AU8142891A – Derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation as well as the compositions containing them
– Google Patents
AU8142891A – Derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation as well as the compositions containing them
– Google Patents
Derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation as well as the compositions containing them
Info
Publication number
AU8142891A
AU8142891A
AU81428/91A
AU8142891A
AU8142891A
AU 8142891 A
AU8142891 A
AU 8142891A
AU 81428/91 A
AU81428/91 A
AU 81428/91A
AU 8142891 A
AU8142891 A
AU 8142891A
AU 8142891 A
AU8142891 A
AU 8142891A
Authority
AU
Australia
Prior art keywords
alkyl
opt
substd
phenyl
benzofuran
Prior art date
1990-08-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU81428/91A
Other versions
AU648569B2
(en
AU648569C
(en
Inventor
Pierre Chatelain
Jean Gubin
Henri Inion
Steven Kilenyi
Jean Lucchetti
Gilbert Rosseels
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1990-08-06
Filing date
1991-07-30
Publication date
1992-02-13
1991-07-30
Application filed by Sanofi Aventis France
filed
Critical
Sanofi Aventis France
1992-02-13
Publication of AU8142891A
publication
Critical
patent/AU8142891A/en
1994-04-28
Publication of AU648569B2
publication
Critical
patent/AU648569B2/en
2000-06-01
Assigned to SANOFI-SYNTHELABO
reassignment
SANOFI-SYNTHELABO
Request to Amend Deed and Register
Assignors: SANOFI
2005-02-24
Assigned to SANOFI-AVENTIS
reassignment
SANOFI-AVENTIS
Request to Amend Deed and Register
Assignors: SANOFI-SYNTHELABO
2012-05-24
Application granted
granted
Critical
2012-05-24
Publication of AU648569C
publication
Critical
patent/AU648569C/en
2016-07-30
Adjusted expiration
legal-status
Critical
Status
Expired
legal-status
Critical
Current
Links
Espacenet
Global Dossier
Discuss
Classifications
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/06—Antiarrhythmics
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/08—Vasodilators for multiple indications
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A—HUMAN NECESSITIES
A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00—Drugs for disorders of the cardiovascular system
A61P9/12—Antihypertensives
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
C07D209/04—Indoles; Hydrogenated indoles
C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
C07D209/12—Radicals substituted by oxygen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D307/80—Radicals substituted by oxygen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
C07D333/56—Radicals substituted by oxygen atoms
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07D—HETEROCYCLIC COMPOUNDS
C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00
C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 – C07D463/00 in which the condensed system contains two hetero rings
C07D471/04—Ortho-condensed systems
Abstract
Heterocycles of formula (I) and their pharmaceutically acceptable salts are new. Het = gp. (i)-(iii), T = RRaN, R and Ra = H, 1-4C alkyl or SO2R1, R1 = 1-6C alkyl, CF3, phenyl, benzyl or benzoyl (all opt. substd.) or Ra and R1 together form a 3-6C cyclic sulphonamide, T’ = H, NO2 or RRaN, T” = benzyloxycarbonyl, T”1-OCO, T”2, T”3N.CO or NRRa, T”1, T”2 and T”3 = H or 1-4C alkyl or T”2 and T”3 together complete a 4-6C ring, X = O or S, Y = CO, CHOR5 or CH2, R5 = H, 1-4C alkyl or COR’4, R’4 = 1-4C alkyl, R1 = 1-6C alkyl or phenyl (opt. substd.), R2 = H or 1-6C alkyl, R3 =- 1-6C alkyl or R6-alk, or R2 and R3 are together a 3-6C alkylene or alkenylene (opt. substd.) and opt. interrupted by O, NH, N= or NR7, alk = bond or 1-5C alkylene, R6 = pyridyl, phenyl, phenoxy (the last 2 opt. substd. by 1 or more of halo or 1-4C alkyl or alkoxy) or 3,4-methylene dioxyphenyl, R7 = 1-4C alkyl or phenyl, R4 = H, 1-4C alkyl, R’1SO2 or R74R”4N-(CH2)m, R’1 = 1-4C alkyl, phenyl or benzyl (both opt. substd.), R’4 and R”4 = 1-4C alkyl, m = 1-3, A = O, S or NHCO. When W and W’ are each =CH- or N, Z = O or S but when W = =CH-and W’ = =CR8-, Z = -CH=CR’8-, R8 and R’8 = H, halo or 1-4C alkyl or alkoxy, n = 1-5 provided than when R4 = SO2R’1, T’ is H, NO2 or cyclised RRaN. 5 Cpds. are specifically claimed, including 2-(n-butyl)-3-(4-(3-di-n-butylamino -propoxy) benzoyl)-5-methylsulphonamido -benzofuran.
AU81428/91A
1990-08-06
1991-07-30
Derivatives of benzofuran, benzothiophene, indole and indolizine, process for their preparation as well as the compositions containing them
Expired
AU648569C
(en)
Applications Claiming Priority (2)
Application Number
Priority Date
Filing Date
Title
FR9010036
1990-08-06
FR9010036A
FR2665444B1
(en)
1990-08-06
1990-08-06
AMINO-BENZOFURAN, BENZOTHIOPHENE OR INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE COMPOSITIONS CONTAINING THEM.
Publications (3)
Publication Number
Publication Date
AU8142891A
true
AU8142891A
(en)
1992-02-13
AU648569B2
AU648569B2
(en)
1994-04-28
AU648569C
AU648569C
(en)
2012-05-24
Family
ID=
Also Published As
Publication number
Publication date
YU134891A
(en)
1994-01-20
AU648569B2
(en)
1994-04-28
BR9103354A
(en)
1992-05-05
HU211656A9
(en)
1995-12-28
IE912595A1
(en)
1992-02-12
PT98576B
(en)
1999-01-29
EP0471609A1
(en)
1992-02-19
SG49205A1
(en)
1998-05-18
HK1000108A1
(en)
1997-11-28
KR100190673B1
(en)
1999-06-01
NO913033L
(en)
1992-02-07
DE69123304T2
(en)
1997-06-12
OA09513A
(en)
1992-11-15
ES2096639T3
(en)
1997-03-16
RU2095357C1
(en)
1997-11-10
CS242791A3
(en)
1992-03-18
ATE145645T1
(en)
1996-12-15
YU48714B
(en)
1999-07-28
NO179042B
(en)
1996-04-15
EP0471609B1
(en)
1996-11-27
ZA915934B
(en)
1993-03-31
TW199095B
(en)
1993-02-01
CA2047773A1
(en)
1992-02-07
TNSN91070A1
(en)
1992-10-25
FR2665444B1
(en)
1992-11-27
GR3022593T3
(en)
1997-05-31
DE69123304D1
(en)
1997-01-09
US5223510A
(en)
1993-06-29
PT98576A
(en)
1992-06-30
NZ239232A
(en)
1993-10-26
HU218271B
(en)
2000-07-28
CZ288527B6
(en)
2001-07-11
NO913033D0
(en)
1991-08-05
CA2047773C
(en)
2000-09-12
MY107655A
(en)
1996-05-30
FI114914B
(en)
2005-01-31
PL168044B1
(en)
1995-12-30
PL291334A1
(en)
1992-10-19
HU912610D0
(en)
1992-01-28
HUT62280A
(en)
1993-04-28
JPH04316554A
(en)
1992-11-06
DK0471609T3
(en)
1997-05-26
IL98991A0
(en)
1992-07-15
NO179042C
(en)
1996-07-24
KR920004371A
(en)
1992-03-27
JP2795759B2
(en)
1998-09-10
FI913704A0
(en)
1991-08-02
FR2665444A1
(en)
1992-02-07
MA22249A1
(en)
1992-04-01
IL98991A
(en)
1995-12-08
FI913704A
(en)
1992-02-07
SK283527B6
(en)
2003-09-11
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Legal Events
Date
Code
Title
Description
2000-06-01
HB
Alteration of name in register
Owner name:
SANOFI-SYNTHELABO
Free format text:
FORMER NAME WAS: SANOFI
