AU5465886A – Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
– Google Patents
AU5465886A – Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
– Google Patents
Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
Info
Publication number
AU5465886A
AU5465886A
AU54658/86A
AU5465886A
AU5465886A
AU 5465886 A
AU5465886 A
AU 5465886A
AU 54658/86 A
AU54658/86 A
AU 54658/86A
AU 5465886 A
AU5465886 A
AU 5465886A
AU 5465886 A
AU5465886 A
AU 5465886A
Authority
AU
Australia
Prior art keywords
loweralkyl
intermediates
preparation
naphthyridines
medicaments
Prior art date
1985-03-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU54658/86A
Other versions
AU590748B2
(en
Inventor
Lawrence L. Martin
Susan J. Scott
Linda L. Setescak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1985-03-13
Filing date
1986-03-12
Publication date
1986-09-18
1986-03-12
Application filed by Hoechst Roussel Pharmaceuticals Inc
filed
Critical
Hoechst Roussel Pharmaceuticals Inc
1986-09-18
Publication of AU5465886A
publication
Critical
patent/AU5465886A/en
1989-11-16
Application granted
granted
Critical
1989-11-16
Publication of AU590748B2
publication
Critical
patent/AU590748B2/en
2006-03-12
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D207/24—Oxygen or sulfur atoms
C07D207/26—2-Pyrrolidones
C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P21/00—Drugs for disorders of the muscular or neuromuscular system
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer’s disease or other forms of dementia
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00
C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains two hetero rings
C07D471/04—Ortho-condensed systems
Abstract
The invention relates to novel compounds of the formula
where X is H, halogen, loweralkyl, loweralkoxy, -CF3, or -OH; R is H, loweralkyl, arylloweralkyl, diarylloweralkyl, loweralkanoyl, arylloweralkanoyl or diarylloweralkanoyl; and R1 is H2, O or -NR2R3, R2 and R3 being independently H or loweralkyl, or taken together with the nitrogen atom to which they are attached constitute
, R4 in turn being H, loweralkyl, hydroxyloweralkyl, aryl, arylloweralkyl or diarylloweralkyl or pharmaceutically acceptable acid addition salts thereof, which are useful for enchancing memory. The invention relates further to a process and intermediates for the preparation of the above compounds.
AU54658/86A
1985-03-13
1986-03-12
Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
Ceased
AU590748B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US06/711,327
US4652567A
(en)
1985-03-13
1985-03-13
Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement
US711327
1985-03-13
Publications (2)
Publication Number
Publication Date
AU5465886A
true
AU5465886A
(en)
1986-09-18
AU590748B2
AU590748B2
(en)
1989-11-16
Family
ID=24857642
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU54658/86A
Ceased
AU590748B2
(en)
1985-03-13
1986-03-12
Benzo(C)-1,5-naphthyridines, a process and intermediates for their preparation and their use as medicaments
Country Status (19)
Country
Link
US
(1)
US4652567A
(en)
EP
(1)
EP0197318B1
(en)
JP
(1)
JPS61212585A
(en)
KR
(1)
KR860007255A
(en)
AT
(1)
ATE52510T1
(en)
AU
(1)
AU590748B2
(en)
CA
(1)
CA1248108A
(en)
DE
(1)
DE3671017D1
(en)
DK
(1)
DK114386A
(en)
ES
(4)
ES8707528A1
(en)
FI
(1)
FI861001A
(en)
GR
(1)
GR860681B
(en)
HU
(2)
HU201756B
(en)
IL
(1)
IL78117A0
(en)
NO
(1)
NO163489B
(en)
NZ
(1)
NZ215439A
(en)
PH
(1)
PH22279A
(en)
PT
(1)
PT82187B
(en)
ZA
(1)
ZA861837B
(en)
Families Citing this family (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US4766217A
(en)
*
1984-01-13
1988-08-23
Boehringer Ingelheim Kg
Preparation of 5,6-dihydro-pyrrolo[2,1-a]isoquinolines
US5202440A
(en)
*
1987-10-05
1993-04-13
Pfizer Inc.
Certain 9-amino-2-(or 4)-oxa 1,2,3,4-tetrahydro- or 1,2,3,4,5,6,7,8-octahydro-acridines
MX13270A
(en)
*
1987-10-05
1993-06-01
Pfizer
PROCEDURE FOR THE PREPARATION OF 4-AMINOPYRIDINE DERIVATIVES
US5994367A
(en)
*
1997-03-07
1999-11-30
The University Of North Carolina At Chapel Hill
Method for treating tumors using 2-aryl-naphthyridin-4-ones
Family Cites Families (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR2273533A1
(en)
*
1974-06-04
1976-01-02
Ferlux Sa
N-Substd.-2-pyrrolidone-5-carboxylic acid derivs. – normolipemics, psycho sedatives analgesics and cardiovascular agents
US4297358A
(en)
*
1979-01-16
1981-10-27
Ciba-Geigy Corporation
Novel 4,7-phenanthroline derivatives and pharmaceutical compositions containing them and their use
BE880455A
(en)
*
1979-01-22
1980-06-06
Sandoz Sa
PHARMACEUTICAL COMPOSITIONS BASED ON A BENZO (C) (1,6) NAPHTYRIDINE
1985
1985-03-13
US
US06/711,327
patent/US4652567A/en
not_active
Expired – Lifetime
1986
1986-03-07
AT
AT86103085T
patent/ATE52510T1/en
not_active
IP Right Cessation
1986-03-07
DE
DE8686103085T
patent/DE3671017D1/en
not_active
Expired – Fee Related
1986-03-07
EP
EP86103085A
patent/EP0197318B1/en
not_active
Expired – Lifetime
1986-03-11
HU
HU885579A
patent/HU201756B/en
not_active
IP Right Cessation
1986-03-11
PH
PH33508A
patent/PH22279A/en
unknown
1986-03-11
NZ
NZ215439A
patent/NZ215439A/en
unknown
1986-03-11
FI
FI861001A
patent/FI861001A/en
not_active
Application Discontinuation
1986-03-11
IL
IL78117A
patent/IL78117A0/en
unknown
1986-03-11
ES
ES552874A
patent/ES8707528A1/en
not_active
Expired
1986-03-11
CA
CA000503758A
patent/CA1248108A/en
not_active
Expired
1986-03-11
HU
HU861028A
patent/HU197007B/en
not_active
IP Right Cessation
1986-03-12
NO
NO860933A
patent/NO163489B/en
unknown
1986-03-12
JP
JP61052750A
patent/JPS61212585A/en
active
Pending
1986-03-12
GR
GR860681A
patent/GR860681B/en
unknown
1986-03-12
ZA
ZA861837A
patent/ZA861837B/en
unknown
1986-03-12
DK
DK114386A
patent/DK114386A/en
not_active
Application Discontinuation
1986-03-12
AU
AU54658/86A
patent/AU590748B2/en
not_active
Ceased
1986-03-13
PT
PT82187A
patent/PT82187B/en
unknown
1986-03-13
KR
KR1019860001804A
patent/KR860007255A/en
not_active
Application Discontinuation
1986-11-17
ES
ES557208A
patent/ES8800941A1/en
not_active
Expired
1986-11-17
ES
ES557207A
patent/ES8801269A1/en
not_active
Expired
1987
1987-10-15
ES
ES557768A
patent/ES8801270A1/en
not_active
Expired
Also Published As
Publication number
Publication date
ES8801270A1
(en)
1988-01-01
KR860007255A
(en)
1986-10-10
FI861001A0
(en)
1986-03-11
DK114386D0
(en)
1986-03-12
HUT40658A
(en)
1987-01-28
DK114386A
(en)
1986-09-14
ES552874A0
(en)
1987-08-01
ES8800941A1
(en)
1987-12-01
ATE52510T1
(en)
1990-05-15
ZA861837B
(en)
1987-06-24
PH22279A
(en)
1988-07-14
ES8707528A1
(en)
1987-08-01
FI861001A
(en)
1986-09-14
ES8801269A1
(en)
1988-01-01
AU590748B2
(en)
1989-11-16
CA1248108A
(en)
1989-01-03
JPS61212585A
(en)
1986-09-20
GR860681B
(en)
1986-07-14
PT82187B
(en)
1988-01-07
DE3671017D1
(en)
1990-06-13
NO860933L
(en)
1986-09-15
ES557768A0
(en)
1988-01-01
HU201756B
(en)
1990-12-28
IL78117A0
(en)
1986-07-31
EP0197318A1
(en)
1986-10-15
ES557207A0
(en)
1988-01-01
NZ215439A
(en)
1990-03-27
HU197007B
(en)
1989-02-28
ES557208A0
(en)
1987-12-01
NO163489B
(en)
1990-02-26
PT82187A
(en)
1986-04-01
US4652567A
(en)
1987-03-24
EP0197318B1
(en)
1990-05-09
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