GB1044406A - Creation of Inventions and Patents with Artificial Intelligence

GB1044406A – 7-acylaminocephalosporanic acids and salts thereof
– Google Patents

GB1044406A – 7-acylaminocephalosporanic acids and salts thereof
– Google Patents
7-acylaminocephalosporanic acids and salts thereof

Info

Publication number
GB1044406A

GB1044406A
GB12377/64A
GB1237764A
GB1044406A
GB 1044406 A
GB1044406 A
GB 1044406A
GB 12377/64 A
GB12377/64 A
GB 12377/64A
GB 1237764 A
GB1237764 A
GB 1237764A
GB 1044406 A
GB1044406 A
GB 1044406A
Authority
GB
United Kingdom
Prior art keywords
ureido
cephalosporanic acid
cephalosporanic
chloropropyl
salts
Prior art date
1963-04-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired

Application number
GB12377/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BASF Schweiz AG

Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
1963-04-03
Filing date
1964-03-24
Publication date
1966-09-28

1964-03-24
Application filed by Ciba AG
filed
Critical
Ciba AG

1966-09-28
Publication of GB1044406A
publication
Critical
patent/GB1044406A/en

Status
Expired
legal-status
Critical
Current

Links

Espacenet

Global Dossier

Discuss

Classifications

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

C07D501/14—Compounds having a nitrogen atom directly attached in position 7

C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3

C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group

A—HUMAN NECESSITIES

A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE

A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES

A61K31/00—Medicinal preparations containing organic active ingredients

A61K31/33—Heterocyclic compounds

A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins

A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame

A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems

A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

C—CHEMISTRY; METALLURGY

C07—ORGANIC CHEMISTRY

C07D—HETEROCYCLIC COMPOUNDS

C07D501/14—Compounds having a nitrogen atom directly attached in position 7

C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3

C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group

C07D501/28—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms

F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING

F21—LIGHTING

F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR

F21V7/00—Reflectors for light sources

F21V7/10—Construction

F21V7/18—Construction with provision for folding or collapsing

Abstract

The invention relates to antibacterial 7-acylamino -cephalosporanic acids of formula in which A is C1- 6 alkyl, substituted by in which A is C1- 6 alkyl, substituted by C1- 6 alkoxy, halogen C1- 6 alkoxy, halogen cycloalkyl or by one or more halogen atoms; and a salt thereof. Typical compounds are 7-[N1-(b -chloroethyl) – ureido] – cephalosporanic acid; 7 – [N1 – (11 – methyl – 21 – chloropropyl) – ureido]-cephalosporanic acid; 7-[N1-(g -chloropropyl)-ureido] -cephalosporanic acid; 7 – [N1 – (21-chloropropyl) – ureido] – cephalosporanic acid; 7 – [N1 – (11:11 – dimethyl – 21 – chloroethyl)-ureido]-cephalosporanic acid; and 7-[N1-(21:31-dichloropropyl) -ureido] – cephalosporanic acid. Salts may be alkali metal, alkaline earth metal, and tertiary organic nitrogen base salts, e.g. alkoxy, halogen C1- 6 alkoxy, halogen cycloalkyl or by one or more halogen atoms; and a salt thereof. Typical compounds are 7-[N1-(b -chloroethyl) – ureido] – cephalosporanic acid; 7 – [N1 – (11 – methyl – 21 – chloropropyl) – ureido]-cephalosporanic acid; 7 – [N1 – (21-chloropropyl) – ureido] – cephalosporanic acid; 7 – [N1 – (11:11 – dimethyl – 21 acid; and 7-[N1-(21:31-dichloropropyl) – ureido] – cephalosporanic acid. – chloroethyl)-ureido]-cephalosporanic Salts may be alkali metal, alkaline earth metal, and tertiary organic nitrogen base salts, e.g. triethylamine and N-ethylpiperidine salt. The compounds are prepared by reacting an isocyanate of formula A-N=C=O in which A has the meaning given above, with a quaternary salt of 7-amino-cephalosporanic acid with a strong organic nitrogeneous base, e.g. triethylamine. 2:2:3:3 – Tetrafluorocyclobutyl methyl isocyanate is prepared by treating 2:2:3:3-tetrafluorocyclobutylamine hydrochloride with phosgene in a solvent. The 7-acylaminocephalosporanic acids and their physiologically tolerable salts in admixture with an adjuvant may be used as tablets, dragees, capsules, solutions, suspensions, emulsions, ointments and injections.

GB12377/64A
1963-04-03
1964-03-24
7-acylaminocephalosporanic acids and salts thereof

Expired

GB1044406A
(en)

Applications Claiming Priority (4)

Application Number
Priority Date
Filing Date
Title

CH424563A

CH448090A
(en)

1963-04-03
1963-04-03

Process for the preparation of new derivatives of 7-amino-cephalosporanic acid

CH1227363

1963-10-04

CH240564A

CH476761A
(en)

1963-04-03
1964-02-27

Process for the preparation of new derivatives of 7-amino-cephalosporanic acid

BE646035A

BE646035A
(en)

1963-04-03
1964-04-02

Publications (1)

Publication Number
Publication Date

GB1044406A
true

GB1044406A
(en)

1966-09-28

Family
ID=27424761
Family Applications (1)

Application Number
Title
Priority Date
Filing Date

GB12377/64A
Expired

GB1044406A
(en)

1963-04-03
1964-03-24
7-acylaminocephalosporanic acids and salts thereof

Country Status (8)

Country
Link

US
(1)

US3264291A
(en)

BE
(1)

BE646035A
(en)

BR
(1)

BR6458041D0
(en)

CH
(2)

CH448090A
(en)

DE
(1)

DE1745612B1
(en)

GB
(1)

GB1044406A
(en)

NL
(1)

NL143237B
(en)

SE
(1)

SE309987B
(en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

US3882100A
(en)

1972-09-22
1975-05-06
Squibb & Sons Inc
Derivatives of 6-amino penicillanic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party

Publication number
Priority date
Publication date
Assignee
Title

DE1120072B
(en)

1960-03-03
1961-12-21
Hoechst Ag

Process for the preparation of optionally N-substituted 6- [ureido-N ‘] – penicillanic acids in submerged culture

DE1141640B
(en)

1960-03-19
1962-12-27
Hoechst Ag

Process for the preparation of acyl derivatives of 6-ureido-penicillanic acids

US3173916A
(en)

1960-06-28
1965-03-16
Pfizer & Co C
Derivatives of 7-aminocephalosporanic acid

1963

1963-04-03
CH
CH424563A
patent/CH448090A/en
unknown

1964

1964-02-27
CH
CH240564A
patent/CH476761A/en
unknown

1964-03-18
US
US352965A
patent/US3264291A/en
not_active
Expired – Lifetime

1964-03-24
GB
GB12377/64A
patent/GB1044406A/en
not_active
Expired

1964-03-28
DE
DE19641745612
patent/DE1745612B1/en
active
Pending

1964-04-02
NL
NL646403526A
patent/NL143237B/en
unknown

1964-04-02
BE
BE646035A
patent/BE646035A/xx
unknown

1964-04-02
BR
BR158041/64A
patent/BR6458041D0/en
unknown

1964-04-02
SE
SE4074/64A
patent/SE309987B/xx
unknown

Also Published As

Publication number
Publication date

CH448090A
(en)

1967-12-15

CH476761A
(en)

1969-08-15

SE309987B
(en)

1969-04-14

NL143237B
(en)

1974-09-16

US3264291A
(en)

1966-08-02

BE646035A
(en)

1964-10-02

NL6403526A
(en)

1964-10-05

DE1745612B1
(en)

1970-11-12

BR6458041D0
(en)

1973-07-17

Contact information