AU5499786A – Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine
– Google Patents
AU5499786A – Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine
– Google Patents
Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine
Info
Publication number
AU5499786A
AU5499786A
AU54997/86A
AU5499786A
AU5499786A
AU 5499786 A
AU5499786 A
AU 5499786A
AU 54997/86 A
AU54997/86 A
AU 54997/86A
AU 5499786 A
AU5499786 A
AU 5499786A
AU 5499786 A
AU5499786 A
AU 5499786A
Authority
AU
Australia
Prior art keywords
amino
pyridine
benzylamino
fluoro
nitro
Prior art date
1985-03-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU54997/86A
Other versions
AU579922B2
(en
Inventor
Peter Emig
Jurgen Engel
Winfried Orth
Hans Pohle
Gerhard Scheffler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AWD Pharma GmbH and Co KG
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1985-03-23
Filing date
1986-03-21
Publication date
1986-09-25
1986-03-21
Application filed by Degussa GmbH
filed
Critical
Degussa GmbH
1986-09-25
Publication of AU5499786A
publication
Critical
patent/AU5499786A/en
1988-12-15
Application granted
granted
Critical
1988-12-15
Publication of AU579922B2
publication
Critical
patent/AU579922B2/en
2000-10-12
Assigned to ASTA MEDICA AKTIENGESELLSCHAFT
reassignment
ASTA MEDICA AKTIENGESELLSCHAFT
Alteration of Name(s) in Register under S187
Assignors: DEGUSSA A.G.
2002-01-10
Assigned to AWD.PHARMA GMBH & CO. KG
reassignment
AWD.PHARMA GMBH & CO. KG
Alteration of Name(s) in Register under S187
Assignors: ASTA MEDICA AKTIENGESELLSCHAFT
2006-03-21
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D213/72—Nitrogen atoms
C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D213/72—Nitrogen atoms
C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
Y02P20/00—Technologies relating to chemical industry
Y02P20/50—Improvements relating to the production of bulk chemicals
Y02P20/582—Recycling of unreacted starting or intermediate materials
Abstract
There is described a process for the production of 2-amino-3-nitro-6-(4-fluorobenzylamino)-pyridine which consists essentially of reacting 2-amino-3-nitro-6-methoxypyridine with 4-fluorobenzylamine in water at elevated temperature; in a given case the nitro group can be subsequently reduced and a carbethoxy group introduced.
AU54997/86A
1985-03-23
1986-03-21
Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine
Expired
AU579922B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
DE3510623
1985-03-23
DE3510623
1985-03-23
Publications (2)
Publication Number
Publication Date
AU5499786A
true
AU5499786A
(en)
1986-09-25
AU579922B2
AU579922B2
(en)
1988-12-15
Family
ID=6266157
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU54997/86A
Expired
AU579922B2
(en)
1985-03-23
1986-03-21
Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine
Country Status (24)
Country
Link
US
(1)
US4785110A
(en)
EP
(1)
EP0199951B1
(en)
JP
(1)
JPS61221172A
(en)
KR
(1)
KR860007214A
(en)
AT
(1)
ATE60322T1
(en)
AU
(1)
AU579922B2
(en)
BR
(1)
BR8601283A
(en)
CA
(1)
CA1273343A
(en)
CS
(1)
CS259887B2
(en)
DD
(1)
DD246761A5
(en)
DE
(1)
DE3677042D1
(en)
DK
(1)
DK162215C
(en)
ES
(1)
ES8702893A1
(en)
FI
(1)
FI84819C
(en)
GR
(1)
GR860745B
(en)
HU
(1)
HU206679B
(en)
IE
(1)
IE58560B1
(en)
IL
(1)
IL78218A
(en)
NO
(1)
NO860825L
(en)
PL
(1)
PL146631B1
(en)
PT
(1)
PT82235B
(en)
TR
(1)
TR22924A
(en)
YU
(1)
YU45086A
(en)
ZA
(1)
ZA862138B
(en)
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU570582B2
(en)
*
1985-06-28
1988-03-17
Degussa A.G.
Pharmaceutical composition of flupirtine and 4-acetamidophenol
Families Citing this family (11)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE4327516A1
(en)
*
1993-08-17
1995-02-23
Asta Medica Ag
Primary and secondary neuroprotective effects in neurodegenerative diseases of flupirtine
JPWO2004069802A1
(en)
*
2003-02-06
2006-05-25
塩野義製薬株式会社
Method for producing 2-amino-3-substituted pyridine
US20080279930A1
(en)
*
2007-05-07
2008-11-13
Bernd Terhaag
Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
EP2206701A1
(en)
2008-12-24
2010-07-14
AWD.pharma GmbH & Co.KG
Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester)
EP2206699A1
(en)
2008-12-24
2010-07-14
AWD.pharma GmbH & Co.KG
Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester)
EP2206700A1
(en)
2008-12-24
2010-07-14
AWD.pharma GmbH & Co.KG
Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester)
DE102009023162B4
(en)
*
2009-05-29
2011-07-07
Corden PharmaChem GmbH, 68305
Process for the preparation of flupirtine
CN102140077A
(en)
*
2010-01-28
2011-08-03
范扶民
Flupirtine A crystal form and preparation method thereof
WO2013080215A1
(en)
2011-11-30
2013-06-06
Arch Pharmalabs Limited
An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof
CN104083335B
(en)
*
2013-07-31
2015-11-11
成都苑东药业有限公司
A kind of flupirtine maleate capsule composition and method of making the same
DE102017007385A1
(en)
2017-08-02
2019-02-07
Christoph Hoock
Maleate-free solid dosage forms
Family Cites Families (4)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE1670522C3
(en)
*
1966-05-12
1978-08-31
Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt
New Benzylaminopyridines
BE764362R
(en)
*
1966-05-12
1971-09-16
Degussa
Subst amino pyridienes production
US4481205A
(en)
*
1980-09-13
1984-11-06
Degussa Aktiengesellschaft
2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate
EP0110091B1
(en)
*
1982-10-27
1987-01-21
Degussa Aktiengesellschaft
Derivatives of 2-amino-3-acylamino-6-benzylamino pyridine with an anti-epileptic activity
1986
1986-03-05
NO
NO860825A
patent/NO860825L/en
unknown
1986-03-15
EP
EP86103517A
patent/EP0199951B1/en
not_active
Expired – Lifetime
1986-03-15
DE
DE8686103517T
patent/DE3677042D1/en
not_active
Expired – Lifetime
1986-03-15
AT
AT86103517T
patent/ATE60322T1/en
not_active
IP Right Cessation
1986-03-19
DK
DK126886A
patent/DK162215C/en
not_active
IP Right Cessation
1986-03-20
GR
GR860745A
patent/GR860745B/en
unknown
1986-03-20
FI
FI861183A
patent/FI84819C/en
not_active
IP Right Cessation
1986-03-21
CA
CA000504732A
patent/CA1273343A/en
not_active
Expired – Lifetime
1986-03-21
AU
AU54997/86A
patent/AU579922B2/en
not_active
Expired
1986-03-21
IL
IL78218A
patent/IL78218A/en
unknown
1986-03-21
PT
PT82235A
patent/PT82235B/en
unknown
1986-03-21
PL
PL1986258543A
patent/PL146631B1/en
unknown
1986-03-21
IE
IE74686A
patent/IE58560B1/en
not_active
IP Right Cessation
1986-03-21
ES
ES553222A
patent/ES8702893A1/en
not_active
Expired
1986-03-21
DD
DD86288169A
patent/DD246761A5/en
unknown
1986-03-21
YU
YU00450/86A
patent/YU45086A/en
unknown
1986-03-21
CS
CS861986A
patent/CS259887B2/en
unknown
1986-03-21
BR
BR8601283A
patent/BR8601283A/en
not_active
IP Right Cessation
1986-03-21
ZA
ZA862138A
patent/ZA862138B/en
unknown
1986-03-22
TR
TR163/86A
patent/TR22924A/en
unknown
1986-03-22
KR
KR1019860002142A
patent/KR860007214A/en
not_active
Application Discontinuation
1986-03-24
JP
JP61064292A
patent/JPS61221172A/en
active
Granted
1986-03-24
US
US06/843,253
patent/US4785110A/en
not_active
Expired – Lifetime
1986-03-24
HU
HU861216A
patent/HU206679B/en
unknown
Cited By (1)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU570582B2
(en)
*
1985-06-28
1988-03-17
Degussa A.G.
Pharmaceutical composition of flupirtine and 4-acetamidophenol
Also Published As
Publication number
Publication date
EP0199951B1
(en)
1991-01-23
TR22924A
(en)
1988-11-24
EP0199951A3
(en)
1987-10-14
BR8601283A
(en)
1986-12-02
FI84819C
(en)
1992-01-27
US4785110A
(en)
1988-11-15
JPS61221172A
(en)
1986-10-01
FI84819B
(en)
1991-10-15
CS259887B2
(en)
1988-11-15
PT82235B
(en)
1988-07-29
DK162215B
(en)
1991-09-30
ES8702893A1
(en)
1987-01-16
KR860007214A
(en)
1986-10-08
IE58560B1
(en)
1993-10-06
DE3677042D1
(en)
1991-02-28
FI861183A
(en)
1986-09-24
ES553222A0
(en)
1987-01-16
IL78218A
(en)
1989-12-15
JPH0146510B2
(en)
1989-10-09
AU579922B2
(en)
1988-12-15
ZA862138B
(en)
1986-11-26
HUT40418A
(en)
1986-12-28
PT82235A
(en)
1986-04-01
DK126886A
(en)
1986-09-24
PL146631B1
(en)
1989-02-28
CS198686A2
(en)
1988-03-15
ATE60322T1
(en)
1991-02-15
CA1273343A
(en)
1990-08-28
DD246761A5
(en)
1987-06-17
IE860746L
(en)
1986-09-23
YU45086A
(en)
1988-02-29
DK126886D0
(en)
1986-03-19
FI861183A0
(en)
1986-03-20
GR860745B
(en)
1986-07-21
IL78218A0
(en)
1986-07-31
NO860825L
(en)
1986-09-24
EP0199951A2
(en)
1986-11-05
HU206679B
(en)
1992-12-28
DK162215C
(en)
1992-03-16
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Legal Events
Date
Code
Title
Description
2000-10-12
PC
Assignment registered
Owner name:
ASTA MEDICA AKTIENGESELLSCHAFT
Free format text:
FORMER OWNER WAS: DEGUSSA AKTIENGESELLSCHAFT
2002-01-10
PC
Assignment registered
Owner name:
AWD.PHARMA GMBH AND CO.KG
Free format text:
FORMER OWNER WAS: ASTA MEDICA AKTIENGESELLSCHAFT