AU5449586A – Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH
– Google Patents
AU5449586A – Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH
– Google Patents
Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH
Info
Publication number
AU5449586A
AU5449586A
AU54495/86A
AU5449586A
AU5449586A
AU 5449586 A
AU5449586 A
AU 5449586A
AU 54495/86 A
AU54495/86 A
AU 54495/86A
AU 5449586 A
AU5449586 A
AU 5449586A
AU 5449586 A
AU5449586 A
AU 5449586A
Authority
AU
Australia
Prior art keywords
charge
insulin
neutral
derivatives
positive compared
Prior art date
1985-03-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU54495/86A
Other versions
AU612964B2
(en
Inventor
Jan Markussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Industri AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1985-03-12
Filing date
1986-03-11
Publication date
1986-09-18
1986-03-11
Application filed by Novo Industri AS
filed
Critical
Novo Industri AS
1986-09-18
Publication of AU5449586A
publication
Critical
patent/AU5449586A/en
1991-07-25
Application granted
granted
Critical
1991-07-25
Publication of AU612964B2
publication
Critical
patent/AU612964B2/en
1991-11-28
Assigned to NOVO NORDISK A/S
reassignment
NOVO NORDISK A/S
Amend patent request/document other than specification (104)
Assignors: NOVO INDUSTRI A/S
2006-03-11
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07K—PEPTIDES
C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
C07K14/575—Hormones
C07K14/62—Insulins
Abstract
Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH, can be used to prepare solutions having prolonged insulin action. In the novel insulin derivatives, a basic amino acid has been substituted in the B27-position and/or a neutral amino acid has been inserted in the A4-, A17-, B13- and/or B21-position. Furthermore, the C-terminal carboxyl group of the B-chain has been blocked with an amido or ester residue.
AU54495/86A
1985-03-12
1986-03-11
Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH
Ceased
AU612964B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
DK1135/85
1985-03-12
DK113585A
DK113585D0
(en)
1985-03-12
1985-03-12
NEW PEPTIDES
Publications (2)
Publication Number
Publication Date
AU5449586A
true
AU5449586A
(en)
1986-09-18
AU612964B2
AU612964B2
(en)
1991-07-25
Family
ID=8101410
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU54495/86A
Ceased
AU612964B2
(en)
1985-03-12
1986-03-11
Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH
Country Status (22)
Country
Link
EP
(1)
EP0194864B1
(en)
JP
(1)
JPS61212598A
(en)
KR
(1)
KR930007433B1
(en)
CN
(1)
CN86101489A
(en)
AT
(1)
ATE77391T1
(en)
AU
(1)
AU612964B2
(en)
CS
(1)
CS259536B2
(en)
DD
(1)
DD244345A5
(en)
DE
(1)
DE3685668T2
(en)
DK
(2)
DK113585D0
(en)
ES
(1)
ES8800276A1
(en)
FI
(1)
FI861007A
(en)
GR
(1)
GR860687B
(en)
HU
(1)
HU201097B
(en)
IL
(1)
IL78103A0
(en)
MY
(1)
MY102102A
(en)
NO
(1)
NO172441C
(en)
NZ
(1)
NZ215445A
(en)
PH
(1)
PH24260A
(en)
PT
(1)
PT82173B
(en)
YU
(1)
YU46001B
(en)
ZA
(1)
ZA861432B
(en)
Cited By (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU596968B2
(en)
*
1985-03-15
1990-05-24
Novo Nordisk A/S
Novel insulin derivatives and pharmaceutical preparations containing these derivatives
AU612324B2
(en)
*
1986-07-21
1991-07-11
Novo Nordisk A/S
Novel peptides and injectable solutions having prolonged insulin action
US5149716A
(en)
*
1989-11-06
1992-09-22
Hoechst Aktiengesellschaft
Insulin derivatives, process for their preparation, their use and a pharmaceutical preparation containing them
WO2000016798A1
(en)
*
1998-09-22
2000-03-30
Curtin University Of Technology
Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1
(en)
1998-09-22
2005-08-23
Erik Helmerhorst
Use of non-peptidyl compounds for the treatment of insulin related ailments
Families Citing this family (29)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US5008241A
(en)
*
1985-03-12
1991-04-16
Novo Nordisk A/S
Novel insulin peptides
DK437786D0
(en)
*
1986-09-12
1986-09-12
Nordisk Gentofte
insulin precursors
AU616205B2
(en)
*
1988-07-20
1991-10-24
Novo Nordisk A/S
Human insulin analogs and preparations containing them
DE3827533A1
(en)
*
1988-08-13
1990-02-15
Hoechst Ag
PHARMACEUTICAL PREPARATION FOR TREATING THE DIABETES MELLITUS
DE3837825A1
(en)
*
1988-11-08
1990-05-10
Hoechst Ag
NEW INSULIN DERIVATIVES, THEIR USE AND A PHARMACEUTICAL PREPARATION CONTAINING THEM
DK134189D0
(en)
*
1989-03-20
1989-03-20
Nordisk Gentofte
INSULIN COMPOUNDS
US5130298A
(en)
*
1989-05-16
1992-07-14
Ethicon, Inc.
Stabilized compositions containing epidermal growth factor
DE10114178A1
(en)
2001-03-23
2002-10-10
Aventis Pharma Gmbh
Zinc-free and low-zinc insulin preparations with improved stability
DE10227232A1
(en)
2002-06-18
2004-01-15
Aventis Pharma Deutschland Gmbh
Sour insulin preparations with improved stability
EP2368579A1
(en)
2004-01-21
2011-09-28
Novo Nordisk Health Care AG
Transglutaminase mediated conjugation of peptides
PL1969004T3
(en)
2005-12-28
2012-01-31
Novo Nordisk As
Compositions comprising an acylated insulin and zinc and method of making the said compositions
DE102006031955A1
(en)
*
2006-07-11
2008-01-17
Sanofi-Aventis Deutschland Gmbh
Process for the preparation of dibasic B chain end insulin analogs
DE102006031962A1
(en)
*
2006-07-11
2008-01-17
Sanofi-Aventis Deutschland Gmbh
Amidated insulin glargine
DE102008003566A1
(en)
*
2008-01-09
2009-07-16
Sanofi-Aventis Deutschland Gmbh
New insulin analogs useful for treating diabetes
WO2009087081A2
(en)
2008-01-09
2009-07-16
Sanofi-Aventis Deutschland Gmbh
Novel insulin derivatives having an extremely delayed time-action profile
JP5695909B2
(en)
*
2008-01-09
2015-04-08
サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
Novel insulin derivatives with extremely delayed time action profiles
CR20170369A
(en)
2008-10-17
2017-11-01
Sanofi Aventis Deutschland
COMBINATION OF AN INSULIN AND A GLP-1 AGONIST (Divisional 2011-0188)
JP2012532177A
(en)
*
2009-07-06
2012-12-13
サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
Thermal and vibration stable insulin formulations
CN102711805A
(en)
2009-11-13
2012-10-03
赛诺菲-安万特德国有限公司
Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine
JP5973918B2
(en)
2009-11-13
2016-08-23
サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング
Pharmaceutical composition comprising a GLP-1 agonist and methionine
MX2012012943A
(en)
*
2010-05-10
2012-11-29
Novo Nordisk As
Process for the preparation of insulin-zinc complexes.
CA2809321C
(en)
2010-08-30
2018-08-14
Sanofi-Aventis Deutschland Gmbh
Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
CN102174495A
(en)
*
2011-01-20
2011-09-07
马忠仁
Method for extracting chymocotrypsin
US9821032B2
(en)
2011-05-13
2017-11-21
Sanofi-Aventis Deutschland Gmbh
Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
ES2550357T3
(en)
2011-08-29
2015-11-06
Sanofi-Aventis Deutschland Gmbh
Pharmaceutical combination for use in glycemic control in type 2 diabetes patients
TWI559929B
(en)
2011-09-01
2016-12-01
Sanofi Aventis Deutschland
Pharmaceutical composition for use in the treatment of a neurodegenerative disease
FI3229828T3
(en)
2014-12-12
2023-05-29
Sanofi Aventis Deutschland
Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B
(en)
2015-03-13
2021-12-11
德商賽諾菲阿凡提斯德意志有限公司
Treatment type 2 diabetes mellitus patients
TW201705975A
(en)
2015-03-18
2017-02-16
賽諾菲阿凡提斯德意志有限公司
Treatment of type 2 diabetes mellitus patients
Family Cites Families (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DK319780A
(en)
*
1980-07-24
1982-01-25
Forenede Bryggerier As
PROCEDURE FOR ENZYMATIC REPLACEMENT OF B-30 AMINO ACID IN INSULINES
DE3326472A1
(en)
*
1983-07-22
1985-02-14
Hoechst Ag, 6230 Frankfurt
NEW INSULIN DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AND PHARMACEUTICAL AGENTS FOR TREATING THE DIABETES MELLITUS
DE3333640A1
(en)
*
1983-09-17
1985-04-25
Hoechst Ag, 6230 Frankfurt
METHOD FOR THE PRODUCTION OF INSULIN DERIVATIVES, THE B-CHAIN C-TERMINAL EXTENDED, NEW BASICALLY MODIFIED INSULIN DERIVATIVES, THE MEANS CONTAINING THEM AND THEIR USE
DK119785D0
(en)
*
1985-03-15
1985-03-15
Nordisk Gentofte
INSULIN PREPARATION
1985
1985-03-12
DK
DK113585A
patent/DK113585D0/en
unknown
1986
1986-02-26
ZA
ZA861432A
patent/ZA861432B/en
unknown
1986-02-27
PH
PH33459A
patent/PH24260A/en
unknown
1986-03-10
YU
YU34586A
patent/YU46001B/en
unknown
1986-03-10
DD
DD86287734A
patent/DD244345A5/en
not_active
IP Right Cessation
1986-03-10
DK
DK107086A
patent/DK158677C/en
active
1986-03-11
ES
ES552879A
patent/ES8800276A1/en
not_active
Expired
1986-03-11
PT
PT82173A
patent/PT82173B/en
not_active
IP Right Cessation
1986-03-11
FI
FI861007A
patent/FI861007A/en
not_active
Application Discontinuation
1986-03-11
NZ
NZ215445A
patent/NZ215445A/en
unknown
1986-03-11
AU
AU54495/86A
patent/AU612964B2/en
not_active
Ceased
1986-03-11
EP
EP86301755A
patent/EP0194864B1/en
not_active
Expired – Lifetime
1986-03-11
NO
NO860920A
patent/NO172441C/en
unknown
1986-03-11
KR
KR1019860001737A
patent/KR930007433B1/en
active
IP Right Grant
1986-03-11
DE
DE8686301755T
patent/DE3685668T2/en
not_active
Expired – Fee Related
1986-03-11
AT
AT86301755T
patent/ATE77391T1/en
not_active
IP Right Cessation
1986-03-11
CS
CS861666A
patent/CS259536B2/en
unknown
1986-03-11
IL
IL78103A
patent/IL78103A0/en
not_active
IP Right Cessation
1986-03-11
JP
JP61051586A
patent/JPS61212598A/en
active
Pending
1986-03-11
HU
HU861024A
patent/HU201097B/en
not_active
IP Right Cessation
1986-03-11
CN
CN198686101489A
patent/CN86101489A/en
active
Pending
1986-03-12
GR
GR860687A
patent/GR860687B/en
unknown
1987
1987-09-30
MY
MYPI87002520A
patent/MY102102A/en
unknown
Cited By (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU596968B2
(en)
*
1985-03-15
1990-05-24
Novo Nordisk A/S
Novel insulin derivatives and pharmaceutical preparations containing these derivatives
AU612324B2
(en)
*
1986-07-21
1991-07-11
Novo Nordisk A/S
Novel peptides and injectable solutions having prolonged insulin action
US5149716A
(en)
*
1989-11-06
1992-09-22
Hoechst Aktiengesellschaft
Insulin derivatives, process for their preparation, their use and a pharmaceutical preparation containing them
WO2000016798A1
(en)
*
1998-09-22
2000-03-30
Curtin University Of Technology
Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1
(en)
1998-09-22
2005-08-23
Erik Helmerhorst
Use of non-peptidyl compounds for the treatment of insulin related ailments
Also Published As
Publication number
Publication date
AU612964B2
(en)
1991-07-25
PT82173B
(en)
1988-07-29
PT82173A
(en)
1986-04-01
YU46001B
(en)
1992-12-21
ATE77391T1
(en)
1992-07-15
NO860920L
(en)
1986-09-15
ZA861432B
(en)
1986-11-26
JPS61212598A
(en)
1986-09-20
EP0194864A3
(en)
1989-01-11
NO172441B
(en)
1993-04-13
KR930007433B1
(en)
1993-08-10
DD244345A5
(en)
1987-04-01
ES8800276A1
(en)
1987-11-01
DK158677C
(en)
1990-12-31
DK107086D0
(en)
1986-03-10
KR860007288A
(en)
1986-10-10
MY102102A
(en)
1992-03-31
FI861007A0
(en)
1986-03-11
DK107086A
(en)
1986-11-07
EP0194864B1
(en)
1992-06-17
HUT41052A
(en)
1987-03-30
CS166686A2
(en)
1987-12-17
GR860687B
(en)
1986-07-11
DE3685668D1
(en)
1992-07-23
EP0194864A2
(en)
1986-09-17
DE3685668T2
(en)
1993-01-14
CS259536B2
(en)
1988-10-14
CN86101489A
(en)
1987-01-21
HU201097B
(en)
1990-09-28
NZ215445A
(en)
1989-07-27
DK113585D0
(en)
1985-03-12
YU34586A
(en)
1988-10-31
PH24260A
(en)
1990-05-04
DK158677B
(en)
1990-07-02
IL78103A0
(en)
1986-07-31
ES552879A0
(en)
1987-11-01
FI861007A
(en)
1986-09-13
NO172441C
(en)
1993-07-21
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Title
AU5449586A
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1986-09-18
Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH
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1988-01-21
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