AU686520B2 – Macrocyclic immunomodulators
– Google Patents
AU686520B2 – Macrocyclic immunomodulators
– Google Patents
Macrocyclic immunomodulators
Info
Publication number
AU686520B2
AU686520B2
AU64483/96A
AU6448396A
AU686520B2
AU 686520 B2
AU686520 B2
AU 686520B2
AU 64483/96 A
AU64483/96 A
AU 64483/96A
AU 6448396 A
AU6448396 A
AU 6448396A
AU 686520 B2
AU686520 B2
AU 686520B2
Authority
AU
Australia
Prior art keywords
pct
date mar
sec
formula
image
Prior art date
1991-09-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU64483/96A
Other versions
AU6448396A
(en
Inventor
Megumi Kawai
Jay R Luly
Yat Sun Or
Rolf Wagner
Paul Wiedeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1991-09-05
Filing date
1996-09-05
Publication date
1998-02-05
1996-09-05
Application filed by Abbott Laboratories
filed
Critical
Abbott Laboratories
1996-12-05
Publication of AU6448396A
publication
Critical
patent/AU6448396A/en
1998-02-05
Application granted
granted
Critical
1998-02-05
Publication of AU686520B2
publication
Critical
patent/AU686520B2/en
2012-09-08
Anticipated expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
239000002955
immunomodulating agent
Substances
0.000
title
1
229940121354
immunomodulator
Drugs
0.000
title
1
150000001408
amides
Chemical class
0.000
abstract
1
150000002148
esters
Chemical class
0.000
abstract
1
150000002678
macrocyclic compounds
Chemical class
0.000
abstract
1
239000008194
pharmaceutical composition
Substances
0.000
abstract
1
239000000651
prodrug
Substances
0.000
abstract
1
229940002612
prodrug
Drugs
0.000
abstract
1
150000003839
salts
Chemical class
0.000
abstract
1
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00
C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 – C07D477/00 in which the condensed system contains three hetero rings
C07D487/14—Ortho-condensed systems
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P17/00—Drugs for dermatological disorders
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P17/00—Drugs for dermatological disorders
A61P17/06—Antipsoriatics
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P17/00—Drugs for dermatological disorders
A61P17/08—Antiseborrheics
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P17/00—Drugs for dermatological disorders
A61P17/14—Drugs for dermatological disorders for baldness or alopecia
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P21/00—Drugs for disorders of the muscular or neuromuscular system
A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P37/00—Drugs for immunological or allergic disorders
A61P37/02—Immunomodulators
A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 – C07D507/00
C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 – C07D507/00 in which the condensed system contains three hetero rings
C07D513/14—Ortho-condensed systems
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
C07F7/02—Silicon compounds
C07F7/08—Compounds having one or more C—Si linkages
C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
C07F7/1804—Compounds having Si-O-C linkages
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
C07F9/02—Phosphorus compounds
C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Abstract
PCT No. PCT/US92/07593 Sec. 371 Date Mar. 7, 1994 Sec. 102(e) Date Mar. 7, 1994 PCT Filed Sep. 8, 1992 PCT Pub. No. WO93/04679 PCT Pub. Date Mar. 18, 1993Immunomodulatory macrocyclic compounds having the formula
AU64483/96A
1991-09-05
1996-09-05
Macrocyclic immunomodulators
Expired
AU686520B2
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
US75520891A
1991-09-05
1991-09-05
US755208
1991-09-05
Related Parent Applications (1)
Application Number
Title
Priority Date
Filing Date
AU26673/92A
Division
AU669337C
(en)
1991-09-05
1992-09-08
Macrocyclic immunomodulators
Publications (2)
Publication Number
Publication Date
AU6448396A
AU6448396A
(en)
1996-12-05
AU686520B2
true
AU686520B2
(en)
1998-02-05
Family
ID=25038171
Family Applications (2)
Application Number
Title
Priority Date
Filing Date
AU25804/92A
Abandoned
AU2580492A
(en)
1991-09-05
1992-09-08
Macrocyclic immunomodulators
AU64483/96A
Expired
AU686520B2
(en)
1991-09-05
1996-09-05
Macrocyclic immunomodulators
Family Applications Before (1)
Application Number
Title
Priority Date
Filing Date
AU25804/92A
Abandoned
AU2580492A
(en)
1991-09-05
1992-09-08
Macrocyclic immunomodulators
Country Status (12)
Country
Link
US
(1)
US5561228A
(en)
EP
(2)
EP0642516B1
(en)
JP
(2)
JP3644957B2
(en)
KR
(3)
KR100298008B1
(en)
AT
(1)
ATE218570T1
(en)
AU
(2)
AU2580492A
(en)
BR
(1)
BR1100412A
(en)
CA
(2)
CA2103454C
(en)
DE
(1)
DE69232630T2
(en)
DK
(1)
DK0642516T3
(en)
ES
(1)
ES2179823T3
(en)
WO
(2)
WO1993004680A1
(en)
Families Citing this family (31)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
US5604294A
(en)
*
1991-09-05
1997-02-18
Luly; Jay R.
Macrocyclic immunomodulators
CA2103454C
(en)
*
1991-09-05
2004-11-02
Jay R. Luly
Macrocyclic immunomodulators
US5708002A
(en)
*
1991-09-05
1998-01-13
Abbott Laboratories
Macrocyclic immunomodulators
US5563172A
(en)
*
1991-09-05
1996-10-08
Abbott Laboratories
Macrocyclic amide and urea immunomodulators
US5561137A
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*
1991-09-05
1996-10-01
Abbott Laboratories
Thio-heterocyclic macrolactam immunomodulators
US5534632A
(en)
*
1991-09-05
1996-07-09
Abbott Laboratories
Macrocyclic carbamate immunomodulators
US5604234A
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1991-09-05
1997-02-18
Abbott Laboratories
Substituted thiol macrolactam immunomodulators
HUT66531A
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1992-05-07
1994-12-28
Sandoz Ag
Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them
WO1994021642A1
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1993-03-17
1994-09-29
Abbott Laboratories
Macrocyclic amide and urea immunomodulators
CA2166892A1
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1993-07-30
1995-02-09
Yat Sun Or
Activated macrolactams having immunomodulatory activities
US5527907A
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1993-11-19
1996-06-18
Abbott Laboratories
Macrolide immunomodulators
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1993-11-30
1997-03-18
Abbott Laboratories
Macrocyclic immunomodulators with novel cyclohexyl ring replacements
WO1995015328A1
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1993-11-30
1995-06-08
Abbott Laboratories
Macrocyclic immunomodulators with novel cyclohexyl ring replacements
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1994-06-15
1999-03-09
Merck & Co., Inc.
Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
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1995-06-07
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1996-11-27
2000-06-20
Emory University
Virus-like particles, methods and immunogenic compositions
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1998-09-30
2001-10-09
The Procter & Gamble Co.
2-substituted heterocyclic sulfonamides
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1998-09-30
2002-08-13
ザ、プロクター、エンド、ギャンブル、カンパニー
2-substituted ketoamide
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1999-03-31
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Phosphate containing macrocyclic immunomodulators.
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1999-08-24
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2012-02-07
Angiotech International Ag
Drug delivery from rapid gelling polymer composition
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2003-06-18
2013-11-19
Tranzyme Pharma, Inc.
Macrocyclic antagonists of the motilin receptor
EP2583678A3
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2004-06-24
2013-11-13
Novartis Vaccines and Diagnostics, Inc.
Small molecule immunopotentiators and assays for their detection
US20060189551A1
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2004-10-04
2006-08-24
Duke University
Combination therapies for fungal pathogens
JP2007519758A
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2004-12-01
2007-07-19
テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ
Method for producing crystalline macrolide
BRPI0519593A2
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2004-12-20
2009-02-25
Wyeth Corp
methods of treating neurodegenerative disorders and complications due to stroke or trauma to the head, and of preparing a compound, and use of a compound
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惠氏公司
Rapamycin analogues and the uses thereof in the treatment of neurological disorders, proliferative diseases and inflammatory disease
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Priority date
Publication date
Assignee
Title
AU5927790A
(en)
*
1989-06-14
1991-01-08
Sandoz Ltd.
Antiinflammatory and immunosuppressant triheterocyclic FK506-like compounds and processes for their preparation
WO1991002736A1
(en)
*
1989-08-18
1991-03-07
Fisons Plc
Macrocyclic compounds
AU8010891A
(en)
*
1990-07-02
1992-01-02
Novartis Ag
Cyclopentylvinyl substituted macrolides
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1984-12-03
1990-01-16
Fujisawa Pharmaceutical Company, Ltd.
Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
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Novel immunosuppressant compound
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Novel macrocyclic compositions and new application method thereof
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Tricyclic compounds containing heteroatoms.
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Tricyclo compounds
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Immunosuppressive macrocyclic compounds
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Fujisawa Pharmaceutical Co
Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
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Fujisawa Pharmaceutical Co
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*
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Jay R. Luly
Macrocyclic immunomodulators
1992
1992-09-08
CA
CA002103454A
patent/CA2103454C/en
not_active
Expired – Lifetime
1992-09-08
KR
KR1019930703661A
patent/KR100298008B1/en
not_active
IP Right Cessation
1992-09-08
US
US08/204,252
patent/US5561228A/en
not_active
Expired – Fee Related
1992-09-08
JP
JP50547093A
patent/JP3644957B2/en
not_active
Expired – Lifetime
1992-09-08
JP
JP5505466A
patent/JPH06510304A/en
active
Pending
1992-09-08
WO
PCT/US1992/007600
patent/WO1993004680A1/en
active
IP Right Grant
1992-09-08
EP
EP92920494A
patent/EP0642516B1/en
not_active
Expired – Lifetime
1992-09-08
CA
CA002103453A
patent/CA2103453A1/en
not_active
Abandoned
1992-09-08
KR
KR1020017001157A
patent/KR100313657B1/en
not_active
IP Right Cessation
1992-09-08
KR
KR1020007004681A
patent/KR100351222B1/en
not_active
IP Right Cessation
1992-09-08
EP
EP92919705A
patent/EP0638082A1/en
not_active
Withdrawn
1992-09-08
DE
DE69232630T
patent/DE69232630T2/en
not_active
Expired – Lifetime
1992-09-08
AU
AU25804/92A
patent/AU2580492A/en
not_active
Abandoned
1992-09-08
AT
AT92920494T
patent/ATE218570T1/en
active
1992-09-08
DK
DK92920494T
patent/DK0642516T3/en
active
1992-09-08
ES
ES92920494T
patent/ES2179823T3/en
not_active
Expired – Lifetime
1992-09-08
WO
PCT/US1992/007593
patent/WO1993004679A1/en
not_active
Application Discontinuation
1996
1996-09-05
AU
AU64483/96A
patent/AU686520B2/en
not_active
Expired
1997
1997-05-02
BR
BR1100412-6A
patent/BR1100412A/en
active
IP Right Grant
Patent Citations (3)
* Cited by examiner, † Cited by third party
Publication number
Priority date
Publication date
Assignee
Title
AU5927790A
(en)
*
1989-06-14
1991-01-08
Sandoz Ltd.
Antiinflammatory and immunosuppressant triheterocyclic FK506-like compounds and processes for their preparation
WO1991002736A1
(en)
*
1989-08-18
1991-03-07
Fisons Plc
Macrocyclic compounds
AU8010891A
(en)
*
1990-07-02
1992-01-02
Novartis Ag
Cyclopentylvinyl substituted macrolides
Also Published As
Publication number
Publication date
JPH06509583A
(en)
1994-10-27
DE69232630D1
(en)
2002-07-11
CA2103454C
(en)
2004-11-02
ES2179823T3
(en)
2003-02-01
KR100313657B1
(en)
2002-03-18
EP0642516B1
(en)
2002-06-05
US5561228A
(en)
1996-10-01
EP0642516A1
(en)
1995-03-15
ATE218570T1
(en)
2002-06-15
AU2580492A
(en)
1993-04-05
BR1100412A
(en)
2000-06-06
DE69232630T2
(en)
2003-10-09
JP3644957B2
(en)
2005-05-11
CA2103454A1
(en)
1993-03-06
WO1993004679A1
(en)
1993-03-18
JPH06510304A
(en)
1994-11-17
KR100298008B1
(en)
2001-10-22
EP0642516A4
(en)
1994-06-15
AU2667392A
(en)
1993-04-05
CA2103453A1
(en)
1993-03-06
EP0638082A4
(en)
1994-06-09
KR100351222B1
(en)
2002-09-05
EP0638082A1
(en)
1995-02-15
WO1993004680A1
(en)
1993-03-18
AU669337B2
(en)
1996-06-06
AU6448396A
(en)
1996-12-05
DK0642516T3
(en)
2002-09-09
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1994-02-27
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AU679132B2
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1997-06-19
New eburnane analogues, a process for the preparation thereof and pharmaceutical compositions containing them
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1992-03-17
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1994-04-01
Benzofuranylimidazole derivatives and therapeutical compositions containing the same
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1995-06-19
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1993-07-29
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2000-02-29
Pharmaceutical compositions containing phenylurea derivatives for inhibiting leukotriene biosynthesis
IL99369A0
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1992-08-18
Pharmaceutical compositions containing substituted 2-cyclohexene derivatives
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1994-04-12
Ureido-acetamide derivatives, preparation thereof and drugs containing same
None