AU556560B2 - Creation of Inventions and Patents with Artificial Intelligence

AU556560B2 – Cis-bicyclo(3,3,0)octane derivatives
– Google Patents

AU556560B2 – Cis-bicyclo(3,3,0)octane derivatives
– Google Patents
Cis-bicyclo(3,3,0)octane derivatives

Info

Publication number
AU556560B2

AU556560B2
AU88813/82A
AU8881382A
AU556560B2
AU 556560 B2
AU556560 B2
AU 556560B2
AU 88813/82 A
AU88813/82 A
AU 88813/82A
AU 8881382 A
AU8881382 A
AU 8881382A
AU 556560 B2
AU556560 B2
AU 556560B2
Authority
AU
Australia
Prior art keywords
compounds
bicyclo
cis
group
image
Prior art date
1981-11-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Application number
AU88813/82A
Other versions

AU8881382A
(en

Inventor
Horst R.E. Bohlke
Gerriet K.H. Loschen
Gudrun E. Michel
Bernd Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Dr Gerriet Loschen

Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1981-11-21
Filing date
1982-09-28
Publication date
1986-11-06

1982-09-28
Application filed by Gruenenthal GmbH
filed
Critical
Gruenenthal GmbH

1983-05-26
Publication of AU8881382A
publication
Critical
patent/AU8881382A/en

1986-11-06
Application granted
granted
Critical

1986-11-06
Publication of AU556560B2
publication
Critical
patent/AU556560B2/en

1993-07-08
Assigned to Dr Gerriet Loschen
reassignment
Dr Gerriet Loschen
Alteration of Name(s) in Register under S187
Assignors: GRUNENTHAL GMBH

2002-09-28
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

150000001875
compounds
Chemical class

0.000
abstract
4

229910052739
hydrogen
Inorganic materials

0.000
abstract
2

239000001257
hydrogen
Substances

0.000
abstract
2

125000004435
hydrogen atom
Chemical group

[H]*

0.000
abstract
2

AEBWATHAIVJLTA-UHFFFAOYSA-N
1,2,3,3a,4,5,6,6a-octahydropentalene
Chemical class

C1CCC2CCCC21
AEBWATHAIVJLTA-UHFFFAOYSA-N
0.000
abstract
1

CIUQDSCDWFSTQR-UHFFFAOYSA-N
[C]1=CC=CC=C1
Chemical compound

[C]1=CC=CC=C1
CIUQDSCDWFSTQR-UHFFFAOYSA-N
0.000
abstract
1

125000005073
adamantyl group
Chemical group

C12(CC3CC(CC(C1)C3)C2)*

0.000
abstract
1

125000000217
alkyl group
Chemical group

0.000
abstract
1

210000001772
blood platelet
Anatomy

0.000
abstract
1

230000036772
blood pressure
Effects

0.000
abstract
1

229910052799
carbon
Inorganic materials

0.000
abstract
1

125000004432
carbon atom
Chemical group

0.000
abstract
1

150000001768
cations
Chemical class

0.000
abstract
1

239000003795
chemical substances by application
Substances

0.000
abstract
1

125000000113
cyclohexyl group
Chemical group

[H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H]

0.000
abstract
1

239000003814
drug
Substances

0.000
abstract
1

239000003112
inhibitor
Substances

0.000
abstract
1

125000006239
protecting group
Chemical group

0.000
abstract
1

208000010110
spontaneous platelet aggregation
Diseases

0.000
abstract
1

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms

C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3

C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P7/00—Drugs for disorders of the blood or the extracellular fluid

A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P9/00—Drugs for disorders of the cardiovascular system

A61P9/12—Antihypertensives

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings

C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system

C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds

C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds

C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom

C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates

C07C49/587—Unsaturated compounds containing a keto groups being part of a ring

C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups

C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System

C07F7/02—Silicon compounds

C07F7/08—Compounds having one or more C—Si linkages

C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages

C07F7/1804—Compounds having Si-O-C linkages

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System

C07F9/02—Phosphorus compounds

C07F9/28—Phosphorus compounds with one or more P—C bonds

C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)

C07F9/40—Esters thereof

C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic

C07F9/4018—Esters of cycloaliphatic acids

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE

Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS

Y02P20/00—Technologies relating to chemical industry

Y02P20/50—Improvements relating to the production of bulk chemicals

Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Cis-bicyclo[3.3.0]octane derivatives corresponding to the formula (I) wherein R1 is hydrogen, a lower alkyl group or a cation and wherein R2 represents a cyclohexyl or an adamantyl group. In these compounds the phenyl radical may be arranged with respect to the double bond in the EZ- or in the E-configuration and at the carbon atom bearing the group R2 the molecule may have the RS- or S-configuration. The compounds are prepared by reacting compounds of the formulae wherein R1 and R2 have the same meaning as above and R6 represents hydrogen or a protecting group. Medicaments containing these compounds act as inhibitors of blood platelet aggregation and (in higher doses) as blood pressure lowering agents.

AU88813/82A
1981-11-21
1982-09-28
Cis-bicyclo(3,3,0)octane derivatives

Ceased

AU556560B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

DE3146278A

DE3146278C2
(en)

1981-11-21
1981-11-21

cis-bicyclo [3.3.0] octane derivatives, medicaments containing them and processes for the preparation of these compounds

DE31462782

1981-11-21

Publications (2)

Publication Number
Publication Date

AU8881382A

AU8881382A
(en)

1983-05-26

AU556560B2
true

AU556560B2
(en)

1986-11-06

Family
ID=6146953
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU88813/82A
Ceased

AU556560B2
(en)

1981-11-21
1982-09-28
Cis-bicyclo(3,3,0)octane derivatives

Country Status (21)

Country
Link

US
(1)

US4510323A
(en)

EP
(1)

EP0080061B1
(en)

JP
(1)

JPS5892637A
(en)

AT
(1)

ATE11668T1
(en)

AU
(1)

AU556560B2
(en)

CA
(1)

CA1202968A
(en)

DD
(1)

DD207196A5
(en)

DE
(2)

DE3146278C2
(en)

DK
(1)

DK155934C
(en)

ES
(1)

ES8308299A1
(en)

GR
(1)

GR77643B
(en)

HK
(1)

HK40488A
(en)

HU
(1)

HU187814B
(en)

IE
(1)

IE53785B1
(en)

MY
(1)

MY8700890A
(en)

PL
(1)

PL137185B1
(en)

PT
(1)

PT75694B
(en)

SG
(1)

SG5788G
(en)

SU
(1)

SU1225482A3
(en)

YU
(1)

YU42604B
(en)

ZA
(1)

ZA826928B
(en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE3408699A1
(en)

1984-03-08
1985-09-12
Schering AG, 1000 Berlin und 4709 Bergkamen

NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS

DE3914735A1
(en)

1989-05-05
1990-11-08
Gruenenthal Gmbh

PHARMACOLOGICALLY ESTER, THE MEDICAMENTS CONTAINING THEM AND THE MANUFACTURE OF THIS ESTER AND MEDICAMENT

Family Cites Families (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

GB201699A
(en)

1922-06-02
1923-08-09
Joseph Gardner
Improvements in mechanical lubricators

DE2912409A1
(en)

1978-03-31
1979-10-11
Ono Pharmaceutical Co

6,9 METHANO PGI LOW 2 ANALOGS

CA1201712A
(en)

1980-02-28
1986-03-11
Paul A. Aristoff
Carbacyclin analogs

JPS56145239A
(en)

1980-04-11
1981-11-11
Sumitomo Chem Co Ltd
Novel bicyclooctane derivative and its preparation

1981

1981-11-21
DE
DE3146278A
patent/DE3146278C2/en
not_active
Expired

1982

1982-09-15
IE
IE2252/82A
patent/IE53785B1/en
not_active
IP Right Cessation

1982-09-20
GR
GR69316A
patent/GR77643B/el
unknown

1982-09-21
ZA
ZA826928A
patent/ZA826928B/en
unknown

1982-09-21
CA
CA000411873A
patent/CA1202968A/en
not_active
Expired

1982-09-28
AU
AU88813/82A
patent/AU556560B2/en
not_active
Ceased

1982-10-18
EP
EP82109592A
patent/EP0080061B1/en
not_active
Expired

1982-10-18
DE
DE8282109592T
patent/DE3262233D1/en
not_active
Expired

1982-10-18
AT
AT82109592T
patent/ATE11668T1/en
not_active
IP Right Cessation

1982-10-18
PT
PT75694A
patent/PT75694B/en
not_active
IP Right Cessation

1982-10-28
SU
SU823505874A
patent/SU1225482A3/en
active

1982-11-17
US
US06/442,240
patent/US4510323A/en
not_active
Expired – Fee Related

1982-11-17
HU
HU823681A
patent/HU187814B/en
not_active
IP Right Cessation

1982-11-18
DK
DK513982A
patent/DK155934C/en
not_active
IP Right Cessation

1982-11-18
PL
PL1982239099A
patent/PL137185B1/en
unknown

1982-11-18
DD
DD82245014A
patent/DD207196A5/en
not_active
IP Right Cessation

1982-11-18
YU
YU2578/82A
patent/YU42604B/en
unknown

1982-11-20
JP
JP57202906A
patent/JPS5892637A/en
active
Granted

1982-11-20
ES
ES517545A
patent/ES8308299A1/en
not_active
Expired

1987

1987-12-30
MY
MY890/87A
patent/MY8700890A/en
unknown

1988

1988-01-25
SG
SG57/88A
patent/SG5788G/en
unknown

1988-06-02
HK
HK404/88A
patent/HK40488A/en
unknown

Also Published As

Publication number
Publication date

IE822252L
(en)

1983-04-21

US4510323A
(en)

1985-04-09

DE3262233D1
(en)

1985-03-21

YU42604B
(en)

1988-10-31

DE3146278A1
(en)

1983-06-01

YU257882A
(en)

1985-03-20

JPS5892637A
(en)

1983-06-02

PL137185B1
(en)

1986-05-31

MY8700890A
(en)

1987-12-31

DE3146278C2
(en)

1984-10-31

EP0080061B1
(en)

1985-02-06

ZA826928B
(en)

1983-11-30

DK155934B
(en)

1989-06-05

PL239099A1
(en)

1983-05-23

SG5788G
(en)

1989-06-02

SU1225482A3
(en)

1986-04-15

EP0080061A1
(en)

1983-06-01

PT75694A
(en)

1982-11-01

DK155934C
(en)

1989-10-09

HK40488A
(en)

1988-06-10

ES517545A0
(en)

1983-08-16

AU8881382A
(en)

1983-05-26

PT75694B
(en)

1985-01-10

DK513982A
(en)

1983-05-22

DD207196A5
(en)

1984-02-22

ATE11668T1
(en)

1985-02-15

ES8308299A1
(en)

1983-08-16

CA1202968A
(en)

1986-04-08

GR77643B
(en)

1984-09-25

HU187814B
(en)

1986-02-28

JPH0336821B2
(en)

1991-06-03

IE53785B1
(en)

1989-02-15

Contact information