AU5953386A - Creation of Inventions and Patents with Artificial Intelligence

AU5953386A – Depolymerized hexosaminoglucan sulfates endowed with an antithrombotic, fibrinolytic, antiinflammatory activity, their process of preparation and related pharmaceutical compositions
– Google Patents
Depolymerized hexosaminoglucan sulfates endowed with an antithrombotic, fibrinolytic, antiinflammatory activity, their process of preparation and related pharmaceutical compositions

Info

Publication number
AU5953386A

AU5953386A
AU59533/86A
AU5953386A
AU5953386A
AU 5953386 A
AU5953386 A
AU 5953386A
AU 59533/86 A
AU59533/86 A
AU 59533/86A
AU 5953386 A
AU5953386 A
AU 5953386A
AU 5953386 A
AU5953386 A
AU 5953386A
Authority
AU
Australia
Prior art keywords
hexosaminoglucan
depolymerized
fibrinolytic
antithrombotic
endowed
Prior art date
1985-05-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Application number
AU59533/86A
Other versions

AU601910B2
(en

Inventor
Pietro Bianchini
Guiseppe Mascellani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

OPOCRIN SpA LABORATORIO FARMACOBIOLOGICO

Original Assignee
Opocrin SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1985-05-17
Filing date
1986-05-15
Publication date
1986-12-04

1986-05-15
Application filed by Opocrin SpA
filed
Critical
Opocrin SpA

1986-12-04
Publication of AU5953386A
publication
Critical
patent/AU5953386A/en

1990-09-20
Application granted
granted
Critical

1990-09-20
Publication of AU601910B2
publication
Critical
patent/AU601910B2/en

2006-05-15
Anticipated expiration
legal-status
Critical

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON

C08B—POLYSACCHARIDES; DERIVATIVES THEREOF

C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 – C08B35/00; Derivatives thereof

C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof

C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P7/00—Drugs for disorders of the blood or the extracellular fluid

A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

C—CHEMISTRY; METALLURGY

C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON

C08B—POLYSACCHARIDES; DERIVATIVES THEREOF

C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 – C08B35/00; Derivatives thereof

C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

C08B37/0078—Degradation products

AU59533/86A
1985-05-17
1986-05-15
Depolymerized hexosaminoglucan sulfates endowed with an antithrombotic, fibrinolytic, antiinflammatory activity, their process of preparation and related pharmaceutical compositions

Expired

AU601910B2
(en)

Applications Claiming Priority (2)

Application Number
Priority Date
Filing Date
Title

IT8520769A

IT1214609B
(en)

1985-05-17
1985-05-17

HEXOSAMINOGLICANS DEPOLYMERIZED SULPHATES FOR ANTI-THROMBOTIC, FIBRINOLITHIC, ANTI-INFLAMMATORY ACTIVITIES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

IT20769/85

1985-05-17

Publications (2)

Publication Number
Publication Date

AU5953386A
true

AU5953386A
(en)

1986-12-04

AU601910B2

AU601910B2
(en)

1990-09-20

Family
ID=11171798
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

AU59533/86A
Expired

AU601910B2
(en)

1985-05-17
1986-05-15
Depolymerized hexosaminoglucan sulfates endowed with an antithrombotic, fibrinolytic, antiinflammatory activity, their process of preparation and related pharmaceutical compositions

Country Status (16)

Country
Link

US
(1)

US4973580A
(en)

EP
(1)

EP0221977B1
(en)

JP
(1)

JP2510177B2
(en)

CN
(1)

CN1009096B
(en)

AR
(1)

AR240461A1
(en)

AT
(1)

ATE55396T1
(en)

AU
(1)

AU601910B2
(en)

CA
(1)

CA1283098C
(en)

DD
(1)

DD251355A5
(en)

DE
(1)

DE3673329D1
(en)

DK
(1)

DK173804B1
(en)

HU
(1)

HU203565B
(en)

IL
(1)

IL78772A
(en)

IT
(1)

IT1214609B
(en)

WO
(1)

WO1986006729A1
(en)

ZA
(1)

ZA863651B
(en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US5707604A
(en)

1986-11-18
1998-01-13
Access Pharmaceuticals, Inc.
Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles

AR243204A1
(en)

1986-11-21
1993-07-30
Ajorca Sa
A method for the chemical depolymerisation of polysaccharides.

US5668116A
(en)

1987-03-19
1997-09-16
Anthropharm Pty. Limited
Anti-inflammatory compounds and compositions

CA1327354C
(en)

1987-03-19
1994-03-01
David Cullis-Hill
Anti-inflamatory compounds and compositions

AU4426289A
(en)

1988-10-05
1990-05-01
Nicola Diferrante
Methods for interfering with hiv multiplication and composition for the treatment of aids

IT1230582B
(en)

1988-10-21
1991-10-28
Opocrin S P A Lab Farmabiologi

DERMATAN SULPHATE AND HEPARIN OILGOSACCHARID WITH ANTI-THEROSCLEROTIC ACTIVITIES

GB8826448D0
(en)

1988-11-11
1988-12-14
Thrombosis Res Inst
Improvements in/relating to organic compounds

CA1340994C
(en)

1989-09-21
2000-05-16
Rudolf Edgar Dr. Falk
Treatment of conditions and disease

IT1240615B
(en)

1990-04-03
1993-12-17
Mediolanum Farmaceutici Spa

USE OF DERMATAN SULPHATE IN THE PREVENTION AND THERAPY OF CEREBRAL AGING AND FUNCTIONAL DEFICIT STATES OF THE CENTRAL NERVOUS SYSTEM

WO1991015217A1
(en)

1990-04-06
1991-10-17
Washington University
Anticoagulant oligosaccharides

IT1243987B
(en)

1990-10-29
1994-06-28
Derivati Organici Lab

PROCEDURE FOR THE PREPARATION OF EPOXY-HEPARID PRODUCTS OBTAINED PHARMACEUTICAL ECOMPOSITIONS CONTAINING THEM

US5629287A
(en)

1991-01-18
1997-05-13
University College London
Depot formulations

US5610148A
(en)

1991-01-18
1997-03-11
University College London
Macroscopically oriented cell adhesion protein for wound treatment

SK120193A3
(en)

1991-05-02
1994-07-06
Yeda Res & Dev
Pharmaceutical composition for the prevention and/or treatment of pathological processes

US5234914A
(en)

1991-06-11
1993-08-10
Patent Biopharmaceutics, Inc.
Methods of treating hemorrhoids and anorecial disease

IT1251183B
(en)

1991-08-28
1995-05-04
Opocrin Spa

HIGH DENSITY DERMATAN SULPHATE, EQUIPPED WITH HIGH THROMBOLITHIC ACTIVITY, AND PHARMACEUTICAL FORMS THAT CONTAIN IT.

FR2682388B1
(en)

1991-10-10
1995-06-09
Pasteur Merieux Serums Vacc

PROCESS FOR THE PREPARATION OF AN OLIGOSIDE BY DEPOLYMERIZATION OF A POLYOSIDE DERIVED FROM A PATHOGENIC AGENT, OLIGOSIDE THUS OBTAINED AND ITS USE IN PARTICULAR AS A VACCINE AGENT.

GB2266239B
(en)

1992-03-25
1996-03-06
Jevco Ltd
Wound healing compositions containing chondroitin sulphate oligosaccharides

US6750207B1
(en)

1992-05-01
2004-06-15
Yeda Research And Development Co. Ltd.
Compositions for the regulation of cytokine activity

US5861382A
(en)

1992-05-01
1999-01-19
Yeda Research And Development Co. Ltd.
Methods for regulation of active TNF-α

US20020055710A1
(en)

1998-04-30
2002-05-09
Ronald J. Tuch
Medical device for delivering a therapeutic agent and method of preparation

CA2150552C
(en)

1993-09-30
1999-12-21
Akikazu Takada
Antithrombotic

US5514665A
(en)

1993-12-30
1996-05-07
University Of British Columbia
Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans

CA2121952A1
(en)

1994-04-22
1995-10-23
Francesco Della Valle
Topical preparations for the treatment of acne and acneiform dermatitis

US5585361A
(en)

1994-06-07
1996-12-17
Genzyme Corporation
Methods for the inhibition of platelet adherence and aggregation

US6106866A
(en)

1995-07-31
2000-08-22
Access Pharmaceuticals, Inc.
In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles, including tumor sites

FR2738009B1
(en)

1995-08-24
1997-10-31
Centre Nat Rech Scient

PROCESS FOR OBTAINING SULPHATE POLYSACCHARIDES

AU717673B2
(en)

1995-09-19
2000-03-30
Seikagaku Corporation
Anti-inflammatory agent

IT1285546B1
(en)

1996-01-16
1998-06-18
Alfa Wassermann Spa

USE OF LOW MOLECULAR WEIGHT DERMATANE SULFATE AND MEDICINAL SPECIALTIES THAT CONTAIN IT IN THE THERAPY AND PREVENTION OF

US6203536B1
(en)

1997-06-17
2001-03-20
Medtronic, Inc.
Medical device for delivering a therapeutic substance and method therefor

US6106454A
(en)

1997-06-17
2000-08-22
Medtronic, Inc.
Medical device for delivering localized radiation

US6013099A
(en)

1998-04-29
2000-01-11
Medtronic, Inc.
Medical device for delivering a water-insoluble therapeutic salt or substance

US6206914B1
(en)

1998-04-30
2001-03-27
Medtronic, Inc.
Implantable system with drug-eluting cells for on-demand local drug delivery

IL147318A0
(en)

1999-06-30
2002-08-14
Hamilton Civic Hospitals Res
Heparin compositions that inhibit clot associated coagulation factors

KR100369518B1
(en)

2000-02-02
2003-01-30
김공수
Method for preparing a low molecular weight polysaccharides and it’s oligomers

JP4585072B2
(en)

2000-02-29
2010-11-24
扶桑薬品工業株式会社

Heparin depolymerization method, depolymerized heparin, derivatives thereof and pharmaceutical composition

US20040038932A1
(en)

2000-09-08
2004-02-26
Jack Hirsh
Antithrombotic compositions

PE20030263A1
(en)

2001-07-31
2003-04-17
Novartis Ag

PHARMACEUTICAL OPHTHALMIC COMPOSITION

US7285536B2
(en)

2001-12-05
2007-10-23
Yeda Research And Development Co., Ltd.
Anti-cancer therapeutic compounds

US8071569B2
(en)

2002-09-20
2011-12-06
Mousa Shaker A
Oxidized heparin fractions and their use in inhibiting angiogenesis

ITMI20031618A1
(en)

2003-08-06
2005-02-07
Inalco Spa

POLYSACCHARIDE DERIVATIVES EQUIPPED WITH HIGH ACTIVITY

PL1711485T3
(en)

2003-12-18
2009-11-30
Tibotec Pharm Ltd
Amino-benzimidazoles derivatives as inhibitors of respiratory syncytial virus replication

FR2871379B1
(en)

2004-06-14
2006-09-29
Ifremer

USE OF HIGHLY SULFATED POLYSACCHARIDE DERIVATIVES WITH LOW MOLECULE MASS TO MODULATE ANGIOGENESIS

ES2284398B2
(en)

2006-04-27
2008-12-16
Universidad Complutense De Madrid

FORMULATION OF LIPOSOMAL VESICLES IN WATER SOLUTIONS WITH CHARACTERISTICS OF LAGRIMAL FILM.

US9539202B2
(en)

2006-04-28
2017-01-10
Universidad Complutense De Madrid
Formulation of liposomal vesicles in aqueous solutions with lachrymal film characteristics

CN101735336B
(en)

2009-11-06
2012-07-18
深圳海王药业有限公司
Oligomeric fucosylated glycosaminoglycan and preparation method thereof

WO2012036152A1
(en)

2010-09-14
2012-03-22
国立大学法人宮崎大学
High purity heparin and production method therefor

CA2828823C
(en)

2011-03-18
2019-10-01
(Inserm) Institut National De La Sante Et De La Recherche Medicale
Chondrogenic differentiation media and methods for inducing chondrogenic differentiation of cells

US20150011501A1
(en)

2012-02-17
2015-01-08
Kimflexor, S.L.
Partially depolymerized glycosaminoglycan silver and gold salts

EP2870974A1
(en)

2013-11-08
2015-05-13
Novartis AG
Salmonella conjugate vaccines

EP3146971A1
(en)

2015-09-28
2017-03-29
Institut Francais de Recherche pour l’Exploitation de la Mer (IFREMER)
An anti-metastatic marine bacterial exopolysaccharide derivative and uses thereof

CN105461830A
(en)

2016-01-08
2016-04-06
东营天东制药有限公司
Method for removing copper ions through poly-chelate resin

CN106947004A
(en)

2017-03-02
2017-07-14
浙江大学
A kind of preparation method of low molecular weight heparin

CN110809474A
(en)

2017-06-20
2020-02-18
加利福尼亚大学董事会
Production of bioactive oligosaccharides

CN109748984A
(en)

2018-12-28
2019-05-14
河北常山生化药业股份有限公司
A kind of Nadroparin Calcium preparation method

FR3091870B1
(en)

2019-01-18
2021-11-05
Adisseo France Sas

AGENT FOR INITIATING A RADICAL ADDITION REACTION AND IMPLEMENTING IT

WO2021097138A1
(en)

2019-11-14
2021-05-20
Bcd Bioscience, Inc.
High-yield peroxide quench-controlled polysaccharide depolymerization and compositions thereof

WO2022003112A1
(en)

2020-07-02
2022-01-06
Institut Francais De Recherche Pour L’exploitation De La Mer (Ifremer)
Marine bacterial exopolysaccharide derivatives and uses thereof in the treatment of mucopolysaccharidoses

CN111909288B
(en)

2020-08-13
2021-09-03
山东辰龙药业有限公司
Refining method of heparin sodium

EP4112060A1
(en)

2021-07-01
2023-01-04
Institut Francais de Recherche pour l’Exploitation de la Mer (IFREMER)
Low-molecular-weight he800 exopolysaccharide derivatives with anti-cancer properties and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US408030A
(en)

1889-07-30

Kenzie hughes

NL286444A
(en)

1961-12-08

USB408030I5
(en)

1973-10-19
1975-01-28

US3935187A
(en)

1973-10-19
1976-01-27
Standard Brands Incorporated
Process for depolymerizing amylaceous polymers

IT1083903B
(en)

1977-08-09
1985-05-25
Lobo Srl

OLIGO-ETEROPOLISACCARIDI WITH HEPARINOSIMIL ACTIVITIES, PROCEDURE FOR THEIR OBTAINING AND RELATED THERAPEUTIC COMPOSITIONS

FR2440376A1
(en)

1978-11-06
1980-05-30
Choay Sa

MUCOPOLYSACCHARIDIC COMPOSITION HAVING REGULATORY COAGULATION ACTIVITY, MEDICAMENT CONTAINING SAME AND METHOD FOR OBTAINING SAME

US4281108A
(en)

1980-01-28
1981-07-28
Hepar Industries, Inc.
Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained

CA1171375A
(en)

1980-09-15
1984-07-24
Ulf P.F. Lindahl
Oligosaccharides having selective anticoagulation activity

DE3118588C2
(en)

1981-05-11
1983-07-07
Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München

Process for the preparation of an injectable high-purity chondroitin polysulfate, product obtainable below and pharmaceutical composition

ZA829463B
(en)

1982-07-19
1983-10-26
Hepar Ind Inc
Process for manufacturing low molecular weight heparins by depolymerization of normal heparin

FR2538404B1
(en)

1982-12-28
1985-08-23
Anic Spa

US4533549A
(en)

1983-01-04
1985-08-06
Lasker Sigmund E
Antithrombotic agent

IT1195497B
(en)

1983-03-08
1988-10-19
Opocrin Spa

PROCEDURE FOR THE PREPARATION OF OLIGOSACCHARIDIC FRACTIONS EQUIPPED WITH PHARMACOLOGICAL PROPERTIES FOR CHEMICAL DEGRADATION OF HEPARIN

US4687765A
(en)

1983-07-25
1987-08-18
Choay S.A.
Method and composition for thrombolytic treatment

JPS624703A
(en)

1985-07-02
1987-01-10
Tooa Eiyoo Kk
Production of low-mw heparin fraction

DK196986D0
(en)

1986-04-30
1986-04-30
Novo Industri As

PREPARATION OF POLYSACCHARIDES

US4745108A
(en)

1986-08-20
1988-05-17
Foley Kevin M
Heparin derivatives having decreased anti-Xa specificity

1985

1985-05-17
IT
IT8520769A
patent/IT1214609B/en
active

1986

1986-05-13
DD
DD86290192A
patent/DD251355A5/en
not_active
IP Right Cessation

1986-05-13
IL
IL78772A
patent/IL78772A/en
not_active
IP Right Cessation

1986-05-15
EP
EP86903331A
patent/EP0221977B1/en
not_active
Expired – Lifetime

1986-05-15
AT
AT86903331T
patent/ATE55396T1/en
not_active
IP Right Cessation

1986-05-15
HU
HU863344A
patent/HU203565B/en
not_active
IP Right Cessation

1986-05-15
JP
JP61503130A
patent/JP2510177B2/en
not_active
Expired – Fee Related

1986-05-15
DE
DE8686903331T
patent/DE3673329D1/en
not_active
Expired – Lifetime

1986-05-15
AU
AU59533/86A
patent/AU601910B2/en
not_active
Expired

1986-05-15
WO
PCT/EP1986/000291
patent/WO1986006729A1/en
active
IP Right Grant

1986-05-16
CA
CA000509396A
patent/CA1283098C/en
not_active
Expired – Lifetime

1986-05-16
AR
AR303986A
patent/AR240461A1/en
active

1986-05-16
ZA
ZA863651A
patent/ZA863651B/en
unknown

1986-05-17
CN
CN86104301A
patent/CN1009096B/en
not_active
Expired

1987

1987-01-13
DK
DK198700157A
patent/DK173804B1/en
not_active
IP Right Cessation

1989

1989-05-10
US
US07/349,706
patent/US4973580A/en
not_active
Expired – Lifetime

Also Published As

Publication number
Publication date

WO1986006729A1
(en)

1986-11-20

CN86104301A
(en)

1987-03-04

DD251355A5
(en)

1987-11-11

IT8520769D0
(en)

1985-05-17

DK15787D0
(en)

1987-01-13

US4973580A
(en)

1990-11-27

JPS63500184A
(en)

1988-01-21

HUT46028A
(en)

1988-09-28

CA1283098C
(en)

1991-04-16

IL78772A
(en)

1991-08-16

CN1009096B
(en)

1990-08-08

ATE55396T1
(en)

1990-08-15

EP0221977A1
(en)

1987-05-20

AU601910B2
(en)

1990-09-20

JP2510177B2
(en)

1996-06-26

DK173804B1
(en)

2001-11-05

EP0221977B1
(en)

1990-08-08

HU203565B
(en)

1991-08-28

DE3673329D1
(en)

1990-09-13

IT1214609B
(en)

1990-01-18

ZA863651B
(en)

1987-01-28

AR240461A1
(en)

1990-04-30

DK15787A
(en)

1987-01-13

IL78772A0
(en)

1986-08-31

Contact information