AU592467B2 - Creation of Inventions and Patents with Artificial Intelligence

AU592467B2 – Stable hydrate of a penicillin derivative and process for preparing same
– Google Patents

AU592467B2 – Stable hydrate of a penicillin derivative and process for preparing same
– Google Patents
Stable hydrate of a penicillin derivative and process for preparing same

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Publication number
AU592467B2

AU592467B2
AU78827/87A
AU7882787A
AU592467B2
AU 592467 B2
AU592467 B2
AU 592467B2
AU 78827/87 A
AU78827/87 A
AU 78827/87A
AU 7882787 A
AU7882787 A
AU 7882787A
AU 592467 B2
AU592467 B2
AU 592467B2
Authority
AU
Australia
Prior art keywords
methyl
trihydrate
asparaginylamoxicillin
water
solution
Prior art date
1986-09-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Application number
AU78827/87A
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AU7882787A
(en

Inventor
Susumu Ohshiro
Masaru Senuma
Mitsuyoshi Wagatsuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Tanabe Seiyaku Co Ltd

Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1986-09-24
Filing date
1987-09-22
Publication date
1990-01-11

1987-09-22
Application filed by Tanabe Seiyaku Co Ltd
filed
Critical
Tanabe Seiyaku Co Ltd

1988-03-31
Publication of AU7882787A
publication
Critical
patent/AU7882787A/en

1990-01-11
Application granted
granted
Critical

1990-01-11
Publication of AU592467B2
publication
Critical
patent/AU592467B2/en

2007-09-22
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
Critical
Current

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Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

C07D499/04—Preparation

C07D499/18—Separation; Purification

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

A61P31/04—Antibacterial agents

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2

C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6

C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical

C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical

C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms

C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Abstract

A stable trihydrate of (2S, 5R, 6R)-6-{(2R)-2-[(2R)-2-amino-3-(N-methylcarbamoyl)propionamido]-2-(p-hyd oxyphenyl)acetamido}-3,3-dimethyl-7-oxo-4-thia-1-azabic yclo[3.2.0]heptane-2-carboxylic acid and process for preparing the same are disclosed.

Description

OF AIaaft 6 7, C 0 M M 0 N W R A L T 11 PATENT ACT 1952 COMPLE~TE SPECIFICATION
(ORIGINAL)
FOR OFFICE USE CLASS INT. CLASS Application Number; Lodged: complete Specification Lodged: Accepted: Published: Priority: 11411Inil~rnt t.5 md 11 r cik(~ciifl 49 and is correet for printing, Related Art-: NAME OF APPLICANT: ADDRESS OF APPLICANT: NAME(S) OF INVENTOR(S) ADDRESS FOR SERVICE: TANABE SEIYAKU CO., LTID, No. 21, Dosho-machi 3-chome, Higashi-ku, Osaka-shi, Osaka’-fu, JAPAN.
Susumu OHSHIRO, Masaru SENUMA, Mitsuyoshi WAGATSUMA DAVIES COLLISON, Patent Attorneys 1 Little Collins Street, Melbourne, 3000.
I
I
COMPLETE SPECIFICATION FOR THE INVENTION ENTITLED: “STABLE HYDRATE OF PENICILLIN DERIVATIVE AND PROCESS FOR PREPARING SAME” The following statement is a full description of this invention, including the best method of performing it known to us IA STABLE HYDRATE OF PENICILLIN DERIVATIVE AND PROCESS FOR PREPARING SANE This invention relates to a~ stable hydrate of a derivative and a process for preparing same. More 0 particularly, it relates to (2S, 5Rr 6R)-6-t(2R)-2- [2R)-2- 0 0amino-3- (N-methylcarbamoyl )propionamidoj (p-hydroxyphenyi 00 00 acetamidoj-3, 3-dimethiyl-7-oxo-4-thia-3.-azabicyclo 2. 0]jheptane- 004 2-carboxylic acid trihydrate (hereinafter referred to as ~tlN 4 _methyl-D-asparaginylanoxicillin”) of the formula: 00 (R00
)R
4H 3HOC -CH-CO-NH-CH-C0-NH 2H 3 NH- 0 N(S) CH 2 Kzz3 OH COOH- 000 4 ethyl-D-asparaginylainoxicillin is useful as chemo- 04 therapeutic agents because it shows potent antimicrobial activity against both of gramn-positive and gram-negacive microorganisms. it has-been known that N 4 -rethyl-D-asparaginylainoxicillin can be prepared either by condensing 6-aminopenicillanic acid with D-2- (D-2-amino-3-N-methylcarbanoylpropionamido) -2-p-hydroxyphenylacetic acid, or (ii) by 2 condensing amoxicillin with D-2-amino-3-N-methylcarbamoylpropionic acid Patent No. 4,03,609). It has also been known that pure N 4 -methyl-D-asparaginylamoxicillin can be obtained as amorphous anhydrate by contacting an aqueous solution of crude N 4 -methyl-D-asparaginylamoxicillin with a non-polar macroporous adsorption resin, eluting the adsorbed product and liophilizing the eluate containing the Oo desired product Patent No. 4,313 875). However, the amorphous N -methy)-D-asparaginylamoxicillin anhydrate o 0 o ,0 obtained by the known method gradually moistens in an ambient o o atmosphere and it is not stable unless it is stored by o* protecting from moisture and light.
It has now been found that N4-methyl-D-asparaginylamoyicillirt S can be obtained in the form of a crystalline trihydrate.
S The new trihydrate of N -methyl-D-asparaginylamoxicillin is of superior quality in terms of its crystallinity and stability.
S In particular, the new trihydrate has been found to have a well-defined crystalline structure and it has been found to be remarkably stable in storage. These properties render the trihydrate of N 4 -methyl-D-asparaginylamoxicillin of value in pharmaceutical use.
According to the present invention, N -methyl-D-asparaginylamoxicillin trihydrate can be prepared by adjusting the pH of a solution of N4-methyl-D-asparaginylamoxicillin or a salt thereof in an aqueous medium to 3 to 6 and crystallizing the desired trihydrate.
1 3 N4-Methyl-D-asparaginylamoxicillin to be used in the present invention may be either a crude product prepared by the method described in U.S. Patent No. 4,053,609 or an amorphous anhydrate prepared by the method described in U.S.
Patent No. 4,313,875. Examples of the salt of N 4 -methyl-Dasparaginylamoxicillin include alkali metal salts sodium or potassium salt), alkaline earth metal salts calcium or magnesium salt), amino acid salts L-lysine, L-arginine, L-histidine or L-ornithine salt) or the salts with organic bases triethylamine, tributylamine or N-methyl- 0 0 S morpholine). Water, aqueous lower alkanols aqueous 0 0 S0 methanol, aqueous ethanol or aqueous propanol) and aqueous o 00 lower alkanones aqueous acetone or aqueous methylethylketone) are preferably used as the aqueous medium. From an oA 6 industrial view-point, water is the most preferable as the S aqueous medium.
In carring out the method of the present invention, the solution of N -methyl-D-asparaginylamoxicillin or a salt thereof in the aqueous medium is firstly adjusted to a pH of 3 to 6, preferably 3.5 to 5.5. For example, when N4-methyl- D-asparaginylamoxicillin is employed in the form of its free Sform, the adjustment of pH is carried out by adding an acid or an alkali to the solution of said compound. When N4-methyl- D-asparaginylamoxicillin is employed in the form of its salt, the adjustment of pH is carried out by adding an acid 4 to the solution of said salt. Examples of the acid to be used for the pH adjustment include a mineral acid such as hydrochloric acid or sulfuric acid or an organic acid such as citric acid, and examples of the alkali include an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide.
After the solution of N4-methyl-D-asparaginylamoxicillin or its salts is adjusted to the prescribed pH, the desired trihydrate is crystallized from said solution. The crystallization of the desired trihydrate may be preferably conducted by cooling or condensation of the solution, or by addition “°oo of a water-miscible organic solvent, or by a combination Soo thereof. For example, when the crystallization is carried a 0
B
out by cooling the solution, it is preferred that the solution o 99 which has previously been warmed to about 30 to 70 0 C is cooled to 0 to 10 0 C. When the crystallization is carried out by condensation, it is preferred that the solution of N -methyl-D-aspar-aginylamoxicillin or its salt is condensed until .the concentration of said compound is 10 to 45 w/w “0 especially about 30 to 40 w/w Further, when the crystallization’ is carried out by the addition of a water-miscible S organic solvent, said water-miscible organic solvent may be added intermittently or continuously to the solution of K 4 N -methyl-D-asparaginylamoxicillin or it salt. Examples of such water-miscible organic solvent include a lower alkanol such as methanol, ethanol or propanol, and a lower alkanone such as acetone or methylethylketone. The precipitated 5 trihydrate can be readily separated by a conventional solidliquid separation technique such as filtration or centrifugation.
As mentioned hereinbefore, N 4 -methyl-D-asparaginylamoxicillin trihydrate of the present invention is difficult to moisten in an ambient atmosphere and is stable in storage.
Therefore, said trihydrate is superior to the known amorphous anhydrate as bulk substance for medicine. Moreover, the trihydrate of the present invention is easy to handle because the bulk density and electrification thereof is less than those of the known amorphous anhydrate. Further, the trihydrate of the present invention is characterized in that it can be readily prepared in an industrial scale because of its good crystallinity.
Experiment (Stability test) ,Each of crystalline N -methyl-D-asparaginylamoxicillin trihydrate of the present invention and amorphous N4-methyl- D-asparaginylamoxicillin anhydrate (prepared according to the method described in U.S. Patent No. 4,313,875) was allowed to stand at 40 0 C in a sealed tube for 5, 10, 15 or days, and the stability of each compound was estimated by measuring the content of N 4 -methyl-D-asparaginylamoxicillin.
The results are shown in the following Table i.
The content of N 4 -methyl-D-asparaginylamoxicillin was measured by high performance liquid chromatography (HPLC) under the conditions mentioned below.
Conditions) Column: Octadecylsilane (4.6 mmeX 150 mm) Mobile phase: Phosphate buffer-acetonitril (87:13)(pH:3.0) Flow speed: 1.0 ml/minute Temperature of column: 400C Remaining ratio 4 of N -methyl-Dasparaginylamoxicillin Content of N -methyl-D-asparaginylamoxicillin after it was allowed to stand Content of N4-methyl-D-asparaginylamoxicillin before it was allowed to stand X 100 Table 1 4 Remaining ratio of N -methyl-D-asparaginylamoxicillin Test compound A period of time during which the test Nos. compound was allowed to stand (days) initial 5 10 15 1. 100.0 100.0 100.0 100.0 99.5 2. 100.0 91.0 90.0 88.5 85.5 Test compound 1. Crystallin N4-methyl-D-asparaginylamoxicillin trihydrate (The compound of the present invention) 2. Amorphous anhydrate of N4-methyl-D-asparaginylamoxicillin (prepared according to U.S. Patent No. 4,313,875) 7 Example 1 Amorphous N 4 -methyl-D-asparaginylamoxicillin anhydrate g) is dissolved at 40 0 C in water (50 ml). The solution is adjusted to pH 4.0 with diluted hydrochloric acid and stirred at 30 0 C for one hour and then cooled to 5 C. The resultant precipitates are collected by filtration, washed 4 with water and dried, whereby N4-methyl-D-asparaginylamoxicillin trihydrate (8 g) is obtained as a white crystalline solid.
Water content (Karl Fisbhr Method): 10.05 (corresponds to 3 moles) Content of product (HPLC): 99.7 D0 179.50 1.0, water) Infrared spectrum: shown in Figure 1 X-ray powder diffraction pattern: shown in the following (Power source; Cu:Ni, 40KV, Table 2 =1.5405) Just for reference, the X-ray powder diffraction pattern 4 of amorphous N -methyl-D-asparaginylamoxicillin anhydrate is also shown in Table 2.
-rn-r8 ji Table 2 Crystalline N -_methyl-D- Amorphous N 4_methyl-Dasparaginylamoxicillin asparaginylanoxicillin trihydrate arihydrate value Relative Id’ value Relative intensity* intensitv* 15.77 w 5.94 vw 10.77 w 5.50 vw 9.21 vw 4.57 vw 7. 89 w 5.98 s 5.57 vs 5.34 w 4.98 vw 4. 62 vs 4.39 w 4.23 m 3.97 rn 3.77 vw 3.64 vw 3.54 w 3.4& w 3.37 w 3.25 m 3.13 vw 3.01 W 2.86 vw 2.81 vw vw 2.60 vw 2.40 w *The relative intensities were estimated by comparing the line intensities against a set of standards: vs= very strong, s= strong, m= medium, w= weak, vw= very weak 9 Example 2 4 Amorphous N -methyl-D-asparaginylamoxicillin anhydrate g) is dissolved in water (500 ml) [The pH of the solution is 4.33. The solution is concentrated under reduced pressure to 250 g, and ethanol (250 g) is added thereto. The resultant precipitates are collected by filtration and dried, whereby N -methyl-D-asparaginylamoxicillin trihydrate (5 g) is obtained as a white crystalline solid.
Water content (Karl Fisher Method): 10.74 (corresponds to 3 moles) S, Content of product (HPLC): 99.3 S9 {l «20 L.o 179.30 1.0, water) Example 3 Water (70 ml) is added to amorphous N 4 -methyl-D-asparaginylamoxicillin anhydrate (22.2 and an aqueous 20 sodium hydroxide solution (5.4 ml) is added dropwise thereto to Sdissolve said anhydrate therein. Activated charcoal is added to the solution, and the mixture is filtered. The filtrate is adjusted to pH 3.5 with 20 hydrochloric acid S (about 5.5 ml). The resultant precipitates are collected by filtration and dried, whereby N -methyl-D-asparaginylamoxicillin trihydrate (17 g) is obtained as a white crystalline solid.
Water content (Karl Fisher Method): 10.21 (corresponds to 3 moles) Content of product (HPLC): 99.7 179.90 1.0, water) water -7 Ifiu usa~– -L I II “r r i 10 o 6o Q (4 6 C r 0 0r 04 6e ‘4F 4I 4i Example 4 Thiobenzamide (20.5 g) is dissolved in ethanol (290 ml), and (2S, 5R, [(2R)-2-(o-nitrophenylsulfenyl)amino-3-(N-methylcarbamoyl)propionamido -2-(p-hydroxyphenyl)acetamidol-3,3-dimethyl-7-oxo-4-thia-l-azabicyclo [3.2.0]heptane- 2-carboxylic acid trihydrate (32.21 g) is added thereto. The mixture is stirred at 15 to 20 0 C for 17 hours to remove the amino-protecting group o-nitrophenylsulfenyl group).
The precipitates N4-methyl-D-asparaginyiamoxicillin) are collected by filtration, dried and then added to a suspension of activated charcoal (3 g) in water (50 ml). The suspension is adjusted to pH 5.5 with 1% hydrochloric acid (about 3 ml) and stirred at room temperature for one hour. Insoluble materials are filtered off, and the filtrate is concentrated under reduced pressure until the concentration of N4-methyl- D-asparaginylamoxicillin is 40 w/w The concentrated solution is stirred at 30 0 C for one hour and then cooled to 5 0 C. The resultant precipitates are collected by filtration and dried, whereby N 4 -methyl-D-asparaginylamoxicillin trihydrate (12.5 g) is obtained as a white crystalline solid.
Water content (Karl Fisher Method): 10.1 (corresponds to 3 moles) Content of product (HPLC): 99.7 2 0 180.00 1.0, water) 101DU

Claims (7)

1. (2S, 5R, [(2R)-2-Amino-3-(N-methyl- carbamoyl)propionamidoj-2-(p-hydroxyphenyl)acetamidol-3,3- dimethyl-7-oxo-4-thia-l-azabicyclo ]heptane-2-carboxylic acid trihydrate.

2. A process for preparing (2S, 5R, S2-amino-3-(N-methylcarbamoyl)propionamido]-2-(p-hydroxyphenyl)- acetamidol-3,3-dimethyl-7-oxo-4-thia-l-azabicyclo [3.2.0]heptane- 2-carboxylic acid trihydrate, which comprises adjusting the pH of a solution of (2S, 5R, [(2R)-2-amino-3- (N-methylcarbamoyl)propionamido]-2-(p-hydroxyphenyl)acetamido>- 3,3-dimethyl-7-oxo-4-thia-l-azabicyclo 3.2. Oheptane-2-carboxylic acid or a salt thereof in an aqueous medium to 3 to 6 and crystallizing the desired trihydrate.

3. The process according to Claim 2, wherein the pH is adjusted to 3.5 to

4. The process according to Claim 2 or 3, wherein the aqueous medium is water, an aqueous lower alkanol or an aqueous lower alkanone.

The process according to Claim 4, wherein the crystal- lization is carried out by cooling or condensation of the solution, or by additio.. of a water-miscible organic solvent. ‘k’o 1, jj I ft I I 1* d ‘I I II lx 12

6. A process according to claim2, substantially as hereinbefore described with reference to the Examples.

7. The stapo, foaturEg.gpoitcn referred to or indicated in the specificatl n ando claims of this application ividually or collP)ctively any and all combinations of any t- o Po f raid steps or ear— Dated this 22nd day of September 1987 TANABE SEIYAKU CO., LTD. By its Patent Attorneys DAVIES COLLISON

AU78827/87A
1986-09-24
1987-09-22
Stable hydrate of a penicillin derivative and process for preparing same

Ceased

AU592467B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

JP61-226423

1986-09-24

JP61226423A

JPS6379888A
(en)

1986-09-24
1986-09-24
Stable hydrate of penicillin derivative

Publications (2)

Publication Number
Publication Date

AU7882787A

AU7882787A
(en)

1988-03-31

AU592467B2
true

AU592467B2
(en)

1990-01-11

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ID=16844890
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Application Number
Title
Priority Date
Filing Date

AU78827/87A
Ceased

AU592467B2
(en)

1986-09-24
1987-09-22
Stable hydrate of a penicillin derivative and process for preparing same

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US
(1)

US4866170A
(en)

EP
(1)

EP0261823B1
(en)

JP
(1)

JPS6379888A
(en)

KR
(1)

KR920003902B1
(en)

CN
(1)

CN1021225C
(en)

AT
(2)

ATE59655T1
(en)

AU
(1)

AU592467B2
(en)

CA
(1)

CA1286285C
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DE
(1)

DE3766921D1
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DK
(1)

DK167319B1
(en)

ES
(1)

ES2026545T3
(en)

FI
(1)

FI86853C
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GR
(1)

GR3001274T3
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HK
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HK42093A
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HU
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HU196810B
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IE
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IE60042B1
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IL
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IL83786A
(en)

MY
(1)

MY102553A
(en)

NO
(1)

NO169717C
(en)

PH
(1)

PH23644A
(en)

PT
(1)

PT85773B
(en)

SG
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SG15393G
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SU
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SU1517764A3
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US5375123A
(en)

1993-02-05
1994-12-20
Telefonakitebolaget L. M. Ericsson
Allocation of channels using interference estimation

US6473602B1
(en)

1996-10-28
2002-10-29
Ericsson Inc.
Mobile assisted handoff in radiocommunication systems

PE20000879A1
(en)

1998-04-29
2000-09-23
Dsm Nv

METHOD TO CRYSTALLIZE A ß-LACTAMIC ANTIBIOTIC

KR101879756B1
(en)

2016-11-30
2018-08-17
주식회사 지앤지비
Heating apparatus for bathroom

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Title

NL6705789A
(en)

1967-03-08
1968-09-09

GB1241844A
(en)

1968-08-23
1971-08-04
Beecham Group Ltd
Penicillins

US4053609A
(en)

1975-09-12
1977-10-11
Tanabe Seiyaku Co., Ltd.
Penicillins and processes for preparing the same

JPS5640686A
(en)

1979-09-11
1981-04-16
Tanabe Seiyaku Co Ltd
Purification of penicillin derivative

1986

1986-09-24
JP
JP61226423A
patent/JPS6379888A/en
active
Granted

1987

1987-09-01
IE
IE234687A
patent/IE60042B1/en
not_active
IP Right Cessation

1987-09-03
DE
DE8787307794T
patent/DE3766921D1/en
not_active
Expired – Fee Related

1987-09-03
AT
AT87307794T
patent/ATE59655T1/en
not_active
IP Right Cessation

1987-09-03
ES
ES198787307794T
patent/ES2026545T3/en
not_active
Expired – Lifetime

1987-09-03
EP
EP87307794A
patent/EP0261823B1/en
not_active
Expired – Lifetime

1987-09-04
IL
IL83786A
patent/IL83786A/en
not_active
IP Right Cessation

1987-09-09
ZA
ZA876739A
patent/ZA876739B/en
unknown

1987-09-11
PH
PH35805A
patent/PH23644A/en
unknown

1987-09-12
CN
CN87106308A
patent/CN1021225C/en
not_active
Expired – Fee Related

1987-09-18
US
US07/098,364
patent/US4866170A/en
not_active
Expired – Fee Related

1987-09-22
MY
MYPI87001873A
patent/MY102553A/en
unknown

1987-09-22
AU
AU78827/87A
patent/AU592467B2/en
not_active
Ceased

1987-09-23
SU
SU874203390A
patent/SU1517764A3/en
active

1987-09-23
CA
CA000547616A
patent/CA1286285C/en
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Expired – Fee Related

1987-09-23
FI
FI874152A
patent/FI86853C/en
not_active
IP Right Cessation

1987-09-23
DK
DK500887A
patent/DK167319B1/en
not_active
IP Right Cessation

1987-09-23
PT
PT85773A
patent/PT85773B/en
not_active
IP Right Cessation

1987-09-23
HU
HU874281A
patent/HU196810B/en
not_active
IP Right Cessation

1987-09-23
NO
NO873969A
patent/NO169717C/en
not_active
IP Right Cessation

1987-09-24
KR
KR1019870010566A
patent/KR920003902B1/en
not_active
IP Right Cessation

1987-10-15
AT
AT0273187A
patent/AT389311B/en
not_active
IP Right Cessation

1991

1991-01-03
GR
GR90400968T
patent/GR3001274T3/en
unknown

1993

1993-02-11
SG
SG153/93A
patent/SG15393G/en
unknown

1993-04-29
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HK420/93A
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IP Right Cessation

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Publication number
Publication date

NO873969L
(en)

1988-03-25

FI874152A0
(en)

1987-09-23

US4866170A
(en)

1989-09-12

HK42093A
(en)

1993-05-07

ZA876739B
(en)

1988-03-14

JPH0448795B2
(en)

1992-08-07

NO169717B
(en)

1992-04-21

PT85773A
(en)

1987-10-01

CA1286285C
(en)

1991-07-16

AT389311B
(en)

1989-11-27

DK500887D0
(en)

1987-09-23

SG15393G
(en)

1993-04-16

CN1021225C
(en)

1993-06-16

JPS6379888A
(en)

1988-04-09

FI874152A
(en)

1988-03-25

ES2026545T3
(en)

1992-05-01

ATA273187A
(en)

1989-04-15

KR880003955A
(en)

1988-05-31

CN87106308A
(en)

1988-04-13

KR920003902B1
(en)

1992-05-18

PH23644A
(en)

1989-09-27

AU7882787A
(en)

1988-03-31

HU196810B
(en)

1989-01-30

EP0261823B1
(en)

1991-01-02

DK500887A
(en)

1988-03-25

IE872346L
(en)

1988-03-14

ATE59655T1
(en)

1991-01-15

PT85773B
(en)

1990-07-31

NO873969D0
(en)

1987-09-23

EP0261823A1
(en)

1988-03-30

MY102553A
(en)

1992-07-31

SU1517764A3
(en)

1989-10-23

IE60042B1
(en)

1994-05-18

HUT45263A
(en)

1988-06-28

DK167319B1
(en)

1993-10-11

NO169717C
(en)

1992-07-29

IL83786A0
(en)

1988-02-29

DE3766921D1
(en)

1991-02-07

FI86853C
(en)

1992-10-26

GR3001274T3
(en)

1992-08-25

FI86853B
(en)

1992-07-15

IL83786A
(en)

1991-11-21

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