AU615711B2 – (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active ingredient
– Google Patents
AU615711B2 – (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active ingredient
– Google Patents
(cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active ingredient
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Publication number
AU615711B2
AU615711B2
AU28670/89A
AU2867089A
AU615711B2
AU 615711 B2
AU615711 B2
AU 615711B2
AU 28670/89 A
AU28670/89 A
AU 28670/89A
AU 2867089 A
AU2867089 A
AU 2867089A
AU 615711 B2
AU615711 B2
AU 615711B2
Authority
AU
Australia
Prior art keywords
methylenebis
phosphonic acid
lower alkyl
compound
cycloalkylamino
Prior art date
1988-01-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU28670/89A
Other versions
AU2867089A
(en
Inventor
Tetsushi Abe
Yasuo Isomura
Shuichi Sakamoto
Makoto Takeuchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-01-20
Filing date
1989-01-20
Publication date
1991-10-10
1989-01-20
Application filed by Yamanouchi Pharmaceutical Co Ltd
filed
Critical
Yamanouchi Pharmaceutical Co Ltd
1989-07-20
Publication of AU2867089A
publication
Critical
patent/AU2867089A/en
1991-10-10
Application granted
granted
Critical
1991-10-10
Publication of AU615711B2
publication
Critical
patent/AU615711B2/en
2009-01-20
Anticipated expiration
legal-status
Critical
Status
Ceased
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K31/00—Medicinal preparations containing organic active ingredients
A61K31/66—Phosphorus compounds
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/28—Phosphorus compounds with one or more P—C bonds
C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
C07F9/3839—Polyphosphonic acids
C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N…..H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N…..O, N…..S, N…..C(=X)- (X =O, S), N…..N, N…C(=X)…N (X =O, S)
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P19/00—Drugs for skeletal disorders
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/28—Phosphorus compounds with one or more P—C bonds
C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
C07F9/40—Esters thereof
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/28—Phosphorus compounds with one or more P—C bonds
C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
C07F9/40—Esters thereof
C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
C07F9/4025—Esters of poly(thio)phosphonic acids
C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N…..H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N…..O, N…..S, N…..C(=X)- (X =O, S), N…..N, N…C(=X)…N (X =O, S)
Abstract
(Cycloalkylamino)methylenebisphosphonic acids and esters (I) and salts thereof
Description
A 4
AUSTRALIA
PATENTS ACT 1952 615711 COMPLETE SPECIFICATION
(ORIGINAL)
FOR OFFICE USE Application Number: Lodged: Complete Specification Lodged: Accepted: Published: Priority: Related Art: o000o0 0 0 0 I TO BE COMPLETED BY APPLICANT 0 0o o ,Name of Applicant: o o* 00 0 0 0 0 SAddress of Applicant: 4 Actual Inventor: e p a 0 9 O0 Address for Service? a 0 0 YAMANOUCHI PHARMACEUTICAL CO.,
LTD.
3-11, Nihonbashi-Honcho 2-chome Chuo-ku, Tokyo, Japan 1. YASUO ISOMURA 2. MAKOTO TAKEUCHI 3. SHUICHI SAKAMOTO 4. TETSUSHI ABE ARTHUR S. CAVE CO.
Patent Trade Mark Attorneys Level Barrack Street SYDNEY N.S.W. 2000
AUSTRALIA
o0 0 “.iomplete Specification for the invention (CYCLOALKYLAMINO)METHYLENEBIS(PHOSPHONIC ACID) AND CONTAINING THE SAME AS AN ACTIVE INGREDIENT.
entitled MEDICINEc The following statement is a full description of this invention including the best method of performing it known to me:- 1 ASC 49
I
To: Yampnouchi Pharmaceutical Co., Ltd.
The Commissioner of Patents 4 Presidnt; Shigeo Morioka ARTHUR S. CAVE CO.
PATENT AND TRADE MARK ATTORNEYS SY YON:
B
:ti: i, Signature of Declarant(s) Ilryr; __W4 .4.
SPECIFICATION
Title of the Invention (Cycloalkylamino)methylenebis(pospshonic acid) and medicines containing the same as an active ingredient Background of the Invention Field of the Invention The present invention relates to (cycloalkylamino)methylenebis(phosphonic acid), lower alkyl ester thereof or pharmaceutically acceptable salts thereof which are useful as medicines having a bone resorption inhibitory effect as well as an anti-inflammatory effect and an antirheumatic effect and also relates to medicines containing the compounds as an active ingredient.
oo0 So oo 000 o oa O 0 oC 0 ,0 <3 e P 0 t 0' tQ Description of the related art o Some derivatives (cycloalkylamino)methylenebis(phosphonic acid) are known. Japanese patent laid-open No. 37,829>Download PDF in English
