AU589484B2 – New substituted amides, their preparation and pharmaceutical compositions which contain them
– Google Patents
AU589484B2 – New substituted amides, their preparation and pharmaceutical compositions which contain them
– Google Patents
New substituted amides, their preparation and pharmaceutical compositions which contain them
Info
Publication number
AU589484B2
AU589484B2
AU67602/87A
AU6760287A
AU589484B2
AU 589484 B2
AU589484 B2
AU 589484B2
AU 67602/87 A
AU67602/87 A
AU 67602/87A
AU 6760287 A
AU6760287 A
AU 6760287A
AU 589484 B2
AU589484 B2
AU 589484B2
Authority
AU
Australia
Prior art keywords
substituted
phenyl
alkyl
het
alkyloxy
Prior art date
1986-01-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU67602/87A
Other versions
AU6760287A
(en
Inventor
Claude Cotrel
Claude Guyon
Gerard Roussel
Gerard Taurand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Sante SA
Original Assignee
Rhone Poulenc Sante SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1986-01-16
Filing date
1987-01-15
Publication date
1989-10-12
1987-01-15
Application filed by Rhone Poulenc Sante SA
filed
Critical
Rhone Poulenc Sante SA
1987-07-23
Publication of AU6760287A
publication
Critical
patent/AU6760287A/en
1989-10-12
Application granted
granted
Critical
1989-10-12
Publication of AU589484B2
publication
Critical
patent/AU589484B2/en
2005-07-17
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00
C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains two hetero rings
C07D471/04—Ortho-condensed systems
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P21/00—Drugs for disorders of the muscular or neuromuscular system
A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/08—Antiepileptics; Anticonvulsants
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/00—Drugs for disorders of the nervous system
A61P25/20—Hypnotics; Sedatives
Abstract
The invention provides new substituted amides of formula: R-CONH-Het in which: either R is cycloalkyl (3 to 6 carbons), cyclohexadienyl, phenyl, substituted phenyl or a heterocyclic systems chosen from 3-pyridyl, alkyloxy-3-pyridyl, thienyl, alkylthienyl, furyl, tetrahydropyridyl, pyridazinyl, and alkylpyridazinyl, and Het is 1,8-naphthyridin-2-yl substituted at the 7-position by alkyloxy, alkylthio or alkylsulphinyl, themselves substituted with alkylamino or dialkylamino (in which the alkyl portions can form, with the nitrogen atom, a 5- or 6-membered heterocyclic system optionally containing another hetero atom chosen from O, S or N, and optionally substituted by alkyl) or by dialkylcarbamoyl or N-alkyl-N-(alkyloxycarbonyl)amino, or substituted at the 7-position by dialkylaminovinyl; or R is 4-(alkylamino)phenyl or 4-(alkyloxycarbonylamino)phenyl and Het is 1,8-naphthyridin-2-yl substituted at the 7-position by alkyloxy or alkylthio, the said alkyl radicals and alkyl portions containing 1 to 4 carbons, their salts, their preparations and pharmaceutical compositions which contain them. These new substituted amides are especially active as anxiolytics, hypnotics, anticonvulsants, antiepileptics and muscle relaxants.
AU67602/87A
1986-01-16
1987-01-15
New substituted amides, their preparation and pharmaceutical compositions which contain them
Ceased
AU589484B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
FR8600556
1986-01-16
FR8600556A
FR2592882B2
(en)
1986-01-16
1986-01-16
NEW SUBSTITUTED AMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
Related Parent Applications (1)
Application Number
Title
Priority Date
Filing Date
AU45090/85A
Addition
AU572672B2
(en)
1984-07-19
1985-07-17
2-quinolyl or 1,8-naphthyridin-2-yl amides
Publications (2)
Publication Number
Publication Date
AU6760287A
AU6760287A
(en)
1987-07-23
AU589484B2
true
AU589484B2
(en)
1989-10-12
Family
ID=9331170
Family Applications (1)
Application Number
Title
Priority Date
Filing Date
AU67602/87A
Ceased
AU589484B2
(en)
1986-01-16
1987-01-15
New substituted amides, their preparation and pharmaceutical compositions which contain them
Country Status (21)
Country
Link
US
(1)
US4753933A
(en)
EP
(1)
EP0234971B1
(en)
JP
(1)
JPS62169787A
(en)
KR
(1)
KR870007169A
(en)
AT
(1)
ATE56213T1
(en)
AU
(1)
AU589484B2
(en)
CS
(1)
CS262446B2
(en)
DD
(1)
DD260069A5
(en)
DE
(1)
DE3764667D1
(en)
DK
(1)
DK19787A
(en)
ES
(1)
ES2018025B3
(en)
FI
(1)
FI870150A
(en)
FR
(1)
FR2592882B2
(en)
HU
(1)
HU196070B
(en)
IE
(1)
IE870126L
(en)
NO
(1)
NO164836C
(en)
PH
(1)
PH24461A
(en)
PL
(1)
PL263677A3
(en)
PT
(1)
PT84101B
(en)
YU
(1)
YU46041B
(en)
ZA
(1)
ZA87292B
(en)
Families Citing this family (5)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US5258356A
(en)
*
1989-03-11
1993-11-02
Basf Aktiengesellschaft
Substituted 1,8-naphthyridines, their preparation and their use as antidotes
EP1195372A1
(en)
*
1994-04-18
2002-04-10
Mitsubishi Pharma Corporation
N-heterocyclic substituted benzamide derivatives with antihypertensive activity
WO1997024401A1
(en)
*
1995-12-27
1997-07-10
Sumitomo Bakelite Company Limited
Process for producing flame-retardant, silane-crosslinked polyolefin
GB9711257D0
(en)
*
1997-05-30
1997-07-30
Smithkline Beecham Plc
Novel compounds
AU777040B2
(en)
*
1999-02-22
2004-09-30
Shire Biochem Inc.
(1,8) naphthyridine derivatives having antiviral activity
Family Cites Families (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
FR1006725A
(en)
*
1948-08-31
1952-04-28
Cilag Spa
New derivatives of naphthyridine and process for their preparation
FR2567887B1
(en)
*
1984-07-19
1986-12-19
Rhone Poulenc Sante
NEW SUBSTITUTED AMIDES, THEIR PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM
CA1265803A
(en)
*
1985-07-11
1990-02-13
Claude Cotrel
Substituted amides, their preparation, and pharmaceuticals containing same
1986
1986-01-16
FR
FR8600556A
patent/FR2592882B2/en
not_active
Expired
1987
1987-01-13
US
US07/002,929
patent/US4753933A/en
not_active
Expired – Fee Related
1987-01-13
PT
PT84101A
patent/PT84101B/en
not_active
IP Right Cessation
1987-01-14
CS
CS87256A
patent/CS262446B2/en
unknown
1987-01-14
JP
JP62005156A
patent/JPS62169787A/en
active
Pending
1987-01-15
DD
DD87299275A
patent/DD260069A5/en
not_active
IP Right Cessation
1987-01-15
ES
ES87400078T
patent/ES2018025B3/en
not_active
Expired – Lifetime
1987-01-15
AU
AU67602/87A
patent/AU589484B2/en
not_active
Ceased
1987-01-15
YU
YU5387A
patent/YU46041B/en
unknown
1987-01-15
ZA
ZA87292A
patent/ZA87292B/en
unknown
1987-01-15
PH
PH34726A
patent/PH24461A/en
unknown
1987-01-15
DE
DE8787400078T
patent/DE3764667D1/en
not_active
Expired – Fee Related
1987-01-15
DK
DK019787A
patent/DK19787A/en
not_active
Application Discontinuation
1987-01-15
NO
NO870166A
patent/NO164836C/en
unknown
1987-01-15
KR
KR870000275A
patent/KR870007169A/en
not_active
Application Discontinuation
1987-01-15
FI
FI870150A
patent/FI870150A/en
not_active
Application Discontinuation
1987-01-15
AT
AT87400078T
patent/ATE56213T1/en
not_active
IP Right Cessation
1987-01-15
EP
EP87400078A
patent/EP0234971B1/en
not_active
Expired – Lifetime
1987-01-15
HU
HU87118A
patent/HU196070B/en
not_active
IP Right Cessation
1987-01-16
PL
PL1987263677A
patent/PL263677A3/en
unknown
1987-01-20
IE
IE870126A
patent/IE870126L/en
unknown
Also Published As
Publication number
Publication date
ATE56213T1
(en)
1990-09-15
CS25687A2
(en)
1988-07-15
PT84101B
(en)
1989-07-31
DK19787D0
(en)
1987-01-15
PT84101A
(en)
1987-02-01
HU196070B
(en)
1988-09-28
FR2592882B2
(en)
1988-03-11
DE3764667D1
(en)
1990-10-11
HUT43603A
(en)
1987-11-30
PH24461A
(en)
1990-06-25
US4753933A
(en)
1988-06-28
NO164836C
(en)
1990-11-21
ES2018025B3
(en)
1991-03-16
DD260069A5
(en)
1988-09-14
YU5387A
(en)
1988-06-30
IE870126L
(en)
1987-07-16
FR2592882A2
(en)
1987-07-17
PL263677A3
(en)
1988-06-09
JPS62169787A
(en)
1987-07-25
KR870007169A
(en)
1987-08-17
NO870166L
(en)
1987-07-17
ZA87292B
(en)
1987-08-26
AU6760287A
(en)
1987-07-23
FI870150A
(en)
1987-07-17
NO870166D0
(en)
1987-01-15
FI870150A0
(en)
1987-01-15
EP0234971B1
(en)
1990-09-05
DK19787A
(en)
1987-07-17
CS262446B2
(en)
1989-03-14
NO164836B
(en)
1990-08-13
YU46041B
(en)
1992-12-21
EP0234971A1
(en)
1987-09-02
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COMPOSITION comprising an active ingredient, preferably in powder or particulate form, as well as a carrier for the active ingredient and process for the preparation of such preparation
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