GB1037019A

GB1037019A – New derivatives of 4,9-dihydrothieno-(2,3-b) benzo(e)-thiepine, and a method of preparing same
– Google Patents

GB1037019A – New derivatives of 4,9-dihydrothieno-(2,3-b) benzo(e)-thiepine, and a method of preparing same
– Google Patents
New derivatives of 4,9-dihydrothieno-(2,3-b) benzo(e)-thiepine, and a method of preparing same

Info

Publication number
GB1037019A

GB1037019A
GB35613/64A
GB3561364A
GB1037019A
GB 1037019 A
GB1037019 A
GB 1037019A
GB 35613/64 A
GB35613/64 A
GB 35613/64A
GB 3561364 A
GB3561364 A
GB 3561364A
GB 1037019 A
GB1037019 A
GB 1037019A
Authority
GB
United Kingdom
Prior art keywords
formula
alkyl
dihydrothieno
benzo
acid
Prior art date
1963-08-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB35613/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Spofa Sdruzeni Podniku Pro Zdravotnickou Vyrobu

Spofa Vereinigte Pharma Werke

Original Assignee
Spofa Sdruzeni Podniku Pro Zdravotnickou Vyrobu
Spofa Vereinigte Pharma Werke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-08-31
Filing date
1964-08-31
Publication date
1966-07-20

1964-08-31
Application filed by Spofa Sdruzeni Podniku Pro Zdravotnickou Vyrobu, Spofa Vereinigte Pharma Werke
filed
Critical
Spofa Sdruzeni Podniku Pro Zdravotnickou Vyrobu

1966-07-20
Publication of GB1037019A
publication
Critical
patent/GB1037019A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms

C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

C07D495/04—Ortho-condensed systems

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings

C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom

C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

C07D333/30—Hetero atoms other than halogen

C07D333/34—Sulfur atoms

Abstract

The invention comprises compounds of the formula wherein R and R1 each represents a hydrogen or halogen atom or a C1- 4 alkyl, alkoxy, alkyl-mercapto or trifluoromethyl group, R1, R2 and R3 represent hydrogen atoms or C1- 4 alkyl groups, in which case NXX1 represents a residue of a C1- 4 aliphatic or saturated heterocyclic amine with 2 to 6 carbon atoms, or each of two of R1, R2 and R3 represents a hydrogen atom, and the third one together with X repesents a straight chain C2- 4 alkylene group and X1 represents a C1- 4 alkyl group; acid addition and quaternary ammonium salts thereof; and a process for their preparation comprising reacting a phthalide of the formula with a 2-mercaptothiophene of the formula to form a 2-(2-thienylmercaptomethyl)-benzoic acid of the formula cyclizing the acid, by the action of poly-phosphoric acid, to a 4,9-dihydrothieno-(2,3-b)-benzo(e)thiepin-4-one of the formula reacting the ketone with a Grignard reagent of the formula ClMgCHR1-CHR2-CHR3-NXX1 to obtain a tertiary alcohol of the formula and dehydrating the tertiary alcohol.

GB35613/64A
1963-08-31
1964-08-31
New derivatives of 4,9-dihydrothieno-(2,3-b) benzo(e)-thiepine, and a method of preparing same

Expired

GB1037019A
(en)

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

CS485063

1963-08-31

Publications (1)

Publication Number
Publication Date

GB1037019A
true

GB1037019A
(en)

1966-07-20

Family
ID=5392157
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB35613/64A
Expired

GB1037019A
(en)

1963-08-31
1964-08-31
New derivatives of 4,9-dihydrothieno-(2,3-b) benzo(e)-thiepine, and a method of preparing same

Country Status (10)

Country
Link

US
(1)

US3519648A
(en)

AT
(1)

AT246170B
(en)

BE
(1)

BE652495A
(en)

CH
(1)

CH469729A
(en)

DE
(1)

DE1239704B
(en)

DK
(1)

DK107103C
(en)

FI
(1)

FI42576B
(en)

GB
(1)

GB1037019A
(en)

NL
(1)

NL139530B
(en)

SE
(1)

SE323691B
(en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3971806A
(en)

*

1974-05-09
1976-07-27
Warner-Lambert Company
Indolothiopyrones

US4025640A
(en)

*

1975-08-26
1977-05-24
American Hoechst Corporation
Oxothienobenzoxepin-acetic acids, precursors and derivatives thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

LU39637A1
(en)

*

1960-01-13

BE607503A
(en)

*

1960-08-26
1962-02-26
Sandoz Sa

New derivatives of homothiaxanthene and their preparation.

NL279409A
(en)

*

1961-06-08

US3306897A
(en)

*

1964-06-08
1967-02-28
Sandoz Ltd
Thieno-benzothiopyran derivatives

1964

1964-08-26
CH
CH1115964A
patent/CH469729A/en
unknown

1964-08-27
DK
DK422264AA
patent/DK107103C/en
active

1964-08-28
FI
FI1834/64A
patent/FI42576B/fi
active

1964-08-29
DE
DES92895A
patent/DE1239704B/en
active
Pending

1964-08-31
SE
SE10450/64A
patent/SE323691B/xx
unknown

1964-08-31
GB
GB35613/64A
patent/GB1037019A/en
not_active
Expired

1964-08-31
NL
NL646410097A
patent/NL139530B/en
unknown

1964-08-31
AT
AT749064A
patent/AT246170B/en
active

1964-08-31
BE
BE652495D
patent/BE652495A/xx
unknown

1968

1968-11-04
US
US774584A
patent/US3519648A/en
not_active
Expired – Lifetime

Also Published As

Publication number
Publication date

SE323691B
(en)

1970-05-11

AT246170B
(en)

1966-04-12

BE652495A
(en)

1964-12-16

US3519648A
(en)

1970-07-07

DK107103C
(en)

1967-04-24

NL139530B
(en)

1973-08-15

DE1239704B
(en)

1967-05-03

NL6410097A
(en)

1965-03-01

FI42576B
(en)

1970-06-01

CH469729A
(en)

1969-03-15

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