AU589387B2 – Bicyclic heterocyclic piperazine derivatives
– Google Patents
AU589387B2 – Bicyclic heterocyclic piperazine derivatives
– Google Patents
Bicyclic heterocyclic piperazine derivatives
Info
Publication number
AU589387B2
AU589387B2
AU51390/85A
AU5139085A
AU589387B2
AU 589387 B2
AU589387 B2
AU 589387B2
AU 51390/85 A
AU51390/85 A
AU 51390/85A
AU 5139085 A
AU5139085 A
AU 5139085A
AU 589387 B2
AU589387 B2
AU 589387B2
Authority
AU
Australia
Prior art keywords
compounds
bicyclic heterocyclic
piperazine derivatives
preparation
heterocyclic piperazine
Prior art date
1984-12-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU51390/85A
Other versions
AU5139085A
(en
Inventor
Jan Hartog
Cornelis Gerrit Kruse
Berend Oliver
Johannes Antonius Maria Van Der Heyden
Ineke Van Wijngaarden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duphar International Research BV
Original Assignee
Duphar International Research BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1984-12-21
Filing date
1985-12-18
Publication date
1989-10-12
1985-12-18
Application filed by Duphar International Research BV
filed
Critical
Duphar International Research BV
1986-07-17
Publication of AU5139085A
publication
Critical
patent/AU5139085A/en
1989-10-12
Application granted
granted
Critical
1989-10-12
Publication of AU589387B2
publication
Critical
patent/AU589387B2/en
2005-12-18
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/04—Centrally acting analgesics, e.g. opioids
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/24—Antidepressants
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/26—Psychostimulants, e.g. nicotine, cocaine
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/12—Antihypertensives
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
C07D249/18—Benzotriazoles
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
C07D317/66—Nitrogen atoms not forming part of a nitro radical
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
The invention relates to a group of new bicyclic heter- oarylpiperazine derivatives which can be used as starting materials for the preparation of other compounds. Moreover, some of the compounds have interesting blood-pressure lowering activity.The compounds can be prepared according to methods known for the preparation of analogous compounds.
AU51390/85A
1984-12-21
1985-12-18
Bicyclic heterocyclic piperazine derivatives
Ceased
AU589387B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
NL8403918
1984-12-21
NL8403918
1984-12-21
Publications (2)
Publication Number
Publication Date
AU5139085A
AU5139085A
(en)
1986-07-17
AU589387B2
true
AU589387B2
(en)
1989-10-12
Family
ID=19844955
Family Applications (2)
Application Number
Title
Priority Date
Filing Date
AU51390/85A
Ceased
AU589387B2
(en)
1984-12-21
1985-12-18
Bicyclic heterocyclic piperazine derivatives
AU51392/85A
Abandoned
AU5139285A
(en)
1984-12-21
1985-12-18
Bicyclic heteroaryl piperazines
Family Applications After (1)
Application Number
Title
Priority Date
Filing Date
AU51392/85A
Abandoned
AU5139285A
(en)
1984-12-21
1985-12-18
Bicyclic heteroaryl piperazines
Country Status (14)
Country
Link
US
(1)
US4782061A
(en)
EP
(2)
EP0190472B1
(en)
JP
(2)
JPS61152662A
(en)
AT
(1)
ATE44528T1
(en)
AU
(2)
AU589387B2
(en)
DE
(1)
DE3571436D1
(en)
DK
(2)
DK589985A
(en)
ES
(2)
ES8704348A1
(en)
GR
(2)
GR853065B
(en)
IE
(1)
IE58916B1
(en)
IL
(1)
IL77396A
(en)
NZ
(2)
NZ214611A
(en)
PH
(2)
PH22040A
(en)
ZA
(2)
ZA859664B
(en)
Families Citing this family (44)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE3586794T2
(en)
*
1984-12-21
1993-05-27
Duphar Int Res
MEDICINAL PRODUCTS WITH PSYCHOTROPER EFFECT.
EP0190472B1
(en)
*
1984-12-21
1989-07-12
Duphar International Research B.V
New pharmaceutical compositions having anti-psychotic properties
US5328905A
(en)
*
1987-07-20
1994-07-12
Duphar International Research B.V.
8,9-anellated-1,2,3,4-tetrahydro-β-carboline derivatives
ATE136032T1
(en)
*
1987-07-20
1996-04-15
Duphar Int Res
8,9-ANNELLATED 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE DERIVATIVES
US4889852A
(en)
*
1987-09-11
1989-12-26
Duphar International Research B.V.
Anxiolytically active piperazine derivatives
US4992441A
(en)
*
1987-10-14
1991-02-12
Mcneilab, Inc.
1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
IL92544A0
(en)
*
1988-12-08
1990-08-31
Duphar Int Res
Piperazine derivatives,their preparation and pharmaceutical compositions containing them
GB8830312D0
(en)
*
1988-12-28
1989-02-22
Lundbeck & Co As H
Heterocyclic compounds
EP0380155A1
(en)
*
1989-01-19
1990-08-01
Duphar International Research B.V
8,9-Annelated-1,2,3,4-tetrahydro-beta-carboline derivatives
EP0398413A1
(en)
*
1989-05-16
1990-11-22
Duphar International Research B.V
“3,4-dehydropiperidine derivatives having psychotropic activity
US5296497A
(en)
*
1989-05-16
1994-03-22
Duphar International Research B.V.
3,4-dehydropiperidine derivatives having psychotropic activity
FR2670491B1
(en)
*
1990-12-14
1993-02-05
Adir
NOVEL 1,4-DISUBSTITUTED PIPERAZINES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IE914218A1
(en)
*
1991-09-11
1993-03-24
Mcneilab Inc
Novel 4-arylpiperazines and 4-arylpiperidines
US5569659A
(en)
*
1991-09-11
1996-10-29
Mcneilab, Inc.
4-arylpiperazines and 4-arylpiperidines
GB9200293D0
(en)
*
1992-01-08
1992-02-26
Wyeth John & Brother Ltd
Piperazine derivatives
FR2692264B1
(en)
*
1992-06-12
1994-08-05
Adir
NOVEL 1,4-DISUBSTITUTED PIPERAZINES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE4219973A1
(en)
*
1992-06-19
1993-12-23
Basf Ag
N-substituted azabicycloheptane derivatives, their preparation and use
US5314885A
(en)
*
1992-09-11
1994-05-24
Mcneilab, Inc.
Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
US5436246A
(en)
*
1992-09-17
1995-07-25
Merrell Dow Pharmaceuticals Inc.
Serotonin receptor agents
DK148392D0
(en)
*
1992-12-09
1992-12-09
Lundbeck & Co As H
Heterocyclic Compounds
HU213569B
(en)
*
1992-12-21
1997-08-28
Duphar Int Res
Enzymatic process for the stereoselective preparation of a heterobicyclic alcohol enantiomer
DK0605033T3
(en)
*
1992-12-21
2000-02-07
Duphar Int Res
Enzymatic method for stereoselective preparation of a heterobicyclic alcohol enantiomer
US5395936A
(en)
*
1993-06-04
1995-03-07
Manzo; Ruben H.
7-(4-[4-aminophenyl)sulphonyl]-1-piperazinyl fluorquinolonic derivatives and synthesis
RU2118322C1
(en)
*
1993-07-05
1998-08-27
Дюфар Интернэшнл Рисерч Б.В.
2,3-dihydro-1,4-benzodioxine-5-yl-pyrerazine derivatives and salts thereof
DE4341403A1
(en)
*
1993-12-04
1995-06-08
Basf Ag
N-substituted 3-azabicycloalkane derivatives, their preparation and use
GB9408872D0
(en)
*
1994-05-03
1994-06-22
Zeneca Ltd
Heterocyclic compounds
MX9700693A
(en)
*
1994-07-26
1997-04-30
Pfizer
4-indole derivatives as serotonin agonists and antagonists.
EP0709375B1
(en)
*
1994-10-25
2005-05-18
AstraZeneca AB
Therapeutic heterocycles
US5998444A
(en)
*
1995-10-24
1999-12-07
Zeneca Ltd.
Piperidinyl compounds as NK1 or NK2 antagonists
US6008223A
(en)
*
1994-10-27
1999-12-28
Zeneca Limited
Therapeutic compounds
GB9508786D0
(en)
1995-04-29
1995-06-21
Zeneca Ltd
Substituted heterocycles
GB9523526D0
(en)
*
1995-11-17
1996-01-17
Zeneca Ltd
Therapeutic compounds
NZ331860A
(en)
*
1996-03-29
2000-04-28
Duphar Int Res
Piperazine and piperidine compounds with affinity for both dopamine D2 and seratonin 5-HT1A receptors
TW530054B
(en)
*
1997-09-24
2003-05-01
Duphar Int Res
New piperazine and piperidine compounds
FR2769312B1
(en)
*
1997-10-03
1999-12-03
Adir
NOVEL INDANOL COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
ATE267183T1
(en)
*
1998-11-13
2004-06-15
Duphar Int Res
PIPERAZINE AND PIPERIDINE DERIVATIVES
AU2001267421A1
(en)
*
2000-05-12
2001-11-20
Solvay Pharmaceuticals B.V.
Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders
NZ522116A
(en)
2000-05-12
2004-04-30
Solvay Pharmaceuticals B
Piperazine and piperidine compounds that have partial agonism towards dopamine D2-receptor subfamily and affinity for relevant serotonin and/or noradrenergic receptors
AR034206A1
(en)
*
2001-02-16
2004-02-04
Solvay Pharm Bv
A PROCEDURE FOR THE PREPARATION OF MESILATES OF PIPERAZINE DERIVATIVES AND SUCH MESILATES
WO2003007956A1
(en)
*
2001-07-20
2003-01-30
Psychogenics, Inc.
Treatment for attention-deficit hyperactivity disorder
US9066903B2
(en)
2006-02-28
2015-06-30
The United States Of America As Represented By The Department Of Veterans Affairs
Pharmacological treatment of Parkinson’s disease
JP2008075402A
(en)
*
2006-09-25
2008-04-03
Jfe Metal Products & Engineering Inc
Bracket for guard fence, and guard fence
PL392436A1
(en)
2010-09-17
2012-03-26
Adamed Spółka Z Ograniczoną Odpowiedzialnością
Arylsulphonamide derivatives for treating the diseases of the central nervous system
RU2013131161A
(en)
*
2010-12-20
2015-01-27
Астразенека Аб
2-CARBOXAMIDE-4-PIPERAZINYL-BENZOFURANE DERIVATIVE
Citations (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU5139285A
(en)
*
1984-12-21
1986-06-26
Duphar International Research B.V.
Bicyclic heteroaryl piperazines
AU5139185A
(en)
*
1984-12-21
1986-06-26
Duphar International Research B.V.
Heterocyclic piperazine derivatives
Family Cites Families (16)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
DE2037852C3
(en)
*
1970-07-30
1980-06-26
Boehringer Sohn Ingelheim
New piperazine derivatives and processes for their preparation
US4118572A
(en)
*
1974-01-04
1978-10-03
Hoffmann-La Roche Inc.
Dibenz(b,f)oxepin derivatives
US4062870A
(en)
*
1974-05-31
1977-12-13
Beecham Group Limited
Chroman derivatives
US4091101A
(en)
*
1977-06-15
1978-05-23
Merck & Co., Inc.
6-(1-Piperazinyl)quinoxaline
US4404383A
(en)
*
1979-07-31
1983-09-13
The Quaker Oats Company
N,N’-Bis[5-hydroxymethylfurfuryl]piperazine
NL8005133A
(en)
*
1980-09-12
1982-04-01
Duphar Int Res
PHENYLPIPERAZINE DERIVATIVES WITH ANTIAGRESSIVE ACTION.
JPS5777676A
(en)
*
1980-10-31
1982-05-15
Otsuka Pharmaceut Co Ltd
Carbostyril derivative
AT380250B
(en)
*
1980-12-18
1986-04-25
Otsuka Pharma Co Ltd
METHOD FOR PRODUCING BENZOHETEROCYCLIC COMPOUNDS
CH653021A5
(en)
*
1981-04-24
1985-12-13
Delalande Sa
PIPERIDINO, PIPERAZINO AND HOMOPIPERAZINO DERIVATIVES, N-SUBSTITUTED BY AN AROMATIC HETEROCYCLIC GROUP, THEIR PREPARATION METHOD AND THERAPEUTIC COMPOSITION CONTAINING THEM.
US4355031A
(en)
*
1981-05-11
1982-10-19
American Home Products Corp.
2,3-Dihydro-3-[4-(substituted)-1-piperazinyl]-1H-isoindol-1-ones
US4426380A
(en)
*
1981-10-28
1984-01-17
Ciba-Geigy Corporation
Benzofuran-2-ones and pharmaceutical compositions
JPS5883677A
(en)
*
1981-11-11
1983-05-19
Otsuka Pharmaceut Co Ltd
Carbostyril derivative
JPS5888314A
(en)
*
1981-11-20
1983-05-26
Otsuka Pharmaceut Co Ltd
Cardiac
JPS5955878A
(en)
*
1982-09-24
1984-03-31
Chugai Pharmaceut Co Ltd
Novel phenylpiperazine derivative
DD212962A5
(en)
*
1982-10-08
1984-08-29
Ciba Geigy Ag
PROCESS FOR THE PRODUCTION OF BENZOFURANES
ZA848005B
(en)
*
1983-10-17
1985-05-29
Duphar Int Res
Blood-pressure lowering piperazine derivatives
1985
1985-12-16
EP
EP85202086A
patent/EP0190472B1/en
not_active
Expired
1985-12-16
AT
AT85202086T
patent/ATE44528T1/en
not_active
IP Right Cessation
1985-12-16
EP
EP85202081A
patent/EP0185429A1/en
not_active
Withdrawn
1985-12-16
DE
DE8585202086T
patent/DE3571436D1/en
not_active
Expired
1985-12-18
IE
IE321885A
patent/IE58916B1/en
not_active
IP Right Cessation
1985-12-18
DK
DK589985A
patent/DK589985A/en
not_active
Application Discontinuation
1985-12-18
ZA
ZA859664A
patent/ZA859664B/en
unknown
1985-12-18
ZA
ZA859662A
patent/ZA859662B/en
unknown
1985-12-18
ES
ES550106A
patent/ES8704348A1/en
not_active
Expired
1985-12-18
GR
GR853065A
patent/GR853065B/el
unknown
1985-12-18
US
US06/810,207
patent/US4782061A/en
not_active
Expired – Fee Related
1985-12-18
GR
GR853063A
patent/GR853063B/el
unknown
1985-12-18
AU
AU51390/85A
patent/AU589387B2/en
not_active
Ceased
1985-12-18
DK
DK590085A
patent/DK590085A/en
not_active
Application Discontinuation
1985-12-18
AU
AU51392/85A
patent/AU5139285A/en
not_active
Abandoned
1985-12-18
NZ
NZ214611A
patent/NZ214611A/en
unknown
1985-12-18
NZ
NZ214612A
patent/NZ214612A/en
unknown
1985-12-19
PH
PH33218A
patent/PH22040A/en
unknown
1985-12-19
PH
PH33217A
patent/PH23958A/en
unknown
1985-12-19
IL
IL77396A
patent/IL77396A/en
not_active
IP Right Cessation
1985-12-20
JP
JP60285842A
patent/JPS61152662A/en
active
Pending
1985-12-20
JP
JP60285843A
patent/JPS61152666A/en
active
Pending
1987
1987-01-29
ES
ES557359A
patent/ES8802516A1/en
not_active
Expired
Patent Citations (2)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU5139285A
(en)
*
1984-12-21
1986-06-26
Duphar International Research B.V.
Bicyclic heteroaryl piperazines
AU5139185A
(en)
*
1984-12-21
1986-06-26
Duphar International Research B.V.
Heterocyclic piperazine derivatives
Also Published As
Publication number
Publication date
AU5139285A
(en)
1986-06-26
US4782061A
(en)
1988-11-01
DK590085A
(en)
1986-06-22
JPS61152662A
(en)
1986-07-11
PH22040A
(en)
1988-05-13
IE853218L
(en)
1986-06-21
EP0185429A1
(en)
1986-06-25
IL77396A
(en)
1990-02-09
EP0190472B1
(en)
1989-07-12
PH23958A
(en)
1990-01-23
ZA859664B
(en)
1986-08-27
ZA859662B
(en)
1986-08-27
DK589985D0
(en)
1985-12-18
EP0190472A1
(en)
1986-08-13
ATE44528T1
(en)
1989-07-15
ES557359A0
(en)
1988-07-16
IE58916B1
(en)
1993-12-01
AU5139085A
(en)
1986-07-17
GR853065B
(en)
1986-04-09
ES8704348A1
(en)
1987-04-01
DK589985A
(en)
1986-06-22
NZ214612A
(en)
1988-06-30
DK590085D0
(en)
1985-12-18
ES550106A0
(en)
1987-04-01
JPS61152666A
(en)
1986-07-11
NZ214611A
(en)
1988-06-30
DE3571436D1
(en)
1989-08-17
ES8802516A1
(en)
1988-07-16
GR853063B
(en)
1986-04-09
Similar Documents
Publication
Publication Date
Title
AU589387B2
(en)
1989-10-12
Bicyclic heterocyclic piperazine derivatives
AU569086B2
(en)
1988-01-21
2-pyrimidinyl-1-piperazine derivatives
AU589732B2
(en)
1989-10-19
Process for the preparation of 2-oxo-1,3-dioxolanes
CA1259074C
(en)
1989-09-05
AU577928B2
(en)
1988-10-06
Labd-14-en-11-one derivatives
IE882594L
(en)
1989-02-26
Water-hardening polymer preparation
AU2856589A
(en)
1989-07-13
Intermediates for the preparation of 11-substituted 5H, 11H-pyrrole (2,1-c) (1,4) benzoxazepines, and a method for their preparation
IE781471L
(en)
1979-01-22
Pyrones
AU574654B2
(en)
1988-07-14
Pyrazolopyridines
ES8705457A1
(en)
1987-05-01
Derivatives of the pluramycin group having anti-tumor activity, process for their preparation and their use as medicaments.
ES8304112A1
(en)
1983-03-01
Xylite derivatives, methods for their production as well as compositions containing them having growth regulatory activity for plants
EP0141354A3
(en)
1986-02-19
Compounds useful for combatting swine dysentery and as growth promoting factors, method for the preparation thereof and compositions containing them
EP0324184A3
(en)
1990-05-02
2-amino-1,2,3,4-tetrahydroisoquinoline derivatives, method for their preparation and their use as medicines
ES8307739A1
(en)
1983-07-01
Thiolactime ethers of delta-1-pyrrolidine, and their preparation.
None