AU5499786A

AU5499786A – Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine
– Google Patents

AU5499786A – Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine
– Google Patents
Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine

Info

Publication number
AU5499786A

AU5499786A
AU54997/86A
AU5499786A
AU5499786A
AU 5499786 A
AU5499786 A
AU 5499786A
AU 54997/86 A
AU54997/86 A
AU 54997/86A
AU 5499786 A
AU5499786 A
AU 5499786A
AU 5499786 A
AU5499786 A
AU 5499786A
Authority
AU
Australia
Prior art keywords
amino
pyridine
benzylamino
fluoro
nitro
Prior art date
1985-03-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU54997/86A
Other versions

AU579922B2
(en

Inventor
Peter Emig
Jurgen Engel
Winfried Orth
Hans Pohle
Gerhard Scheffler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AWD Pharma GmbH and Co KG

Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1985-03-23
Filing date
1986-03-21
Publication date
1986-09-25

1986-03-21
Application filed by Degussa GmbH
filed
Critical
Degussa GmbH

1986-09-25
Publication of AU5499786A
publication
Critical
patent/AU5499786A/en

1988-12-15
Application granted
granted
Critical

1988-12-15
Publication of AU579922B2
publication
Critical
patent/AU579922B2/en

2000-10-12
Assigned to ASTA MEDICA AKTIENGESELLSCHAFT
reassignment
ASTA MEDICA AKTIENGESELLSCHAFT
Alteration of Name(s) in Register under S187
Assignors: DEGUSSA A.G.

2002-01-10
Assigned to AWD.PHARMA GMBH & CO. KG
reassignment
AWD.PHARMA GMBH & CO. KG
Alteration of Name(s) in Register under S187
Assignors: ASTA MEDICA AKTIENGESELLSCHAFT

2006-03-21
Anticipated expiration
legal-status
Critical

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members

C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D213/72—Nitrogen atoms

C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members

C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom

C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D213/72—Nitrogen atoms

C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE

Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

Y02P20/00—Technologies relating to chemical industry

Y02P20/50—Improvements relating to the production of bulk chemicals

Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

There is described a process for the production of 2-amino-3-nitro-6-(4-fluorobenzylamino)-pyridine which consists essentially of reacting 2-amino-3-nitro-6-methoxypyridine with 4-fluorobenzylamine in water at elevated temperature; in a given case the nitro group can be subsequently reduced and a carbethoxy group introduced.

AU54997/86A
1985-03-23
1986-03-21
Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine

Expired

AU579922B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE3510623

1985-03-23

DE3510623

1985-03-23

Publications (2)

Publication Number
Publication Date

AU5499786A
true

AU5499786A
(en)

1986-09-25

AU579922B2

AU579922B2
(en)

1988-12-15

Family
ID=6266157
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU54997/86A
Expired

AU579922B2
(en)

1985-03-23
1986-03-21
Process for the preparation of 2-amino-3-nitro-6-(4-fluoro- benzylamino)-pyridine and 2-amino-3-carbethoxy-amino-6- (4-fluoro-benzylamino)-pyridine

Country Status (24)

Country
Link

US
(1)

US4785110A
(en)

EP
(1)

EP0199951B1
(en)

JP
(1)

JPS61221172A
(en)

KR
(1)

KR860007214A
(en)

AT
(1)

ATE60322T1
(en)

AU
(1)

AU579922B2
(en)

BR
(1)

BR8601283A
(en)

CA
(1)

CA1273343A
(en)

CS
(1)

CS259887B2
(en)

DD
(1)

DD246761A5
(en)

DE
(1)

DE3677042D1
(en)

DK
(1)

DK162215C
(en)

ES
(1)

ES8702893A1
(en)

FI
(1)

FI84819C
(en)

GR
(1)

GR860745B
(en)

HU
(1)

HU206679B
(en)

IE
(1)

IE58560B1
(en)

IL
(1)

IL78218A
(en)

NO
(1)

NO860825L
(en)

PL
(1)

PL146631B1
(en)

PT
(1)

PT82235B
(en)

TR
(1)

TR22924A
(en)

YU
(1)

YU45086A
(en)

ZA
(1)

ZA862138B
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU570582B2
(en)

*

1985-06-28
1988-03-17
Degussa A.G.
Pharmaceutical composition of flupirtine and 4-acetamidophenol

Families Citing this family (11)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE4327516A1
(en)

*

1993-08-17
1995-02-23
Asta Medica Ag

Primary and secondary neuroprotective effects in neurodegenerative diseases of flupirtine

JPWO2004069802A1
(en)

*

2003-02-06
2006-05-25
塩野義製薬株式会社

Method for producing 2-amino-3-substituted pyridine

US20080279930A1
(en)

*

2007-05-07
2008-11-13
Bernd Terhaag
Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof

EP2206701A1
(en)

2008-12-24
2010-07-14
AWD.pharma GmbH & Co.KG
Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester)

EP2206699A1
(en)

2008-12-24
2010-07-14
AWD.pharma GmbH & Co.KG
Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester)

EP2206700A1
(en)

2008-12-24
2010-07-14
AWD.pharma GmbH & Co.KG
Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester)

DE102009023162B4
(en)

*

2009-05-29
2011-07-07
Corden PharmaChem GmbH, 68305

Process for the preparation of flupirtine

CN102140077A
(en)

*

2010-01-28
2011-08-03
范扶民
Flupirtine A crystal form and preparation method thereof

WO2013080215A1
(en)

2011-11-30
2013-06-06
Arch Pharmalabs Limited
An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof

CN104083335B
(en)

*

2013-07-31
2015-11-11
成都苑东药业有限公司
A kind of flupirtine maleate capsule composition and method of making the same

DE102017007385A1
(en)

2017-08-02
2019-02-07
Christoph Hoock

Maleate-free solid dosage forms

Family Cites Families (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE1670522C3
(en)

*

1966-05-12
1978-08-31
Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt

New Benzylaminopyridines

BE764362R
(en)

*

1966-05-12
1971-09-16
Degussa
Subst amino pyridienes production

US4481205A
(en)

*

1980-09-13
1984-11-06
Degussa Aktiengesellschaft
2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate

EP0110091B1
(en)

*

1982-10-27
1987-01-21
Degussa Aktiengesellschaft
Derivatives of 2-amino-3-acylamino-6-benzylamino pyridine with an anti-epileptic activity

1986

1986-03-05
NO
NO860825A
patent/NO860825L/en
unknown

1986-03-15
EP
EP86103517A
patent/EP0199951B1/en
not_active
Expired – Lifetime

1986-03-15
DE
DE8686103517T
patent/DE3677042D1/en
not_active
Expired – Lifetime

1986-03-15
AT
AT86103517T
patent/ATE60322T1/en
not_active
IP Right Cessation

1986-03-19
DK
DK126886A
patent/DK162215C/en
not_active
IP Right Cessation

1986-03-20
GR
GR860745A
patent/GR860745B/en
unknown

1986-03-20
FI
FI861183A
patent/FI84819C/en
not_active
IP Right Cessation

1986-03-21
CA
CA000504732A
patent/CA1273343A/en
not_active
Expired – Lifetime

1986-03-21
AU
AU54997/86A
patent/AU579922B2/en
not_active
Expired

1986-03-21
IL
IL78218A
patent/IL78218A/en
unknown

1986-03-21
PT
PT82235A
patent/PT82235B/en
unknown

1986-03-21
PL
PL1986258543A
patent/PL146631B1/en
unknown

1986-03-21
IE
IE74686A
patent/IE58560B1/en
not_active
IP Right Cessation

1986-03-21
ES
ES553222A
patent/ES8702893A1/en
not_active
Expired

1986-03-21
DD
DD86288169A
patent/DD246761A5/en
unknown

1986-03-21
YU
YU00450/86A
patent/YU45086A/en
unknown

1986-03-21
CS
CS861986A
patent/CS259887B2/en
unknown

1986-03-21
BR
BR8601283A
patent/BR8601283A/en
not_active
IP Right Cessation

1986-03-21
ZA
ZA862138A
patent/ZA862138B/en
unknown

1986-03-22
TR
TR163/86A
patent/TR22924A/en
unknown

1986-03-22
KR
KR1019860002142A
patent/KR860007214A/en
not_active
Application Discontinuation

1986-03-24
JP
JP61064292A
patent/JPS61221172A/en
active
Granted

1986-03-24
US
US06/843,253
patent/US4785110A/en
not_active
Expired – Lifetime

1986-03-24
HU
HU861216A
patent/HU206679B/en
unknown

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU570582B2
(en)

*

1985-06-28
1988-03-17
Degussa A.G.
Pharmaceutical composition of flupirtine and 4-acetamidophenol

Also Published As

Publication number
Publication date

EP0199951B1
(en)

1991-01-23

TR22924A
(en)

1988-11-24

EP0199951A3
(en)

1987-10-14

BR8601283A
(en)

1986-12-02

FI84819C
(en)

1992-01-27

US4785110A
(en)

1988-11-15

JPS61221172A
(en)

1986-10-01

FI84819B
(en)

1991-10-15

CS259887B2
(en)

1988-11-15

PT82235B
(en)

1988-07-29

DK162215B
(en)

1991-09-30

ES8702893A1
(en)

1987-01-16

KR860007214A
(en)

1986-10-08

IE58560B1
(en)

1993-10-06

DE3677042D1
(en)

1991-02-28

FI861183A
(en)

1986-09-24

ES553222A0
(en)

1987-01-16

IL78218A
(en)

1989-12-15

JPH0146510B2
(en)

1989-10-09

AU579922B2
(en)

1988-12-15

ZA862138B
(en)

1986-11-26

HUT40418A
(en)

1986-12-28

PT82235A
(en)

1986-04-01

DK126886A
(en)

1986-09-24

PL146631B1
(en)

1989-02-28

CS198686A2
(en)

1988-03-15

ATE60322T1
(en)

1991-02-15

CA1273343A
(en)

1990-08-28

DD246761A5
(en)

1987-06-17

IE860746L
(en)

1986-09-23

YU45086A
(en)

1988-02-29

DK126886D0
(en)

1986-03-19

FI861183A0
(en)

1986-03-20

GR860745B
(en)

1986-07-21

IL78218A0
(en)

1986-07-31

NO860825L
(en)

1986-09-24

EP0199951A2
(en)

1986-11-05

HU206679B
(en)

1992-12-28

DK162215C
(en)

1992-03-16

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Legal Events

Date
Code
Title
Description

2000-10-12
PC
Assignment registered

Owner name:
ASTA MEDICA AKTIENGESELLSCHAFT

Free format text:
FORMER OWNER WAS: DEGUSSA AKTIENGESELLSCHAFT

2002-01-10
PC
Assignment registered

Owner name:
AWD.PHARMA GMBH AND CO.KG

Free format text:
FORMER OWNER WAS: ASTA MEDICA AKTIENGESELLSCHAFT

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