AU622454B2 - Creation of Inventions and Patents with Artificial Intelligence

AU622454B2 – Blood reservoir
– Google Patents

AU622454B2 – Blood reservoir
– Google Patents
Blood reservoir

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Publication number
AU622454B2

AU622454B2
AU36674/89A
AU3667489A
AU622454B2
AU 622454 B2
AU622454 B2
AU 622454B2
AU 36674/89 A
AU36674/89 A
AU 36674/89A
AU 3667489 A
AU3667489 A
AU 3667489A
AU 622454 B2
AU622454 B2
AU 622454B2
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AU
Australia
Prior art keywords
blood
casing
blood reservoir
diaphragm
reservoir according
Prior art date
1988-06-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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Application number
AU36674/89A
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AU3667489A
(en

Inventor
Hiroaki Oshiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Terumo Corp

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Terumo Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1988-06-21
Filing date
1989-06-20
Publication date
1992-04-09

1989-06-20
Application filed by Terumo Corp
filed
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Terumo Corp

1990-01-04
Publication of AU3667489A
publication
Critical
patent/AU3667489A/en

1992-04-09
Application granted
granted
Critical

1992-04-09
Publication of AU622454B2
publication
Critical
patent/AU622454B2/en

2009-06-20
Anticipated expiration
legal-status
Critical

Status
Ceased
legal-status
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Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR

A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems

A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits

A61M1/3621—Extra-corporeal blood circuits

A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters

Description

COMPLETE
622454
SPECIFICATION
FOR OFFICE USE Application Number: Lodged: Complete Specification Priority; Class Int. Class Lodged: Accepted: Published: Related Art: TO BE COMPLETED BY APPLICANT Name of Applicant: Address of Applicant: Actual Inventor: Address for Service: TERUMO KABUSHI KAISLIA 44-1, Hatagaya 2-chome, Shibuya-ku, Tokyo, Japan Hiroaki OSHTYAMA SMIfT SHEI$TON BEADLE 207 Riversdale Road Box 410) Hawthorn, Victoria, Australia Complete Specification., for the invention entitled: BLOOD RESERVOIR The following stakZ-ement is a full description of this invention, including the best method of performing it known to us: Page 1 Our Ref: #3575 PS:WB 2Oter reservoir for use in the medical field. The blood reservoir is inserted in an extracorporeal circuit, typically an artificial heart-lung circuit for temporarily storing Llood drained from the patient.
BACKGROUND OF THE INVENTION 15 variations in the flow rate of blood, for example, when the amount of blood drained from the patient decreases or when the amount of blood fed to the patient must be increased.
An extra amount of blood should be stored in the circuit toan accommodate such variations in blood flow rate. To this end, a blood reservoir is inserted in the circuit for d temporarily storing venous blood drained from the patient.
i AThis type of reservoir is often called a venous reservoir.
c One typical venous reservoir includes a pair of plastic sheets sealed along their four sides for defining a closed space therein. This closed type of venous reservoir has no risks of contact with air, entry of foreign matters, or Spamouming-in of air even when the amount decreasesf blood drained decreasesmount of blood fed to the patient must be increased.
The venous reservoir should preferably have the following functions.
Blood storage function: The reservoir should have a sufficient volume or pace to accommodrained a necessay volumethe patient.
of blod f reservoir is often called a venous reservoir.
Debubbling function: Air bubbles can be introduced into a drainage ubei when a blood drainage catheter is unsteadilys no dwelled in the vein or when the oatheter is withdrawn froed decreases.
TERUMO KABUSHIKI KAISHA NO ATTESTATION OR SEAL Masatoshi IWADE Director General Manager of Patent Division Signature(s) of declarant(s).
To: The Commissioner of Patents, Australia
V
ss e ^1 -2the vein. It is required to remove air from the drained blood in the reservoir.
No stagnation: The reservoir should be free of local stagnation of blood.
Requirement debubbling or air removal is a critical factor. If the reservoir does not function well in air removal, there is a possibility that ai- be introduced into the patient, causing thrombi in blood capillaries of various organs of the patient, particularly of the brain, eventually inviting cerebropathy after the operation and leaving a life threatening crisis.
In general, debubbling ability is improved as the blood soo storage volume of the reservoir increases. However, it is a not recommendable to increase the blood storage volume. An 15 increased blood storage volume increases the priming 0 CO oao quantity of an overall extracorporeal circuit and requires a a”0 correspondingly increased amount of blood transfused, which a° increases the possible ciccurrence of hepatitis after the operation. An increased blood storage volume is also undesirable from the standpoint of blood saving.
‘0 a For this reason, efforts have been made to develop a blood reservoir capable of efficient removal of air bubbles without increasing the blood storage volume.
0 oo oo One such attempt is the venous reservoir disclosed in Japanese Patent Application Kokai No. 67962/1984. Referring to FIG. 15, there is illustrated a venous reservoir at 100 as comprising a flexible container casing 101 defining a C E! blood storage space 102 therein. The casing 101 is formed by sealing a pair of plastic sheets along their four sides.
A blood inlet port in the form of a tube 105 is attached to the lower portion of the casing 101 such that the distal end 105a of the tube protrudes into the space 102. The distal portion 105a of the inlet tube 105 is provided with a plurality of apertures 106 so that drainage blood may be introduced into the space 102 through the inlet tube 105 in a dispersed manner. Then blood ioderately flows into the
L
-3space 102 from the inlet tube 105, contributing to maintenance of an environment where air bubbles will risevertically upward through the blood under the impetus of buoyancy of bubbles themselves.
A blood outlet port in the form of a tube 107 is attached to the lower portion of the casing 101 at a predetermined spacing from the inlet port 105 and in parallel with the inlet port 105. A vent port 108 is disposed at the upper portion of the casing 101 in communication with the blood storage space 102. The casing 101 includes an extra sealed portion 101c defining aslant upper wall for the space 102 so that rising air bubbles may move along the slant upper wall 101c toward the vent port 108. Air bubbles escape outside the casing 101 through the “4 15 vent port 108.
The venous reservoir 100 of the above-described I construction has a likelihood of occurrence of a blood short-circuit that part. of blood entering the space 102 from the apertures 106 in the inlet tube 105 directly flows toward the outlet port 107. Then some blood can be 4 discharged or fed back to the extracorporeal circuit through the outlet port 107 without being fully debubbled. As a whole, this reservoir shows a less sufficient debubbling function.
The venous reservoir 100 of the prior art has an additional drawback that blood tends to locally stagnate in j. corners T near the bottom and the top of the space 102 l surrounding the inlet tube 105 and the vent port 108, respectively.
There is a need for an improved blood reservoir which has overcome the above-mentioned problems.
4 SUMMARY OF THE INVENTtO A primary object of the present invention is to provide a new and improved blood reservoir having an efficient debubbling function and unsusceptible to local blood stagnation.
According to the present invention there is provided a blood reservoir, comprising: a container casing defining a space, said casing having a generally rectangular contour in a vertical plane defining a pair of upper and lower sides and a pair of laterally opposed sides, partition means for separating the space into first and second compartments for accommodating blood, but allowing fluid communication between the first and second compartments, an inlet port in one said lateral side of said casing is’ communication with said first compartment, an outlet port disposed in the lower side of said i casing in communication with said second compartment, and a vent port disposed in the upper side of said casing in communication with said first compartment.
In a typical example, the blood reservoir is incorporated in an artificial heart-lung circuit such that blood is draAned from the patient into the reservoir before it is pumped to the oxygenator. The blood inlet port is disposed in one lateral side of the reservoir casing and the outlet port is disposed in the bottom side of the casing at a location remote from the inlet port. This ps23/3575tkk.res 92 1 22 0I a c r having a eeal etnua otu navria ln 4aarrangement of the inlet and outlet ports causes blood to travel a relatively long path from the inlet to the outlet.
The blood inlet port is located relatively near to the vent port at the top, allowing air bubbles to travel a relatively short path to the vent port, ensuring more efficient debubbling.
Upon entry into the space through the inlet port, blood is distributed in multiple directions and thus forms a moderate flow, increasing the chance and time for entrained air bubbles to rise through the blood under the impetus of their own buoyancy. Since a blood stream is not so intense in the reservoir, little bubbles are positively entrained in 2 2 s23/355tkk1re 92 1 22 l
I
I ii I I ff I t the blood stream, ensuring spontaneous upward motion of bubbles.
Local stagnation of blood is minimized since the inlet port is disposed in the lateral side of the reservoir casing above the bottom.
According to a second aspect of the present invention, there is provided a blood reservoir comprising a container casing defining a space. The casing has a generally rectangular contour in a vertical plane defining a pair of upper and lower sides and a pair of laterally opposed sides, provided that the casing assumes a vertically upright attitude. Partition means separates the space into first and second compartments for accommodating blood, but allows partial fluid communication between the first and second compartments. 1in” inlet port is in communication with the first compartment, and an outlet port is disposed in the lower side of the casing in communication with the second compartment. A vent port is disposed in the upper side of the casing in communication with the first compartment.
In the second form, the bloud storage space of the reservoir is separated into two compartments which are in fluid communication through an opening. The flow of blood from the inlet port to the outlet port becomes more moderate, allowing more efficient rise of bubbles through the blood. More efficient debubbling is ensured.
More particularly, the blood which is drained from the patient along with air bubbles is first introduced into the first compartment of the reservoir through the inlet port.
At this point, blood is distributed in multiple directions through a plurality of apertures formed in the inlet conduit, forming a moderate stream in the first compartment.
Since the blood stream in the first compartment is not vigorous, air bubblf; can readily rise by virtue of their buoyancy without being entrained on the stream. Upwardly collecting bubbles are then discharged to the exterior through the vent port.
I
r_ i j I c* I I -7- FIG. 13 is a front elevation of a further variant blood reservoir according to the second embodiment of the invention; FIG. 14 diagrammatically illustrates an artificial heart-lung circuit to which the blood reservoir of the invention is applicable; and FIG. 15 is a front elevation of a prior art blood reservoir.
Throughout the figures, like parts are designated by the same numerals.
DESCRIPTION OF THE PREFERRED EMBODIMENTS 0.130 Several preferred embodiments of tha blood reservoir of 0 the present invention are illustrated with reference to the S a” o 15 drawings.
ooo Before entering the description of embodiments, it will 040 be helpful to briefly refer to an artificial heart-lung circuit to which the blood reservoir of the invention is applicable. FIG. 14 is a diagram showing such an artiJficial 20 heart-lung circuit system S. The system includes an I 00 artificial lung or oxygenator L and a pump P in a circuit line C. Blood is drained from the patient (now shown) on 4 the left side, pumped to lung L, and then fed back to the patient by passing along circuit line C. A blood reservoir designated at 10 is disposed in circuit line C upstream of pump P for the purpose of temporarily storing blood to accommodate any variations of blood flow rate through the system.
FIG. 1 is a tront elevation of a blood reservoir according to a first embodiment of the invention. The blood reservoir normally assumes a vertical upright attitude as viewed in FIG. 1. FIG. 2 is a vertical cross section taken along lines I1-II in FIG. 1.
The blood reservoir 10 includes a flexible container casing 11 defining a space 12 for storing blood therein.
The blood storage space 12 has a predatermined volume. In Ij i i^ -8the illustrated embodiment, the casing 11 is of the structure consisting essentially of a pair of generally rectangular plastic front and rear sheets 11a and 11b. The sheets may be of flexible vinyl chloride resin or similar flexible resin. They are placed in registry and joined together along the four sides as by heat sealing or RF welding. A seal S extends the entire perimeter of the sheets.
The casing 11 has a generally rectangular contour in a vertical plane (as viewed in FIG. 1) defining a pair of vertically opposed sides 11f and 11d and a pair of laterally opposed sides 11c and 11e. For the sake of brevity, the vertically opposed sides 11f and 11d are designated as top and bottom sides, and the laterally opposed sides 11c and 15 11e are designated as right and left sides, respectively.
0A blood inlet port in the form of a conduit 15 is 0t0″ 0 disposed in the right side 11c of casing 11, preferably at r o6″o approximately a midpoint thereof, for introducing blood drained from the patient into the space 12. The inlet conduit 15 is integrally sealed between sheets 11a and 11b o (see FIG. 2).
0 “6 The inlet conduit 15 extends laterally into the space 12 and has a closed distal end 15a. The inlet conduit may be a plastic tube having an inner diameter of 12.5 mm and an outer diameter of 17 mm, for example. An outer end S 15b of inlet conduit 15 is adapted to be connected to the 4 t circuit line C of the artificial heart-lung system S 4, t diagrammatically shown in ISG. 14.
The inlet conduit 15 includes a plurality of apertures 16 formed in the cylindrical wall near the distal end These apertures 16 constitute sparger means for distributing blood into the space 12 as a plurality of radial fine streams. Thus blood enters the space 12 through the inlet port 15 in a dispersed manner to ensure that blood calmly flows in the space 12. To this end, about 4 to 24 apertures each having a diameter of about 2 to about 5 mm, say about -9mm, are arranged in the cylindrical wall of inlet conduit 15. For examples, two rows of 8 apertures (total 16 apertures) may ;De distributed.
A blood outlet port in the form of a conduit 17 is disposed in the bottom side lid of casing 11, preferably at a location remote from the right side 11ic where the inlet port 15 is disposed, that is, near the left side lie. The outlet conduit 17 is integrally sealed between sheets 11a and 11b. The outlet oonduit 17 extends vertically into the space 12 and has an inner end flush with the bottom of space 12. The outlet conduit 17 may be a plastic tube having an inner diameter of 10 mm and an outer diameter of 14 mm, for example.
The outlet conduit 17 is for discharging bubble-free isoad from the space 12. An outer end of outlet conduit 17 isaapted to be connected to the circuit line C of the artificial heart-lung system S shown In FIG. 14.
Thei outlet port 17 is located relative to the inlet port 15 such that drained blood may follow a longer path from the inlet port 15, precisely sparging apertures 16 to the outlet port 17f increasing the chance or time for air bubbles in the blood to rise under the impetus of their own I buoyancy.
Such a long path for blood can be obtained by arranging the respective elements in a preferred set of dimensions as given below. Provided that V L is. the lateral distance of the interior space 12 in the casing 11; Wl is the lateral distance of the inlet conduit protruding f rom the casing right side 11c to the distal end 1 L2 is the lateral distance from tht6 centerline of the outlet Port 17 to the left side, 11e; 11 is the maximum height or vertical distance of the interior space 12 in the casing 11; and Hi is the vertical distance from the centerline of the inlet port 15 to the bottom side lid in FIG. 1, boetter results arr- achieved by determining these dimensions to the following ranges: Ll/L 0.1 to 0.5, especially 0.1 to 0.3, L2/L 0.1 to 0.5, especially 0,.1 to 0.3, Hi/H 0 (exclusive) to 0.8, etopecially 0.3 to 0.6, L 5 to 30 cm, and H 5 to 30 cm.
The blood reservoir 10 of the first embodiment is advantageous over the prior art blood reservoir shown in VIG. 15 in that the casing 11 can be of smaller dimensions.
This is because the distal end 15a of the blood inlet conduit 15 can be set at a sufficient vertical distance to achieve the desired debubbling function without increasing coo 0 the distance of the inlet conduit 15 extending into the space 12.
A vent port 18 is disposed in the top side 11f of the casing 11 which is the top wall of the blood storage space 0 20 12, preferably At the highest point of the space 12. The vent port 18 serves to discharge air resulting from debubbling of the drained blood in the space 12. The vent port 18 may be in the form of a vent line tube. The vent tube 18 is integral~ly sealed between sheets 11a and 11b (see FIG. The location of the vent port 18 is not particularly limited as long as it is at the highest point of the space 12.
Preferably, the casing 11 includes a larger seal area near the top side 11f defining a slant ridge 11g for the space 12. The slant ridge 11g extends obliquely upward from the left side lie at an appropriate lower position toward -the right side. 11c to the highest point where the vent port I$ is disposed. Then bubbles leaving the blood move upward along the ridge 11f toward the vent port 18. Preferably the ridt 11f is set at a slant angle of 300 to 600 with respect to t~e bottomt oide lid or a horizontal direction.
i -11- FIGS. 3 through 13 show different examples of the blood reservoir according to the second embodiment of the present invention.
The blood reservoir 10 includes a flexible container casing 11 defining a space 12 for storing blood therein.
The blood storage space 12 has a predetermined volume. In the illustrated embodiment, the casing 11 is of the structure consisting essentially of a pair of generally rectangular plastic front and rear sheets 11a and 11b. They are sealed together along the four sides, A seal S extends the entire perimeter of the sheets. The casing 11 has a generally rectangular contour in a vertical plane (as viewed in FIGS. 3, 5-8 and 13) defining a pair of vertically opposed top and bottom sides 11f and 11d and a pair of laterally opposed right and left sides 11c and lhe.
A blood inlet port in the form of a conduit 15 is disposed in the right side 11c of casing 1 preferably at approximately a midpoint thereof, for introducing blood into the space 12. A blood outlet port in the form of a conduit 17 is disposed in the casing bottom side 11d. A vent port 18 is disposed in the casing top side 11f. The inlet conduit 15 is not particularly limited as long as it is connectable at a rear end 15b to the extracorporeal circuit (not shown). Preferably, the inlet conduit 15 has a closed i 25 inner end and a plurality of sparger apertures 16 in the cylindrical wall near the inner end as in the first i embodiment.
The above-mentioned arrangement is approximately the same as that of the first embodiment.
The difference of the second embodiment from the first embodiment is the provision of partition means in the form of a diaphragm 14 for separating the casing interior space into two compartments.
As shown in FIG. 4, the diaphragm 14 is extended between the casing front and rear sheets 11a and 11b to cionstitute the partition means in the casing 11. The L I I -1 2diaphragm 14 vertically separates the interior blood space 12 of the casing 11 into two blood compartments, a first or upper compartment 13A and a second or lower compartment 13B.
Moro particularly, the diaphragm 14 in the form of a flexible plastic sheet, preferably a flexible vinyl chloride resin sheet is attached at an upper side 14a to the casing front sheet lla and at a lower side 14b to the casing reor sheet lib to form seals S as by heat seatling or RF welding, The lateral sides of the diaphragm 14 are also sealed between the front and rear sheets lla and 11b to form parts of the perimeter seall as seen from FIG. 3, for example.
The diaphragm 14 not only divides the interior blood space 12 of the casing 11 into two blood compartments, but 4 also isolates the inlet port 15 and the outlet port 17 from each other. The diaphragm, 14 separates the space 12 into the upper compartment 13A in communication with the inlet 4~ 11 2 port 15 and the lower compartment 13B In communication with the outlet port 17.
As viewed in FIGS. 3 and 4, one side 14a of the 14 secured to the rear sheet lib is vettiq~ally tabove the other side 14b of the diaphragm 14 seare-. tr the front sheet lla. Thus the diaphragm 14 extends SOUVI-tat diagonally with respect to the opposed sheets 11a and lib as seen from FIG. 4. The oblique arrangemant of the diaphragm 14 minimizes deformation or distortion~ of the diaphragm due to variations of the blood volume in the casing while maintaining the necessary interior space volume.
In the Oxamples shown in FIGS. 3 and 5f the diaphragm 14 has such a plane shape that the left side corresponding to the casing left side Ilie is wider than the right side corresponding to the casing right side lie where the inlet port 15 is disposed, The partition means fuirther Includes blood communication means. The diaphragm 14 near the casing left side lie is provided with communicating means 19 for blood communication between the upper and lower compartments 13A -13and 13B. The communicating means 19 is most often a plurality of apertures as will be described later.
The communicating means 19 is located for the following purposes. Since blood must pass the communicating means on its way through the casing 11 from the inlet port 15 to the outlet port 17, the blood travels a longer distance through the casing 11. The communicating means 19 limits the velocity at which blood flows from the upper compartment 13A to the lower compartment 13B, thereby moderating the streams of blood in both the compartments, eventually IJ zreasing the chance and time for bubbles to escape from the blood by floating upward by virtue of their own buoyancy.
To effectively achieve the purposes, the communicating means 19 is preferably located in a relatively lower portion 15 of the diaphragm 14 adjacent or near the left side lle remote from the inlet port Better results are obtained in this configuration when the outlet port 17 is provided in the bottom side 11d of casing 11 adjacent or near the right side 11c where the inlet port 15 is disposed.
Such a long path for blood and blood flow moderation can be achieved by arranging the respective elements in a preferred set of dimensions as given below. Provided that L is the lateral distance of the interior space 12 in the casing 11; L1 is the lateral distance of the inlet conduit I protruding from the casing right side 11c to the distal end L2 is the lateral distance from the centerline of the outlet port 17 to the left side 11e; L3 is the lateral distance f,;om the left side 1le to the farthest aportues of the communicating means 19; H is the maximum height or vertical distance of the interior space 12 in the casing 11; HI is the vertical distance from the centerline of the !-4let port 15 to the bottom side 11d; and L i -14- H2 is the vertical distance between the centerline of the inlet port 15 to the vertical center of the communicating mieans 19 in FIG. 3, better results are achieved by determining these dimensions to the following ranges: L1/L =0.1 to 0.5, especially 0.1 to 0.3, L2/L 0.5 to 1 (exclusive), especially 0.7 to 0.9, L3/L 0.1 to 0.5, especially 0.1 to 0.2, Hi/H 0 (exclusive) to 0.8, especially 0.3 to 0.6, H2/H 0 (exclusive) to 0.6, especially 0 (exclusive) to 0.3, L =5 to 30 cm, and H 5 to 30 cm.
Various examples of the communicating means 19 are described. The communicating means 19 is most often constructed, from a plurality of apertures. FG h More particularly, in the example sonin FI.3,th communicating means 19 includes two rows of 4 vertically spaced-apart circular apertures 195 (eight apertures in 220 total). In the example shown in FIG. 5, the communicating means 19 includes four rows of 3 vertically spaced-apprt circular tpertures 195 (twelve apertures in total). The examplIes shown in FIGS. 7 and 13 also use a similar arrangement of circular apertures like FIGS., 3 and 5 as the communication means 19. Apertures are in rows in FIG. 3, and 7 while they are in a zigzag arrangement in PIG. 13.
In the example shown in FIG. 6, the communicating means 19 includes only one relatively I 1rge circular aperture 195.
in the example shown in FIG. 8, the communicating means 19 is a generally rectangular slit 191 which is formed open between the diaphragm and the front sheet by leaving the relevant portions unsealed.
An arrangement of plural apevttires 1 Is preferred as the communicating means 19 in order to effectively prevent.
entry of bubbles into the lower compartment 13B from the upper compartment 1,3A. The communicating apertures 195 are isufficient volume or space to accommodate a necessary volume of blood.
Debubbling function: Air bubbles can be introduced into a drainage tube when a blood drainage catheter is unsteadily dwelled in the vein or when the catheter is withdrawn from preferably arranged at a diameter of about 1 to about 5 mm, a total number of 5 to 20, and a total area of about 100 to about 300 mm 2 Larger apertures 195 are rather less effective in preventing bubbles from entering the lower compartment 13B. A large pressure loss occurs across too smaller apertures, causing hemolysis.
A plurality of apertures 195 are preferably distributed in a vertically elongated rectangular region having a larger vertical distance than a lateral distance as shown in FIGS.
3 and 13 rather than a laterally elongated rectangular region having a larger lateral distance than a vertical distance. This distribution allows setting of a reduced value of L3/L which is more effective in preventing bubbles from entering the lower compartment 13B.
For the communicating means 19, a desired number of apertures with a desired size may be formed by any conventional mechanical processing techniques as by punching out the diaphragm sheet.
I
I portion 105a of the inlet tube 105 is provided with a plurality of apertures 106 so that drainage blood may be introduced into the space 102 through the inlet tube 105 in a dispersed manner. Then blood moderately flows into the -16- The partition means further includes an intermediate vent port 20. More particularly, the intermediate vent port is formed in the diaphragm 14 or between the diaphragm 14 and the rear sheet 11b.
In the example shown in FIG. 3, the diaphragm 14 is in the forr of a plastic sheet having a wider left side and a narrower right side corresponding to the irlet port 15. The upper side of the plastic sheet diaphragm 14 is slanted such that the upper end of plastic sheet diaphragm 14 on the left side is at the vertically highest point. The diaphragm sheet 14 near the left side upper end is left unsealed to the rear sheet 11b to form a slit opening which constitutes the intermediate vent port The intermediate vent port 20 is provided for the purposes of allowing air to escape from the lower compartment upon priming and for allowing the air bubbles isolating from the blood in the lower compartment 13B to rise into the upper compartment 13A whereby the air bubbles will eventually escape to the exterior of the reservoir through the vent port 18.
For these purposes, the intermediate vent port 20 is S located at the vertically highest point of the diaphragm 14.
The upper side of the diaphragm 14 along which it is sealed to the rear sheet 11b is slanted toward the intermediate vent port 20 at a sufficient angle to allow the iir bubbles isolating from the blood in the lower compartment 13B to travel along the upper side toward the intermediate vent K port 20. Preferably the diaphragm upper side is at an angle of 30° to 60° with respect to a horizontal direction.
It is preferred that the intermediate vent port takes the form of a slit formed as an unsealed area between the diaphragm 14 and the casing rear sheet 11b as shown in FIG. 3. The operation of the intermediate vent port 20 in the form of a slit is bst shown in FIGS. and 10. When some pressure is applied to the second or lower compartment 13B upon priming for the purpose of discharging air in the 1 I i/ -17casing, the slit 20 is opened as shown in FiG. 9 allowing air to pass therethrough from the second or lower compartment 13B to the first or upper compartment 13A.
During service for blood circulation, the pressure in the first or upper compartment 13A on the upstream side forces the diaphragm section against the rear sheet 11b to close the slit 20 as shown in FIG. 10, preventing blood communication therethrough. During service, air bubbles isolating from the bloo&., in the lower compartment 13B gradually collect near the highest point or intermediate vent port 20. When such collecting bubbles exceed a certain volume, they act to open the slit 20 to escape from the lower compartment 13B to the upper compartment 13A. The air bubbles eventually go out of the reservoir through the vent port 18.
In the example of FIG. 5, the intermediate vent port cutting out a rectangular portion surrounding the slit shown in FIG. 3. The upper side seal S is slanted toward the highest point or intermediate vent port In the examples of FIGS. 6, 7, and 8, the diaphragm 14 is in the form of a plastic sheet whose vertical width is largest at a middle. The upper side of the diaphragm sheet at the highest middle point is left unsealed to the rear sheet 11b to form a slit or intermediate vent port 20. A slit-forming portion of the upper side of the diaphragm sheet 14 is cut out in arch form in the illustrated example.
The upper side seal segments S are slanted toward the middle highest point or intermediate vent port 20 from the opposite sides.
The intermediate vent port 20 may be a slit or small opening in the diaphragm sheet 14 near its highest point.
It is seen that the vent port 18 at the top is located farthest from the inlet port 15 in the examples of FIGS. 3, 5, and 13, but on the same side as the inlet port 15 in the examples of FIGS. 6, 7, and 8. The location of the vent e i -18port 18 is not particularly limited as long as it is at the top of space 12. The blood storage space 12 preferably has an upper ridge 11g slanted toward the vent port 18 for allowing air bubbles to rise therealong. The slant ridge 11g preferably extends over at least one half of the lateral distance of the casing space Such a requirement can be met independent of whether the vent port 18 at the top is Slocated on the left or right side.
FIG. 13 shows a modified blood reservoir 10. A cardiotomy line inlet conduit 25 is connected to the casing 11 on the right side 11c above the blood inlet conduit A medication conduit 24 is connected to the casing 11 on the top side 11f near the vent port 18.
The preferred embodiments of the present invention have been described. Many modifications and variations may be added to the first embodiment as long as a blood inlet port is on at least one of the lateral sides of the container casing and a blood outlet port is on the bottom side of the casing.
Also, many modifications and variations may be added to the second embodiment as long as the casing space is divided by partition means into two compartments, a blood inlet port and a vent port are connected to one of the compartments, and a blood outlet port is connected to the other of the compartments.
Although a flexible blood reservoir has been described in the embodiments, the present invention may be applicable to a non-flexible blood reservoir if desired. In such a case, many modifications and variations are made on the location of the blood inlet and outlet ports and the vent port and the structure of the partition means.
EXAMPLE
Examples of the present invention are given below by way of illustration and not by way of limitation.
s23/3575tkk.res 92 1 22 i -19- Example 1 A blood reservoir of the two-compartment configuration shown in FIG. 5 was prepared using a pair of flexible vinyl chloride resin sheets. The reservoir had an overall interior volume of 1000 ml and a maximum blood circulating flow rate of 6 liter/min.
The inlet and outlet ports 15 and 17 were formed from flexible vinyl chloride resin tubes having an inner diameter of 10 mm. The inlet tube 15 laterally protruded 40 mm into the first compartment 13A from the right side 11c of the casing (L1 40 mm). The wall of inlet tube 15 near the inner end 15a was provided with sixteen sparging apertures 16 having a diameter of 3 mm in equally spaced-apart relation. The outlet tube 17 was connected to the bottom 15 side 11d of the casing near the right side 11c.
Oo The diaphragm 14 was a flexible vinyl chloride resin S sheet having a vertical distance of 50 mm at the left side S: o and 40 mm at the right side. The diaphragm sheet 14 near the left side was provided with twelve apertures 195 having a diameter of 5 mm.
The vent port 18 in the form of a flexible vinyl 99s chloride resin tube and the slant ridge 11 g of the space 4 were as shown in FIG. The dimensions shown in FIG. 5 had the following 25 values.
L 160 mm L1 40 mm 0 9| 9 L2 110 mm 4AJ .Oo, L3 40 mm H 230 mm H1 110 mm H2 35 mm Example 2 This is a comparative example.
L. I vigorous, air bubbles can readily rise by virtue of their buoyancy without being entrained on the stream. Upwardly collecting bubbles are then discharged to the exterior through the vent port.
4 4 A blood reservoir of the configuration shown in FIG. was prepared using a pair of flexible vinyl chloride resin sheets. The reservoir defined a single space 102 having a volume of 1000 ml and a maximum blood circulating flow rate of 6 liter/min.
The inlet and outlet ports 105 and 107 were formed from flexible vinyl chloride resin tubes having an inner diameter of 10 mm. The inlet tube 105 vertically protruded 110 mm into the space 102 from the bottom side of the casing. The wall of inlet tube 105 near the inner end 105a was provided with sixteen sparging apertures 106 having a diameter of 3 mm in symmetric relation. The outlet tube 107 was connected to the bottom side of the casing in parallel to the inlet tube 105.
15 The vent port 108 and the slant ridge of the space were approximately the same as in Example 1 So 0 Example 3 04.0 S°6 A blood reservoir of the configuration shown in FIG. 1 was prepared. The materials and size of respective elements were substantially the same as in Example 1.
44 The dimensions shown in FIG. 1 had the following o values.
SL 160 mm S° 25 LI 50 mm H 230 mm SH1 110 mm t S Experiment 1: Blood stagnation in blood reservoir Each of the blood reservoirs of Examples 1 to 3 was connected to an experimental circuit through which water was circulated at a flow rate of 4 liter/min. Black ink was introduced into the circuit line through a Luer port connector in the line upstream of the reservoir. Residence of black ink in the reservoir was observed.
L A J I j -21- In the reservoir of Example 2, black ink stagnation was observed in the shaded regions T in FIG. 15. Little or no stagnation was observed in the reservoirs of Examples 1 and 3.
Experiment 2: Debubbling Each of the blood reservoirs of Examples 1 to 3 was connected to an experimental circuit through which bovine blood was circulated at a flow rate of 4 liter/min. Air was introduced into the circuit line at a flow rate of 100 ml/min. through a Luer port connector in the line upstream of the reservoir.
A ultrasonic bubble detector (Hatteland Bd100 system) was connected to the outlet port (17 or 107) of the blood reservoir to measure the size and number of air bubbles coming out of the outlet port.
The results are shown in Table 1.
Table 1 Bubble Number of bubbles size (pm) Example 1 Example 2* Example 3 10-20 75 140 112 21-30 15 44 27 31-40 1 19 4 41-50 0 6 2 51-60 0 1 0 61-70 0 0 0 outside the scope of the invention As seen from Table 1, the blood reservoirs of the present invention exhibit significantly improved debubbling function over the prior art reservoir. The prior art blood reservoir of Example 2 should undesirably be increased in volume to increase its debubbling performance. The blood reservoirs of the present invention achieve sufficient -22debubbling in a proper volume, that is, without increasing the volume.
Examples 4 and These examples are to demonstrate the debubbling effect of means 19 in the diaphragm 14 for communicjation between two compartments.
Blood reservoirs of the configurations shown in FIGS. 7 and 8 were prepared. The materials and size of respective elements were substantially the same as in Example 1. The shape and size of the communicating means 19 are shown below.
In the reservoir of Example 4 shown in FIG. 7, the communicating means 19 was constructed by arranging ten 15 apertures 195 having a diameter of 6 mm in a zigzag fashion (somewhat different from the figure). The apertures were equally spaced 10 mm.
i In the reservoir of Example 5 shown in FIG. 8, the l communicating means 19 was constructed by forming a rectangular slit 191 of 15 mm by 30 mm at the lower side of the diaphragm sheet adjacent the left side.
‘Each of the blood reservoirs of Examples 4 and 5 was connected to an experimental circuit which was primed with 1000 ml of bovine blood. Bovine blood was circulated through the circuit at a flow rate of 4 liter/min. Air was introduced into the circuit line at a flow rate of 50 sec. (300 ml/min.) through a Luer port connector in the line upstream of the reservoir.
A ultrasonic bubble detector (Hatteland Bd100 system) was connected to the outlet port 17 of the blood reservoir to measure the size and number of air bubbles coming out of the outlet port.
The results are shown in Table 2.
I
K-
-23- Table 2 Bubble Number of bubbles size (im) Example 4 Example 11-20 60 21-30 13 31 31-40 2 41-50 0 1 As seen from Table 2, an arrangement of apertures is more effective in debubbling than a slit as the means 19 for communication between two compartments.
Examples 6 and 7 tit These examples are to demonstrate the debubbling effect 15 of an arrangement of apertures in the diaphragm 14 as the means 19 for communication between two compartments.
Blood reservoirs of the configuration shown in FIG. S were prepared. The materials and size of respective elements were sub-tantially the same as in Example 1. The communicating means 19 used were an array of eight apertures 195 each having a diameter of 6 mm.
4444 In the reservoir of Example 6, eight apertures are arranged in a vertically elongated region in a zigzag manner, more exactly in four lateral lines each containing 25 two apertures as shown in FIG. 11.
In the reservoir of Example 7, eight apertures are arranged in a laterally elongated region in a zigzag manner, 4 more exactly in fo,r vertical rows each containing two 4″ apertures as shown in FIG. 12.
Each of the blood reservoirs of Examples 6 and. 7 was connected to an experimental circuit which was primed with 1000 ml of bovine blood. Bovine blood was circulated through the circuit at a flow rate of 4 liter/min. Air was introduced into the circuit line at a flow rate of 100 sec. (600 ml/min.) through a LUer port connector in the line upstream of the reservoir.
-24- A ultrasonic bubble detector (Hatteland Bd100 system) was connected to the outlet port 17 of the blood reservoir to measure the size and number of air bubbles coming out of the outlet port.
The results are shown in Table 3.
Table 3 Bubble Number of bubbles size (Um) Example 6 Example 7 11-20 195 224 21-30 47 63 31-40 7 41-50 0 0 As seen from Table 3, an arrangement of apertures in a vertically elongated region as shown in FIG. 11 is more effective in debubbling.
A novel blood reservoir having an improved debubbling function and free of local blood stagnation has been described.
Although some preferred embodiments have been described, many modifications and variations may be made thereto in the light of the above teachings. It is therefore to be understood that within the scope of the appended claims, the invention may be practiced otherwise than as specifically described.
The claims form part of the disclosure of this specific :ion.

Claims (8)

1. A blood reservoir comprising a container casing defining a space, said casing having a generally rectangular contour in a vertical plane defining a pair of upper and lower sides and a pair of laterally opposed sides, partition means for separating the space into first and second compartments for accommodating blood, but allowing fluid communication between the first and second compartments, an inlet port in one said lateral side of said casing in communication with said first compartment, an outlet port disposed in the lower side of said casing in communication with said second compartment, and a vent port disposed in the upper side of said casing S” in communication with said first compartment.

2. A blood reservoir according to claim 1 wherein said inlet port comprises a cylindrical conduit extending side of said casing, and the portion of said conduit in the Scasing includes a closed distal end and a plurality of Iapertures formed in the cylindrical wall thereof for introducing blood into said space in a dispersed manner.

3. A blood reservoir according to claim 1, wherein 25 said upper and er sides each have a length L, said casing has a height H, said inlet port comprises a cylindrical conduit which ps23/3575tkk.res 92 1 22 i 11 26 extends into said case horizontally a distance of Li and has a centre axis spaced apart from the lower side of said casinq by a distance of HI, a centre axis of said outlet port is spaced apart from the other one of said laterally opposed sides by a distance of L2, and the following dimensional relationships are established: LI/L is in the range of about 0.1 to 0.3; L2;’L iz in the range of about 0.1 to 0.3; and HI/H is in the range of about 0,3 to 0.6,

4. A blood reservoir according to claim I wherein said ,’,toiner casing is flexible. A bIlood reservoir according to claim 1 wherein .aid inlat port is disposed in one lateral side of said casing, said outlet port is disposed in the lower side of said casing near the other lateral side.

6. A blood reservoir according to claim 1 wherein the upper side of said container casing includes a bevel portion extending toward said vent port. 1. A blood reservoir according to claim 1 wherein said contaiyer caging includes a pair of generally rectangular sheets which are sealed together along the four sides with said inlet port, said outlet port, said vent po-.t, and said partition means interposed therebetween.

8. A blood reservoir according to claim 1 wherein ps23/3575tkk.res 92 1 22 4,4

9. 449 44 a a a a a !a a abII a i An arrangement of plural apertures 19L) is preferred as i the communicating means 19 in order to effectively prevent entry of bubbles into the lower compartment 13B from the upper compartment 13A. The communicating apertures 195 are S

27- 27 said partition means includes a flexible diaphragm separating the space into the first and second compartments and means formed in said diaphragm for said fluid communication between said first and second compartments. 9. A blood reservoir according to claim 8 wherein said first compartment is vertically above said second compartment and said inlet port is disposed in one of the laterally opposed sides of said casing. A blood reservoir according to claim 9 wherein said communicating means in said diaphragm is near the other lateral side of said casing remote from the one lateral side where said inlet port is disposed. 11. A blood reservoir according to claim 8 wherein said communicating means includes a plurality of apertures formed in said diaphragm. 12. A blood reservoir according to claim 11 wherein t said diaphragm extends between said laterally opposed sides and said apertures are distributed over a region on said diaphragm near the other lateral side of said casing remote from the one lateral side where said inlet port is disposed, said region having a longer vertical distance i than a lateral distance. 13. A blood reservoir according to claim 9 wherein said outlet port is disposed in the lower side of said casing near the on, lateral side where said inlet port is disposed. 14. A blood reservoir according to claim 8 which ps23/3575tkk.res 92 1 22 I 28 further comprises an intermediate vent port disposed in said diaphragm or between said diaphragm and said casing near a vertically upper portion of said diaphragm for air communication from said second compartment to said vent port. A blood reservoir according to claim 14 wherein said Lintermediate vent port is in the form of a slit. 16. A blood reservoir according to claim 1 wherein the upper side of said container casing includes a bevel portion for said first compartment extending toward said vent port. 17. A blood reservoir according to claim 7 wherein said partition means is a flexible diaphragm extending diagonally with respect to the opposed sheets and having opposed sides sealingly afttached to said pair of sheets, ‘I respectively, for separating the space into the first and second compartments, and one side of said diaphragm S t attached to one sheet is vertically above the other side of i said diaphragm attached to the other sheet. 20 18. A blood reservoir according to claim 3, wherein I I said plurality of apertures are formed in substantially the entirs cylindrical wall of said conduit forming the inlet port within said space. 19. A blood reservoir according to claim 8, wherein said plurality of apertures are formed in substantially the entire cylindrical wall of said conduit forming the inlet port within said space. s23/35t.res 92 1 22 29 A blood reservoir substantially as hereinbefore described with reference to any one of the specific embodiments shown in Figures 1-14 of the accompanying drawings. DATED this 22 January 1992 CARTER SMITH BEADLE Fellows Institute of Patent Attorneys of Australia Patent Attorneys for the Applicant: TERUMO KABUSHIKI KAISHA Ips23/3575tkk.res 92 1 22 1

AU36674/89A
1988-06-21
1989-06-20
Blood reservoir

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JP63-153020

1988-06-21

JP15302088

1988-06-21

JP63-311590

1988-12-09

JP63311590A

JPH0622614B2
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1988-06-21
1988-12-09

Blood reservoir

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1990-01-04

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1989-06-20
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EP0350675A3
(en)

1990-01-31

EP0350675B1
(en)

1993-03-10

JPH0298364A
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1990-04-10

DE68905249D1
(en)

1993-04-15

JPH0622614B2
(en)

1994-03-30

CA1304644C
(en)

1992-07-07

DE68905249T2
(en)

1993-08-12

EP0350675A2
(en)

1990-01-17

AU3667489A
(en)

1990-01-04

US4976708A
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1990-12-11

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