AU586200B2 - Creation of Inventions and Patents with Artificial Intelligence

AU586200B2 – 2-(1-(3-chloroallyloxyamino)alkyl)-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides
– Google Patents

AU586200B2 – 2-(1-(3-chloroallyloxyamino)alkyl)-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides
– Google Patents
2-(1-(3-chloroallyloxyamino)alkyl)-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides

Info

Publication number
AU586200B2

AU586200B2
AU49541/85A
AU4954185A
AU586200B2
AU 586200 B2
AU586200 B2
AU 586200B2
AU 49541/85 A
AU49541/85 A
AU 49541/85A
AU 4954185 A
AU4954185 A
AU 4954185A
AU 586200 B2
AU586200 B2
AU 586200B2
Authority
AU
Australia
Prior art keywords
compound
effective amount
trans
plants
cyclohexane
Prior art date
1985-08-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
AU49541/85A
Other versions

AU4954185A
(en

Inventor
Tatao Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Arysta LifeScience Corp

Original Assignee
Chevron Research and Technology Co
Chevron Research Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1985-08-23
Filing date
1985-09-19
Publication date
1989-07-06

1985-09-19
Application filed by Chevron Research and Technology Co, Chevron Research Co
filed
Critical
Chevron Research and Technology Co

1987-04-07
Publication of AU4954185A
publication
Critical
patent/AU4954185A/en

1989-07-06
Application granted
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Critical

1989-07-06
Publication of AU586200B2
publication
Critical
patent/AU586200B2/en

1994-04-28
Assigned to TOMEN CORPORATION
reassignment
TOMEN CORPORATION
Alteration of Name(s) in Register under S187
Assignors: CHEVRON RESEARCH COMPANY

2004-05-27
Assigned to ARYSTA LIFESCIENCE CORPORATION
reassignment
ARYSTA LIFESCIENCE CORPORATION
Alteration of Name(s) in Register under S187
Assignors: TOMEN CORPORATION

2005-09-19
Anticipated expiration
legal-status
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Expired
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Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton

C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups

C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms

C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton

C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings

A—HUMAN NECESSITIES

A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING

A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS

A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical

A01N35/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen

A01N35/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen containing a carbon-to-nitrogen double bond

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton

C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups

C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings

Description

2-[l-(3-CHLOROALLYLOXYAMINO) ALKYLIDENE]-5- ALKYLTHIOAL-KYL-CYCLOHEXANE-1,3-DIONE HERBICIDES
BACKGROUND OF THE INVENTION
This invention relates to trans-2- .l-(3-chloro- allylamino) propylidene]-5-(2->-ethylthiopropyl)cyclohexane- 1,3-dione and salts thereof and to the use of such com- pounds as herbicides.
In my U.S. Patent No. 4,440,566, issued April 3, 1984, I disclosed compounds having the formula:

wherein R is most preferably alkyl or 1 to 3 carbon atoms, most preferably ethyl or propyl;
R1 is most preferably 3-trans-chloroallyl or 4-chlo- robenzyl;
R 2 and R3 are preferably each alkyl or 1 to 3 carbon atoms or one of R or R-* is hydrogen and the other is alkylthioalkyl having 2 through 8 carbon atoms, most pre¬ ferably R2 and R3 are each methyl or one of R2 or R3 is hydrogen and the other is 2-ethylthiopropyl.
My patent also teaches that these compounds exhibit herbicidal activity against grasses and are safe with respect to broad-leaf crops.
SUMMARY OF THE INVENTION
It is has now been discovered that one of the compounds (i.e., see Formula I below R is ethyl) encom¬ passed within U.S. Patent No. 4,440,566, exhibits surpris¬ ingly superior herbicidal activity as compared with others, including its homolog where R is propyl. This is

especially surprising because such homolog where R is propyl is a very good herbicide. As well as exhibiting pre-emergence activity, the present compound exhibits excellent post-emergence herbicidal activity against Bermudagrass, foxtail, crab- grass, volunteer corn, volunteer sorghum, barnyardgrass, broad-leaf signalgrass, goosegrass, red rice, sprangletop, seedling Johnsongrass and Rhizone Johnsongrass.
The compound of Formula I exhibits excellent phytotoxicity against grasses at even very low application rates and may be safely applied with respect to broad-leaf crops at such rates. Thus, the present compound is espe- cially useful for controlling grassy weeds in broad-leaf crops and is’ especially useful to control grassy weeds in soybean crops.
The compound of the present invention can be represented by the following formula:

(I)
wherein Rx is 3-transchloroallyl.
The invention also comprises compatible salts of the compound of Formula I.
As is well recognized, compounds of the nature of Formula (I) exist as tautomers. The compounds also have two asymmetric carbon atoms and can also exist as optical iso ers. The above formula is intended to encom¬ pass the respective tauto eric forms as well as the

individual optical isomers as well as mixtures thereof and the respective tautomers and optical isomers as well as mixtures thereof are encompassed within the invention. In a further aspect the invention provides a herbicidal composition comprising a compatible carrier and a herbicidally effective amount of the compound(s) of the invention or mixtures thereof. The present invention also provides a method for preventing or controlling the growth of unwanted grassy vegetation, which comprises treating the growth medium and/or the foliage of such vegetation with a herbicidally effective amount of the compound(s) of the invention or mixtures thereof.
The present invention also provides a method for regulating plant growth which comprises treating the growth medium and/or the foliage of such vegetation with a plant growth regulating effective amount of the co – pound(s) of the invention or mixtures thereof, effective to alter the normal growth pattern of said plants.
The present invention also provides chemical intermediates and processes for preparing the compounds of the invention. The invention will be further described herein- below.
FURTHER DESCRIPTION OF THE INVENTION AND THE PREFERRED EMBODIMENTS
The compound of Formula (I) can be conveniently prepared by the following schematically represented pro¬ cess:

(A)

wherein R1 is 3-trans-chloroallyl.
This process can be conveniently effected by contacting Compound (A) with 3-trans-chloroallyloxyamine (B), preferably in an inert organic solvent.
Typically, this process is conducted at tempera¬ tures in the range of about from 0 to 80°C, preferably about from 20 to 40°C, for about from 1 to 48 hours, pre- ferably about from 4 to 12 hours, using about from 1 to 2, preferably 1.05 to 1.2 moles of 3-trans-chloroallyloxy- amine (B) per mole of Compound (A) . Suitable inert organic solvents which can be used include, for example, lower alkanols, e.g., ethanol, ethanol, ethers, e.g., ethyl ether; methylene chloride. Two-phase water and immiscible organic solvent (e.g.,- hexane), and the like, and compatible mixtures thereof can also be used.
Trans-chloroallyloxyamine is a known compound and can be prepared via known procedures, such as, for example, described in my U.S. Patent No. 4,440,566. Con¬ veniently, a hydrochloride salt of- trans-chloroallyloxy¬ amine can be used by neutralizing the salt with an alkali metal alkoxide, in situ.
The starting materials of Formula (A) can be prepared via the general procedure described in my U.S. Patent No. 4,440 ,566.
The compatible salts of Formula (I) can be pre¬ pared by conventional procedures, for example, via the reaction of the compound of Formula I with a base, such as, for example, sodium hydroxide, potassium hydroxide and the like, having the desired cation. Additional varia¬ tions in the salt cation can also be effected via ion exchange with an ion exchange resin having the desired cation. General Process Conditions
The reaction product can be recovered from its reaction product mixture by any suitable separation and purification procedure, such as, for example, chromato- graphy. Suitable separation and purification procedures

“5- * – – – . .
are, for example, illustrated in the Examples set forth hereinbelow. Generally, the reactions described above are conducted as liquid phase reaction and hence pressure is generally not significant except as it affects temperature (boiling point) where reactions are conducted at reflux. Therefore, these reactions are generally conducted at pressures of about from 300 to 3,000 mm of mercury and conveniently are conducted at about atmospheric or ambient pressure.
It should also be appreciated that where typical or preferred process conditions (e.g., reaction tempera- tures, times, mole ratios of reactants, solvents, etc.) have been given, that other process conditions could also be used. Optimum reaction conditions (e.g., temperature, reaction time, mol ratios, solvents, etc.) may vary with the particular reagents or organic solvents used but can be determined by routine optimization procedures.
Where optical iso er mixtures are obtained, the respective optical isomers can be obtained by conventional resolution procedures. Geometric isomers can be separated by conventional separation procedures which depend upon differences. in physical properties between the geometric isomers. However, it is generally preferable to use the desired isomeric starting material in the reaction. Definitions
As used herein the following terms have the following meanings unless expressly stated to the contrary:
The term “compatible salts” refers to salts which do not significantly adversely alter the herbicidal properties of the parent compound. Suitable salts include cation salts such as, for example, the cation salts of lithium, sodium, potassium, alkali earth metals, copper, zinc, ammonia, quaternary ammonium salts, and the like.
The term “room temperature” or “ambient tempera¬ ture” refers to about 20-25°C.

Utility
The compound of Formula (I) and its salts exhibit both pre- and post-emergent herbicidal activity and exhibit especially good herbicidal activity against grasses. The compounds exhibit especially good phyto¬ toxicity against foxtail, Ber udagrass, crabgrass, rhizone Johnsongrass and volunteer corn which are weed species which are generally very difficult to control.
Generally, for post-emergent applications, the herbicidal compounds are applied directly to the foliage or other plant parts. For pre-emergence applications, the herbicidal compounds are applied to the growth medium, or prospective growth medium, for the plant. The optimum amount of the herbicidal compound or composition will vary with the particular plant species, and the extent of plant growth, if any, and the particular part of the plant which is contacted and the extent of contact. The optimum dosage can also vary with the general location, or environment (e.g., sheltered areas such as greenhouses compared to exposed areas such as fields) , and type and degree of control desired. Generally, for both pre- and post-emergent control, the present compounds are applied at rates’ of about from 0.02 to 60 kg/ha, preferably about from 0.02 to 10 kg/ha.
Also, although in theory the compounds can be applied undiluted, in actual practice they are generally applied as a composition or formulation comprising an effective amount of the compound(s) and an acceptable car¬ rier. An acceptable or compatible carrier (agriculturally acceptable carrier) is one which does not significantly adversely affect the desired biological effect achieved by the active compounds, save to dilute it. Typically, the composition contains about from 0.05 to 95% by weight of the compound of Formula (I) or mixtures thereof. Concen¬ trates can also be made having high concentrations designed for dilution prior to application. The carrier can be a solid, liquid, or aerosol. The actual compositions can take the form of granules, powders,

dusts, solutions, emulsions, slurries, aerosols, and the like. Suitable solid carriers which can be used include, for example, natural clays (such as kaolin, atta- pulgite, montmorillonite, etc.), talcs, pyrophyllite, diatomaceous silica, synthetic fine silica, calcium alumi- nosilicate, tricalciu phosphate, and the like. Also, organic materials, such as, for example, walnut shell flour, cotton-seed hulls, wheat flour, wood flour, wood bark flour, and the like can also be used as carriers. Suitable liquid diluents which can be used include, for example, water, organic solvents (e.g., hydrocarbons such as benzene, toluene, dimethylsulfoxide, kerosene, diesel fuel, fuel oil, petroleum naphtha, etc.), and the like. Suitable aerosol carriers which can be used include con¬ ventional aerosol carriers such as halogenated alkanes, etc. The composition can also contain various promo¬ ters and surface-active agents which enhance the rate of transport of the active compound into the plant tissue such as, for example, organic solvents, wetting agents and oils, and in the case of compositions designed for pre- emergence application agents which reduce the leachability of the compound or otherwise enhance soil stability. Crop oils, such as, for example, soybean oils, paraffin oils and olefinic oils, are especially advantageous as carriers or additives in that they enhance phytotoxicity. The composition can also contain various com¬ patible adjuvants, stabilizers, conditioners, insecti¬ cides, fungicides, and if desired, other herbicidally active compounds.
One convenient concentrate formulation which can be used comprises 23-27% by weight of the active herbicide of the invention, 2 to 4% by weight of an emulsifier, for example, calcium alkylbenzene sulfonates, octylphenol- ethoxylate, etc., or mixtures thereof, and about 70-75% organic solvent, for example, xylene, etc. The concen- trate is mixed with water and preferably a crop oil prior

to application and applied as a water emulsion containing about 0.5 to 2% of a crop oil, for example, soybean oils, and paraffinic oils and olefinic oils. Conveniently, the herbicide is applied as water emulsion containing about 0.02-0.6 wt. %, preferably 0.07-0.15 wt. % of the herbi¬ cide, of the invention; about’ 0.001-0.01 wt. % of an emul- sifier; about 0.08-2.5 wt. % of an organic solvent and about 95 to 99 wt. % water. Preferably, the composition also contains about 0.25 to 2 wt. % of a crop oil. The application composition can be conveniently prepared by mixing the concentrate formulation with about 1/4 to 1/2 the desired amount of water. Then admixing the crop oil and then adding the remaining amount of water. If no crop oil is used, then the water and concentrate formulation are simply admixed together.
A further understanding of the invention can be had in the following non-limiting Preparation(s) and Example(s). Wherein,’ unless expressly stated to the con¬ trary, all temperatures and temperature ranges refer to the Centigrade system and the term “ambient” or “room temperature” refers to about 20-25°C. The term “percent” or “%” refers to weight percent and the term “mole” or “moles” refers to gram moles. The term “equivalent” refers to a quantity of reagent equal in moles, to the moles of the preceding or succeeding reactant recited in that example in terms of finite moles or finite weight or volume. Where given, proton-magnetic resonance spectrum (p.m.r. or NMR) were determined at 60 mHz, signals are assigned as singlets (s), broad singlets (bs), doublets (d), double doublets (dd) , triplets (t), double triplets (dt), quartets (q) , and multiplets ( ) ; and cps refers to cycles per second. Also where necessary examples are repeated to provide additional starting material for sub¬ sequent examples.

EXAMPLES
Example 1
05 Trans-2-[l-(3-chloroallyloxyamino) propylidene]-5- (2-ethylthiopropyl)-cyclohexane-l,3-dione
In this example, 17.2 g (0.0636 mol) of 2-pro- pionyl-5-(2-ethylthiopropyl)αyclohexane-l,3-dione; 0.9 g
(0.0153 mol) of acetic acid, ‘and 10.9 g (0.0757 mol) of
3-trans-chloroallyloxyamine in 35 ml of water were added
10 to 20 ml of hexane and stirred. Aqueous 5 wt. % sodium hydroxide was slowly added over about 15 minutes until 3.0 g (0.0757 m + small excess) of sodium hydroxide had been added – pH of reaction mixture about 6. The mixture was
15 heated to and maintained at 40°C for 2-1/2 hours and then cooled to room temperature. The organic (i.e., hexane) phase was separated and washed with 10 ml of aqueous 5 wt.
% hydrochloric acid and then aqueous 6.25 wt. % sodium hydroxide added until pH12. The aqueous phase was
20 separated and admixed with 25 ml of hexane and the pH adjusted to 5.4 by the dropwise addition of aqueous 36 wt. % hydrochloric acid over an ice bath. The organic phase was separated, dried over magnesium sulfate and then concentrated by evaporation affording 18.0 g of a crude
–. product. The crude product was purified by column chromatography over silica gel eluting with hexane:methylene chloride affording the purified title compound as an oil. Elemental analysis carbon calculated 56.73%, found 56.63%; Hydrogen calculated 7.28%, found
30 7.55%; Nitrogen 3.89%, found 3.55%.
Example 2
Sodium 2-[l-(3-trans-chloroallyloxyamino) propylidene-3-oxo-5-(2-ethylthiopropyl)- cyclohex-1-en-l-olate
This example illustrates a procedure which can 35 be used to prepare the title compound.
A solution containing 0.01 mole of sodium hydroxide dissolved in 2 ml of wate is added to a solu¬ tion containing 0.01 mole of 2-[l-(3-trans-chloroallyl- oxyamino) propylidene-5-(2-ethylthiopropyl)-cyclohexane 40 1,3-dione at room temperature. After the reaction is

completed, the solvents are evaporated off under vacuum affording the 1-hydroxy sodium salt of 2-[l-(3-trans-chlo- roallyloxyamino) propylidene-3-oxo-5-(2-ethylthiopropyl)- cyclohex-1-en-l-ol.
Example 3 In this example, the title compound of Example 1, i.e., 2-[l-(3-trans-chloroallyloxyamino) propylidene]- 5-(2-ethylthiopropyl)-cyclohexane-l ,3-dione was tested, using the procedures described hereinbelow, for pre-e er- gent and post-emergent phytotoxic activity against a variety of grasses and broad-leaf plants including one grain crop and one broad-leaf crop. Pre-Emergent Herbicide Test
Pre-emergence herbicidal activity was determined in the following manner.
Test solutions of the respective compounds were prepared as follows: 355.5 mg of test compound was dissolved in 15 ml of acetone. 2 ml of acetone containing 110 mg of a non- ionic surfactant was added to the solution. 12 ml of this stock solution was then added to 47.7 ml of water which contained the same nonionic surfactant at a concentration of 625 mg/1.
Seeds of the test vegetation were planted in a pot of soil and the test solution was sprayed uniformly onto the soil surface at a test compound dose of 27.5 micrograms/cm unless otherwise specified in the following Tables. The pot was watered and placed in a greenhouse. The pot was watered intermittently and observed for seedling emergence, health of emerging seed¬ lings, etc., for a 3-week period. At the end of this period, the herbicidal effectiveness of the compound was rated based on the physiological observations. A O-to-100 scale was used, 0 representing no phytotoxicity, 100 representing complete kill. The results of these tests are summarized in Table 1.

Post-Emergent Herbicidal Test The test compound was formulated in the same manner as described above for the pre-emergent test.
This formulation was uniformly sprayed on 2 similar pots containing plants 2 to 3 inches tall (except wild oats, soybean and watergrass which were 3 to 4 inches tall) (approximately 15 to 25 plants per pot) at a test compound dose of 27.5 microgram/cm2 unless otherwise specified in the following Tables. After the plants had dried, they were placed in a greenhouse and then watered intermit¬ tently at their bases as needed. The plants were observed periodically for phytotoxic effects and physiological and morphological responses to the treatment. After 3 weeks, the herbicidal effectiveness of the compound was rated based on these observations. A O-to-100 scale was used, 0 representing no phytotoxicity, 100 representing complete kill. The results of these tests are summarized in Table 2.

01
TABLE 1
Pre-Emergence Herbicidal Activity
05 Application Rate: 27.5 icrograms/cm , unless otherwise noted
Broad-leaf Plants Grasses
% Phytotoxicity % Phytotoxicity
Compound Barnyard
10 No. Lambsquarter Mustard Pigweed Soybean Grass Crabgrass Wild Oats Rice π
25 30 25 30 100 100 100 100
15
20

01
TABLE 2 Post-Emergence Herbicidal Activity 05 Application Rate: 27.5 micrograms/cm2, unless otherwise noted
Broadleaf Plants Grasses % Phytotoxicity % Phytotoxicity
Compound Barnyard
No. Lambsquarter Mustard Pigweed Soybean Grass Crabgrass Wild Oats Rice
10
1 30 45 40 40 100 100 100 100
15

Example 3 In this example, the title compound of Example 1, of the present invention, (“1”) was tested for post-emergence herbicidal activity at moderately low dosage rates side-by-side with its butylidene homolog, i.e. , trans-2-[l-(3-chloroal’lyloxyamino)butylidene]-5-(2- ethylthiopropyl)-cyclohexane-1,3-dione. The tests were conducted in the same manner as described in Example 2, hereinabove, with the exception that the application rates specified in Table 3 were used and 4 replicate pots were used per test instead of 2. The average result of the four replicates are reported in Table 3 herein below, wherein 0 indicates no phytotoxicity and 100 indicates complete kill. Generally, phytotoxici- ties below about 20-30% are not considered significant because the plant can typically grow out of this amount of injury.

01
TABLE 3 Post-Emergence Herbicidal Activity
05 Moderate Low Dosage Tests Broadleaf Plants Grasses
Phytotoxicity % Phytotoxicity
Com¬ Barn¬ pound Dosage Lambs¬ Pig¬ Crab¬ yard Wild
10 No.* γ/cm ** quarter Mustard weed Soybean grass grass Oats Rice
1 1.8 0 3 0 7 100 100 98 98
1 0.7 0 0 0 2 100 100 80 85
C-l 1.8 0 0 0 N.T. 87 100 95 – ?7
C-l 0.7 0 0 0 N.T. 60 98 80 87
15
N.T. = Not tested, but based on other tests the comparison compound is also safe with respect to soybeans at this dosage rate.
20 1 = trans-2-[l-(3-chloroallyloxyamino)propylidene]-5-(2-ethylthiopropyl)-cyclohexane- 1,3-dione
C-l = trans-2-[l-(3-chloroallyloxyamino)butylidene]-5-(2-ethylthiopropyl)-eyelohexane- 1,3-dione
**γ/cm = micrograms per square centimeter.
25

As can be seen from Table 3, Compound 1 was substantially superior to comparison Compound C-l against crabgrass, even at moderately low dosages. The superior¬ ity of Compound 1 will become more apparent at the low dosages used in Example 4 hereinbelow.
Example 4 In this example, the title compound (“1”) was tested for post-emergence herbicidal activity at very low dosage rate side by side with trans-2-[l-(3-chloroallyl- oxyamino)butylidene]-5-(2-ethylthiopropyl)-cyclohexane- 1,3-dione (“C-l”) and the commercial herbicide Sethoxdm (“C-2”) (i.e., 2-[l-(ethoxyamino)butylidene]-5-(2- ethylthiopropyl)-cyclohexane-l,3-dione against an expanded list of weed grasses.
The tests were conducted in the same manner as described in Example 3, hereinabove, with the exception that the dosages indicated in Table 4 were used. The results of this testing are summarized in Table 4 wherein 0 indicates no phytotoxicity and 100 indicates complete kill. Generally, phytotoxicities below about 20-30% are not considered meaningful because the plant can typically grow out of this amount of injury.

01
TABLE 4 Post-Emergence Herbicidal Activity
05 Low Dosage Tests Broadleaf Plants Grasses
% Phytotoxicity % Phytotoxicity
Com¬ Barn¬ Rhizone pound Dosage Crab¬ yard Wild Johnson¬ Yellow Yellow
10 No.* γ/cm2* grassi grass Oats grass Foxtail Nutsedge Soybean Rice
1 0.28 71 99 66 99 99 0 0 93
1 0.11 63 90 46 92 92 0 0 83

■

1 0.05 40 60 6 63 63 0 o … 71
1 0.02 5 8 0 21 21 0 0 1
15
C-l 0.28 55 96 60 68 80 0 0 78
C-l 0.11 25 70 43 43 53 0 0 70
C-l 0.05 15 40 26 21 40 0 0 40
C-l 0.02 0 8 0 0 0 0 0 10
20
C-2 0.28 53 80 36 73 68 63
C-2 0.11 16 68 16 31 48 0 0 41
C-2 0.05 10 20 0 0 10 0 0 10
C-2 0.02 0 0 0 0 0 0 0 0
25

As can be seen from Table 4, with the exception of wild oats and yellow nutsedge. Compound 1 was superior to Comparison Compound C-l with respect to teach of the other weed species tested. Compounds 1 and C-l were about equivalent with respect to wild oats and both, compounds were inactive at these dosage, rates against yellow nut- sedge. Compounds 1 and C-l were both superior to Compound C-2.
In terms of dosages required to evoke equivalent responses, an application rate of Compound 1 of 0.11 q/cm2 was about equivalent to an application rate of Compound C-l of 0.28 q/cm2 to control crabgrass and barnyardgrass. An application rate of Compound 1 of 0.05 q/c was about equivalent to an application rate of Compound C-l of 0.28 q/c to control yellow foxtail and an application rate of Compound 1 of 0.11 q/cm2 was superior to an application rate of Compound C-l of 0.28 q/cm to control Johnsongrass Obviously, many modifications and variations of the invention described hereinabove and below can be made without departing from the essence and scope thereof.

Claims (14)

WHAT IS CLAIMED IS:

1. A compound having the formula:

wherein R1 is 3-trans-chloroallyl; and compatible salts thereof.

2. The compound of Claim 1 wherein said compound is 2-[l-(3-trans-chloroallylamino) propylidene]-5-(2-ethyl¬ thiopropyl)-cyclohexane-l,3-dione.

3. A herbicidal composition comprising a herbici¬ dally effective amount of a compound according to Claim 1, and a compatible carrier.

4. A herbicidal composition comprising a herbici¬ dally effective amount of the compound of Claim 2, and a compatible carrier.

5. A herbicidal composition comprising a herbi¬ cidally effective amount of the compound according to Claim 1 and a crop oil.

6. A method for controlling grassy plants which comprises applying a herbicidally effective amount of a compound according to Claim 1, to the foliage or habitat of said plants.

7. A method for controlling grassy plants which comprises applying a herbicidally effective amount of the compound of Claim 2, or mixtures thereof, to the foliage or habitat of said plants.

8. A method for controlling the grass species of foxtail, Bermudagrass, volunteer sorghum, broad-leaf signalgrass, goosegrass, red rice, sprangletop,
Johnsongrass or volunteer corn which comprises applying a herbicidally effective amount of the compound of Claim 1 to said grass species or their habitat.

9. A method for preparing the compound of Claim 1 which comprises the step of contacting 2-propionyl-5-(2- methylthiopropyl)-cyclohexane-l,3-dione with 3-trans- chloroallyloxyamine under reactive conditions thereby pro¬ ducing the corresponding compound of Formula I.

10. The method of Claim 9 wherein said method is conducted in an inert organic solvent at temperatures in the range of about from 0 to 80°C.

11- A process for preparing the compounds of Claim 1, substantially as described herein.

12. A herbicidal composition comprising 0.02-0.6 wt. % of a compound according to Claim 1; 0.001-0.15 wt.. % of an emulsifier; 0.08-2.5 wt. % of an organic solvent and about 95 to 99 wt. % water.

13. The composition of Claim 12 wherein said compo¬ sition comprises about 0.25-2 wt. % of a crop oil.

14. A herbicidal concentrate composition comprising 23-27 wt. % of a compound according to Claim 1; 2 to 4 wt. % of an emulsifier and about 70-75 wt. % of an organic solvent.

AU49541/85A
1985-08-23
1985-09-19
2-(1-(3-chloroallyloxyamino)alkyl)-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides

Expired

AU586200B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

US76830185A

1985-08-23
1985-08-23

US79867085A

1985-11-15
1985-11-15

Publications (2)

Publication Number
Publication Date

AU4954185A

AU4954185A
(en)

1987-04-07

AU586200B2
true

AU586200B2
(en)

1989-07-06

Family
ID=27118040
Family Applications (2)

Application Number
Title
Priority Date
Filing Date

AU49541/85A
Expired

AU586200B2
(en)

1985-08-23
1985-09-19
2-(1-(3-chloroallyloxyamino)alkyl)-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides

AU59380/86A
Ceased

AU585999B2
(en)

1985-08-23
1986-06-30
2-“1-(3-chloroallyloxyamino)alkylidene“-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides

Family Applications After (1)

Application Number
Title
Priority Date
Filing Date

AU59380/86A
Ceased

AU585999B2
(en)

1985-08-23
1986-06-30
2-“1-(3-chloroallyloxyamino)alkylidene“-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides

Country Status (14)

Country
Link

EP
(1)

EP0236313A1
(en)

KR
(1)

KR920010518B1
(en)

CN
(2)

CN1011782B
(en)

AU
(2)

AU586200B2
(en)

BE
(1)

BE903349A
(en)

CA
(1)

CA1271644A
(en)

CH
(2)

CH666890A5
(en)

DE
(1)

DE3627410A1
(en)

FR
(1)

FR2586416B1
(en)

GB
(2)

GB2188321B
(en)

NL
(2)

NL193944C
(en)

NO
(1)

NO162555C
(en)

SE
(1)

SE458683B
(en)

WO
(1)

WO1987001699A1
(en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

CH666890A5
(en)

1985-08-23
1988-08-31
Chevron Res

2- (1- (3-CHLORALLYLOXYAMINO) ALKYLIDES) -5-ALKYLTHIOALKYL-CYCLOHEXAN-1,3-DION.

DE3762742D1
(en)

1986-04-24
1990-06-21
Ciba Geigy Ag

ACYL-CYCLOHEXANDIONE AND THEIR OXIMAETHER WITH HERBICIDAL AND REGULATING EQUIPMENT REGULATING EFFECT.

GB8722838D0
(en)

1987-09-29
1987-11-04
Shell Int Research
Oximino ether compounds

JP2536075B2
(en)

1988-06-27
1996-09-18
住友化学工業株式会社

Herbicidal composition

US5108488A
(en)

1989-07-21
1992-04-28
Valent U.S.A. Corporation
Synergistic herbicidal composition

US6300281B1
(en)

2000-07-03
2001-10-09
Valent U.S.A. Corporation
Optically pure(−) clethodim, compositions and methods for controlling plant growth comprising the same

CA2733544C
(en)

2008-08-19
2013-12-17
Dow Agrosciences Llc
Improved process for the addition of thiolates to alpha, beta-unsaturated carbonyl or sulfonyl compounds

CN105418470B
(en)

2015-11-17
2017-12-15
江苏长青农化股份有限公司
A kind of synthetic method of clethodim

CN106187841B
(en)

2016-07-08
2018-01-30
山东润博生物科技有限公司
A kind of industrialized process for preparing of clethodim

US11503830B2
(en)

2019-02-20
2022-11-22
Valent U.S.A., Llc
Clethodim compositions and methods of use thereof

CN113024425B
(en)

2019-12-24
2022-05-17
沈阳科创化学品有限公司
Preparation method of clethodim

CN112225682B
(en)

2020-10-19
2022-02-25
中国科学院大连化学物理研究所
Method for improving reaction speed of synthesizing clethodim

Citations (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4440566A
(en)

1982-08-05
1984-04-03

Chevron Research Company

Herbicidal substituted 2-(1-(oxyamino)-alkylidene)-cyclohexane-1,3-diones

AU556148B2
(en)

1982-01-29
1986-10-23

Ici Australia Limited

Cyclohexane -1,3- dione derivatives

AU5938086A
(en)

1985-08-23
1987-02-26

Chevron Research Company

2-“1-(3-chloroallyloxyamino)alkylidene“-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides

1985

1985-09-19
CH
CH1974/87A
patent/CH666890A5/en
not_active
IP Right Cessation

1985-09-19
WO
PCT/US1985/001786
patent/WO1987001699A1/en
active
Application Filing

1985-09-19
NL
NL8520309A
patent/NL193944C/en
not_active
IP Right Cessation

1985-09-19
AU
AU49541/85A
patent/AU586200B2/en
not_active
Expired

1985-09-19
EP
EP85904913A
patent/EP0236313A1/en
active
Pending

1985-09-19
GB
GB8708127A
patent/GB2188321B/en
not_active
Expired

1985-09-19
KR
KR1019860700645A
patent/KR920010518B1/en
not_active
IP Right Cessation

1985-09-30
BE
BE0/215661A
patent/BE903349A/en
not_active
IP Right Cessation

1986

1986-06-30
AU
AU59380/86A
patent/AU585999B2/en
not_active
Ceased

1986-07-22
NL
NL8601900A
patent/NL8601900A/en
not_active
Application Discontinuation

1986-07-30
CN
CN86105662A
patent/CN1011782B/en
not_active
Expired

1986-07-30
CN
CN90107624A
patent/CN1021282C/en
not_active
Expired – Lifetime

1986-08-13
DE
DE19863627410
patent/DE3627410A1/en
not_active
Withdrawn

1986-08-18
FR
FR8611806A
patent/FR2586416B1/en
not_active
Expired

1986-08-19
CH
CH3344/86A
patent/CH667086A5/en
not_active
IP Right Cessation

1986-08-20
CA
CA000516351A
patent/CA1271644A/en
not_active
Expired – Fee Related

1986-08-21
GB
GB8620373A
patent/GB2179352B/en
not_active
Expired

1986-09-15
SE
SE8603868A
patent/SE458683B/en
not_active
IP Right Cessation

1986-09-18
NO
NO86863733A
patent/NO162555C/en
not_active
IP Right Cessation

Patent Citations (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

AU556148B2
(en)

1982-01-29
1986-10-23
Ici Australia Limited
Cyclohexane -1,3- dione derivatives

US4440566A
(en)

1982-08-05
1984-04-03
Chevron Research Company
Herbicidal substituted 2-(1-(oxyamino)-alkylidene)-cyclohexane-1,3-diones

AU5938086A
(en)

1985-08-23
1987-02-26
Chevron Research Company
2-“1-(3-chloroallyloxyamino)alkylidene“-5-alkylthioalkyl- cyclohexane-1,3-dione herbicides

Also Published As

Publication number
Publication date

NO162555C
(en)

1990-01-17

AU4954185A
(en)

1987-04-07

GB8708127D0
(en)

1987-05-13

NL193944B
(en)

2000-11-01

CN1051285A
(en)

1991-05-15

FR2586416A1
(en)

1987-02-27

CH666890A5
(en)

1988-08-31

AU5938086A
(en)

1987-02-26

BE903349A
(en)

1986-04-01

FR2586416B1
(en)

1989-06-02

EP0236313A1
(en)

1987-09-16

CH667086A5
(en)

1988-09-15

GB8620373D0
(en)

1986-10-01

CA1271644A
(en)

1990-07-17

CN1011782B
(en)

1991-02-27

CN1021282C
(en)

1993-06-23

NO863733L
(en)

1987-03-26

AU585999B2
(en)

1989-06-29

NL8601900A
(en)

1987-03-16

GB2179352A
(en)

1987-03-04

SE8603868D0
(en)

1986-09-15

WO1987001699A1
(en)

1987-03-26

KR920010518B1
(en)

1992-12-04

GB2188321A
(en)

1987-09-30

CN86105662A
(en)

1987-04-08

NL193944C
(en)

2001-03-02

GB2179352B
(en)

1989-08-09

NO863733D0
(en)

1986-09-18

SE458683B
(en)

1989-04-24

KR870700287A
(en)

1987-12-28

NL8520309A
(en)

1985-09-19

SE8603868L
(en)

1987-03-20

NO162555B
(en)

1989-10-09

DE3627410A1
(en)

1987-02-26

GB2188321B
(en)

1989-08-31

Contact information