GB1003494A

GB1003494A – Derivatives of iodinated benzoic acid and a process for their preparation
– Google Patents

GB1003494A – Derivatives of iodinated benzoic acid and a process for their preparation
– Google Patents
Derivatives of iodinated benzoic acid and a process for their preparation

Info

Publication number
GB1003494A

GB1003494A
GB8354/64A
GB835464A
GB1003494A
GB 1003494 A
GB1003494 A
GB 1003494A
GB 8354/64 A
GB8354/64 A
GB 8354/64A
GB 835464 A
GB835464 A
GB 835464A
GB 1003494 A
GB1003494 A
GB 1003494A
Authority
GB
United Kingdom
Prior art keywords
alkyl
acid
reacting
alcohol
carbon atoms
Prior art date
1963-03-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB8354/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

STWB Inc

Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-03-01
Filing date
1964-02-28
Publication date
1965-09-02

1964-02-28
Application filed by Sterling Drug Inc
filed
Critical
Sterling Drug Inc

1965-09-02
Publication of GB1003494A
publication
Critical
patent/GB1003494A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings

C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms

C07D307/12—Radicals substituted by oxygen atoms

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS

C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids

C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring

Abstract

The invention comprises compounds of formula where R represents an alkyl, alkenyl, alkoxy-alkyl, alkylthio – alkyl or tetrahydrofurfuryl group, containing 1-8 carbon atoms, R1 is hydrogen or an alkoxy group having 1-4 carbon atoms, n is 2-7 and the iodine atom is in the meta or para position with regard to the carboxyl group, which are prepared either by reacting a substituted benzoyl halide with the ester of a hydroxy acid in the presence of a base, or by reacting the metal salt of a substituted benzoic acid with the ester of a halo acid. The hydroxy acid esters may be prepared by reacting the appropriate lactone and alcohol in the presence of sodium hydroxide. The halo-acid esters may be prepared by esterification of the appropriate acid with an alcohol, by reacting the appropriate lactone and alcohol in the presence of a hydrogen halide, or by reacting a halo-acid nitrile with an alcohol in the presence of sulphuric acid.ALSO:X-ray contrast media particularly applicable as myelographic agents comprise compounds of formula in which R represents an alkyl, alkenyl, alkoxy-alkyl alkylthio-alkyl or tetrahydrofurfuryl group, containg 1-8 carbon atoms, R1 is hydrogen or an alkoxy group having 1-4 carbon atoms n is 2-7, and the iodine atom is in the meta or para position with respect to the carboxyl group, and a carrier.

GB8354/64A
1963-03-01
1964-02-28
Derivatives of iodinated benzoic acid and a process for their preparation

Expired

GB1003494A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

US262186A

US3317569A
(en)

1963-03-01
1963-03-01
Esters of monoiodinated benzoyloxyalkanoic acids

Publications (1)

Publication Number
Publication Date

GB1003494A
true

GB1003494A
(en)

1965-09-02

Family
ID=22996527
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB8354/64A
Expired

GB1003494A
(en)

1963-03-01
1964-02-28
Derivatives of iodinated benzoic acid and a process for their preparation

Country Status (3)

Country
Link

US
(1)

US3317569A
(en)

BE
(1)

BE654785A
(en)

GB
(1)

GB1003494A
(en)

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4321368A
(en)

*

1975-10-20
1982-03-23
Mallinckrodt, Inc.
Glycosyl triidobenzoic acid derivatives

Families Citing this family (5)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4284619A
(en)

*

1978-11-29
1981-08-18
Medi-Physics, Inc.
Esters useful as brain imaging agents

US5322679A
(en)

*

1992-12-16
1994-06-21
Sterling Winthrop Inc.
Iodinated aroyloxy esters

US5312616A
(en)

*

1993-03-11
1994-05-17
Sterling Winthrop Inc.
Compositions of iodobenzoic acid derivatives in film-forming materials for visualization of the gastrointestinal tract

US5484585A
(en)

*

1993-03-11
1996-01-16
Sterling-Winthrop Inc.
Compositions of iodobenzoic acid derivatives and pharmaceutically acceptable clays for visualization of the gastrointestinal tract

DE4339208A1
(en)

*

1993-11-17
1995-05-18
Hoechst Ag

Process for the preparation of alkyl fluorobenzoates in high purity and yield

Family Cites Families (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3013052A
(en)

*

1958-11-19
1961-12-12
Velsicol Chemical Corp
2-methoxy-3-methyl-5-chloro-6-nitrobenzoates

US3073848A
(en)

*

1958-10-14
1963-01-15
Wasson Burton Kendall
Tetrahydrofurfuryl carbamates

US3097229A
(en)

*

1960-03-04
1963-07-09
Monsanto Chemicals
Cycloaliphatic chlorocarbanilates

US3014927A
(en)

*

1960-10-05
1961-12-26
Merck & Co Inc
Monoesters of tetrahydrofuran glycol

1963

1963-03-01
US
US262186A
patent/US3317569A/en
not_active
Expired – Lifetime

1964

1964-02-28
GB
GB8354/64A
patent/GB1003494A/en
not_active
Expired

1964-10-23
BE
BE654785D
patent/BE654785A/xx
unknown

Cited By (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US4321368A
(en)

*

1975-10-20
1982-03-23
Mallinckrodt, Inc.
Glycosyl triidobenzoic acid derivatives

Also Published As

Publication number
Publication date

BE654785A
(en)

1965-04-23

US3317569A
(en)

1967-05-02

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