU530060B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE29005047

1979-01-08

DE19792900504

DE2900504A1
(en)

1979-01-08
1979-01-08

NEW SUBSTITUTED 4-AMINOPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT

Publications (2)

Publication Number
Publication Date

AU5439780A

AU5439780A
(en)

1980-07-17

AU530060B2
true

AU530060B2
(en)

1983-06-30

Family
ID=6060184
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU54397/80A
Ceased

AU530060B2
(en)

1979-01-08
1980-01-07
Amino pyridine derivatives

Country Status (14)

Country
Link

US
(1)

US4289765A
(en)

EP
(1)

EP0013408B1
(en)

JP
(1)

JPS5594365A
(en)

AT
(1)

ATE1097T1
(en)

AU
(1)

AU530060B2
(en)

CA
(1)

CA1138449A
(en)

DE
(2)

DE2900504A1
(en)

DK
(1)

DK153398C
(en)

ES
(4)

ES487411A1
(en)

FI
(1)

FI71131C
(en)

IE
(1)

IE49038B1
(en)

IL
(1)

IL59079A
(en)

NO
(1)

NO154633C
(en)

ZA
(1)

ZA8066B
(en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

NL8003120A
(en)

1979-05-30
1980-12-02
Italiana Schoum Spa

DIPHENYLPROPYLAMINOPYRIDINE COMPOUNDS, AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS.

US4734275A
(en)

1983-08-19
1988-03-29
Research Corporation
Anti-curare agents

DE3514073A1
(en)

1985-04-18
1986-10-23
Hoechst Ag, 6230 Frankfurt

MULTIPLE-SUBSTITUTED PYRIDINE-1-OXIDES, METHOD FOR THE PRODUCTION THEREOF, THE MEDICINAL PRODUCTS CONTAINING IT AND THEIR USE

DE3541428A1
(en)

1985-11-23
1987-05-27
Hoechst Ag

NEW BASICALLY SUBSTITUTED PYRIDINE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, THE MEDICINAL PRODUCTS CONTAINING IT AND THEIR USE

GB8819307D0
(en)

1988-08-13
1988-09-14
Pfizer Ltd
Antiarrhythmic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3547935A
(en)

1967-08-07
1970-12-15
American Cyanamid Co
Certain nitro-4-pyridinols,n-oxides thereof and derivatives thereof

US3517021A
(en)

1968-05-20
1970-06-23
Engelhard Min & Chem
4-amino-3-cyanopyridines and methods of preparation

GB1386091A
(en)

1971-03-19
1975-03-05
Ici Ltd
Amino pyridine compounds and compositions

1979

1979-01-08
DE
DE19792900504
patent/DE2900504A1/en
not_active
Withdrawn

1979-12-21
AT
AT79105320T
patent/ATE1097T1/en
active

1979-12-21
EP
EP79105320A
patent/EP0013408B1/en
not_active
Expired

1979-12-21
DE
DE7979105320T
patent/DE2962972D1/en
not_active
Expired

1980

1980-01-02
ES
ES487411A
patent/ES487411A1/en
not_active
Expired

1980-01-02
ES
ES487405A
patent/ES487405A1/en
not_active
Expired

1980-01-02
ES
ES487410A
patent/ES487410A1/en
not_active
Expired

1980-01-02
ES
ES487412A
patent/ES487412A1/en
not_active
Expired

1980-01-04
FI
FI800030A
patent/FI71131C/en
not_active
IP Right Cessation

1980-01-06
IL
IL59079A
patent/IL59079A/en
unknown

1980-01-07
NO
NO800033A
patent/NO154633C/en
unknown

1980-01-07
IE
IE18/80A
patent/IE49038B1/en
unknown

1980-01-07
AU
AU54397/80A
patent/AU530060B2/en
not_active
Ceased

1980-01-07
US
US06/109,913
patent/US4289765A/en
not_active
Expired – Lifetime

1980-01-07
DK
DK006880A
patent/DK153398C/en
not_active
IP Right Cessation

1980-01-07
ZA
ZA00800066A
patent/ZA8066B/en
unknown

1980-01-07
CA
CA000343136A
patent/CA1138449A/en
not_active
Expired

1980-01-08
JP
JP36380A
patent/JPS5594365A/en
active
Granted

Also Published As

Publication number
Publication date

EP0013408B1
(en)

1982-05-26

FI71131C
(en)

1986-11-24

ATE1097T1
(en)

1982-06-15

JPS5594365A
(en)

1980-07-17

NO154633C
(en)

1986-11-19

AU5439780A
(en)

1980-07-17

JPS6325584B2
(en)

1988-05-26

DK153398C
(en)

1988-12-12

DK153398B
(en)

1988-07-11

DK6880A
(en)

1980-07-09

IL59079A0
(en)

1980-05-30

EP0013408A1
(en)

1980-07-23

IE49038B1
(en)

1985-07-10

ES487411A1
(en)

1980-07-01

FI800030A
(en)

1980-07-09

NO154633B
(en)

1986-08-11

US4289765A
(en)

1981-09-15

DE2900504A1
(en)

1980-07-24

NO800033L
(en)

1980-07-09

ES487412A1
(en)

1980-06-16

ZA8066B
(en)

1980-12-31

CA1138449A
(en)

1982-12-28

IL59079A
(en)

1984-02-29

ES487410A1
(en)

1980-06-16

ES487405A1
(en)

1980-06-16

FI71131B
(en)

1986-08-14

DE2962972D1
(en)

1982-07-15

IE800018L
(en)

1980-07-08

Contact information