GB1040891A - Creation of Inventions and Patents with Artificial Intelligence

GB1040891A – Novel process for 3-oxo-í¸-steroids
– Google Patents

GB1040891A – Novel process for 3-oxo-í¸-steroids
– Google Patents
Novel process for 3-oxo-í¸-steroids

Info

Publication number
GB1040891A

GB1040891A
GB38682/63A
GB3868263A
GB1040891A
GB 1040891 A
GB1040891 A
GB 1040891A
GB 38682/63 A
GB38682/63 A
GB 38682/63A
GB 3868263 A
GB3868263 A
GB 3868263A
GB 1040891 A
GB1040891 A
GB 1040891A
Authority
GB
United Kingdom
Prior art keywords
steroids
oxo
rings
carbon atoms
general formula
Prior art date
1963-10-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB38682/63A
Inventor
Hugh Latimer Dryden
Max John Kalm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

GD Searle LLC

Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-10-01
Filing date
1963-10-01
Publication date
1966-09-01

Priority to DENDAT1250818D
priority
Critical
patent/DE1250818B/en

1963-10-01
Application filed by GD Searle LLC
filed
Critical
GD Searle LLC

1963-10-01
Priority to GB38682/63A
priority
patent/GB1040891A/en

1964-09-30
Priority to US400560A
priority
patent/US3270008A/en

1964-10-01
Priority to FR990067A
priority
patent/FR1499857A/en

1966-09-01
Publication of GB1040891A
publication
Critical
patent/GB1040891A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol

A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J75/00—Processes for the preparation of steroids in general

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07J—STEROIDS

C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Abstract

3-Oxo-D 4,6-steroids in which rings A and B have the general formula are obtained by contacting the appropriate D 5-steroid starting material in which rings A and B have the general formula wherein A is hydrogen, an alkyl radical containing 1-6 carbon atoms or an alkanoyl radical containing 2-7 carbon atoms, and the wavy lines indicate alternate a – and b -configurations, with a minimum of approximately 4 gramatoms of bromine per mole of starting material in the presence of a hydrogen bromide acceptor and a reaction solvent which is relatively inert to the reactants. Preferably an inorganic bromide salt is also present. As solvents ethers and N-substituted amides may be used. Alkali metal and alkaline earth metal carbonates and aromatic bases are suitable hydrogen bromide acceptors.

GB38682/63A
1963-10-01
1963-10-01
Novel process for 3-oxo-í¸-steroids

Expired

GB1040891A
(en)

Priority Applications (4)

Application Number
Priority Date
Filing Date
Title

DENDAT1250818D

DE1250818B
(en)

1963-10-01

Process for the production of 3-oxozl4.asteroids

GB38682/63A

GB1040891A
(en)

1963-10-01
1963-10-01
Novel process for 3-oxo-í¸-steroids

US400560A

US3270008A
(en)

1963-10-01
1964-09-30
Novel process for 3-oxo-delta4, 6 steroids

FR990067A

FR1499857A
(en)

1963-10-01
1964-10-01

New process for preparing 3-oxo-delta4. 6-steroids

Applications Claiming Priority (1)

Application Number
Priority Date
Filing Date
Title

GB38682/63A

GB1040891A
(en)

1963-10-01
1963-10-01
Novel process for 3-oxo-í¸-steroids

Publications (1)

Publication Number
Publication Date

GB1040891A
true

GB1040891A
(en)

1966-09-01

Family
ID=10405020
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB38682/63A
Expired

GB1040891A
(en)

1963-10-01
1963-10-01
Novel process for 3-oxo-í¸-steroids

Country Status (4)

Country
Link

US
(1)

US3270008A
(en)

DE
(1)

DE1250818B
(en)

FR
(1)

FR1499857A
(en)

GB
(1)

GB1040891A
(en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3492292A
(en)

1966-04-21
1970-01-27
Merck & Co Inc
20-spirox-4,6-dien-3-one aldosterone inhibitors

US3682894A
(en)

1970-02-24
1972-08-08
Searle & Co
Process for preparing 3-oxo-delta4,6-steroids

CH612953A5
(en)

1975-06-13
1979-08-31
Ciba Geigy Ag
Process for the preparation of steroid carbolactones

CH631462A5
(en)

1976-03-05
1982-08-13
Schering Ag

METHOD FOR PRODUCING NEW STEROIDS OF THE ANDROSTANE OR OESTRANE SERIES.

DE
DENDAT1250818D
patent/DE1250818B/en
active
Pending

1963

1963-10-01
GB
GB38682/63A
patent/GB1040891A/en
not_active
Expired

1964

1964-09-30
US
US400560A
patent/US3270008A/en
not_active
Expired – Lifetime

1964-10-01
FR
FR990067A
patent/FR1499857A/en
not_active
Expired

Also Published As

Publication number
Publication date

DE1250818B
(en)

1967-09-28

US3270008A
(en)

1966-08-30

FR1499857A
(en)

1967-11-03

Información de contacto