AU5439990A - Creation of Inventions and Patents with Artificial Intelligence

AU5439990A – Nucleoside derivatives and their use as medicaments
– Google Patents

AU5439990A – Nucleoside derivatives and their use as medicaments
– Google Patents
Nucleoside derivatives and their use as medicaments

Info

Publication number
AU5439990A

AU5439990A
AU54399/90A
AU5439990A
AU5439990A
AU 5439990 A
AU5439990 A
AU 5439990A
AU 54399/90 A
AU54399/90 A
AU 54399/90A
AU 5439990 A
AU5439990 A
AU 5439990A
AU 5439990 A
AU5439990 A
AU 5439990A
Authority
AU
Australia
Prior art keywords
nhr4
mono
alkoxy
halogen
alkyl
Prior art date
1989-07-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Application number
AU54399/90A
Inventor
Werner Bourgeois
Reiner Gumbiowski
Edith Koch
Bernhard Konig
Alfred Mertens
Angelika Roling
Helmut Rosemeyer
Frank Seela
Harald Zilch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Roche Diagnostics GmbH

Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1989-07-24
Filing date
1990-04-23
Publication date
1991-02-22

1990-04-23
Application filed by Boehringer Mannheim GmbH
filed
Critical
Boehringer Mannheim GmbH

1991-02-22
Publication of AU5439990A
publication
Critical
patent/AU5439990A/en

Status
Abandoned
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS

C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof

C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

A61P31/12—Antivirals

Abstract

Nucleosides of formula (I), their anomers, N7 and N9 regioisomeric tautomers and salts, and nucleic acids based on them are new, where Ba= a gp. of formula (A), (B), (C), (D), (E) or (F). R1-3= H, halogen, alkyl, OH, SH, NO2, NH2, thioalkyl, alkoxy, aralkyl, aralkoxy, aminoalkyl, (di)alkylaminoalkyl, NHR4, N(R4)2 or N=CHR4. R4= alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, alkoxyalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, mono- or di- alkylaminoalkyl or aralkyl or heteroarylalkyl both opt. substd. with alkyl, alkoxy, halogen or OH; and when R4 occurs in NHR4 or N=CHR4 it may also be NH2, mono- or di-alkylamino or alkoxy. Y=H, alkylcarbonyl or mono-, di- or tri- phosphate. R5-R8= H or 1-2 of R5-R8 are OH, halogen, CN, N3, NHR4, N(R4)2, or R5 and R7 together form an additional bond between C2′ and C3′. Provided that: (a) when Ba=(B) R6 is not H, N3 or NH2. (b) when Ba=(D) and R2=H then R1 is not Cl or NH2 and R6 is not H or Cl. (c) when Ba=(E) then R5 and R7 do not form a bond. Prepn. of (I), their use in DNA sequencing and antiviral compsns. contg. new and known (I) are also claime

AU54399/90A
1989-07-24
1990-04-23
Nucleoside derivatives and their use as medicaments

Abandoned

AU5439990A
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE3924424

1989-07-24

DE3924424A

DE3924424A1
(en)

1989-07-24
1989-07-24

NUCLEOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINAL PRODUCT AND THEIR USE IN THE SEQUENCING OF NUCLEIC ACID

Publications (1)

Publication Number
Publication Date

AU5439990A
true

AU5439990A
(en)

1991-02-22

Family
ID=6385699
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU54399/90A
Abandoned

AU5439990A
(en)

1989-07-24
1990-04-23
Nucleoside derivatives and their use as medicaments

Country Status (13)

Country
Link

US
(1)

US5446139A
(en)

EP
(2)

EP0666269A3
(en)

JP
(1)

JPH04507086A
(en)

AT
(1)

ATE130306T1
(en)

AU
(1)

AU5439990A
(en)

CA
(1)

CA2064024A1
(en)

DD
(1)

DD296687A5
(en)

DE
(2)

DE3924424A1
(en)

IE
(1)

IE902665A1
(en)

IL
(1)

IL95128A0
(en)

PT
(1)

PT94788A
(en)

WO
(1)

WO1991001325A1
(en)

ZA
(1)

ZA905760B
(en)

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Priority date
Publication date
Assignee
Title

US5721356A
(en)

1989-09-15
1998-02-24
Gensia, Inc.
Orally active adenosine kinase inhibitors

US5594121A
(en)

1991-11-07
1997-01-14
Gilead Sciences, Inc.
Enhanced triple-helix and double-helix formation with oligomers containing modified purines

GB9301000D0
(en)

1993-01-20
1993-03-10
Glaxo Group Ltd
Chemical compounds

KR0177372B1
(en)

1994-12-13
1999-04-01
아키라 마츠다
3′-substituted nucleoside derivatives

US6004939A
(en)

1995-07-06
1999-12-21
Ctrc Research Foundation Board Of Regents
Methods for modulation and inhibition of telomerase

AU6485996A
(en)

1995-07-06
1997-02-05
Board Of Regents, The University Of Texas System
Methods and compositions for modulation and inhibition of teomerase

AU2253297A
(en)

1996-01-23
1997-08-20
Regents Of The University Of Michigan, The
Imidazo{1,2-a}pyridine c-nucleosides as antiviral agents

GB2309969B
(en)

1996-02-01
2000-08-09
Amersham Int Plc
Nucleoside analogues

GB9602028D0
(en)

1996-02-01
1996-04-03
Amersham Int Plc
Nucleoside analogues

TW530058B
(en)

1997-07-22
2003-05-01
Astra Pharma Prod
Triazolo [4,5-d]pyrimidine compounos and their use and process for preparation

JP2003513756A
(en)

1999-11-12
2003-04-15
アンジオテックファーマシューティカルズ，インコーポレイテッド

Compositions of a combination of radiotherapy and a cell cycle inhibitor

US20030216758A1
(en)

2001-12-28
2003-11-20
Angiotech Pharmaceuticals, Inc.
Coated surgical patches

CA2474482A1
(en)

2002-01-25
2003-08-07
Applera Corporation
Methods for placing, accepting, and filling orders for products and services

EP1556400B1
(en)

2002-09-25
2013-05-01
Brigham Young University
Method for the preparation of 2-halo-2 -deoxyadenosine compounds from 2 -deoxyguanosine

AU2003300076C1
(en)

2002-12-30
2010-03-04
Angiotech International Ag
Drug delivery from rapid gelling polymer composition

PT2604620T
(en)

2003-05-30
2016-08-18
Gilead Pharmasset Llc
Modified fluorinated nucleoside analogues

WO2006016978A1
(en)

2004-06-30
2006-02-16
Applera Corporation
Analog probe complexes

CN101023094B
(en)

2004-07-21
2011-05-18
法莫赛特股份有限公司
Preparation of alkyl-substituted 2-deoxy-2-fluoro-d-ribofuranosyl pyrimidines and purines and their derivatives

SG192409A1
(en)

2004-09-14
2013-08-30
Gilead Pharmasset Llc
2-deoxy-2-fluoro-2-c-methyl-ribono lactones, and preparation thereof and 1,3-dioxolanes

US20060292586A1
(en)

2004-12-17
2006-12-28
Schroth Gary P
ID-tag complexes, arrays, and methods of use thereof

US7622583B2
(en)

2005-01-14
2009-11-24
Chemocentryx, Inc.
Heteroaryl sulfonamides and CCR2

WO2008147454A1
(en)

2006-11-16
2008-12-04
Case Western Reserve University
Selective inhibitors of translesion dna replication

US8114847B2
(en)

2005-03-16
2012-02-14
Case Western Reserve University
Selective inhibitors of translesion DNA replication

US20060286590A1
(en)

2005-06-20
2006-12-21
Applera Corporation.
Cis-regulatory modules

GB0514809D0
(en)

2005-07-19
2005-08-24
Glaxo Group Ltd
Compounds

EP1994182B1
(en)

2006-03-15
2019-05-29
Siemens Healthcare Diagnostics Inc.
Degenerate nucleobase analogs

US8519135B2
(en)

2006-07-14
2013-08-27
Chemocentryx, Inc.
Heteroaryl sulfonamides and CCR2/CCR9

US8399194B2
(en)

2006-12-26
2013-03-19
Siemens Healthcare Diagnostics Inc.
Heteropolynucleotide duplexes with purine—purine base pairing

US8796241B2
(en)

2007-08-29
2014-08-05
Adam Lubin
Therapy of tumors and infectious agents deficient in methylthioadenosine phosphorylase

US20120142004A1
(en)

2009-05-21
2012-06-07
Siemens Healthcare Diagnostics Inc.
Universal Tags With Non-Natural Nucleobases

WO2013033705A2
(en)

2011-09-01
2013-03-07
Case Western Reserve University
Non-natural nucleosides as theranostic agents

GEP20166496B
(en)

2011-12-22
2016-06-27
Alios Biopharma Inc
Substituted nucleosides, nucleotides and analogs thereof

USRE48171E1
(en)

2012-03-21
2020-08-25
Janssen Biopharma, Inc.
Substituted nucleosides, nucleotides and analogs thereof

US9441007B2
(en)

2012-03-21
2016-09-13
Alios Biopharma, Inc.
Substituted nucleosides, nucleotides and analogs thereof

US9821173B2
(en)

2013-02-08
2017-11-21
Case Western Reserve University
Anti-cancer agents and methods of use

EP3544602A4
(en)

2016-11-23
2020-07-08
ChemoCentryx, Inc.
Method of treating focal segmental glomerulosclerosis

SG11202002975YA
(en)

2017-10-11
2020-04-29
Chemocentryx Inc
Treatment of focal segmental glomerulosclerosis with ccr2 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB696952A
(en)

1950-05-19
1953-09-09
British Drug Houses Ltd
Improvements in or relating to the manufacture of heterocyclic compounds

CH477470A
(en)

1966-05-04
1969-08-31
Merck & Co Inc

Process for the preparation of ribofuranosides

US3817982A
(en)

1971-12-29
1974-06-18
Syntex Inc
2{40 ,3{40 -unsaturated nucleosides and method of making

GB1474299A
(en)

1975-06-27
1977-05-18
Icn Pharmaceuticals
3-deazaguanine and derivatives thereof

US4246408A
(en)

1979-03-08
1981-01-20
Icn Pharmaceuticals
Imidazo[1,2-a]-s-triazine

EP0038569B1
(en)

1980-04-23
1985-01-30
The Wellcome Foundation Limited
Deazapurine nucleosides, formulations and preparation thereof

US4315000A
(en)

1980-07-07
1982-02-09
Warner-Lambert Company
β-D-Arabinofuranosylimidazo(4,5-c)pyridine compounds and methods for their production

CA1317291C
(en)

1987-12-14
1993-05-04
Naeem Botros Hanna
Antitumor 6-sulfenamide, 6-sulfinamide and 6-sulfonamide purines, purine nucleosides, purine nucleotides and related compounds

US4996308A
(en)

1988-03-25
1991-02-26
Merrell Dow Pharmaceuticals Inc.
Derivatives with unsaturated substitutions for the 5′-hydroxymethyl group

1989

1989-07-24
DE
DE3924424A
patent/DE3924424A1/en
not_active
Withdrawn

1990

1990-04-23
DE
DE59009888T
patent/DE59009888D1/en
not_active
Expired – Fee Related

1990-04-23
AT
AT90906204T
patent/ATE130306T1/en
not_active
IP Right Cessation

1990-04-23
WO
PCT/EP1990/000650
patent/WO1991001325A1/en
active
IP Right Grant

1990-04-23
EP
EP95106043A
patent/EP0666269A3/en
not_active
Withdrawn

1990-04-23
EP
EP90906204A
patent/EP0484333B1/en
not_active
Expired – Lifetime

1990-04-23
JP
JP2506235A
patent/JPH04507086A/en
active
Pending

1990-04-23
CA
CA2064024A
patent/CA2064024A1/en
not_active
Abandoned

1990-04-23
US
US07/809,506
patent/US5446139A/en
not_active
Expired – Fee Related

1990-04-23
AU
AU54399/90A
patent/AU5439990A/en
not_active
Abandoned

1990-07-19
IL
IL95128A
patent/IL95128A0/en
unknown

1990-07-23
DD
DD90342998A
patent/DD296687A5/en
not_active
IP Right Cessation

1990-07-23
PT
PT94788A
patent/PT94788A/en
not_active
Application Discontinuation

1990-07-23
ZA
ZA905760A
patent/ZA905760B/en
unknown

1990-07-23
IE
IE266590A
patent/IE902665A1/en
unknown

Also Published As

Publication number
Publication date

WO1991001325A1
(en)

1991-02-07

IE902665A1
(en)

1991-02-27

DE3924424A1
(en)

1991-01-31

IL95128A0
(en)

1991-06-10

EP0484333A1
(en)

1992-05-13

CA2064024A1
(en)

1991-02-07

EP0484333B1
(en)

1995-11-15

JPH04507086A
(en)

1992-12-10

ZA905760B
(en)

1991-06-26

DE59009888D1
(en)

1995-12-21

PT94788A
(en)

1991-03-20

DD296687A5
(en)

1991-12-12

EP0666269A2
(en)

1995-08-09

US5446139A
(en)

1995-08-29

ATE130306T1
(en)

1995-12-15

EP0666269A3
(en)

1996-04-24

Información de contacto